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The Impact of Black Sea Sand Treatment Effectively Reducing Different Type of Pain

Open Journal of Therapy and Rehabilitation 2024年第1期12卷 18-27页

作者： Mahmut Tokaç abdulbari bener Fatma Nur Kesiktaş Bahar Dernek Semra Alkal Akkaya Zeynep Esra Akgün Department of Medicine and Education Unit School of Medicine Istanbul Medipol University Istanbul Türkiye Department of Biostatistics & Medical Informatics School of Medicine Istanbul Medipol University Istanbul Türkiye Department of Evidence for Population Health Unit School of Epidemiology and Health Sciences The University of Manchester Manchester UK Faculty of Medicine Health Sciences University Istanbul Physiotherapy Rehabilitation Training and Research Hospital Istanbul Türkiye Faculty of Medicine Health Sciences University Department of Physical Medicine and Rehabilitation Umraniye Training and Research Hospital Istanbul Türkiye Physical Medicine and Rehabilitation Vatan Clinics School of Medicine Istanbul Medipol University Istanbul Türkiye

Purpose: Low back pain (LBP), Gonarthrosis, knee, and Carpal Tunnel Syndrome have been regarded as affecting more than three-quarters’ of individuals in their lifetime. The aim of this study was conducted to determine and compare the effects of topical patients with sand compared with control related to Gonarthrosis, LBP, knee, and Carpal Tunnel Syndrome pain. Methods: This is a prospective case and control designed study based on 101 pain case with Sand and 101 control subjects. The interventional groups in addition either topical sand or without sand 2 months after the intervention were assessed. We assessed tolerability of an established pain perception scale by the Numeric Rating Scale (NRS). Categorical variables were compared using the chi-square (χ2) test. The paired t-test was used to compare the two groups before and after the intervention. One-way analysis of variance (ANOVA) was employed for comparison of several group means. Results: The study was based on 202 patients, 41 males (20.3%) and 161 females (79.7%). There were statistically significant differences between subjects with and without Sand in term of Gonarthrosis, Rheumatoid Arthritis LBP, knee, and Carpal Tunnel Syndrome pain (p = 0.033). Majority of patients were over age 55 years old (55%) and females 78 (77.2%). The mean score of total pain experience before and after the intervention was 7.41 ± 1.1 for black sand, and 4.24 ± 2.38 for without sand as control group. The mean scores of these 5 groups were highly significant before and after the intervention (p There was statistically highly significant in regarding subjects with Sand as compared with those before Sand after treatment mean score specifically with gonarthrosis before pain 7.23 ± 1.86 vs after treatment 4.54 ± 2.18 p < 0.001;rheumatoid arthritis before 8.28 ± 1.48 vs after treatment 4.80 ± 3.71 p < 0.001;Low Back Pain before 8.42 ± 1.83 vs after treatment 4.37 ± 1.52 p < 0.001;knee pain before 8.93 ± 0.89 vs after treatment 4.24 ± 0.24 p < 0.001;Carpal Tunnel Syndrom

关键词： Therapies Sand LBP Musculoskeletal Rheumatoid Arthritis Carpal Tunnel Syndrome

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Effect of nicotinamide on newly diagnosed type 1 diabetic children

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Acta Pharmacologica Sinica 2006年第6期27卷 724-727页

作者： Madeeha KAMAL Abdul-JabbarAlABBASY AhoodAlMUSLEMANI abdulbari bener Department of Pediatrics Salmaniya Medical ComplexManamaBahrain School of Health Department of PediatricsHamad Medical CorporationDohaQatar Department of Pediatrics.Salmaniya Medical Complex ManamaBahrain Department of Medical Statistics and Epidemiology Hamad General HospitalHamad Medical CorporationDohaQatar Department of Evidence for Population Health Unit School of Epidemiology and Health SciencesUniversity of ManchesterManchester.UK

