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Association of H pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases

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World Journal of Gastroenterology 2006年第32期12卷 5205-5210页

作者： Eskandar Kamali-Sarvestani abdulah bazargani Malihe Masoudian Kamran Lankarani Ali-Reza Taghavi Mehdi Saberifiroozi Department of Immunology and Autoimmune Diseases Research Center Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of Bacteriology and virology Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of cellular and molecular sciences Khatam University TehranIran Gastrointestinal and Hepatology Research center Shiraz Medical School Shiraz University of Medical SciencesShirazIran Department of Internal medicine Shiraz Medical School Shiraz University of Medical SciencesShirazIran

AIM： To find out if a functional promoter polymorphism in the IL-8 gene along with cagA status and polymorphisms in vacA gene influence the type of diseases in Iranian patients infected by Hpylori. METHODS： IL-8 -251 A/T polymorphism was genotyped by oligonucleotide allele specific PCR （ASO-PCR） in a sample of 233 patients with Hpylori infection undergoing upper gastrointestinal endoscopy. The presence of cagA gene and polymorphisms in vacA gene was also determined by PCR. Association of these genetic polymorphisms with the development of gastritis, peptic ulcers as well as gastric cancer was tested. RESULTS： When the patients with different clinical manifestations were compared according to the presence of cagA gene or various vacA genotypes, only the vacA genotypes were significantly different among gastritis, peptic ulcer and gastric cancer patients （χ^2= 17.8; P=0.001）. Furthermore, there was a significant difference in the frequency of IL-8 -251 A/T genotypes between patients with gastric cancer and benign diseases （χ^2=10.47;P=0.005） CONCLUSION： The IL-8 -251 A/T polymorphism and the polymorphisms in H pylor/ vacA gene are involved in limiting the infection outcome to gastritis and peptic ulcer or in favoring cancer onset in Iranian patients.

关键词： Interleukin 8 Hpylori Gastric cancer Peptic ulcer Polymorphism

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