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湿地科学 2006年第4期4卷 247-252页

作者： Chee Kong Yap Ahmad ismail abdul rahim ismail Soon Guan Tan Department of Biology Faculty of Science University Putra Malaysia UPM 43400 Serdang Selangor Malaysia

The distribution and concentrations of Cd, Cu, Pb and Zn were determined in the gills and remaining soft tissues of Perna viridis collected from 12 geographical sites (10 from the west and 2 from the east coastal waters) of Peninsular Malaysia. All samples showed that the levels of Cd, Pb and Zn were generally higher in the gill than those in the remaining soft tissues. These results could be due to the fact that gills are the first organ of metal accumulation and larger surface area with mucus sheets in the organ. Since the mussel gill is a better accumulator of Cd, Pb and Zn of ambient seawater than remaining soft tissue, it is a potential indicator of ambient levels of dissolved metals in the ambient seawater. However, further validations based on laboratory conditions are needed.

关键词： gill heavy metals Perna viridis

Biochemical studies on malathion resistance, inheritance and association of carboxylesterase activity in brown planthopper, Nilaparvata lugens complex in Peninsular Malaysia

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Insect Science 2010年第6期17卷 517-526页

作者： M. A. Latif Mohd Yosuh Omar Soon Guan Tan S.S. Siraj abdul rahim ismail Department of Crop Science Faculty of Agriculture Department of Biology Faculty of Science Department of Cell and Molecular Biology Faculty of Biotechnology and Molecular Science Department of Aquaculture Faculty of Agriculture Universiti Putra Malaysia Serdang Selangor Malaysia

Two sympatric populations of brown planthopper （BPH）, one from rice and the other from Leersia hexandra were collected from each of five locations in Malaysia. All the tested malathion-resistant individuals of the rice BPH population and F1 generation （cross between malathion-resistant [usually caught on rice] and malathion- susceptible [usually caught on Leersia]） showed high esterase activity, while all malathion- susceptible individuals on L. hexandra showed low esterase activity. In the F2 generation, all the individuals tested against malathion were approximately 75% resistant and 25% susceptible and the inheritance pattern of esterase activity （high and low esterase activity） segregated in the same manner to a 3：1 ratio. This confirms that resistance to malathion is mono-factorial and inheritance pattern ofesterase activity is also linked to malathion resistance. Carboxylesterase or total esterase activity in BPH is inherited in a simple Mendelian fashion that is encoded by a single dominant gene. For the total esterase assay, average esterase activity levels in the rice-infesting population ranged from 17.64 to 19.37 nmoles 1-napthol/mg protein while that in the Leersia-infesting population ranged from 5.29 to 6.11 nmoles 1-napthol/mg protein. In terms of esterase activity, the two sympatric Nilaparvata lugens populations separated into two distinct groups. Results based on the tube color intensity test showed 96% and 98% resistant and susceptible individuals were present in the rice- and Leersia-infesting populations, respectively. In a filter paper test, the rice-infesting population had 94% with high esterase activity while the Leersia-infesting population had 96% with low esterase activity.

关键词： brown planthopper carboxylesterase assay inheritance study insecticide resistance rice

A comprehensive review of radiation effects on solder alloys and solder joints

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Defence Technology（防务技术） 2024年第9期39卷 86-102页

作者： Norliza ismail Wan Yusmawati Wan Yusoff Nor Azlian abdul Manaf Azuraida Amat Nurazlin Ahmad Emee Marina Salleh Department of Physics Centre for Defence Foundation StudiesUniversiti Pertahanan Nasional MalaysiaKem Sungai BesiKuala Lumpur 57000Malaysia Department of Mineral and Geoscience Malaysia Mineral Research CentreJalan Sultan Azlan ShahIpoh 31400PerakMalaysia

In the realm of military and defence applications, exposure to radiation significantly challenges the performance and reliability of solder alloys and joints in electronic systems. This comprehensive review examines radiation-induced effects on solder alloys and solder joints in terms of microstructure and mechanical properties. In this paper, we evaluate the existing literature, including experimental studies and fundamental theory, to provide a comprehensive overview of the behavior of solder materials under radiation. A review of the literature highlights key mechanisms that contribute to radiation-induced changes in the microstructure, such as the formation of intermetallic compounds, grain growth,micro-voids and micro-cracks. Radiation is explored as a factor influencing solder alloy hardness,strength, fatigue and ductility. Moreover, the review addresses the challenges and limitations inherent in studying the effects of radiation on solder materials and offers recommendations for future research. It is crucial to understand radiation-induced effects on solder performance to design robust and radiationresistant electronic systems. A review of radiation effects on solder materials and their applications in electronics serves as a valuable resource for researchers, engineers, and practitioners in that field.

