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Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma

World Journal of Gastroenterology 2012年第15期18卷 1793-1799页

作者： Jaudah Al-Maghrabi Abdelbaset Buhmeida Eman Emam Kari Syrjnen abdulrahman Sibiany Mohmmad Al-Qahtani Mahmoud Al-Ahwal Department of Pathology King Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Excellence in Genomic Medicine Research King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Oncology and Radiotherapy Turku University HospitalT-Hospital(Administration)FIN20521 TurkuFinland Department of Surgery King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Medicine Scientific Chair for Colorectal CancerKing Abdulaziz UniversityJeddah 21589Saudi Arabia

AIM:To correlate cyclooxygenase-2(COX-2)expression profile with clinical and pathological variables to assess their prognostic/predictive value in colorectal carcinoma(CRC).METHODS:Archival tumor samples were analyzed using immunohistochemistry for COX-2 expression in 94 patients with *** were diagnosed and treatedat the Departments of Surgery and Oncology,King Abdulaziz University Hospital,Saudi ***:Fifty-six percent of the tumors showed positive cytoplasmic COX-2 expression,whereas 44%of cases were completely *** were no significant correlations between COX-2 expression and sex,age,grade or tumor ***,COX-2 expression revealed a significant correlation with tumor stage(P=0.01)and distant metastasis(P=0.02),and a borderline association with lymph node involvement(P =0.07).Tumors with high COX-2 expression showed a higher recurrence rate than tumors with no expression(P<0.009).In univariate Kaplan-Meier survival analysis,there was a significant(P=0.026)difference in disease-free survival between COX-2-positive and negative tumors in favor of the ***-2 expression did not significantly predict disease-specific survival,which was much shorter for COX-2-positive *** multivariate(COX)models,COX-2 did not appear among the independent predictors of disease-free survival or disease-specific ***:COX-2 expression seems to provide useful prognostic information in CRC,while predicting the patients at high risk for recurrent disease.

关键词： Colorectal carcinoma Cyclooxygenase-2 Immunohistochemistry Disease outcome Adjuvant therapy

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Therapeutic benefits of zinc sulfate on neonatal hyperbilirubinemia

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World Journal of Pediatrics 2022年第4期18卷 300-304页

作者： abdulrahman Al-Matary Abdullah AlGhamdi Bandar Alenaze Rasha Abdulaziz Mandili Dhuha Abdulaziz Alhawsawi Duha Magzoub Ahmed Abu-Zaid Department of Neonatology King Fahad Medical CityRiyadhSaudi Arabia Department of Pediatrics King Abdullah Specialized Children HospitalKing Abdulaziz Medical CityMinistry of National GuardHealth AffairsRiyadhSaudi Arabia King Abdullah International Research Medical Research Center RiyadhSaudi Arabia King Saud Bin Abdulaziz University for Health Sciences RiyadhSaudi Arabia College of Medicine Umm Al-Qura UniversityMeccaSaudi Arabia School of Public Health University of MemphisMemphisTNUSA Department of Pharmacology College of Graduate Health SciencesUniversity of Tennessee Health Science CenterMemphisTN 38163USA College of Medicine Alfaisal UniversityRiyadhSaudi Arabia

Neonatal hyperbilirubinemia is a common phenomenon shortly after birth and a frequent cause of prolonged hospitalization[1].Increased enterohepatic circulation of indirect bilirubin is one of the elucidated mechanisms implicated in the pathophysiology of neonatal hyperbilirubinemia[2,3].According to various in vitro and in vivo evidence from animal[3]and human[2]trials,zinc salts have been depicted to reduce bilirubin levels.

关键词： neonatal hepatic Therapeutic

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Using Artificial Intelligence to Combat Money Laundering

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Intelligent Information Management 2023年第4期15卷 284-305页

作者： Rashid Alhajeri abdulrahman Alhashem School of Law Case Western Reserve University Cleveland USA Naif Arab University for Security Sciences Riyadh Saudi Arabia

Banks and other financial institutions handle sensitive records regarding people, trusts, and corporations. Money, as a sensitive and useful commodity, makes financial organizations valuable and prone to criminal elements. Common criminal activities that target the banking sector include money laundering, identity and personal records theft, and terrorism financing. These are global issues that have garnered the attention of international bodies and governments. One method proposed to deal with illicit finance and money laundering is artificial intelligence (AI). AI implements various algorithms and techniques to monitor customers, markets, and financial transactions that help identify various banking habits. Understanding clients’ transactions and the nature of bank transfers enables AI to prevent and combat money laundering. This research offers an understanding of how artificial intelligence is used in the financial system to combat fraudulent activities such as money laundering. It is organized into five chapters covering various aspects of artificial intelligence and money laundering.

