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Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 234-239页

作者： Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath Abdulrahman Alghassab abdullah ali alghabban Department of Biochemistry College of MedicineHa'il UniversityHa'ilSaudi Arabia Department of Chemistry Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Department of Pharmacology College of MedicineHa'il UniversityHa'ilSaudi Arabia

Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L.(T. foenum-graecum) seeds and Punica granatum L.(P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea ***: Sixty guinea pigs were divided into six groups(10 guinea pigs per group).Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, *** animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were ***: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters(blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters ***: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs.

关键词： Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin

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Prognostic significance of peritoneal metastasis from colorectal cancer treated with first-line triplet chemotherapy

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World Journal of Clinical Cases 2022年第8期10卷 2429-2438页

作者： Shouki Bazarbashi Abdulrahman alghabban Mohamed Aseafan ali H Aljubran Ahmed Alzahrani Tusneem AM Elhassan Oncology Center King Faisal Specialist Hospital&Research CenterRiyadh 11211RiyadhSaudi Arabia

BACKGROUND Peritoneal metastasis from colorectal cancer(CRC)carries a poor prognosis in most *** majority of those studies used either a single-agent or doublet chemotherapy regimen in the first-line *** To investigate the prognostic significance of peritoneal metastasis in a cohort of patients treated with triplet chemotherapy in the first-line *** We retrospectively evaluated progression-free survival(PFS)and overall survival(OS)in 51 patients with metastatic CRC treated in a prospective clinical trial with capecitabine,oxaliplatin,irinotecan,and bevacizumab in the first-line setting according to the presence and absence of peritoneal ***,univariate and multivariate analyses for PFS and OS were performed to assess the prognostic significance of peritoneal metastasis at the multivariate *** Fifty-one patients were treated with the above triplet *** had peritoneal *** patient characteristics of both groups showed a significant difference in the sidedness of the primary tumor(left-sided primary tumor in 60%of the peritoneal group vs 86%in the nonperitoneal group,P=0.03)and the presence of liver metastasis(40%for the peritoneal group vs 75%for the nonperitoneal group,P=0.01).Univariate analysis for PFS showed a statistically significant difference for age less than 65 years(P=0.034),presence of liver metastasis(P=0.046),lung metastasis(P=0.011),and those who underwent metastasectomy(P=0.001).Only liver metastasis and metastasectomy were statistically significant for OS,with P values of 0.001 and 0.002,*** analysis showed that age(less than 65 years)and metastasectomy were statistically significant for PFS,with P values of 0.002 and 0.001,*** the other hand,the absence of liver metastasis and metastasectomy were statistically significant for OS,with P values of 0.003 and 0.005,*** Peritoneal metastasis in patients with metastatic CRC tre

关键词： Colorectal cancer Peritoneal carcinomatosis Triplet chemotherapy Survival Prognostic factors Metastasectomy

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