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Novel 2-aryl-3,4,5-trihydroxypiperidines:Synthesis and glycosidase inhibition

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Chinese Chemical Letters 2013年第12期24卷 1059-1063页

作者： Hui Zhao Wu-Bao Wang Shinpei Nakagawa Yue-Mei jia Xiang-Guo Hu George W.j.Fleet Francis X.Wilson Robert j.nash Atsushi Kato Chu-Yi Yu Beijing National Laboratory for Molecular Science (BNLMS) CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of Sciences Department of Hospital Pharmacy University of Toyama2630 SugitaniToyama 930-0194Japan Chemistry Research Laboratory Department of ChemistryUniversity of Oxford Summit PLC 91Milton ParkAbingdonOxon OX14 4RYUK Phytoquest Limited IBERSPlas GogerddanCeredigionAberystwyth SY23 3EBWalesUK

Three pairs of novel 2-aryl-3,4,5-trihydroxypiperidines （6-8 and their enantiomers）, the piperidine analogues of the pyrrolidine alkaloids radicamine A and radicamine B, were prepared from six- membered cyclic nitrones through a concise two-step procedure, i.e., Grignard reagent addition and deprotection. These novel polyhydroxylated piperidine iminosugars were assayed against 10 types of enzymes. Only compound 8 exhibited weak inhibition （IC50 1080 μmol/L） against β-galactosidase from rat intestinal lactases.

关键词： 2-Aryl polyhydroxylated piperidine lminosugars Radicamine mimics Glycosidase inhibitors

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大流域汇流演算的线性扰动模型

水力发电学报 1991年第2期10卷 14-28页

作者：梁庚辰 j.E.nash 清华大学爱尔兰戈尔威学院

本文提出了多输入—单输出线性扰动模型及其识别方法,并在中国长江上的两个不同的河段与一个支流流域上进行了验证。为了作比较,对现今常用的简单线性模型也作了类似的计算。结果表明,这两类模型在河道汇流演算中都能给出很高的精度。... 详细信息

本文提出了多输入—单输出线性扰动模型及其识别方法,并在中国长江上的两个不同的河段与一个支流流域上进行了验证。为了作比较,对现今常用的简单线性模型也作了类似的计算。结果表明,这两类模型在河道汇流演算中都能给出很高的精度。对输入、输出关系复杂的大流域,线性扰动模型能够作出比简单线性模型好得多的预报。最后,基于对模型预报误差的分析,提出了实时预报校正的手段。

关键词：河道汇流线性扰动模型径流模型预报

Development of Nursing Research in Qatar: 15-Year Status Report

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Open journal of Nursing 2017年第2期7卷 242-252页

作者： abdulqadir j. nash.an Dana B. Mansour Abdulkarim Alzayyat Sindhumole K. Nair Amer I. Zawahreh National Center for Cancer Care & Research (NCCCR)-Hamad Medical Corporation (HMC) Doha Qatar University of Calgary Doha Qatar Qatar Cancer Society Doha Qatar College of Nursing University of Florida Gainesville FL USA

Purpose: The aim was to provide an overview of nursing research in Qatar over the previous 15 years. Methods: Several online databases were searched for published articles between 2000 and 2015 related to nursing research in Qatar. Findings: The initial search identified 6540 articles, whose titles, abstracts, and texts were screened for satisfying the eligibility criteria. Only 57 articles met the eligibility criteria. The highest percentage of studies (42%) focused on clinical practice issues. Eighty-seven percent (87%) were published in peer-reviewed journals;84% (N = 48) were conducted between 2011 and 2015 with 16-fold growth rate compared to 2000-2005. The majority of authors were postgraduate qualified nurses, mainly 67% of them with hospital and academic affiliation (88%). The vast majority of identified studies were conducted in hospital settings (63%), and only 14% of the studies used a nursing theory or conceptual framework. Sixty-three percent (63%) of the studies were quantitative, and 25% were funded mostly by hospitals. The majority of the included studies have been done in collaboration with other disciplines (60%), especially with physicians (65%). Conclusion: Nursing research in Qatar has dramatically developed and improved over the last 15 years. However, nurses need to be more motivated to conduct and publish research in collaboration with national, regional, and international research bodies. Implications for Nursing & Health Policy: Building and sustaining nursing research infrastructure considered as a top priority for nursing leaders, academic, and ministry of public health in Qatar. Furthermore, preparing nurses with higher academic degrees is an essential step in advancing research utilization in Qatar and the region.

关键词： Literature Review Nursing Research Nurses Qatar

Design and Performance of PV Dust Cleaning System in Medina Region

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journal of Power and Energy Engineering 2019年第11期7卷 1-14页

作者： Khaled S. Al Qdah Saleh A. abdulqadir Nawaf Y. Al Harbi Abdullah Z. Soqyyah Kamal j. Isa Mohmmed Y. Alharbi Nasser M. Binsaad Mechanical Engineering Dept. College of Engineering Taibah University Madinah KSA

This work aims to design a cleaning system for the solar PV panels under Medina climatic conditions. This system powered by the PV module itself. Full cleaning system has been designed and tested utilizing a wiper and water jet to remove the accumulated dust and other dirt from solar panels surface. The proposed cleaning system can be worked for long time efficiently. All the strength system components were examined and found to be stable and reliable. Also, the performance of cleaning system evaluated and comparison between the clean and dusty module performance has been conducted. The system performance has been evaluated for both clean and dusty panel at variable inputs of solar radiation. At input power of 805 W/m2, the efficiency found to be 13.78% for the cleaning panel and 9% for dusty panel, whereas at the input power of 460 W/m2, the estimated efficiency was 12.6% and 7.3% for clean and dusty panel respectively. Significant reduction in the efficiency has been reported as 35% and 42% for both cases. Therefore, the present work can be considering as a promising and efficient system to solve the problem of poor performance of the photovoltaic cells in areas that experience dusty environment and external pollutants. In addition, it is safe clean and economic system.