关键词： Defence technology Solder alloy Solder joints Radiation-induced effect Microstructure Mechanical properties

Partial Fusion (F) Gene Analysis of Newcastle Disease Virus Detected in Pakistan during 2021-2022

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Journal of Biosciences and Medicines 2024年第5期12卷 256-275页

作者： Muhammad Danish Mehmood Huma Anwar Ul-Haq Rauf Khalid Yasir Amin Muhammad Usman Ghani Muhammad ismail Rabia Habib Fareeha Arshed abdul Rasheed Shaukat Institute of Molecular Biology & Biotechnology University of Lahore Lahore Pakistan Research & Development Division Ottoman Pharma Lahore Pakistan Quality Assurance Department Ottoman Pharma Lahore Pakistan Veterinary Research and Disease Investigation Center Abbottabad Pakistan Quality Control Department Ottoman Pharma Immuno Lahore Pakistan Production Department Ottoman Pharma Lahore Pakistan Poultry Production Department Sabir&#8217s Poultry Pvt. Ltd. Sabroso Pakistan

Newcastle disease (ND) virus is a leading threat to commercial and domestic poultry in Pakistan. The virus infects and constitutes irreversible impairment to the nervous system, damages the respiratory system, and marks severe gastrointestinal lesions leading to heavy mortality in short-living birds and substantial losses in layers and breeders. The continuous emergence and evolution of the virus made it inclined to evade the humoral response and indirectly the circumvention of artificial active immunization. Newcastle disease is caused by the orthoavula genus of the paramyxoviridae family and has shown high genetic diversity even in their genotypes while information regarding enzootic trends of the virus is scanty in Pakistan. A total of 40 tracheal samples of NDV were collected from different commercial broiler farms and 11 isolates of NDV were identified. In the current study, we determined the genetic diversity of the Newcastle disease virus based on the partial sequencing of the fusion protein gene available in the NCBI database. Genetic analysis showed that seven isolates belonged to class I genotype VII and four belonged to class II genotype II. Interestingly, two isolates had epidemiological connections with vaccine-like class II genotype II. Our findings, concerning the recent outbreaks of class I genotype VII and class II genotype II of NDV in vaccinated commercial flocks, suggest possible potential partial mutations in the fusion protein gene. Genetic diversity and formation of the new cleavage site in an important neutralizing protein of wild strain are linked with the potency of artificial active immunization and a major cause of vaccine failure.

关键词： Newcastle Disease Virus Haemagglutination Inhibition Polymerase Chain Reaction Phylogenetic Tree Mutation Analysis

Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model

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World Journal of Experimental Medicine 2024年第1期14卷 113-123页

作者： Suriati Mohd Nasir Anis Farihan ismail Tuan Salwani Tuan ismail Wan Faiziah Wan abdul Rahman Wan Amir Nizam Wan Ahmad Tengku Ahmad Damitri Al-Astani Tengku Din Kuttulebbai Nainamohammed Salam Sirajudeen Department of Chemical Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Endocrinology Laboratory Department of Chemical PathologySchool of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Biomedicine Program School of Health SciencesHealth CampusUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Basic Medical Sciences Kuliyyah of MedicineInternational Islamic University MalaysiaBandar Indera MahkotaKuantan 25200PahangMalaysia

BACKGROUND Diabetes is known damage the liver and kidney,leading to hepatic dysfunction and kidney *** is believed to help in lowering the blood glucose levels of diabetic patients and reducing diabetic ***,the effect of stingless bee honey(SBH)administration in relieving liver and kidney damage in diabetes has not been *** To investigate the effect of SBH administration on the kidney and liver of streptozotocin-induced(STZ;55 mg/kg)diabetic Sprague Dawley *** The rats were grouped as follows(n=6 per group):non-diabetic(ND),untreated diabetic(UNT),metformin-treated(MET),and SBH+metformin-treated(SBME)*** successful diabetic induction,ND and UNT rats were given normal saline,whereas the treatment groups received SBH(2.0 g/kg and/or metformin(250 mg/kg)for 12 *** biochemical parameters and histological changes using hematoxylin and eosin(H&E)and periodic acid–Schiff(PAS)staining were *** On H&E and PAS staining,the ND group showed normal architecture and cellularity of Bowman’s capsule and tubules,whereas the UNT and MET groups had an increased glomerular cellularity and thickened basement *** SBH-treated group showed a decrease in hydropic changes and mild cellularity of the glomerulus vs the ND group based on H&E staining,but the two were similar on PAS ***,the SBME-treated group had an increase in cellularity of the glomerulus on H&E staining,but it was comparable to the SBH and ND groups on PAS *** diabetic rats had tubular hydropic tubules,which were smaller than other *** fatty vacuole formation and dilated blood sinusoids in liver tissue were seen in the SBH ***,the UNT group had high glucose levels,which subsequently increased MDA levels,ultimately leading to liver *** treatment reduced this damage,as evidenced by having the lowest fasting glucose,serum alanine transaminase,aspartate transaminase,and alkaline phosphatase l

关键词： Diabetes Streptozotocin Stingless bee honey Hematoxylin and eosin Periodic acid-Schiff Liver Kidney

Epidemiological observations of invasive group B Streptococcus infections in six major hospitals in Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第9期17卷 384-391页