关键词： Artificial Intelligence Machine Learning Money Laundry Financial Institutions

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Automated Disassembly Sequence Prediction for Industry 4.0 Using Enhanced Genetic Algorithm

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Computers, Materials & Continua 2021年第11期69卷 2531-2548页

作者： Anil Kumar Gulivindala M.V.A.Raju Bahubalendruni R.Chandrasekar Ejaz Ahmed Mustufa Haider Abidi abdulrahman Al-Ahmari Department of Mechanical Engineering Industrial Robotics and Manufacturing Automation LaboratoryNational Institute of TechnologyKariakal609609India Department of Computer Science Engineering National Institute of TechnologyKariakal609609India Raytheon Chair for Systems Engineering Advanced Manufacturing InstituteKing Saud UniversityRiyadh11421Saudi Arabia Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

The evolution of Industry 4.0 made it essential to adopt the Internet of Things(IoT)and Cloud Computing(CC)technologies to perform activities in the new age of *** technologies enable collecting,storing,and retrieving essential information from the manufacturing *** collected at sites are shared with others where execution automatedly *** obtained information must be validated at manufacturing to avoid undesirable data losses during the de-manufacturing ***,information sharing from the assembly level at the manufacturing stage to disassembly at the product end-of-life state is a major *** current research validates the information optimally to offer a minimum set of activities to complete the disassembly *** optimal disassembly sequence plan(DSP)can possess valid information to organize the necessary actions in ***,finding an optimal DSP is complex because of its combinatorial *** genetic algorithm(GA)is a widely preferred artificial intelligence(AI)algorithm to obtain a near-optimal solution for the DSP *** converging nature at local optima is a limitation in the traditional *** study improvised the GA workability by integrating with the proposed priori crossover *** optimality function is defined to reduce disassembly effort by considering directional changes as *** enhanced GA method is tested on a real-time product to evaluate the *** obtained results reveal that diversity control depends on the operators employed in the disassembly *** proposed method’s solution can be stored in the cloud and shared through IoT devices for effective resource allocation and disassembly for maximum recovery of the *** effectiveness of the proposed enhanced GA method is determined by making a comparative assessment with traditional GA and other AI methods at different population sizes.

关键词： Automation internet of things disassembly sequence planning priori cross over operator enhanced GA disassembly predicates

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Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing

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Bioactive Materials 2023年第12期30卷 129-141页

作者： Lipeng Qiao Yongping Liang Jueying Chen Ying Huang Saeed A.Alsareii abdulrahman Manaa Alamri Farid A.Harraz Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an710049China Frontier Institute of Science and Technology State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an710049China Department of Surgery College of MedicineNajran UniversityNajran11001Saudi Arabia Promising Centre for Sensors and Electronic Devices(PCSED) Advanced Materials and Nano-Research CentreNajran UniversityNajran11001Saudi Arabia Department of Orthopaedics The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China

In clinical applications,there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing *** this study,a series of adhesive self-healing conductive antibacterial hydrogel dressings based on oxidized sodium alginate-grafted dopamine/carboxymethyl chitosan/Fe3+(OSD/CMC/Fe hydrogel)/polydopamine-encapsulated poly(thiophene-3-acetic acid)(OSD/CMC/Fe/PA hydrogel)were prepared for the repair of infected *** Schiff base and Fe3+coordination bonds of the hydrogel structure are dynamic bonds that can be repaired automatically after the hydrogel network is ***,the hydrogel exhibits self-healing properties,allowing the hydrogel dressing to adapt to complex wound *** OSD/CMC/Fe/PA hydrogel showed good conductivity and photothermal antibacterial properties under near-infrared(NIR)light *** addition,the hydrogels exhibit tunable rheological properties,suitable mechanical properties,antioxidant properties,tissue adhesion properties and hemostatic ***,all hydrogel dressings improved wound healing in the infected full-thickness defect skin wound repair test in *** wound size repaired by OSD/CMC/Fe/PA3 hydrogel+NIR was much smaller(12%)than the control group treated with Tegaderm™film after 14 *** conclusion,the hydrogels have high antibacterial efficiency,suitable conductivity,great self-healing properties,good biocompatibility,hemostasis and antioxidant properties,making them promising candidates for wound healing dressings for the treatment of infected skin wounds.

