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Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients

World Journal of Gastroenterology 2012年第1期18卷 55-63页

作者： Abdulrahman A aljumah Mohamed A Saeed Ahmed I al Flaiw Ibrahim H al Traif Abduljaleel M al alwan Salem H al Qurashi Ghormallah A al Ghamdi Fayez F al Hejaili Mohammed A al Balwi abdulla a al sayyari Division of Hepatology Department of Hepatobiliary Sciences and Liver Transplantation King Abdulaziz Medical City and King Saud bin Abdulaziz University for Health Sciences National Guard Health Affairs Division of Nephrology and Renal Transplantation Department of Medicine King Abdulaziz Medical City and King Saud bin Abdulaziz University for Health Sciences National Guard Health Affairs Division of Molecular Pathology and Genetics King Abdulaziz Medical City and King Saud bin Abdulaziz University for Health Sciences National Guard Health Affairs

AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (alT) levels at baseline, 78.9% had their alT normalized (including the virological non responders). alT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. all patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in su

关键词： allograft rejection Hepatitis C Pegylated interferon Ribavirin Renal transplant

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Problems and prospects of fish farming in the Chattogram Hill Tracts of Bangladesh:Community-based aquaculture might be a right choice

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Aquaculture and Fisheries 2024年第2期9卷 306-313页

作者： Saifuddin Rana MdNazmul Hasan abdulla al Bari Shahida Arfine Shimul SkIstiaque Ahmed Sk.Ahmad al Nahid Department of Fisheries Resource Management Faculty of FisheriesChattogram Veterinary and Animal Sciences UniversityKhulshi4225ChattogramBangladesh Department of Oceanography University of ChittagongChittagong4331Bangladesh

The study was carried out in Matiranga Upazila,Bandarban district,which is considered one of Bangladesh’s major hill tract *** study aimed to identify present farming conditions,prospects,and problems and suitable solutions to the problems of fish *** participatory rapid appraisal tools such as focus group discussion,field visits,and farmers’interviews were used to collect relevant fish farming information in the study *** polyculture method was the most practised aquaculture *** the selected farms,eleven fish species were identified as culture *** transportation cost for seeds purchased from remote areas was high(11%of total seed cost).The average transportation-related mortality of fish fry and fingerlings was 7.2%and 2.8%.Feed cost was found as the major cost(58.4%)in *** and revenue for fish production per decimal varied from BDT 311 to 3528 and BDT 23 to *** of vacant lake,youth and women engagement,integrated aquaculture,the desire of people to engage in aquaculture,and available human resources were found as significant *** major problems identified were lack of hatchery,high feed cost,lack of stakeholder linkage,lack of capital for fish farming,and lack of proper knowledge,guidelines,and consultancy for fish culture.A community-based aquaculture model was proposed to overcome the present challenges and problems in the study *** model may help to expand aquaculture and thus improve the livelihood and socio-economic status of the people of the hilly areas of Bangladesh.

关键词： Hilly area Aquaculture model Tribal people Fish farming prospects

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Complex Decision Modeling Framework with Fairly Operators and Quaternion Numbers under Intuitionistic Fuzzy Rough Context

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1893-1932页

作者： Nadeem Salamat Muhammad Kamran Shahzaib Ashraf Manal Elzain Mohammed abdulla Rashad Ismail Mohammed M.al-Shamiri Institute of Mathematics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan64200Pakistan Department of Mathematics Thal University BhakkarPunjab30000Pakistan Department of Mathematics Faculty of Science and ArtsKing Khalid UniversityMuhayl Assir61913Saudi Arabia

