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Impact of multifocal gas-permeable lens designs on short-term choroidal response, axial length, and retinal defocus profile

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 247-256页

作者： Muteb alanazi Patrick Caroline Amane Alshamrani Maria Liu Optometry department College of Applied Medical SciencesKing Saud UniversityRiyadh 14813Saudi Arabia College of Optometry Pacific UniversityForest GroveOregon 97116-1756United States Optometry School University of California at BerkeleyCalifornia 94720United States

AIM:To investigate the impact of multifocal gas permeable contact lens(MFGPCL)in various add power and distance/near area allocation on short-term changes of choroidal thickness(ChT),axial length(AL),and retinal defocus profile in young ***:Seventeen young adults(2 males and 15 females;age 23.17±4.48y)were randomly assigned to wear two designs binocularly with a one-week washout period in *** of four MFGPCL designs were *** designs were distance-center that varied in two add power(+1.50 and 3.00 d)and/or two distance zone(dZ)diameters(1.50 and 3.00 mm;design A:dZ 1.5/add 3.0,B:dZ 1.5/add 1.5,C:dZ 3.0/add 3.0,d:dZ 3.0/add 1.5).ChT,AL,and peripheral refraction data were collected on each subject at baseline,on days 1 and 7 of MFGPCL daily *** was assessed in four quadrants using a spectraldomain optical coherence ***:AL was shortened by-26±44μm with lens C,-18±27μm with lens d,-13±29μm with lens A,and-8±30μm with lens B(all Pd with all 4 designs(lens A:+6±6μm,B:+3±7μm,C:+8±7μm,and d:+8±7μm).Temporal and superior choroid exhibited more choroidal thickening associated with *** designs induced significant relative peripheral myopia(RPM)beyond the central 20o across the horizontal meridian in both nasal and temporal fields(Pd AL,which are associated with significant increase in RPM after short-term *** reliability and feasibility of quantifying short-term changes in ChT support its use as a promising marker for the long-term efficacy of myopia-controlling treatments.

关键词： choroid gas-permeable contact lens retinal defocus axial length myopia

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Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.Baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.alanazi Abdul-Badi Abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India department of Human Genetics-Precision Medicine in diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,dNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

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Improving the operational stability of perovskite solar cells with cesium-doped graphene oxide interlayer

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Journal of Energy Chemistry 2024年第9期96卷 483-490页

作者： Masaud Almalki Katerina Anagnostou Konstantinos Rogdakis Felix T.Eickemeyer Mostafa Othman Minas M.Stylianakis dimitris Tsikritzis Anwar Q.alanazi Nikolaos Tzoganakis Lukas Pfeifer Rita Therisod Xiaoliang Mo Christian M.Wolff Aïcha Hessler-Wyser Shaik M.Zakeeruddin Hong Zhang Emmanuel Kymakis Michael Grätzel Laboratory of Photonics and Interfaces École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland department of Electrical and Computer Engineering Hellenic Mediterranean UniversityHeraklionCrete 71410Greece Institute of Electrical and Microengineering(IEM)Photovoltaics and Thin-Film Electronics Laboratory(PV-Lab) École Polytechnique Fédérale de Lausanne(EPFL)Neuchâtel 2000Switzerland department of Nursing Faculty of Health SciencesHellenic Mediterranean UniversityCrete 71410Greece Centre Interdisciplinaire de Microscopie Electronique École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Future Energy Technology Institute King Abdulaziz City for Science and Technology(KACST)P.O.Box 6086Riyadh 11442Saudi Arabia State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionInstitute of OptoelectronicsDepartment of Materials ScienceFudan UniversityShanghai 200433China

Perovskite solar cells(PSCs)have made great advances in terms of power conversion efficiency(PCE),yet their subpar stability continues to hinder their *** interface between the perovskite layer and the charge-carrier transporting layers plays a crucial role in undermining the stability of *** this work,we propose a strategy to stabilize high-performance PSCs with PCE over 23%by introducing a cesium-doped graphene oxide(GO-Cs)as an interlayer between the perovskite and hole-transporting *** GO-Cs treated PSCs exhibit excellent operational stability with a projected T80(the time where the device PCE reduces to 80%of its initial value)of 2143 h of operation at the maximum powering point under one sun illumination.

