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Nano-crystallites Imine-based Copper(II) Complexes as Mimetics for Copper Oxidase Proteins: Synthesis,Characterization,DFT and Oxidase Mimicking Activity

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Chemical Research in Chinese Universities 2024年第6期40卷 1068-1081页

作者： ALHADHRAMI abdulrahman RAMADAN Abd El-Motaleb FATHY ahmed Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Chemistry Department Faculty of ScienceKafr El-Sheikh UniversityKafr El-SheikhEgypt Chemistry Department Faculty of ScienceZagazig UniversityZagazigEgypt

Three tridentate imine ligands containing N2S donors were synthesized via Schiff condensation between derivatives of both amino triazine and 2-carbonyl *** reaction of these ligands with CuCl2 in a molar ratio of 1:1 provides three Cu(II) complexes with the general formula [CuLn·Cl_(2)].Analytical,electrical,magnetic,and spectroscopic studies were used to assign the molecular formulae of these metallic *** function theory (DFT) calculations confirmed the structural analysis results obtained from spectroscopic *** various characterization techniques used demonstrated the penta-coordinated slightly distorted square pyramidal structure for the present Cu(II) complexes 1,2,and *** of cyclic voltammetry were done in methanol to define the electrochemical behavior of the current Cu(II) *** biomimetics of catechol oxidase (C.O.);phenoxazinone synthase (PHS) have been studied in the aerobic oxidation of some phenolic substrates,such as 3,5-di-tert-butylcatechol (3,5-DTBCH2);ortho-aminophenol (o-APH3).The three candidate oxidase mimetics showed promising activity in the order 3 > 1 > *** catalytic activity related to the structural properties of existing oxidase mimetics was *** driving force (-ΔG°) controlling the redox reactions of the present biomolecules was calculated from the redox data of Cu(II) complexes 1,2,and *** potential catalytic reaction pathway for the oxidation of the studied phenolic substrates was discussed.

关键词： Nano-crystallite Imine-based copper(II)complex Mimetics of copper oxidase protein Synthesis and characterization Density function theory(DFT)calculation

Implications of Onshore Development on Global Software Engineering

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Computers, Materials & Continua 2023年第2期74卷 3029-3044页

作者： abdulrahman M.Qahtani ahmed S.Ghiduk College of Computers and Information Technology Taif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Mathematics and Computer Science Faculty of ScienceBeni-Suef UniversityBeni-Suef62521Egypt

Recently software industry has paid significant attention to customizing software products across distributed *** the requirements of multiple clients across distributed borders is a crucial challenge for the software customization *** decision-making and local development at the client site are considered methods for reducing difficulties in communicating the requirements of multiple clients across distributed *** paper introduces a new model called the onshore development model(ODM)for accomplishing the customization requests in the distributed development process of *** model presents a scenario for enhancing the onsite development of specific requirements to reduce delays andmisunderstandings between the clients and the team *** model depends on moving the development process to the client’s *** empirical studies were conducted to evaluate the proposed model to measure its productivity,time performance,and cost *** proposed model has been compared with two other models:the basic model(BM),which allocates the decision-making process and the development process for teams at the vendor’s location,and the local decision-making model(LDec),which assigns the decision-making process for team at the client’s *** results of the empirical studies showed significant outperforming of the proposed model over the basic model and local decision-making model in productivity,time performance,and cost *** productivity of the proposed model improved by 39%and 10%more than the basic model and the local decision-making model,*** addition,the time performance of the proposed model became faster by 49%and 20.8%than the basic model and the local decision-making model,***,it reduced the total cost of the development process by 31%in terms of the salaries of all persons involved in requirements collecting,decision-making,and development.

