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Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

Nano Research 2019年第5期12卷 973-990页

作者： abdullah a.ghawanmeh Gomaa A.M.Ali H.Algarni Shaheen M.Sarkar Kwok Feng Chong Faculty of Industrial Sciences & Technology Universiti Malaysia PahangGambang26300 KuantanMalaysia Chemistry Department Faculty of ScienceAl-Azhar UniversityAssiut71524Egypt Department of Physics Faculty of SciencesKing Khalid UniversityAbha 61413P. O. Box 9004Saudi Arabia Research Center for Advanced Materials Science (RCAMS) King Khalid UniversityAbha 61413P. O. Box 9004Saudi Arabia Bernal Institute Department of Chemical SciencesUniversity of LimerickCastletroyV94 LimerickIreland

Graphene oxide (GO) possesses excellent mechanical strength,biocompatibility,colloidal stability,large surface area and high adsorption *** has driven to cancer nanotechnology to defeat cancer therapy obstacles,via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier,and controllable release of anticancer ***,the surface of GO affords π-π stacking and hydrophilic interactions with anticancer ***,modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability,drug loading,and target *** this review,GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies,preparation methods,the model drug,polymer conjugation and modification with targeting ***,swelling kinetics,drug release profile and biological activity in vivo and in vitro are *** biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio *** from that,the clinical potential of GO based hydrogels and its major challenges are addressed in ***,this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug *** is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels,such as large surface area,chemical purity,high loading capacity of drug,chemical stability,and the nature of lipophilic for cell membrane penetration.

关键词： graphe ne oxide cancer nan otechnology hydrogel nanocarrier drug delivery

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Real-Time Maqam Estimation Model in Max/MSP Configured for the Nāy

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International Journal of Communications, Network and System Sciences 2016年第2期9卷 39-52页

作者： Fadi M. Al-ghawanmeh Mohammad T. Al-ghawanmeh Mohammad W. Abed Music Department University of Jordan Amman Jordan Music Department Yarmouk University Irbid Jordan

Automatic maqam estimation is considered significant toward improving multimedia live music performances and automatic accompaniment. This contribution proposed a real-time maqam estimation model developed in the visual programming language MAX/MSP and configured for the nāydukah. The model’s design stood on basic formulas of Arab music maqamat as explained in theory and applied in practice. The model consisted of different layers of competition;the first was for the identification of the instant tonic of the melodic figure, and the second was for the recognition of its identifying E (E, E half-flat and E flat). Those two competitions were used to estimate the maqam in real-time. Then, accumulated estimation results were used to estimate the maqam in longer durations;five-second and full duration. The model was evaluated using professionally performed nāy improvisations. Results reflected a success in estimating all the studied maqamat when the full improvisation was considered. In addition, results were very good for real-time and five-second estimation where average estimation confidence was 75.98% and 80.04%, respectively.

关键词： Real-Time Music Systems Arab Music Maqam Estimation Nāy Music Signal Processing

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Automatic Accompaniment to Arab Vocal Improvisation: From Technical to Commercial Perspectives

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Journal of Software Engineering and Applications 2015年第1期8卷 16-25页

作者： Fadi M. Al-ghawanmeh Zaid R. Shannak Music Department University of Jordan Amman Jordan SRS International Amman Jordan

In this multidisciplinary study, the main research question was how to improve the value of entrepreneurial initiatives that provide the web service of automatic accompaniment to Arab singing. As an example and case study, we considered the Mawaweel website that offered an automatic accompaniment to Arab vocal improvisation as a main service. After overviewing the website, we conducted a survey examining the satisfaction of its visitors in regard to presentation and quality of service. It was found that the Mawaweel website had potential to achieve success as the majority of the 22 respondents expressed general satisfaction after their first visit to the website, with an average rate of 75%. However, respondents’ ratings were strict when discussing specific aspects about the website presentation and service quality, and the means of average rates were 68.32% and 50.23% respectively. The standard deviations of average rates were 15.70% and 19.13%, respectively. This revealed a sense of inhomogeneity in the values of the different aspects of the website presentation, and an expanded sense of inhomogeneity in the quality of the different services delivered by the website. We then compared the Mawaweel website to other websites and proposed specific improvements to the aspects with average rate below 50%.

关键词： Music Informatics Entrepreneurial Web Business Automatic Accompaniment Arab Music Survey Research

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