Aim:To determine whether a low dose of nicotinamide(NA)therapy for pediatricpatients with type 1 diabetes,initiated within the first 24 h of diagnosis,prolongsthe"honeymoon"period and lowers their insulin requirements.Methods:Allchildren(n=66)with newly diagnosed type 1 diabetes admitted to Salmaniya MedicalComplex between 1998 and 2000,received NA 1-2 mg/kg per day,in addition tosc insulin bid.The patients were followed for 24 months(NA group).Findings inthis group were compared with records from a similarly diagnosed control group(n=37),who were admitted to the same hospital between 1995 and 1997 and did notreceive NA treatment.The insulin dose per kg bodyweight required at baselineand at 3-monthly intervals up to 2 years after diagnosis was determined.Results:At baseline,the two groups did not differ with respect to age,ethnic background,weight,insulin dose per kg bodyweight or glucose levels on admission.However,NA group had lower insulin requirements than control group at each 3-monthinterval up to 2 years after diagnosis.Conclusion:Our study results suggest thateven low doses of oral NA given to children with newly diagnosed type 1 diabetesmay reduce insulin requirements and prolong the"honeymoon"period.

关键词： type 1 diabetes nicotinamide insulin therapy insulin dose glycated hemoglobin A

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Microalbuminuria in hepatitis C-genotype 4:Effect of pegylated interferon and ribavirin

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World Journal of Gastroenterology 2010年第10期16卷 1226-1231页

作者： Moutaz Derbala Fatma M Shebl Awad Rashid Aliaa Amer abdulbari bener Department of Gastroenterology and Hepa-tology Hamad Medical Corporation Department of Medicine Weill Cornell Medical College in Qatar Infections & Immunoepidemiology Branch Division of Cancer Epidemiology and GeneticsNational Cancer Institute Epidemiology Branch National Liver Institute Department of Nephrology Hamad Medical Corporation Department of Laboratory Medicine and Histo-pathology Hematology SectionHamad Medical Corporation Department of Medical Statistics and Epidemiology Hamad Medical Corporation

AIM:To study the relation between hepatitis C virus (HCV) genotype 4 and microalbuminuria and renal impairment in relation to hepatic histology, and viremia in the absence of cryoglobulinemia, and to examine the effect of treatment on microalbuminuria.METHODS: Three hundred subjects, including 233 HCV genotype-4 infected patients, were tested for cryoglobulinemia, microalbuminuria, albumin creatinine ratio (ACR), urea, creatinine, and estimated glomerular filtration rate (eGFR). The parameters were measured again in the HCV patients after 48 wk of treatment with pegylated interferon and ribavirin.RESULTS: Significantly higher levels of microalbumin- uria were detected in HCV-positive patients compared to HCV-negative controls (median 9.5 vs 5.9, respectively, Kruskal-Wallis P=0.017). Log microalbuminuria was significantly correlated with hepatic inflammation (r=0.13, P=0.036) and f ibrosis (r=0.12, P=0.061), but not with viral load (r=-0.03, P=0.610), or alanine transaminase (r=-0.03, P=0.617). Diabetes mellitus neither significantly moderated (χ2=0.13, P=0.720), nor mediated (Sobel test P=0.49) the HCV effect. HCV status was signifi cantly associated with log microalbu-minuria (χ2=4.97, P=0.026), adjusting for age, gender, diabetes, cryoglobulinemia, urea and creatinine. A positive HCV status was not significantly associated with low eGFR (<60 mL/min every 1.73 m2) [odds ratio (OR): 0.5, 95% confidence interval (CI):0.2-1.4], nor with high ACR (OR: 1.7, 95% CI:0.7-4.1). End-of-treatment response (ETR) was achieved in 51.9% of patients. Individuals with ETR had significantly lower microalbuminuria post-treatment (χ2=8.19, P=0.004).CONCLUSION: HCV affected the development of microalbuminuria independent of diabetes or cryoglobulinemia. Combination therapy of pegylated interferon-ribavirin had a positive effect in reducing microalbuminuria.