关键词： Dust Performance Photovoltaic Solar Radiation Climatic Conditions

Pulmonary Hypertension Induced by Thalidomide (and Derivatives) in Patients with Multiple Myeloma: A Systematic Review

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journal of Cancer Therapy 2016年第13期7卷 971-978页

作者： abdulqadir j. nash.an Nader I. Al-Dewik Hisham M. Al Sabah Mohamed A. Yassin Shehab F. Mohamed Nabil H. Omar Dana B. Mansour National Center for Cancer Care & Research (NCCCR)-Hamad Medical Corporation Doha Qatar University of Calgary Doha Qatar Qatar Medical Genetics Center Hamad General Hospital (HGH) Hamad Medical Corporation (HMC) Doha Qatar Interim Translational Research Institute (iTRI) HMC Doha Qatar Medical Oncology/Hematology Department National Center for Cancer Care and Research Hamad Medical Corporation Doha Qatar National Center for Cancer Care & Research (NCCCR)-Hamad Medical Corporation Doha Qatar Qatar Cancer Society Doha Qatar

Thalidomide is widely used in the treatment of multiple myeloma (MM). In recent years, several cases of pulmonary hypertension have been reported following treatment with thalidomide. The aim of this review was to evaluate the published literature on multiple myeloma patients with pulmonary hypertension following thalidomide treatment. A literature search was performed between 2000 and 2016. A total of 7 eligible studies were identified and deemed eligible, including 11 cases—approximately 37% (4 cases) with IgA (k), 27% (3 cases) with IgG (λ) MM, 27% (3 cases) with IgG (k) MM, and one case (9%) with primary plasma cell leukemia (PPCL). The vast majority of cases—82% (9 cases)—are associated with thalidomide, while only 18% (2 cases) are related to thalidomide derivatives (lenalidomide and pomalidomide). In conclusion, pulmonary hypertension induced by thalidomide or derivatives in multiple myeloma (MM) patients is related to a multifactorial etiology including the pathophysiology of the disease, thromboembolic events, preexisted cardiovascular conditions, comorbidities, and combination with other chemo- or bio-therapeutic agents. MM patients should be evaluated for signs and symptoms underlying cardiopulmonary disease before initiating, and during treatment with thalidomide.

关键词： Thalidomide Thalidomide Derivatives Pulmonary Hypertension Multiple Myeloma

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缺血时三维心室外膜Map多重分形的变化

科学通报 2005年第22期50卷 2479-2483页

作者：陈颖 Martyn P.nash 宁新宝王业琳 David j.Paterson 王俊南京大学电子科学与工程系近代声学国家重点实验室生物医学电子工程研究所 Engineering Scienceand Bioengineering Institute University of AucklandPrivate Bag 92019NZ Laboratory of Physiology University of OxfordParks RoadOxford OX13PTUK

对三维心室外膜Map的电压信号时间序列进行了研究,分析了一个短时的缺血-再灌注动物模型,研究心肌缺血与心室外膜电位多重分形特性变化的关系.提出了一个新的多重分形奇异谱的分析参数SARD,来着重刻画系统的多重分形随时间的变化.通过... 详细信息

对三维心室外膜Map的电压信号时间序列进行了研究,分析了一个短时的缺血-再灌注动物模型,研究心肌缺血与心室外膜电位多重分形特性变化的关系.提出了一个新的多重分形奇异谱的分析参数SARD,来着重刻画系统的多重分形随时间的变化.通过对比心外膜心肌激活序列等时图与心外膜的三维SARD图,发现心肌缺血对于心外膜电位的多重分形特性的变化有显著的影响,SARD值在心室外膜上的分布与缺血部位有密切的联系.

关键词：非线性动力学多重分形心脏心室外膜Map 心肌缺血

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最黑暗的时刻

作者： j.R.·纳什(j.R. nash)

来源：南通市图书馆图书评论

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地球在变暗吗?

当代外语研究 2004年第9期 12-14页

作者： j.Madeleine nash 陈融

太阳并没有在变弱,然而它发出的光似乎在变得暗淡了。部分科学家相信,在1960至1990年其间,太阳照到地球表面的光有可能减少了10％——

关键词：温室气体地球变暖气候系统地球气象台地球表面科学家粒子污染物辐射探测仪太阳光线太阳能收集器

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孕育心灵(一)

现代特殊教育 1999年第2期 9-10页

作者： j. MADELEINE nash 郑宇琳

如果科学家对一个怀孕10周或12周胎儿的大脑进行监听,他们会听到惊奇的吵闹声:砰砰砰,砰砰砰,砰砰砰。在子宫里,当光第一次照入眼睛的视网膜或透过皮层形成最初的朦胧闪烁的像很久之前,被研究的大脑神经细胞已开始有目的地闪耀活动。就... 详细信息

如果科学家对一个怀孕10周或12周胎儿的大脑进行监听,他们会听到惊奇的吵闹声:砰砰砰,砰砰砰,砰砰砰。在子宫里,当光第一次照入眼睛的视网膜或透过皮层形成最初的朦胧闪烁的像很久之前,被研究的大脑神经细胞已开始有目的地闪耀活动。就像十几岁的小孩打电话一样,大脑里一个区域的神经细胞给另一个区域的朋友打电话。加尼弗利亚大学伯克利分校的神经生物学家 *** 说:"好像它们总是自动地拨打电话。"

关键词：大脑神经细胞科学家神经生物学神经元视网膜皮层形成伯克利分校心灵出生前婴儿