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Potential for sodium-glucose cotransporter-2 inhibitors in the management of metabolic syndrome: A systematic review and metaanalysis

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World Journal of Cardiology 2022年第11期14卷 599-616页

作者： abdulbaril olagunju Naser Yamani Dorothy Kenny Martina Mookadam Farouk Mookadam Samuel Unzek Internal Medicine Creighton University School of MedicinePhoenixAZ 85013United States Cardiology Heart CenterUniversity of Arizona College of Medicine-PhoenixBanner University Medical CenterPhoenixAZ 85006United States Department of Family Medicine Mayo ClinicScottsdaleAZ 85260United States

BACKGROUND Landmark trials have established the benefits of sodium-glucose cotransporter-2 inhibitors(SGLT2-Is)in cardiovascular disease including heart failure with reduced and preserved ejection fraction and renal diseases regardless of the presence of diabetes ***,studies evaluating the role of SGLT2-Is in metabolic syndrome(MetS)are *** This study primarily aimed to evaluate the impact of SGLT2-Is on the components of *** Two independent reviewers and an experienced librarian searched Medline,Scopus and the Cochrane central from inception to December 9,2021 to identify placebo controlled randomized controlled trials that evaluated the impact of SGLT2-Is on the components of MetS as an ***-and post-treatment data of each component were obtained.A meta-analysis was performed using the RevMan(version 5.3;Copenhagen:The Nordic Cochrane Center,The Cochrane Collaboration).RESULTS Treatment with SGLT2-Is resulted in a decrease in fasting plasma glucose(–18.07 mg/dL;95%CI:-25.32 to–10.82),systolic blood pressure(–1.37 mmHg;95%CI:-2.08 to–0.65),and waist circumference(–1.28 cm;95%CI:-1.39 to–1.18)compared to *** impact on highdensity lipoprotein cholesterol was similar to placebo(0.01 mg/dL;95%CI:-0.05 to 0.07).CONCLUSION SGLT2-Is have a promising role in the management of MetS.

关键词： Metabolic syndrome Sodium-glucose cotransporter 2 inhibitors Dapagliflozin Empagliflozin Cardiovascular disease

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Virulent endocarditis due to Haemophilus parainfluenzae:A systematic review of the literature

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World Journal of Cardiology 2022年第10期14卷 546-556页

作者： abdulbaril olagunju Jake Martinez Dorothy Kenny Philip Gideon Farouk Mookadam Samuel Unzek Department of Internal Medicine Creighton University School of MedicinePhoenixAZ 85013United States Department of Cardiology Heart CenterUniversity of Arizona College of Medicine-PhoenixBanner University Medical CenterPhoenixAZ 85006United States Department of Cardio-oncology Banner MD Anderson Cancer CenterPhoenixAZ 85006United States

BACKGROUND Haemophilus parainfluenzae(HPI)belongs to the HACEK(Haemophilus spp.,Aggregatibacter spp.,Cardiobacterium spp.,Eikenella spp.,and Kingella spp.)group of *** HACEK group of organisms are a part of the oropharyngeal flora and can cause invasive opportunistic infection such infective endocarditis(IE)in hosts with compromised immunological *** To perform a 20-year systematic review of the literature characterizing the clinical presentation,epidemiology and prognosis of HPI *** We performed a systematic review of Medline,Pubmed,Scopus and Embase from 2000 to 2022 to identify all cases of HPI *** Thirty-nine adult cases were *** IE was found to affect males slightly more than females and is common in patients with predisposing risk factors such as underlying valvular *** mostly affected the mitral valve and had an indolent course;significantly sized vegetations(>1 cm)developed in most *** nervous system septic embolization was *** had a favorable prognosis compared to staphylococcal and streptococcal *** Clinicians should be attentive to the indolent course of HPI IE and the presence of predisposing risk factors in order to allow for timely management.

关键词： Haemophilus parainfluenzae Infective endocarditis Mitral valve Vegetation

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