The main goal of informal computing is to overcome the limitations of hypersensitivity to defects and uncertainty while maintaining a balance between high accuracy,accessibility,and *** paper investigates the potential applications of intuitionistic fuzzy sets(IFS)with rough sets in the context of sparse *** it comes to capture uncertain information emanating fromboth upper and lower approximations,these intuitionistic fuzzy rough numbers(IFRNs)are superior to intuitionistic fuzzy sets and pythagorean fuzzy sets,*** use rough sets in conjunction with IFSs to develop several fairly aggregation operators and analyze their underlying *** present numerous impartial laws that incorporate the idea of proportionate dispersion in order to ensure that the membership and non-membership activities of IFRNs are treated equally within these *** operations lead to the development of the intuitionistic fuzzy rough weighted fairly aggregation operator(IFRWFA)and intuitionistic fuzzy rough ordered weighted fairly aggregation operator(IFRFOWA).These operators successfully adjust to membership and non-membership categories with fairness and *** highlight the unique qualities of these suggested aggregation operators and investigate their use in the multiattribute decision-making *** use the intuitionistic fuzzy rough environment’s architecture to create a novel strategy in situation involving several decision-makers and non-weighted ***,we developed a novel technique by combining the IFSs with quaternion *** establish a unique connection between alternatives and qualities by using intuitionistic fuzzy quaternion numbers(IFQNs).With the help of this framework,we can simulate uncertainty in real-world situations and address a number of decision-making *** the examples we have released,we offer a sophisticated and systematically constructed illustrative scenario that is intricately wo

关键词： Intuitionistic fuzzy set quaternion numbers fuzzy logic decision-making rough set

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Hydroxychloroquine: A Safe, Effective and Inexpensive Maintenance Therapy for Chronic Spontaneous Urticaria

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International Journal of Clinical Medicine 2024年第6期15卷 225-232页

作者： Kamel El-Reshaid Shaima al-Bader abdulla al-Refaee Department of Medicine Faculty of Medicine Kuwait University Kuwait Kuwait Asad al-Hamad Dermatology Center Ministry of Health Kuwait Kuwait

Background: Chronic spontaneous urticaria (CSU) is an autoimmune skin disorder that lasts for >6 weeks and may last for years. It is a disabling skin disease that impairs quality of life. Set-up treatment with antihistamines, immunosuppressives, immune modulators and lately Omalizumab are expensive or have significant side effects. In this retrospective study, we describe our experience with the use of hydroxychloroquine (HCQ) as a maintenance therapy for those with severe forms of CSU after Corticosteroids (C) induction phase. Patients and Methods: 16 adult patients (aged 44 ± 7) with severe CSU for 5 ± 1 months, were included in the study. Eight patients had attacks of angioneurotic oedema. Their previous treatments were antihistaminic and short-courses of C. Results: After 2 weeks of remission with C and HCQ 200 mg twice daily, the dose of C was tapered down and discontinued by the end of the first month. The seven days Urticaria Activity Score decreased from 30 ± 3 to 6 ± 1 by the first month and remained low at 3 ± 1 by the end of 2 years of follow-up. Moreover, IgE levels and CRP had similar trends. Remission persisted after 37 ± 9 months of follow-up. Conclusion: HCQ is a safe, efficacious and inexpensive drug for the treatment of CSU.

关键词： Autoimmune Disease Chronic Spontaneous Urticaria Corticosteroids Hydroxychloroquine Omalizumab

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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： Kannan Sridharan Shamik Shah Mona al Hammad Fatima ali Mohammed Sindhan Veeramuthu Mona abdulla Taher Mustafa Mohamed Hammad Lamees Jawad Eman Farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFRal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFRal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

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Purification of Produced Water from a Sour Oilfield in South Kuwait. 1. Oil-Water Separation and Industrial Salt Production

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Journal of Water Resource and Protection 2024年第2期16卷 156-180页

作者： Feras al Salem Hessa al Shamsi Mariam Mohammed abdulla alaryani Basmalah Abdelazim Mohamed Khalaf Omnia Elsheikh Vijo Poulose Yosef al Jasem Thies Thiemann Department of Biology United Arab Emirates University Al Ain United Arab Emirates Department of Chemistry United Arab Emirates University Al Ain United Arab Emirates Department of Process & Design Engineering Solid Mechanical Equipment Co Abu Dhabi United Arab Emirates

Produced water from an oil extraction site in South Kuwait was sampled after primary oil – water separation had been carried out. The produced water was filtered through a mixture of activated charcoal and esterified cellulosic material gained from spent coffee grounds as a tertiary adsorption treatment. The earth-alkaline metal ions and heavy metals were separated from the de-oiled produced water by addition of either sodium or potassium hydroxide in the presence of carbon dioxide or by direct addition of solid sodium carbonate. The resulting filtrate gave salt of industrial purity upon selective crystallization on evaporation.