关键词： Hepatitis C virus Genotype Kidney diseases Albuminuria Proteinuria Peginterferon α-2a Ribavirin

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Driver sleepiness,fatigue,careless behavior and risk of motor vehicle crash and injury:Population based case and control study

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第5期4卷 496-502页

作者： abdulbari bener Erol Yildirim Turker Ozkan Timo Lajunen Department of Biostatistics and Medical Informatics Cerrahpasa Faculty of MedicineIstanbul UniversityIstanbulTurkey Department of Euidence for Population Health Unit School of Epidemiology and Health SciencesUniuersity of ManchesterManchesterUK International School of Medicine Istanbul Medipol UniversityIstanbulTurkey Department of Psychology Istanbul Medipol UniversityIstanbulTurkey Safety Research Unit Department of PsychologyMiddle East Technical UniversityAnkaraTurkey Department of Psychology Norwegian Uniuersity of Science and Technology(NTNU)TrondheimNorway

Background： A few studies have been conducted to determine the relationship between road motor vehicle crashes （MVC） and serious injuries related to tiredness, fatigues and sleeping. Aim： To determine the effects of aggressive behaviour, driver sleepiness and fatigue on MVC and related injuries among Turkish population. Design and setting： Population-based case and control study conducted at the accident emergency departments of hospitals and roads. Subjects： 515 car drivers involved in crashes with injury were admitted to hospital and 1030 car drivers involved while driving on public roads as control group during the study period. Methods： The Manchester driver behaviour questionnaire （DBQ） measured the aberrant driving behaviours leading to accidents. Participants completed a fatigue severity scale （FSS） and Stanford Sleeping questionnaire an epworth scale with items related to socio-demographic information, driving experiences, adherence to traffic laws （such as speed limits and seat belt）, and drivers＇ driving records. Results： In a representative sampling, participant＇s age ranged from 25 to 65 and the mean and standard deviation were 36.5 _＋ 7.8 for cases and 37.0 4- 8.0 for controls. There was a significant difference in both group of drivers regarding BMI, level of education, marital status, driving experience, seat belt use, excessive speed limits, physical activity number of sleeping hours, mobile phone use, and cigarette smoking habit （p = 0.017）. Also, there was a significant higher mean score on all the DBQ violation questions among case group in comparison with the control group （p 〈 0.001）. Further, cases had higher prevalence of Epworth sleeping disorders （p 〈 0.001） and fatigue severity （p - 0.003） compared to control drivers. Multivariate logistic regression revealed that excessive speed, fatigue, lapses, errors, Stanford sleepiness score, violations, mobile phone use and Epworth sleepiness scale were significantly associated with injury involvement in vehicle crash, after adjusting for driving

关键词： Driver Stanford sleeping FatigueRisk Road traffic crash and injury

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Effects of family history and consanguinity in primary immunodeficiency diseases in children in Qatar

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Open Journal of Immunology 2013年第2期3卷 47-53页

作者： Mohammad Ehlayel abdulbari bener Mohammad Abu Laban Department of Medical Statistics and Epidemiology Hamad Medical Corporation Department of Public Health Weill Cornell Medical College Doha Qatar Department of Evidence for Population Health Unit School of Epidemiology and Health Sciences University of Manchester Manchester UK Section of Pediatrics Hematology-Oncology Hamad Medical Corporation Department of Pediatrics Doha Qatar Weill Cornell Medical College Doha Qatar Section of Pediatric Allergy-Immunology Department of Pediatrics Hamad Medical Corporation Doha Qatar

