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siRNA therapeutics:a clinical reality

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Science China(Life Sciences) 2020年第4期63卷 485-500页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan School of Medicine Breast SurgeryGuangzhou 510080China

Since the revolutionary discovery of RNA interference(RNAi),a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism;especially in small interfering RNA(siRNA)*** its tremendous potential benefits,major challenges in most siRNA therapeutics remains unchanged-safe,efficient and target oriented delivery of *** years after the discovery of RNAi,siRNA therapeutics finally charts its way into *** we journey through the decades,we reminisce the history of siRNA discovery and its application in a myriad of disease ***,we highlight the breakthroughs in si RNA therapeutics,with special feature on the first FDA approved RNAi therapeutics Onpattro(Patisiran)and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical ***,we present some challenges and multiple barriers that are yet to be fully overcome in siRNA therapeutics.

关键词： siRNA therapeutic disease treatment systemic siRNA delivery clinical application

Phage display screening of therapeutic peptide for cancer targeting and therapy

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Protein & Cell 2019年第11期10卷 787-807页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Recently,phage display technology has been announced as the recipient of Nobel Prize in Chemistry *** display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process;proving to be a powerful technique in the screening of peptide with high affinity and *** this review,we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ,in vitro,in vivo,and ex vivo screening *** will then discuss prominent examples of solid tumor targeting-peptides;namely peptide targeting tumor vasculature,tumor microenvironment(TME)and overexpressed receptors on cancer cells identified through phage display *** will also discuss the current challenges and future outlook for targeting peptidebased therapeutics in the clinics.

关键词： phage display tumor targeting peptide,tumor vasculature tumor microenvironment tumor stromal cells over-expressed receptor

Simple Traits among Diaspore Weight/Number,Plant Height and Ability of Vegetative Propagation

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Journal of Integrative Plant Biology 2008年第12期50卷 1563-1569页

作者： Bozena erá Institute of Systems Biology and Ecology Academy of Sciences of the Czech Republiceské Budějovice 37005

Several expected correlations among followed internal plant traits were confirmed using the dataset of 492 herbaceous species from the temporal zone of Central Europe. Average diaspore weight （seed mass）, reproductive capacity of population （number of produced diaspores）, species height, and ability of lateral spread were the plant traits considered. The evident correlations were confirmed among all investigated traits：（i） The reproductive capacity of population negatively correlated with diaspore weight, plant height, and vegetative propagation. The diaspore weight and their number are closely correlated and co-adapted. （ii） Bigger plant species produce bigger diaspores. These trends are obvious at the inter- and intra-family levels. （iii） Larger plant species showed higher ability to vegetative propagation.

关键词： comparison lateral spread reproduction seed production seed weight strategy trade-off.

New Physicochemical Treatment Method of Poppy Seeds for Agriculture and Food Industries

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Plasma Science and Technology 2013年第9期15卷 935-938页

作者： Bozena er Iveta GAJDOV Michal er'Y Petr PATENKA Institute of Nanobiology and Structural Biology GCRC Academy of Sciences of the Czech RepublicDepartment of NanobiotechnologyNa Sadkach 7Ceske Budejovicecz-37005Czech Republic Department of Biology Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic Department of Applied Physics and Technics Faculty of EducationUniversity of South Bohemia in Ceske BudejoviceJeronymova 10Ceske Budejovicecz-37115Czech Republic

Poppy seeds （Papaver somniferum L.） are often attacked by various fungal dis- eases, and their field germination rate is low. The aim of this experiment was to increase the germination rate and growth of seedlings by modifying the poppy seeds using cold plasma dis- charge. The seeds were treated in a Plasonic AR-550-M under power of 500 W with argon gas flow of 50 mL/min, oxygen gas flow of 50 mL/min for different time durations in seconds （0, 180, 300, 600, 1800, 3000, 4200, and 5400）. The seed germination rate and growth of the seedlings were recorded. Cold plasma positively affected the seed germination rate for time exposure between 180～3000 s. Seedling acceleration on the sixth day of the experiment showed the highest values at exposure 180～600 s. Cold plasma seems to be a good physicochemical way to modify seeds without chemical agronomical application.