关键词： Perovskite solar cells doped graphene oxide Graphene related material Long-term operational stability

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Green synthesis,characterization,acaricidal,larvacidal,and repellent activities of copper nanoparticles of Astragalus sinicus against Hyalomma anatolicum

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Asian Pacific Journal of Tropical Biomedicine 2023年第6期13卷 250-257页

作者： Hattan S.Gattan Bassam M.Al-Ahmadi abdullah F.Shater Qais A.H.Majeed Maha S.Alazemi abdullah.d alanazi department of Medical Laboratory Sciences Faculty of Applied Medical SciencesKing Abdulaziz UniversityJeddahSaudi Arabia Special Infectious Agents UnitKing Fahad Medical Research CenterJeddahSaudi Arabia department of Biology Faculty of ScienceTaibah UniversitySaudi Arabia department of Medical Laboratory Technology Faculty of Applied Medical SciencesUniversity of TabukTabuk 71491Saudi Arabia department of Science College of Basic EducationPAAETPost code 23167AridiyaKuwait department of Biological Sciences Faculty of Science and HumanitiesShaqra UniversityP.O.Box 1040Ad-Dawadimi 11911Saudi Arabia

Objective:To green synthesize and characterize copper nanoparticles(Cu NPs)using Astragalus sinicus,as well as evaluate the acaricidal,larvacidal,and repellent activities of Cu NPs against Hyalomma anatolicum(***),one of the most prevalent ticks infesting cattle in Saudi ***:Cu NPs were green synthesized by adding the Astragalus sinicus extract to a copper sulfate *** acaricidal,larvicidal,and repellent activities of Cu NPs against *** were assessed via the adult immersion test,the larval packet test,and the vertical movement behavior of tick larvae,*** effects of Cu NPs on acetylcholinesterase as well as oxidative enzyme activities were ***:The green synthesized Cu NPs displayed a spherical form with a size range of 15-75 *** exposure of adult *** to different concentrations of Cu NPs,the viability rate of adult *** and the mean number,weight,and hatchability of eggs were noticeably reduced,in comparison to the control group(Pddition,the viability rate of larvae considerably declined(Pd LC_(90)values of 11.30 and 20.34μg/m L,*** maximum repellent activity of Cu NPs was observed at 50,100,and 200μg/m L with complete repellent activity after 60,120,and 180 min of exposure,*** NPs,mainly at 1/2 LC_(50)and LC_(50)concentrations,markedly suppressed the acetylcholinesterase activity of the larval stage of ***(Pdose,significantly elevated malondialdehyde level while declining glutathione-S-transferase level in *** larvae(Pdal,larvicidal,and repellent activities against adults and larvae of ***,further studies must be performed to clarify the precise mechanisms and the efficacy of Cu NPs in practical use.

关键词： Insecticide Tick Pesticide Astragalus sinicus Nanomedicine Hyalomma anatolicum Acaricidal activity Larvacidal activity

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24-Hour movement behaviours and COVId-19 among children in the Kingdom of Saudi Arabia:A repeat cross-sectional study

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Sports Medicine and Health Science 2022年第3期4卷 177-182页

作者： Yazeed A.alanazi Anne-Maree Parrish Anthony d.Okely Early Start and School of Health&Society University of WollongongWollongongNSW2522Australia College of Sport Science and Physical Activity King Saud UniversityRiyadh12372Saudi Arabia Illawarra Health and Medical Research Institute WollongongNSW2522Australia

This study investigated how children's 24-hour(24-h)movement behaviours were affected by SARS-CoV-2(COVId-19)in the Kingdom of Saudi *** research examined 24-h movement behaviours in Saudi Arabia seven months after the World Health Organization(WHO)declared COVId-19 a global *** repeat cross-sectional study examined changes in 24-h movement behaviours 12 months after the WHO *** Time 2 survey repeated five months(1 March–15 May 2021)after Time 1 survey(1 October–11 November 2020).The survey was distributed to parents of children aged 6–12 years across Saudi Arabia via an online *** were classified as meeting 24-h movement guidelines if they reported uninterrupted sleep for 9–11 h per night,2 h of recreational sedentary screen time(RST)per day and-60 min of moderate-to vigorous-intensity physical activity(MVPA)per day.A total of 1045 parents from all regions of Saudi Arabia responded(42.4%).Only 1.8%of children met all components of the guidelines,compared to 3.4%in Time *** the present study,girls spent more days per week in MVPA-60 min duration than boys(3.0 vs 2.6;p=0.025),while boys had spent more days per week engaged in activities that strengthened muscle and bone than girls(3.0 vs 2.8;p=0.019).Healthy levels of physical activity(PA),sedentary behaviour(SB)and sleep further declined in Saudi children five months after the Time 1 *** challenges require urgent intervention to ensure children's movement behaviours improve as Saudi Arabia moves out of the COVId-19 pandemic.