Background: The high consanguinity in Middle East increases the risk of genetic diseases, including primary immunodeficiency diseases (PID). Objectives: This study was aimed at determining the rate of positive family history of PID, the overall rate and type of consanguinity, and their effects on delay age during diagnosis of PID. Materials and methods: A retrospective analysis was conducted on 131 children with PID (aged 0 - 14 years) managed at Hamad General Hospital during 1998-2012. Results: Data on 131 patients (75 males & 56 females) of 82 families was analyzed. The most common phenotype of PID was predominantly antibody deficiency (23.7%). The onset age was 24.01 months and delay age 18.7 months. Family history of PID was 66.4% (38.7% in predominantly antibody deficiency and 100% in diseases of immune dysregulation). Positive family history significantly (p = 0.004) reduced the delay age of PID diagnosis by 52.9%. The consanguinity rate was 61.1% (32.3% in the predominantly antibody ID to 96% in the phagocyte defects group), where paternal cousin ranked the highest type (57.5%). Conclusions: This study indicates that family history is common in children with PID and helpful in reducing the delay age. Consanguinity among families of affected children is also high (higher than healthy population). Paternal parallel cousin marriages are the most common type of consanguinity. For a practicing physician, family history is a simple and useful tool when suspecting PID in children. Primary prevention of PID in Middle East communities should consider consanguinity reduction through public awareness and education and premarital counseling programs.

关键词： Pediatric Primary Immunodeficiency Diseases Family History Consanguinity

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The Impact of Aggressive Behaviour, Sleeping, and Fatigue on Road Traffic Crashes as Comparison between Minibus/Van/Pick-up and Commercial Taxi Drivers

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Journal of Traffic and Transportation Engineering 2017年第1期5卷 21-31页

作者： abdulbari bener Timo Lajunen Turker Ozkan Erol Yildirim Khair S. Jadaan Department of Biostatistics and Medical Informatics Cerrahpasa Faculty of Medicine Istanbul University Istanbul 34098Turkey Department of Evidence for Population Health Unit School of Epidemiology and Health Sciences University of ManchesterManchester M13 9PL UK Department of Psychology Istanbul Medipol University Kavacik 34810 Beykoz istanbul Turkey Safety Research Unit Department of Psychology Middle East Technical University Ankara 06800 Turkey Department of Civil Engineering Faculty of Engineering University of Jordan Amman 11942 Jordan Department of Transportation Engineering University of Illinois at Urbana-Champaign IL 61820-6983 USA

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Clinico-Radiological Correlation in Children with Ataxia Telangiectasia in Qatar

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Open Journal of Immunology 2015年第1期5卷 33-38页

作者： Mohammad Ehlayel Mahmoud F. Elsaid Rana Shami Khalid Salem abdulbari bener Weill Cornell Medical College Doha Qatar Section of Pediatric Allergy-Immunology Department of Pediatrics Hamad Medical Corporation Doha Qatar Section of Pediatric Neurology Department of Pediatrics Hamad Medical Corporation Doha Qatar Department of Radiology Hamad Medical Corporation Doha Qatar Deptartment of Biostatistics & Medical Informatics Cerrahpa&scedil a Faculty of Medicine Istanbul University Istanbul Turkey Department Evidence for Population Health Unit School of Epidemiology and Health Sciences The University of Manchester Manchester UK

Introduction: Ataxia telangiectasia (AT) is a rare disease characterized by immunodeficiency and neurological manifestations. Ataxia, resulting from cerebella atrophy, runs a progressive incapacitating course. Clinical monitoring of the disease course is mandatory for early treatment. Aim: To study clinical severity of AT and correlate it with the degree of cerebellar atrophy. Patients and Methods: We retrospectively studied all children (less than 14 years) with AT seen at Hamad General Hospital Clinics between 1998-2013. We collected basic demographic data, parental consan-guinity, family history, AT clinical severity scores, and reviewed CBC with differential counts;alpha-fetoprotein, serum immunoglobulins and lymphocyte subsets. Cranial MRI scans of each subject were reviewed by a neuroradiologist. Cerebellar atrophy was visually and semi-quantitatively scored. Results: We analyzed data on 18 AT children (10 males and 8 females), mean age of 76.9 months. 77.8% had a positive family history of AT and 41.7% parental consanguinity. Lymphopenia was observed in 77.8% and high serum alpha-fetoprotein in 87.5% of children. Clinical severity of ataxia was 17.1 ± 8.4 (mean ± SD);86.7% of patients were moderate-severe. MRI cerebellar atrophy score was 1.9 ± 1.3 (mean ± SD), and moderate in 51% of patients. AT clinical severity score correlated (coefficient r = 0.566) but not statistically significant p = 0.088) with MRI cerebellar atrophy scores. Conclusions: Moderate to severe ataxia and marked cerebellar atrophy are quite common in AT children. There is a correlation between AT clinical severity and cerebellar atrophy. Larger prospective studies might further determine the significance of our observations and help practicing practitioners monitor the progression of the disease.