关键词： Dynamic crosslinking Self-healing Infected wound Photothermal antibacterial Wound healing

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A Case of Serratia marcescens Conjunctivitis in a Young Male after Exposure to Contaminated Shampoo in a Fitness Club

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Open Journal of Ophthalmology 2023年第2期13卷 233-237页

作者： Muhammad abdulrahman Halwani Faculty of Medicine Department of Medical Microbiology Al Baha University Al Baha Saudi Arabia

The contamination of shampoo with bacteria is not very common but can happen and can be a potential cause of conjunctivitis. This case report describes a 24-year-old male who developed conjunctivitis after using a Serratia marcescens contaminated shampoo in a fitness club. The patient had redness, swelling, and discharge in both eyes. Cultures of the shampoo and eye swabs were positive for S. marcescens with indistinguishable DNA fingerprints. The patient was treated with an eye drop antibiotic and his symptoms resolved within a week. This case highlights the possibility of exposure in places where shampoos containers are refilled or shared. The avoidance of refilling them and using replaceable cartridges, single-sealed refill bags, or bringing personal shampoo is highly recommended to prevent such incidents.

关键词： Serratia Marcescens Conjunctivitis Contaminated Shampoo Eye Swabs

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Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 234-239页

作者： Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath abdulrahman Alghassab Abdullah Ali Alghabban Department of Biochemistry College of MedicineHa'il UniversityHa'ilSaudi Arabia Department of Chemistry Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Department of Pharmacology College of MedicineHa'il UniversityHa'ilSaudi Arabia

Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L.(T. foenum-graecum) seeds and Punica granatum L.(P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea ***: Sixty guinea pigs were divided into six groups(10 guinea pigs per group).Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, *** animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were ***: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters(blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters ***: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs.

关键词： Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin

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Weapons Detection for Security and Video Surveillance Using CNN and YOLO-V5s

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Computers, Materials & Continua 2022年第2期70卷 2761-2775页

作者： Abdul Hanan Ashraf Muhammad Imran abdulrahman M.Qahtani Abdulmajeed Alsufyani Omar Almutiry Awais Mahmood Muhammad Attique Mohamed Habib Department of Computer Science Shaheed Zulfikar Ali Bhutto Institute of Science and TechnologyIslamabad44000Pakistan Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia College of Applied Computer Science King Saud University(Almuzahmiyah Campus)Riyadh11543Saudi Arabia Department of Computer Science HITEC UniversityTaxila47080Pakistan College of Computing and Informatics Saudi Electronic UniversityRiyadhSaudi Arabia Faculty of Engineering Port Said UniversityPort Fuad CityEgypt

In recent years,the number of Gun-related incidents has crossed over 250,000 per year and over 85%of the existing 1 billion firearms are in civilian hands,manual monitoring has not proven effective in detecting *** is why an automated weapon detection system is *** automated convolutional neural networks(CNN)weapon detection systems have been proposed in the past to generate good ***,These techniques have high computation overhead and are slow to provide real-time detection which is essential for the weapon detection *** models have a high rate of false negatives because they often fail to detect the guns due to the low quality and visibility issues of surveillance *** research work aims to minimize the rate of false negatives and false positives in weapon detection while keeping the speed of detection as a key *** proposed framework is based on You Only Look Once(YOLO)and Area of Interest(AOI).Initially,themodels take pre-processed frames where the background is removed by the use of the Gaussian blur *** proposed architecture will be assessed through various performance parameters such as False Negative,False Positive,precision,recall rate,and F1 *** results of this research work make it clear that due to YOLO-v5s high recall rate and speed of detection are *** reached 0.010 s per frame compared to the 0.17 s of the Faster *** is promising to be used in the field of security and weapon detection.