关键词： Distributed development local development software customization

Mining Patterns from Change Logs to Support Reuse-Driven Evolution of Software Architectures

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Journal of Computer Science & Technology 2018年第6期33卷 1278-1306页

作者： Aakash Ahlnad Claus Pahl ahmed B. Altamimi abdulrahman Alreshidi College of Computer Science and Engineering University of Ha'il Ha'il 2440 Saudi Arabia Faculty of Computer Science Free University of Bozen-Bolzano Bozen-Bolzano 39100 Italy

Modern software systems are subject to a continuous evolution under frequently varying requirements andchanges in systems＇ operational environments. Lehman＇s law of continuing change demands for long-living and continuouslyevolving software to prolong its productive life and economic value by accommodating changes in existing software. Reusableknowledge and practices have proven to be successful for continuous development and evolution of the software effectivelyand efficiently. However, challenges such as empirical acquisition and systematic application of the reusable knowledge andpractices must be addressed to enable or enhance software evolution. We investigate architecture change logs -- mininghistories of architecture-centric software evolution -- to discover change patterns that 1） support reusability of architecturalchanges and 2） enhance the efficiency of the architecture evolution process. We model architecture change logs as a graphand apply graph-based formalism （i.e., graph mining techniques） to discover software architecture change patterns. Wehave developed a prototype that enables tool-driven automation and user decision support during software evolution. Wehave used the ISO-IEC-9126 model to qualitatively evaluate the proposed solution. The evaluation results suggest that theproposed solution 1） enables the reusability of frequent architectural changes and 2） enhances the efficiency of architecture-centric software evolution process. The proposed solution promotes research efforts to exploit the history of architecturalchanges to empirically discover knowledge that can guide architecture-centric software evolution.

关键词： software architecture software maintenance and evolution evolution pattern repository mining

A Novel Cultural Crowd Model Toward Cognitive Artificial Intelligence

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Computers, Materials & Continua 2021年第12期69卷 3337-3363页

作者： Fatmah abdulrahman Baothman Osama ahmed Abulnaja Fatima Jafar Muhdher Faculty of Computing and Information Technology King Abdulaziz UniversityJeddah21431Kingdom of Saudi Arabia

Existing literature shows cultural crowd management has unforeseen issues due to four dynamic elements;time,capacity,speed,and *** variations are increasing the complexity level because each mass and event have different characteristics and ***,no prior study has employed the six Hofstede Cultural Dimensions(HCD)for predicting crowd *** study aims to develop the Cultural Crowd-Artificial Neural Network(CC-ANN)learning model that considers crowd’s HCD to predict their physical(distance and speed)and social(collectivity and cohesion)*** model was developed towards a cognitive intelligent decision support tool where the predicted characteristics affect the estimated regulation plan’s time and *** designed the experiments as four groups to analyze the proposed model’s outcomes and extract the interrelations between the HCD of crowd’s grouped individuals and their physical and social ***,the extracted interrelations were verified with the dataset’s statistical correlation analysis with a P-value<*** demonstrate that the predicted crowd’s characteristics were positively/negatively affected by their considered cultural ***,analyzing outcomes identified the most influential HCD for predicting crowd *** results also show that the CC-ANN model improves the prediction and learning performance for the crowd behavior because the achieved accepted level of accuracy does not exceed 10 to 20 epochs in most ***,the performance improved by 90%,93%respectively in some ***,all prediction best cases were related to one or more cultural features with a low error of 0.048,0.117,0.010,and 0.014 mean squared error,indicating a novel cultural learning model.

关键词： Cultural crowds learning model artificial neural network hHofstede cultural dimensions predicting group behaviors crowd management

Bibliometric mapping of solid lipid nanoparticles research(2012–2022)using VOSviewer

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Medicine in Novel Technology and Devices 2023年第1期17卷 132-140页

作者： Siddig Ibrahim Abdelwahab Manal Mohamed Elhassan Taha Sivakumar S.Moni abdulrahman A.alsayegh Medical Research Centre Jazan UniversityJazanP.O.Box 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan45142Saudi Arabia Department of Clinical Nutrition College of Applied Medical SciencesJazan UniversityJazan45142Saudi Arabia

Nanotechnology is a rapidly expanding discipline,and solid lipid nanoparticles(SLN)are at the forefront of this *** offer various possible clinical and pharmaceutical research applications and numerous other fields.A quantitative review technique called bibliometric analysis uses statistics,data mining,and mathematics to find emerging trends in a particular academic *** is currently more widely utilized and is employed in many academic *** a result,the current study looked through Scopus-indexed research documents on SLNs from 2012 to 2022 to assess the growth and expansion of this body of knowledge and predict its course in the *** VOSviewer package and Scopus Analytics were used to conduct the bibliometric *** offers two distinct viewing modes:network and overlay visualization.A total of 3768 journal articles(n=3709)and conference papers(n=59)were *** number of research documents published by 12,367 authors was steadily increasing *** therapy,development and detection methods,bioavailability,and controlled release have been important research ***,E.B.,of the University of Porto in Portugal,is considered the most prolific and frequently cited *** University(India)is the top-publishing *** is the leading country in the number of publications and research *** International Journal of Pharmaceutics is the top *** current results keep pace with global scientific efforts in nanotechnology and successfully integrate them into the pharmaceutical industry.

