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Primary glomerular diseases in the elderly

World Journal of Nephrology 2015年第2期4卷 263-270页

作者： abdullah sumnu Meltem Gursu Savas Ozturk Okmeydani Training and Research Hospital Nephrology Clinic Haseki Training and Research Hospital Nefroloji Klinigi Haseki Egitim ve Arastirma

Primary glomerular diseases in the elderly population are a frustrating topic due to difficulties in both the diagnosis and decision making about treatment. The most frequent type of primary glomerular disease in elderly is membranous nephropathy; while its counterpart in younger population is Ig A nephropathy. The most frequent cause of nephrotic syndrome in the elderly is also membranous nephropathy. Pauci-immune crescentic glomerulonephritis(GN) rate increases both in elderly and very elderly population. Pauci-immune crescentic GNs should be regarded as urgencies in elderly patients as in their younger counterparts due to potential for causing end-stage renal disease in case of delayed diagnosis and treatment, and also causing mortality due to alveolar hemorrhage in patients with pulmonary involvement. Renal biopsy is the inevitable diagnostic method in the elderly as in all other age groups. Renal biopsy prevents unnecessary treatments and provides prognostic data. So advanced age should not be the sole contraindication for renal biopsy. The course of primary glomerular diseases may differ in the elderly population. Acute kidney injury is more frequent in the course and renal functions may be worse at presentation. These patients are more prone to be hypertensive. The decision about adding immune suppressive therapies to conservative methods should be made considering many factors like co-morbidities, drug side effects and potential drug interactions, risk of infection, patient preference, life expectancy and renal functions at the time of diagnosis.

关键词： Elderly Membranous nephropathy Renal biopsy Pauci-immune crescentic glomerulonephritis Primary glomerular disease

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Skin disorders in peritoneal dialysis patients:An underdiagnosed subject

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World Journal of Nephrology 2016年第4期5卷 372-377页

作者： Meltem Gursu Sami Uzun Derya Topcuoglu Leyli Kadriye Koc Lamiye Yucel abdullah sumnu Egemen Cebeci Oktay Ozkan Ahmet Behlul Leyla Koc Savas Ozturk Rumeyza Kazancioglu Department of Nephrology Bezmialem Vakif University Medical Faculty34093 IstanbulTurkey Department of Nephrology Haseki Training and Research Hospital34093 IstanbulTurkey Department of Dermatology Haseki Training and Research Hospital34093 IstanbulTurkey

AIM： To examine all skin changes in peritoneal dialysis （PD） patients followed up in our ***： Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all fndings recorded. The demographic, clinical and laboratory data including measures of dialysis adequacy of patients were recorded also. Statistical Package for Social Sciences （SPSS） for Windows 16.0 standard version was used for statistical ***： Among the patients followed up in our PD unit, those without exclusion criteria who gave informed consent, 38 patients were included in the study with male/female ratio and mean age of 26/12 and 50.3 ± 13.7 years, respectively. The duration of CKD was 7.86 ± 4.16 years and the mean PD duration was 47.1 ± 29.6 mo. Primary kidney disease was diabetic nephropathy in 11, nephrosclerosis in six, uropathologies in four, chronic glomerulonephritis in three, chronic pyelonephritis in three, autosomal dominant polycystic kidney disease in three patients while cause was unknown in eight patients. All patients except for one patient had at least one skin lesion. Loss of lunula, onychomycosis and tinea pedis are the most frequent skin disorders recorded in the study group. Diabetic patients had tinea pedis more frequently （ P = 0.045）. No relationship of skin findings was detected with primary renal diseases, comorbidities and medications that the patients were ***： Skin abnormalities are common in in PD patients. The most frequent skin pathologies are onychomycosis and tinea pedis which must not be overlooked.

关键词： Skin Peritoneal dialysis Onychomycosis Tinea pedis Xeroderma

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Citric acid cross-linked curcumin/chitosan/chickpea flour film: An active packaging for chicken breast storage

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Food Bioscience 2022年第6期50卷 1074-1082页

作者： Eda Yildiz Ayca Aydogdu Emir Gulum sumnu Leyla Nesrin Kahyaoglu Department of Food Engineering Middle East Technical UniversityAnkaraTurkey Department of Food Technology Canakkale 18 Mart UniversityCanakkaleTurkey

Since there has been an increasing interest in natural, non-toxic, and biodegradable food packages instead of plastic ones, scientists put great effort into eliminating the potential drawbacks of these biodegradable films. In this study, citric acid (CA) was utilized as a crosslinker for the films produced by chitosan (CS), chickpea flour (CF), and active agent curcumin (CUR) by a solvent casting technique. CA was introduced into the film formulations at different concentrations (0, 0.5%, 1%, 1.5% w/v), and the influence on the functional film characteristics were extensively *** CA concentration in formulation caused a reduction in water vapor permeability (WVP) of the films such that the film with the highest CA concentration (1.5-CUR/CF/CS) was 62.6% more resistant to water vapor than film without CA (0-CUR/CF/CS). When CA concentration in the film formulation was increased, elongation at break (EAB) value increased from 1.64% ± 0.13%, to 11.1%± 1.21% whereas tensile strength (TS) value decreased from 7.83± 0.08 MPa to 3.58± 0.20 MPa. Contrary to expectations, antioxidant activity of the films decreased with increasing CA concentration. X-Ray Diffraction (XRD) patterns of the films proved the amorphous nature and inhibitory characteristic of CA against retrogradation. In addition to all these, CA concentration significantly influenced Thermogravimetric analysis (TGA) pattern of the films with the increasing number of degradation stages. Besides the cross-linker characteristic of CA, it also extensively enhanced the antibacterial characteristic of the films. Films formulated with 1.5% (w/v) CA (1.5-CUR/CF/CS) showed antibacterial effect against both Escherichia coli (***) (ATCC 11229) and Staphylococcus aureus (***) (ATCC 43300). Finally, chicken breast packed with 1.5-CUR/CF/CS films remained below unacceptable microbial threshold limits even at the end of the 9th -day of storage compared to samples packaged with the film with no antibacte

关键词： Chitosan Chickpea flour Curcumin Citric acid Antimicrobial activity Chicken

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