关键词： Video surveillance weapon detection you only look once convolutional neural networks

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An Optimization Approach for Convolutional Neural Network Using Non-Dominated Sorted Genetic Algorithm-Ⅱ

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Computers, Materials & Continua 2023年第3期74卷 5641-5661页

作者： Afia Zafar Muhammad Aamir Nazri Mohd Nawi Ali Arshad Saman Riaz abdulrahman Alruban Ashit Kumar Dutta Badr Almutairi Sultan Almotairi Faculty of Computer Science and Information Technology Universiti Tun Hussein Onn MalaysiaMalaysia School of Electronics Computing and MathematicsUniversity of DerbyUK Department of Computer Science National University of TechnologyIslamabadPakistan Department of Information Technology College of Computer and Information SciencesMajmaah UniversityAl Majmaah11952Saudi Arabia Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityRiyadh13713Kingdom of Saudi Arabia Department of Information Technology College of Computer Sciences and Information Technology CollegeMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Natural and Applied Sciences Faculty of Community CollegeMajmaah UniversityMajmaah11952Saudi Arabia Department of Information Systems Faculty of Computer and Information SciencesIslamic University of MadinahMadinah42351Saudi Arabia

In computer vision,convolutional neural networks have a wide range of *** representmost of today’s data,so it’s important to know how to handle these large amounts of data *** neural networks have been shown to solve image processing problems ***,when designing the network structure for a particular problem,you need to adjust the hyperparameters for higher *** technique is time consuming and requires a lot of work and domain *** a convolutional neural network architecture is a classic NP-hard optimization *** the other hand,different datasets require different combinations of models or hyperparameters,which can be time consuming and *** approaches have been proposed to overcome this problem,such as grid search limited to low-dimensional space and queuing by random *** address this issue,we propose an evolutionary algorithm-based approach that dynamically enhances the structure of Convolution Neural Networks(CNNs)using optimized *** study proposes a method using Non-dominated sorted genetic algorithms(NSGA)to improve the hyperparameters of the CNN *** addition,different types and parameter ranges of existing genetic algorithms are *** study was conducted with various state-of-the-art methodologies and *** have shown that our proposed approach is superior to previous methods in terms of classification accuracy,and the results are published in modern computing literature.

关键词： Non-dominated sorted genetic algorithm convolutional neural network hyper-parameter optimization

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Clinical epidemiology of ulcerative colitis in Arabs based on the Montréal classification

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World Journal of Gastroenterology 2014年第46期20卷 17525-17531页

作者： Othman R Alharbi Nahla A Azzam Ahmed S Almalki Majid A Almadi Khalid A Alswat Nazia Sadaf abdulrahman M Aljebreen Gastroenterology Division King Khalid University Hospital King Saud University Riyadh 11461Saudi Arabia Gastroenterology Division Riyadh Military HospitalRiyadh 11461Saudi Arabia Gastroenterology Division the Mc Gill University Health Center Montréal General Hospital Mc Gill UniversityMontréal H3A 1W9Canada

AIM:To determine the clinical,epidemiological and phenotypic characteristics of ulcerative colitis(UC)in Saudi Arabia by studying the largest cohort of Arab UC ***:Data from UC patients attending gastroenterology clinics in four tertiary care centers in three cities between September 2009 and September 2013were entered into a validated web-based registry,inflammatory bowel disease information system(IBDIS).The IBDIS database covers numerous aspects of inflammatory bowel *** characteristics,disease phenotype and behavior,age at diagnosis,course of the disease,and extraintestinal manifestations were ***:Among 394 UC patients,males comprised51.0%and females 49.0%.According to the Montréal classification of age,the major chunk of our patients belonged to the A2 category for age of diagnosis at17-40 years(68.4%),while 24.2%belonged to the A3category for age of diagnosis at>40 *** to the same classification,a majority of patients had extensive UC(42.7%),35.3%had left-sided colitis and29.2%had only ***,51.3%were in remission,16.6%had mild UC,23.4%had moderate UC and 8.6%had severe *** relapse occurred in17.4%patients,infrequent relapse in 77%and 4.8%had chronic disease.A majority(85.2%)of patients was steroid *** regard to extraintestinal manifestations,arthritis was present in 16.4%,osteopenia in 31.4%,osteoporosis in 17.1%and cutaneous involvement in 7.0%.CONCLUSION:The majority of UC cases were young people(17-40 years),with a male *** the disease course was found to be similar to that reported in Western countries,more similarities were found with Asian countries with regards to the extent of the disease and response to steroid therapy.

关键词： Ulcerative colitis Inflammatory bowel disease information system Saudi Arabia Epidemiology

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