关键词： Sleep Sedentary behaviour Physical activity Children COVId-19

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Perfluorosulfonic acid proton exchange membrane with double proton site side chain for high-performance fuel cells at low humidity

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Journal of Materials Science & Technology 2023年第35期166卷 155-163页

作者： Hongyun Tan Shengqiu Zhao S.Eltahir Ali Shuhong Zheng abdullah K.alanazi Rui Wang Haining Zhang Hala M.Abo-dief Ben Bin Xu Hassan Algadi Handong Li Priyanka Wasnik Zhanhu Guo Haolin Tang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China department of Science and Technology University College-RanyahTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen ValleyFoshan 528200China Integrated Composites Laboratory(ICL) Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China department of Electrical Engineering Faculty of EngineeringNajran UniversityNajran11001Saudi Arabia

Structural optimization of ionomers is an effective strategy for achieving high-performance proton ex-change membranes(PEMs)under low relative humidity(RH)*** this study,sulfonimide group and trifluoromethanesulfonate acid(TFSA)ionic liquids were introduced to the perfluorosulfonic acid(PFSA)side chain,resulting in polymer membranes with varying chain lengths(i.e.,PFC_(2)-TF-SI,PFC_(4)-TF-SI,and PFC_(5)-TF-SI).This dual proton-conducting structure extended the length of the hydrophilic side chain and enhanced the hydrophobic-hydrophilic phase separation,aiding in the formation of proton transport ***,the proton conductivity of PFC_(5)-TF-SI and PFC_(2)-TF-SI membranes reached 7.1 and 10.6 mS/cm at 30%RH and 80℃,respectively,which were approximately 29.1%and 92.7%higher than that of the pristine PFC_(5)-SA membrane(5.5 mS/cm).Furthermore,the maximum power density of the PFC_(5)-TF-SI and PFC_(2)-TF-SI membranes from the built single fuel cell achieved 649 and 763 mW/cm^(2) at 30%RH and 80℃,respectively,which were higher than that of the pristine PFC_(5)-SA membrane(567 mW/cm^(2))by about 14.5%and 34.6%,***,this study provides a strategy for PEM design under low RH conditions.

关键词： Proton exchange membrane Structural design dual proton conduction Hydrophilic channel Proton conductivity Fuel cells

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Screening for variants in the <i>MUTYH</i>gene in Saudis

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Open Journal of Genetics 2011年第3期1卷 70-77页

作者： Jameela Shinwari Abdulla Alamri Mohammad alanazi Nada Al Tassan 不详

MUTYH is a base excision repair glycosylase responsible for correcting the G:A mismatches that arise from replication of a damaged dNA, such impairment results from attacks by reactive oxygen species that are produced from different sources including cigarette smoking. The produced reactive oxygen species trigger the oxidation of guanine in to 8-oxo-G and the latter mispairs with adenine. Alterations in the MUTYH gene can affect its glycosylase function and hence the dNA repair capacity that is tightly linked to cancer development. defects in the MUTYH were found to be associated with predisposition to colorectal cancer;the third most common cancer in the world. Although some studies suggested the existence of an ethnic differentiation among MUTYH mutations, there are no documented reports regarding this gene in Saudi cases or controls so far. 153 healthy Saudi individuals including smokers were screened for the IVS1 + 5 G/C, V22M, Y165C, R231C, H324Q and G382d MUTYH variants using either ARMS or RFLP or direct sequencing. Allelic frequencies were calculated and were found to be as follows: IVS1 + 5 G/C = 1/0, V22M = 0.99/0.01, Y165C = 1/0, R231C = 1/0, H324Q = 0.29/0.71 and G382d = 0.997/0.003. Comparison of the allele frequencies between Saudis and other populations revealed a significant difference between the Saudis and Europeans for the V22M (p-value: 0.0003, OR: 5.899, 95% CI: 1.999 - 17.408);and between the Saudis and Asians for the H324Q (p-value: MUTYH variants in Saudi populations and support the existence of an ethnic difference between MUTYH variants which is beneficial as some MUTYH common polymorphisms in certain populations may correlate with disease predisposition in other rare populations.

