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Mallory-Denk Bodies in chronic hepatitis

World Journal of Gastroenterology 2011年第17期17卷 2172-2177页

作者： Metin Basaranoglu Nesrin Turhan abdullah sonsuz Gkcen Basaranoglu Gastroenterology and Hepatology ConsultingEndoscopyAnkara Yüksek Ihtisas HospitalAnkara06420Turkey Department of Pathology Ankara Yüksek Ihtisas HospitalAnkara06420Turkey Gastroenterology Cerrahpasa Medical FacultyUniversity of IstanbulIstanbul34500Turkey Department of Anaesthesiology Vakif Gureba University HospitalIstanbul34500Turkey

Mallory-Denk Bodies(MDB) are important as investigators,suggesting MDB as an indicator of the histologic severity of chronic hepatitis,causes of which include hepatitis C,primary biliary cirrhosis(PBC),and nonalcoholic fatty liver disease(NAFLD).Matteoni et al scored MDB in patients with NAFLD as none,rare and many,and reported that MDB plays a prominent role in this classification scheme in an earlier classification *** this study,we evaluated 258 patients with chronic hepatitis due to metabolic,autoimmune and viral *** biopsy samples were evaluated with hematoxylin and eosin,periodic acid-Schiff-diastase,Gordon and Sweet's reticulin,Masson's trichrome,and iron *** staging and grading were ***,MDB were evaluated and discussed for each *** examined patients with nonalcoholic steatohepatitis(NASH;50 patients),alcoholic hepatitis(10 patients),PBC(50 patients),Wilson disease(WD;20 patients),hepatitis B(50 patients),hepatitis C(50 pati-ents) and hepatocellular carcinoma(HCC;30 patients).Frequency of MDB was as follows;NASH:10 patients with mild in 60% and moderate in 40% and observed in every stage of the disease and frequently seen in zone ***:11 patients with mild in 10%,moderate in 70%,and cirrhosis in 20%,and frequently seen in zone ***:16 patients with moderate and severe in 60% and cirrhosis in 40% and frequently seen in zone *** B:3 patients with mild in 66% and severe in 34%.Hep C:7 patients with mild in 40% and moderate in 60% and observed in every ***:3 patients with hep B in 2 *** found that there is no relationship between MDB and any form of chronic hepatitis regarding histologic severity such as alcoholic steatohepatitis and NAFLD and variable zone distribution by etiology.

关键词： Non-alcoholic fatty liver disease MalloryDenk Bodies Hepatitis B and C Hepatocellular carcinoma Primary biliary cirrhosis Wilson disease

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Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2010年第18期16卷 2223-2226页

作者： Metin Basaranoglu Serra Kayacetin Nevin Yilmaz Ertugrul Kayacetin Orhan Tarcin abdullah sonsuz Division of Gastroenterology Ankara Yüksek Ihtisas Hospital Department of Pathology Konya Education and Teaching Hospital Mugla University School of MedicineGI/Transplant Hepatology Division of Gastroenterology Meram Medical FacultySelcuk University Division of Gastroenterology Yeni Yüzyil University Division of Gastroenterology Cerrahpasa Medical FacultyIstanbul University

A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully *** the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in *** of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet fed or murine steatohepatitis,and high-fat or sucrose diet fed *** these animal models have provided useful information,none of them accurately reflect genetic,metabolic and biochemical characteristics of the human disease.

关键词： Nonalcoholic fatty liver disease Pathogenesis Rat Rodents

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非酒精性脂肪性肝炎和慢性病毒性肝炎的血清铁水平和肝脏铁过载

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 11-12页

作者： Uraz S. Aygun C. sonsuz A. Ozbay G. 王志宇 Department of Gastroenterology Kocaeli University Faculty of Medicine Ibni Sina Mah. Fatih Cad No. 75 Derince Kocaeli 41900 Turkey Dr.

Our objective was to determine the effect of serum iron levels and hepatic iron overload on hepatocellular damage in nonalcoholic steatohepatitis (NASH) and to compare this with chronic viral hepatitis. Twenty-five patients who had elevated transaminase levels on at least two occasions, without any evidence of viral and autoimmune hepatitis and diabetes, without a history of significant alcohol use, and with a liver biopsy consistent with NASH were enrolled in the study. Twenty-five patients with chronic viral hepatitis (13 patients with chronic hepatitis C and 12 with chronic hepatitis B) who were not under any antiviral treatment were taken as controls. Metabolic factors were studied in the NASH and chronic hepatitis groups. Biopsy specimens were stained with hematoxylin-eosin, and the grade of steatosis and the stage of fibrosis were evaluated as Ⅰ, Ⅱ, or Ⅲ, Ⅰbeing mild and Ⅲbeing severe. Iron overload in the hepatic tissue was studied by Prussian blue staining. Serum ALT, AST, ALP, GGT, globulin, and ferritin levels were comparable in both steatohepatitis and chronic viral hepatitis groups. However, patients with chronic hepatitis had a lower albumin level and a higher serum iron level, with higher transferrin saturation. Among patients with NASH, mild, moderate, and severe steatosis was found in 7, 10, and 8 patients, respectively. Inflammatory infiltration was grade I in 24 patients and grade III in 1 patient. Fibrosis was mild in 12 patients and 13 patients had no fibrosis. Among patients with chronic viral hepatitis, inflammatory infiltration of grade I was seen in 11 patients, grade II in 11 patients, and grade III in 3 patients. Fibrosis was mild in 9 patients, moderate in 13 patients, and severe in 2 patients; 1 patient had no fibrosis. Compared to patients with NASH, those with chronic viral hepatitis cases had more severe inflammatory infiltration and fibrosis (P < 0.01). While five patients with chronic viral hepatitis had mild iron overload, patients

关键词：慢性病毒性肝炎血清铁自身免疫性肝炎纤维化程度重度脂肪肝肝活检标本慢性丙型肝炎炎性浸润乙型肝炎病毒治疗

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