关键词： Solid lipid nanoparticles Bibliometric analysis Scientific mapping Knowledge structure Performance analysis

Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves

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Journal of Animal Science and Biotechnology 2020年第2期11卷 453-467页

作者： ahmed Elolimy abdulrahman Alharthi Mohamed Zeineldin Claudia Parys Juan J.Loor Mammalian NutriPhysioGenomics Department of Animal SciencesUniversity of IllinoisUrbanaILUSA Department of Animal Sciences University of IllinoisUrbanaILUSA Department of Animal Production National Research CentreDokkiGizaEgypt Carl R.Woese Institute for Genomic Biology University of IllinoisUrbanaIllinoisUSA Department of Animal Medicine College of Veterinary MedicineBenha UniversityBenhaEgypt Evonik Nutrition&Care GmbH Hanau-WolfgangGermany Division of Nutritional Sciences Illinois Informatics InstituteUniversity of IllinoisUrbanaILUSA

Background:Recent studies underscored that divergence in residual feed intake(RFI)in mature beef and dairy cattle is associated with changes in ruminal microbiome and metabolome profiles which may contribute,at least in part,to better feed *** the rumen in neonatal calves during the preweaning period is underdeveloped until close to weaning,they rely on hindgut microbial fermentation to breakdown undigested diet *** leads to production of key metabolites such as volatile fatty acids(VFA),amino acids,and vitamins that could potentially be absorbed in the hind-gut and help drive growth and *** RFI divergence in neonatal calves is associated with changes in hindgut microbial communities and metabolites is largely ***,the objective of the current study was to determine differences in hindgut microbiome and metabolome in neonatal Holstein heifer calves retrospectively-grouped based on feed efficiency as mostefficient(M-eff)or least-efficient(L-eff)calves using RFI divergence during the preweaning ***:Twenty-six Holstein heifer calves received 3.8 L of first-milking colostrum from their respective dams within 6 h after *** were housed in individual outdoor hutches bedded with straw,fed twice daily with a milk replacer,and had ad libitum access to a starter grain mix from birth to weaning at 42 d of *** were classified into M-eff[n=13;RFI coefficient=−5.72±0.94 kg DMI(milk replacer+starter grain)/d]and L-eff[n=13;RFI coefficient=5.61±0.94 kg DMI(milk replacer+starter grain)/d]based on a linear regression model including the combined starter grain mix and milk replacer DMI,average daily gain(ADG),and metabolic body weight(MBW).A deep sterile rectal swab exposed only to the rectum was collected immediately at birth before colostrum feeding(i.e.,d 0),and fecal samples at d 14,28,and 42(prior to weaning)for microbiome and untargeted metabolome analyses using 16S rRNA gene sequencing and LC-MS.M

关键词： Feed efficiency Gut Metabolomics Microbiota Neonates Newborn Preweaning RFI

Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 234-239页

作者： Nabil Abdel Salam ahmed Hasona Mohammed ahmed Qumani Turki ahmed Alghassab Muath abdulrahman Alghassab Abdullah Ali Alghabban Department of Biochemistry College of MedicineHa'il UniversityHa'ilSaudi Arabia Department of Chemistry Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Department of Pharmacology College of MedicineHa'il UniversityHa'ilSaudi Arabia

Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L.(T. foenum-graecum) seeds and Punica granatum L.(P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea ***: Sixty guinea pigs were divided into six groups(10 guinea pigs per group).Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, *** animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were ***: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters(blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters ***: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs.

关键词： Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin

Design & Implement of Smart Office Control based on RS-485 Protocol

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Design & Implement of Smart Office Control based on RS-485 P...

