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Im.act of Thyroglobulin on Survival and Prognosis of Differentiated Thyroid Cancer

Journal of Cancer Therapy 2018年第9期9卷 706-713页

作者： Hanan Ahm.d Wahba Hend Ahm.d El-Hadaad abeer.hussien anter.alaa m. wafa Ahm.d Negm Clinical Oncology & Nuclear m.dicine Departm.nt Faculty of Medicine Mansoura University Hospital Mansoura Egypt Internal m.dicine Departm.nt Faculty of Medicine Mansoura University Hospital Mansoura Egypt General Surgery Departm.nt Faculty of Medicine Mansoura University Hospital Mansoura Egypt

Proper assessm.nt of risk factors contributes to the principle m.nagem.nt of differentiated thyroid carcinom. post operatively. Aim.of the study: to investigate the effect of Thyroglobulin (Tg) levels on prognosis together with other risk factors for Differentiated Thyroid Cancer (DTC). Patients and m.thods: m.dical records of all patients with DTC presented to Clinical Oncology and Nuclear m.dicine Departm.nt referred from.Diabetes & Endocrine unit (Internal m.dicine Hospital) and Surgery Departm.nt m.nsoura University from.2011-2016 were retrospectively reviewed. Patients with distant m.tastasis or who lost follow-up were excluded. So data of 220 patients were analyzed. Data collected included pre-surgical assessm.nt, also surgical interference either total or near total thyroidectom. with or without lym.h node neck dissection were reviewed. Different prognostic factors that affect progression free survival (PFS) include age, um.rsize, ym.h node status, ex, m.ltifocality, capsular infiltration, vascular invasion and Tg level were evaluated through m.ltivariate analysis. Results: m.st of the patients included were m.le (80%) with papillary type predom.nance (80.9%). About 59.5% of cases presented with tum.r size ≤ 2 cm.and m.ltifocality was reported in 13.6%. While 30% had lym.h node m.tastasis, 11% had vascular invasion. Capsular infiltration was observed in 15% and m.st of them.showed Tg level ≤ 10 ng/m. (68.2%). About 70% received ablative radioiodine. The 5-year Progression Free Survival (PFS) was 85%. On m.ltivariate analysis of variable prognostic factors on PFS, we found that tum.r size, age, lym.h node status, capsular infiltration, Tg level and vascular invasion significantly affected PFS (P = 0.01, 0.005, 0.004, 0.005, 0.02, 0.003) respectively. While sex, pathological type and m.ltifocality were not (P = 0.9, 0.4, 0.6) respectively. Conclusion: Postoperative Tg level is a statistically significa

关键词： Thyroglobulin Thyroid Cancer Differentiated Thyroid Cancer Risky Factors

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