关键词： Ataxia Telangiectasia Cerebellar Atrophy MRI Clinical Severity Children

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Association between psychological distress and gastrointestinal symptoms in diabetes mellitus

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World Journal of Diabetes 2012年第6期3卷 123-129页

作者： abdulbari bener Suhaila Ghuloum Abdulla OAA Al-Hamaq Elnour E Dafeeah Department of Medical Statistics and Epidemiology Hamad Medical CorporationDohaPO Box 3050Qatar Department of Public Health Weill Cornell Medical CollegeDohaPO Box 3050Qatar Department of Evidence for Population Health Unit School of Epidemiology and Health SciencesUniversity of ManchesterManchesterM13 9PLUnited Kingdom Department of Psychiatry Psychology UnitRumailah HospitalHamad Medical CorporationDohaPO Box 3050Qatar Qatar Diabetic Associations and Qatar Foundation DohaPO Box 5825Qatar

AIM:To examine the possible association between gastrointestinal symptoms and anxiety and depression in type 2 diabetes mellitus(T2DM).METHODS:The study was a matched case-control study based on a face to face interview with designed diagnostic screening questionnaires for gastrointestinal(GI) symptoms and T2DM,Patient Health Questionnaire(PHQ-9) for depression and General Anxiety Disorders(GAD-7) for anxiety.The questionnaire consisted of questions about symptoms and signs of anxiety and depression disorders.Also,socio-demographic characteristics,life style habits and the family history of patients were collected.It was carried out from June 2010 to May 2011 among Qatari and other Arab nationals over 20 years of age at Primary Health Care Centers of the Supreme Council of Health,Qatar,including patients with diabetes mellitus and healthy subjects over 20 years of age.RESULTS:In the studied sample,most of the studied T2DM patients with GI symptoms(39.3%) and healthy subjects(33.3%) were in the age group 45-54 years(P < 0.001).The prevalence of severe depression(9.5% vs 4.4%,P < 0.001) and anxiety(26.3% vs 13.7%,P < 0.001) was significantly higher in T2DM patients with GI symptoms than in general population.Obesity(35.7% vs 31.2%) and being overweight(47.9% vs 42.8%) were significantly higher in T2DM patients with GI symptoms than in healthy subjects(P = 0.001).Mental health severity score was higher in T2DM patients with GI symptoms than in healthy subjects;depression(8.2 ± 3.7 vs 6.0 ± 3.6) and anxiety(7.6 ± 3.3 vs 6.0 ± 3.7).The most significant GI symptom which was considerably different from controls was early satiety [odds ratio(OR) = 10.8,P = 0.009] in depressed T2DM patients and loose/watery stools(OR = 2.79,P = 0.029) for severe anxiety.Anxiety was observed more than depression in T2DM patients with GI symptoms.CONCLUSION:Gastrointestinal symptoms were significantly associated with depression and anxiety in T2DM patients,especially anxiety disorders.