关键词： Produced Water Oil and Gas Adsorption Filtration Crystallization

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Current interventional options for palliative care for patients with advanced-stage cholangiocarcinoma

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World Journal of Clinical Oncology 2024年第3期15卷 381-390页

作者： Maryam Makki Malak Bentaleb Mohammed Abdulrahman Amal abdulla Suhool Salem al Harthi Marcelo AF Ribeiro Jr Department of Surgery Division of TraumaCritical Care and Acute Care SurgerySheikh Shakhbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Surgery College of Medicine and Health SciencesKhalifa UniversityAbu Dhabi 11001United Arab Emirates Department of Surgery Division of Hepato-Pancreato-Biliary(HPB)SurgerySheikh Shakhbout Medical CityAbu Dhabi 91888United Arab Emirates

Primary biliary tract tumors are malignancies that originate in the liver,bile ducts,or *** tumors often present with jaundice of unknown etiology,leading to delayed diagnosis and advanced ***,several palliative treatment options are available for primary biliary tract *** include percutaneous transhepatic biliary drainage(PTBD),biliary stenting,and surgical interventions such as biliary *** therapy is also commonly used for the palliative treatment of primary biliary tract *** involves the administration of chemotherapy drugs,such as gemcitabine and cisplatin,which have shown promising results in improving overall survival in patients with advanced biliary tract *** is another palliative treatment option for patients with unresectable or inoperable malignant biliary *** stenting can also be used as a palliative treatment option to alleviate symptoms in patients with unresectable or inoperable malignant biliary *** interventions,such as biliary diversion,have traditionally been used as palliative options for primary biliary tract ***,biliary diversion only provides temporary relief and does not remove the *** biliary tract tumors often present in advanced stages,making palliative treatment the primary option for improving the quality of life of patients.

关键词： Cholangiocarcinoma Palliative care Endoscopic treatment Surgery Complications Interventional radiology

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Metabolomic changes in children with autism

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World Journal of Clinical Pediatrics 2024年第2期13卷 171-197页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain Department of Pediatric University Medical CenterDr.Sulaiman Al Habib Medical GroupManamaBahrainManama 26671Bahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12Bahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBahrainBusaiteen 15503MuharraqBahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Chest Disease University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain Department of Chest Disease University Medical CenterDr.Sulaiman Al Habib Medical GroupManamaManama 26671Bahrain Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain

BACKGROUND Autism spectrum disorder(ASD)is a neurodevelopmental condition characterized by deficits in social communication and repetitive *** profiling has emerged as a valuable tool for understanding the underlying metabolic dysregulations associated with *** To comprehensively explore metabolomic changes in children with ASD,integrating findings from various research articles,reviews,systematic reviews,meta-analyses,case reports,editorials,and a book *** A systematic search was conducted in electronic databases,including PubMed,PubMed Central,Cochrane Library,Embase,Web of Science,CINAHL,Scopus,LISA,and NLM catalog up until January *** criteria encompassed research articles(83),review articles(145),meta-analyses(6),systematic reviews(6),case reports(2),editorials(2),and a book chapter(1)related to metabolomic changes in children with *** criteria were applied to ensure the relevance and quality of included *** The systematic review identified specific metabolites and metabolic pathways showing consistent differences in children with ASD compared to typically developing *** metabolic biomarkers may serve as objective measures to support clinical assessments,improve diagnostic accuracy,and inform personalized treatment *** profiling also offers insights into the metabolic alterations associated with comorbid conditions commonly observed in individuals with *** Integration of metabolomic changes in children with ASD holds promise for enhancing diagnostic accuracy,guiding personalized treatment approaches,monitoring treatment response,and improving *** research is needed to validate findings,establish standardized protocols,and overcome technical challenges in metabolomic *** advancing our understanding of metabolic dysregulations in ASD,clinicians can improve the lives of affected individuals and their families.