作者： abdulrahman Mohammed ahmed Alshaikh 湖南大学

学位级别：硕士

本文介绍了基于RS-485通信协议的远程智能办公控制系统的基本原理。该系统主要包括个人计算机、接口工具和收发装置。利用PC串行端口和ART电缆在PC遥控器和微控制器之间建立通信,当数据信号转换为RS-485信号后,可以远距离(高达4000英尺... 详细信息

本文介绍了基于RS-485通信协议的远程智能办公控制系统的基本原理。该系统主要包括个人计算机、接口工具和收发装置。利用PC串行端口和ART电缆在PC遥控器和微控制器之间建立通信,当数据信号转换为RS-485信号后,可以远距离(高达4000英尺)发送和接收数据,实现信号长距离传输。本文借助Visual Basic平台,利用C语言对微控制器(pic16f960)进行程,利用RS-232实现PC远程控制器和微控制器(pic16f960)之间实现串行连接。基于上述方法,用户可以轻松读取驱动程序在LCD模块上发送的数据。此外,本文利用RS-485的操作原理将RS-232信号转换成RS-485信号,以便其长距离传输。接收器则将RS-485信号转换回原始信号,供单片机使用,进而实现用户远程控制办公设备的开启与关闭。本文研究了RS-485使用的双绞线电缆的电气性能,与其他电缆相比,双绞线电缆抗干扰能力强,价格相对便宜。通过对该系统样机的测试,验证了该系统理论的可行性。

关键词：微控制器 RS-485通信协议智能办公控制系统 C语言电器设备

Advanced glycation end product signaling and metabolic complications:Dietary approach

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World Journal of Diabetes 2023年第7期14卷 995-1012页

作者： Mohammad Idreesh Khan Fauzia Ashfaq abdulrahman A alsayegh Alshaimaa Hamouda Fahmida Khatoon Tahani Nasser Altamimi Fahad Saad Alhodieb Mirza Masroor Ali Beg Department of Clinical Nutrition College of Applied Health Sciences in Ar RassQassim UniversityAr Rass 51921Saudi Arabia Clinical Nutrition Department Applied Medical Sciences CollegeJazan UniversityJazan 82817Saudi Arabia Department of Biochemistry College of MedicineUniversity of HailHail 2240Saudi Arabia Department of Family and Community Medicine College of MedicineUniversity of HailHail 2240Saudi Arabia Faculty of Medicine Alatoo International UniversityBishkek 720048Kyrgyzstan

Advanced glycation end products(AGEs)are a heterogeneous collection of compounds formed during industrial processing and home cooking through a sequence of nonenzymatic glycation *** modern western diet is full of heat-treated foods that contribute to AGE *** high in AGEs in the contemporary diet include processed cereal *** to industrialization and marketing strategies,restaurant meals are modified rather than being traditionally or conventionally ***,grilled,baked,and boiled foods have the greatest AGE *** AGE-content foods include dry nuts,roasted walnuts,sunflower seeds,fried chicken,bacon,and *** proteins and processed plant foods contain furosine,acrylamide,heterocyclic amines,and ***(2-furoil-methyl-lysine)is an amino acid found in cooked meat products and other processed *** concentrations of carboxymethyl-lysine,carboxyethyl-lysine,and methylglyoxal-O are found in heat-treated nonvegetarian foods,peanut butter,and cereal *** plasma levels of AGEs,which are harmful chemicals that lead to age-related diseases and physiological aging,diabetes,and autoimmune/inflammatory rheumatic diseases such as systemic lupus erythematosus and rheumatoid *** in the pathophysiology of metabolic diseases have been linked to individuals with diabetes mellitus who have peripheral nerves with high amounts of AGEs and diabetes has been linked to increased myelin *** resistance and hyperglycemia can impact numerous human tissues and organs,leading to long-term difficulties in a number of systems and organs,including the cardiovascular *** AGE levels are linked to all-cause mortality in individuals with diabetes who have fatal or nonfatal coronary artery disease,such as ventricular *** levels of tissue AGEs are independently associated with cardiac systolic dysfunction in diabetic patients with heart failure compared with diabetic pat

关键词： Advanced glycation end products Receptor for advanced glycation end products Heat-treated diets Food safety Maillard reaction products Metabolic disorder Diabetes Cardiac complication