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Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model

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Neural Regeneration Research 2015年第2期10卷 266-270页

作者： Ibrahim Erkutlu Mehmet Alptekin Sirma geyik Abidin Murat geyik Inan gezgin abdulvahap g?k Department of Neurosurgery Faculty of Medicine University of Gaziantep Department of Neurology Faculty of Medicine University of Gaziantep Department of Neurosurgery Sanko University Department of Neurosurgery Private Park Hospital

Injury to peripheral nerves during injections of therapeutic agents such as penicillin g potas-sium is common in developing countries. It has been shown that cyclosporin A, a powerful immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies are reported on the effects of cyclosporin A on peripheral nerve drug in-jection injury. This study aimed to assess the time-dependent efifcacy of cyclosporine-A as an immunosuppressant therapy in an experimental rat nerve injection injury model established by penicillin g potassium injection. The rats were randomly divided into three groups based on the length of time after nerve injury induced by cyclosporine-A administration （30 minutes, 8 or 24 hours）. The compound muscle action potentials were recorded pre-injury, early post-injury （within 1 hour） and 4 weeks after injury and compared statistically. Tissue samples were taken from each animal for histological analysis. Compared to the control group, a significant im-provement of the compound muscle action potential amplitude value was observed only when cyclosporine-A was administered within 30 minutes of the injection injury （P 〈 0.05）; at 8 or 24 hours after cyclosporine-A administration, compound muscle action potential amplitude was not changed compared with the control group. Thus, early immunosuppressant drug therapy may be a good alternative neuroprotective therapy option in experimental nerve injection injury induced by penicillin g potassium injection.

关键词： nerve regeneration peripheral nerve injury injection injury cyclosporine A penicillin g potassium Wallerian degeneration neuroelectrophysiology neural regeneration

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Endoscopic tympanoplasty

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Journal of Otology 2017年第2期12卷 62-67页

作者： abdulvahap Akyigit Oner Sakallioglu Turgut karlidag Elazig Education and Research Hospital Clinic of ENTElazigTurkey Firat University Faculty of MedicineDepartment of OtolaryngologyElazigTurkey

Middle ear surgery is usually performed using a surgical microscope. Initially, in otorhinolaryngology practice, endoscopes were used for paranasal sinus surgeries. It was only later that they were applied in the area of otology. In otologic surgeries, endoscopes were first used to visualize the middle ear, before being used to assist with visualization of instruments during cholesteatoma surgeries, although they are still not used alone in various otologic surgeries. As in other surgical fields, there is also a trend towards minimally invasive intervention in the field of otorhinolaryngology. Smaller incisions performed under the guidance of endoscopes are preferred over conventional large incisions. Using this approach, improved outcomes can be achieved and postoperative morbidities can be reduced. In addition, the outcomes of grafts performed using the endoscopic approach are similar to that achieved by the microscopic approach. Therefore, endoscopic ear surgery implementations are becoming increasingly popular.

关键词： Endoscopic Tympanoplasty Myringoplasty

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