关键词： Autism spectrum disorder Metabolic dysregulations Metabolomic changes Children Mitochondrial dysfunction Oxidative stress Amino acids

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Fecal calprotectin in pediatric gastrointestinal diseases:Pros and cons

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World Journal of Clinical Pediatrics 2024年第2期13卷 198-220页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatrics University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Department of Pediatrics University Medical CenterDr.Sulaiman Al Habib Medical GroupBahrainManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12ManamaBahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBahrainBusaiteen 15503MuharraqBahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Department of Pulmonology University Medical CenterKing Abdulla Medical CityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain

BACKGROUND Fecal calprotectin is a valuable biomarker for assessing intestinal inflammation in pediatric gastrointestinal ***,its role,pros,and cons in various conditions must be comprehensively *** To explore the role of fecal calprotectin in pediatric gastrointestinal diseases,including its advantages and *** A comprehensive search was conducted on PubMed,PubMed Central,Google Scholar,and other scientific research engines until February 24,*** review included 88 research articles,56 review articles,six metaanalyses,two systematic reviews,two consensus papers,and two letters to the *** Fecal calprotectin is a non-invasive marker for detecting intestinal inflammation and monitoring disease activity in pediatric conditions such as functional gastrointestinal disorders,inflammatory bowel disease,coeliac disease,coronavirus disease 2019-induced gastrointestinal disorders,gastroenteritis,and cystic fibrosis-associated intestinal ***,its lack of specificity and susceptibility to various confounding factors pose challenges in *** these limitations,fecal calprotectin offers significant advantages in diagnosing,monitoring,and managing pediatric gastrointestinal *** Fecal calprotectin holds promise as a valuable tool in pediatric gastroenterology,offering insights into disease activity,treatment response,and *** protocols and guidelines are needed to optimize its clinical utility and mitigate interpretation *** research is warranted to address the identified limitations and enhance our understanding of fecal calprotectin in pediatric gastrointestinal diseases.

关键词： Fecal calprotectin Pediatric gastrointestinal diseases Functional gastrointestinal disorders Inflammatory bowel disease Coeliac disease COVID-19-induced gastrointestinal disorders Infectious gastroenteritis Cystic fibrosis

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Pre-autism:Advancing early identification and intervention in autism

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World Journal of Clinical Cases 2024年第34期12卷 6748-6753页

作者： Mohammed al-Beltagi Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511Egypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain

Autism spectrum disorder(ASD)is often diagnosed long after symptoms have become *** delay can make it difficult to provide early intervention,which can impact long-term *** concept of"pre-autism"highlights the phase before a formal diagnosis of ASD,providing an opportunity for earlier identification and intervention,which could be a turning point in ASD *** a previous article,we explored different ways of diagnosing pre-autism,including historical records,physical markers,laboratory tests,and radiological *** manuscript builds on that foundation by emphasizing the importance of early diagnosis and intervention in *** research advancements have clarified that ASD presentations can be complex,and individualized support strategies are *** significance of pre-autism lies in its potential to alter the trajectory of ASD through early detection and intervention despite challenges such as limited awareness and variability in symptom *** and diagnostic tools have shown promise as avenues for early detection,but it is essential to exercise caution and not rely too heavily on yet-tobe-established *** these challenges requires a collaborative effort to increase awareness,improve access to diagnostic tools,and foster inclusive ***,this manuscript calls for ongoing research,advocacy,and resource allocation to enhance early detection and intervention efforts,ensuring optimal outcomes for individuals on the autism spectrum.

关键词： Pre-autism Early diagnosis Children Intervention Biomarkers Autism spectrum disorder Individualized support Collaboration

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