关键词： Gastrointestinal Type 2 diabetes mellitus Distress Depression Anxiety Qatar

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Parental transmission of type 2 diabetes mellitus in a highly endogamous population

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World Journal of Diabetes 2013年第2期4卷 40-46页

作者： abdulbari bener Mohammad T Yousafzai Abdulla OAA Al-Hamaq Abdul-Ghani Mohammad Ralph A DeFronzo Department of Medical Statistics and Epidemiology Hamad Medical Corporation Department of Evidence for Population Health Unit School of Epidemiology and Health Sciences The University of Manchester Qatar Diabetic Association and Qatar Foundation Division of Diabetes University of Texas Health Science Center at San Antonio

AIM: To determine the parental transmission of diabetes mellitus (DM) and evaluate its influence on the clinical characteristics. METHODS: This was a cross sectional study. The survey was carried out in urban and semi-urban primary health care centers. Of the 2400 registered with diagnosed diabetes, 1980 agreed and gave their consent to take part in this study, thus giving a response rate of 82.5%. Face to face interviews were conducted using a structured questionnaire followed by laboratory tests. DM was defined according to the World Health Organization expert group. A trained nurse performedphysical examinations and measurements. RESULTS: Of the study population, 72.9% reported a family history of DM. Family history of DM was significantly higher in females (54.2%; P = 0.04) and in the age group below 30 years (24%; P < 0.001). The prevalence of diabetes was higher among patients with a diabetic mother (25.4% vs 22.1%) and maternal aunts/uncles (31.2% vs 22.2%) compared to patients with a diabetic father and paternal aunts/ uncles. Family history of DM was higher in patients of consanguineous parents (38.5%) than those of non-consanguineous parents (30.2%). The development of type 2 diabetes mellitus (T2DM) complications was higher in patients with either a paternal or maternal history of DM than in those without. No significant difference was observed in the metabolic characteristics of patients with/without family history of DM except for hypertension. Complications were higher in diabetic patients with a family history of DM. CONCLUSION: The present study found a significant maternal effect in transmission of T2DM. Family history is associated with the increased incidence of diabetes.

关键词： Diabetes mellitus Family history Parental transmission Genetic disorders Consanguinity Maternal transmission

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Attosecond magnetization dynamics in non-magnetic materials driven by intense femtosecond lasers

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npj Computational Materials 2023年第1期9卷 1959-1968页

作者： Ofer Neufeld Nicolas Tancogne-Dejean Umberto De Giovannini Hannes Hübener Angel Rubio Max Planck Institute for the Structure and Dynamics of Matter and Center for Free-Electron Laser Science Hamburg 22761Germany Universitàdegli Studi di Palermo Dipartimento di Fisica e Chimica—Emilio SegrèPalermo I-90123Italy Center for Computational Quantum Physics(CCQ) The Flatiron InstituteNew YorkNY 10010USA

Irradiating solids with ultrashort laser pulses is known to initiate femtosecond timescale magnetization dynamics.However,sub-femtosecond spin dynamics have not yet been observed or predicted.Here,we explore ultrafast light-driven spin dynamics in a highly nonresonant strong-field regime.Through state-of-the-art ab initio calculations,we predict that a nonmagnetic material can transiently transform into a magnetic one via dynamical extremely nonlinear spin-flipping processes,which occur on attosecond timescales and are mediated by cascaded multi-photon and spin–orbit interactions.These are nonperturbative nonresonant analogs to the inverse Faraday effect,allowing the magnetization to evolve in very high harmonics of the laser frequency(e.***.here up to the 42nd,oscillating at~100 attoseconds),and providing control over the speed of magnetization by tuning the laser power and wavelength.Remarkably,we show that even for linearly polarized driving,where one does not intuitively expect the onset of an induced magnetization,the magnetization transiently oscillates as the system interacts with light.This response is enabled by transverse light-driven currents in the solid,and typically occurs on timescales of~500 attoseconds(with the slower femtosecond response suppressed).An experimental setup capable of measuring these dynamics through pump–probe transient absorption spectroscopy is simulated.Our results pave the way for attosecond regimes of manipulation of magnetism.

关键词： tuning transient dynamics

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