关键词： MUTYH Allele Frequencies Single Nucleotide Polymorphism Mutations Colorectal Cancer

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The role of eosinophils in asthma

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Health 2013年第2期5卷 339-343页

作者： Faris Q. Alenzi Fahad G. B. alanazi Abdulaziz d. Al-Faim Mohamed W. Al-Rabea Waleed Tamimi Bassel Tarakji Omar Kujan Ali Al-Jabri Richard K. H. Wyse College of Applied Medical Sciences Salman bin Abdulaziz University Al-Kharj Saudi Arabia College of Medicine King Abdulaziz University Jeddah Saudi Arabia department of Microbiol & Immunology College of Medicine Sultan Qaboos University Muscat Oman department of Pathology and Laboratory Medicine King Abdulaziz Medical City Riyadh Saudi Arabia department of Pathology Al-Farabi Medical College Riyadh Saudi Arabia department of Pharmacy Ministry of Health Riyadh Saudi Arabia department of Preventive Medicine Ministry of Health Riyadh Saudi Arabia Imperial College of Medicine London UK

Asthma is a chronic inflammatory disorder of the airways characterized by recurring episodes of reversible airway obstruction, hyper-responsiveness, wheezing, breathlessness and coughing. Clinical diagnosis of asthma is based on the pattern of clinical symptoms and pulmonary fuction tests. Asthma affectes 5% - 10% of the population and the number of worldwide cases is approximately 300 milliones. The incidence of this disease is increasing particulry in western countries [1]. It is the cause of a huge economic burden to national healthcare services. In a minority of cases, asthma is potentially fatal. After a period when fatalities appeared to be increasing [2], in recent years asthma-related mortality has progressively declined due to the develop- ment of specific asthma disease management programs, as well as the extensive use of in- haled corticosteroids [3]. Inflammation of the airways is a central component in asthma. In- flammation is associated with infliltration of the airway wall with eosinophiles and or neutron- philes mast cell degranulation and T cell active- tion. Other pathological features include, sub- basement membrane thickening, loss of epithet- lial cell integrity, goblet cells hyperplasia In- crease in airway smooth muscle mass. Eosino- phils are thought to be vital in the development of airway hyperreactivity, with the eosinophil cationic protein playing a crucial role [4]. The fact that treatment of asthma with corticos-teroids reduces eosinophils numbers and decreases airway reactivity further supports this hypothesis.

关键词： Eosinophils Asthma

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Towards Sustainable Agricultural Systems:A Lightweight deep Learning Model for Plant disease detection

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Computer Systems Science & Engineering 2023年第10期47卷 515-536页

作者： Sana Parez Naqqash dilshad Turki M.alanazi Jong Weon Lee department of Software Sejong UniversitySeoul05006Korea department of Convergence Engineering for Intelligent drone Sejong UniversitySeoul05006Korea department of Electrical Engineering College of EngineeringJouf UniversitySakakaSaudi Arabia

A country’s economy heavily depends on agricultural ***,due to several plant diseases,crop growth rate and quality are highly *** identification of these diseases via a manual procedure is very challenging and time-consuming because of the deficiency of domain experts and low-contrast ***,the agricultural management system is searching for an automatic early disease detection *** this end,an efficient and lightweight deep Learning(dL)-based framework(E-GreenNet)is proposed to overcome these problems and precisely classify the various *** the end-to-end architecture,a MobileNetV3Smallmodel is utilized as a backbone that generates refined,discriminative,and prominent ***,the proposed model is trained over the PlantVillage(PV),data Repository of Leaf Images(dRLI),and a new Plant Composite(PC)dataset individually,and later on test samples,its actual performance is *** extensive experimental analysis,the proposed model obtained 1.00%,0.96%and 0.99%accuracies on all three included ***,the proposed method achieves better inference speed when compared with other State-Of-The-Art(SOTA)*** addition,a comparative analysis is conducted where the proposed strategy shows tremendous discriminative scores as compared to the various pretrained models and other Machine Learning(ML)and dL methods.

关键词： Computer vision deep learning embedded vision agriculture monitoring classification plant disease detection Internet of Things(IoT)

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