关键词： biotechnology early growth low-pressure discharge Papaver somniferum,seed modification seed germination

Gravitational lensing properties of an isothermal universal halo profile

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Research in Astronomy and Astrophysics 2013年第5期13卷 517-525页

作者： Xin-Zhong er National Astronomical Observatories Chinese Academy of Sciences

N-body simulations predict that dark matter halos with different mass scales are described by a universal model, the Navarro-Frenk-White （NFW） den- sity profiles. As a consequence of baryonic cooling effects, these halos will become more concentrated, and similar to an isothermal sphere over a large range in radii （～ 300 h-1 kpc）. The singular isothermal sphere （SIS） model however has to be trun- cated artificially at large radii since it extends to infinity. We model a massive galaxy halo as a combination of an isothermal sphere and an NFW density profile. We give an approximation for the mass concentration at different baryon fractions and present exact expressions for the weak lensing shear and flexion for such a halo. We compare the lensing properties with the SIS and NFW profiles. We find that the combined pro- file can generate higher order lensing signals at small radii and is more efficient in generating strong lensing events. In order to distinguish such a halo profile from the SIS or NFW profiles, one needs to combine strong and weak lensing constraints for small and large radii.

关键词： gravitational lensing -- galaxies: halos -- cosmology: dark matter

Study of the Structural Evolution of the Babadag-Honaz and Pamukkale Fault Zones and the Related Earthquake Risk Potential of the Buldan Region in SW Anatolia, East of the Mediterranean

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Journal of Earth Science 2013年第3期24卷 397-409页

作者： Mete Han er Geological Engineering Department Pamukkale University

Denizli graben （DG） is bounded in the NE by the Pamukkale fault zone and in the SW by the Babadag-Honaz fault zone. The Babada and Honaz fault zones are generally made up as nearly E-W directed two segments. The Pamukkale fault also contains many overlapping segments in the Denizli area along the NE margin of the graben. The DG contains an NW-SE trending horst （Karakova） controlled by normal faults with oppositely dipping high angles and that truncate the Plio-Quaternary rock units. The faults that bound the DG are likely to have been initiated during the Early to Late Miocene and appear to be active today. The faults of the DG are active and the potential energy that accumulates in them is easily conducted to the other faults that they come in contact with. This signifies that a movement in one of the faults forming the grabens in the Denizli region affects the other structures as well. Earthquakes in the Buldan region usually occur 2-3 years after seismical movements occur in the Denizli Basin. The Buldan region is a ridge between DG and Ala ehir graben （ALG）. Based on the fact that DG in its south and ALG in its north move seismically, there is a probability that a break would appear in the Buldan region in the near future.

关键词： Denizli Turkey Anatolia Pamukkale graben fault.

Non-coding RNAs:the new central dogma of cancer biology

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Science China(Life Sciences) 2021年第1期64卷 22-50页

作者： Phei er Saw Xiaoding Xu Jianing Chen er-Wei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China

The central dogma of molecular biology states that the functions of RNA revolve around protein *** the last decade,most researches were geared towards characterization of RNAs as intermediaries in protein translation,namely,messenger RNAs(mRNAs)as temporary copies of genetic information,ribosomal RNAs(rRNAs)as a main component of ribosome,or translators of codon sequence(t RNAs).The statistical reality,however,is that these processes account for less than 2%of the genome,and insufficiently explain the functionality of 98%of transcribed *** discoveries have unveiled thousands of unique non-coding RNAs(ncRNAs)and shifted the perception of them from being"junk"transcriptional products to"yet to be elucidated"—and potentially monumentally important—*** ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and *** major cancers,ncRNAs have been identified as both oncogenic drivers and tumor suppressors,indicating a complex regulatory network among these ***,we provide a comprehensive review of the various ncRNAs and their functional roles in cancer,and the pre-clinical and clinical development of nc RNA-based therapeutics.A deeper understanding of ncRNAs could facilitate better design of personalized therapeutics.

关键词： non-coding RNAs anti-cancer therapeutics personalized intervention miRNA lncRNA circRNA

Jacobi Elliptic Function Solutions of Some Nonlinear Evolution Equations

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Communications in Theoretical Physics 2006年第5X期46卷 804-806页

作者： YE Cai-er Department of Mathematics Zhejiang Forestry University Lin'an 311300 China

In this letter, the modified Jacob/elliptic function expansion method is extended to solve M-coupled KdV equation, M-coupled Ito equation, vKdV equation, and AKNS equation. Some new Jacob/elliptic function solutions are obtained by using Mathematica. When the modulus m→1, those periodic solutions degenerate as the corresponding soliton solutions.

关键词： KdV equation Ito equation vKdV equation AKNS equation exact solution

New Exact Solutions of Multi-component mKdV Equation

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Communications in Theoretical Physics 2006年第5期45卷 777-780页

作者： YE Cai-er Department of Mathematics Zhejiang Forestry College Lin＇an 311300 China

In this paper, new Jacobi elliptic function solutions of multi-component mKdV equation are obtained directly in a unified way. When the modulus m → 1, those periodic solutions degenerate as the corresponding hyperbolic function solutions. Then, to the three-component mKdV equation, five types of effective solution are presented in detail.

关键词： multi-component mKdV equation exact solution Jacobi elliptic function hyperbolic function