作者： abdulRahman Muthanna Mohd Nasir Mohd Desa Nurul Asyikin abdul Rahman Nurul Diana Dzaraly Nurul Hana Zainal Baharin Nur Afiza Aziz Chua Hui Shan Zalina ismail Lailatul Akmar Mat Nor Marlindawati Mohd Ali Nur Hanani Ahmad Mohammad Noor Amal Azmai Syafinaz Amin-Nordin Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia School of Biology Faculty of Applied SciencesUniversiti Teknologi MARANegeri Sembilan72000 Kuala PilahMalaysia Department of Oral Biology&Biomedical Sciences Faculty of DentistryMAHSA University42610 JenjaromSelangorMalaysia School of Bioscience Faculty of Pharmacy and Biomedical SciencesMAHSA University42610 JenjaromSelangorMalaysia Department of Pathology Sultanah Aminah Hospital80100 Johor BahruJohorMalaysia Department of Pathology Melaka General Hospital75400 MelakaMalaysia Department of Medical Microbiology and Immunology Faculty of MedicineUniversiti Kebangsaan Malaysia56000 CherasKuala LumpurMalaysia Department of Pathology Sultan Idris Shah Serdang Hospital43000 KajangSelangorMalaysia Department of Pathology Tuanku Ja'afar Hospital70300 SerembanNegeri SembilanMalaysia Department of Pathology Sungai Buloh Hospital47000 Sungai BulohSelangorMalaysia Department of Biology Faculty of ScienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Aquatic Animal Health and Therapeutics Laboratory Institute of BioscienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Sultan Abdul Aziz Shah HospitalUniversiti Putra MalaysiaPersiaran MARDI-UPM43400SelangorMalaysia

Objective:To address the lack of research on invasive group B Streptococcus(GBS)infections in Malaysia and Southeast Asia through a comprehensive analysis of GBS isolates obtained from ***:Medical records from patients with GBS infection isolated from the sterile site,such as blood and cerebrospinal fluid from 14 July 2019 to 15 December 2020,were reviewed from six major hospitals in Peninsular *** criteria were invasive GBS,sterile sites and non-repeated GBS isolated from the same patients in the same *** isolates were re-identified for GBS and ***:A total of 118 patients were eligible,with a majority of non-pregnant adults(76.3%).Over half of the patients(62.7%)had underlying medical conditions,with diabetes as the most common disease,followed by respiratory disease,renal disease,cardiovascular disease and skin and soft tissue *** most common manifestations were sepsis,followed by soft tissue abscess,diabetic foot ulcer,wet gangrene and *** overall mortality was 7.6%.The most common serotype was serotype桋.Conclusions:Invasive GBS infection among non-pregnant adults showed a rising trend,particularly among diabetic *** study underscores the importance of reducing risk factors and highlights the necessity of developing GBS vaccination as a preventive strategy for both infants and adults.

关键词： Streptococcus agalactiae Group B Streptococcus Invasive GBS infections Malaysia

Morpholine hydrazone scaffold： Synthesis, anticancer activity and docking studies

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Chinese Chemical Letters 2017年第3期28卷 607-611页

作者： Muhammad Taha Syed Adnan Ali Shah Muhammad Afifi Manar Zulkeflee Sadia Sultan abdul Wadood Fazal rahim Nor Hadiani ismail Atta-ur-Rahman Institute for Natural Product Discovery (AuRlns) Universiti Teknologi MARA Puncak Alam Campus 42300 Bandar Puncak Alam SelangorD. E. Malaysia Faculty of Applied Science UiTM Shah Alam 40450 Shah Alam Selangor D.E. Malaysia Faculty of Pharrnacy Universiti Teknologi MARA Puncat~ Alam Campus 42300 Baadar Puncak Alam Selangor D.E. Malaysia Department of Biochemistry Abdul Wali Khan University Mardan 23200 Pakistan Department of Chemistry Hazara University Mansehra 21300 Pakistan

In this paper, synthesis and anticancer activities of morpholine hydrazones scaffold（1-17） thoroughly studied. Small series of morpholine hydrazones synthesized by treating 5-morpholinothiophene-2-carbaldehyde with different aryl hydrazides to form morpholine hydrazones scaffold（1-17）. The in vitro anticancer potential of all these compounds was checked against human cancer cell lines like Hep G2（human hepatocellular liver carcinoma） and MCF-7（human breast adenocarcinoma）. Analogs 13 had similar substantial cytotoxic effects towards Hep G2 with IC_（50） value 6.31±1.03μmmol/L when compared with the standard Doxorubicin（IC_（50）value 6.00±0.80μmmol/L）; while compounds 5,8 and 9 showed potent cytotoxicity against MCF-7 with IC_（50） value 7.08±0.42μmmol/L, 1.26±0.34μmmol/L and11.22±0.22μmmol/L respectively when compared with the standard Tamoxifen（IC_（50）= 11.00±0.40μmol/L）. Molecular docking studies also performed to understand the binding interaction.

关键词： Morpholine hydrazones Synthesis HepG2 MCF-7 Molecular docking

Trichomonas vaginalis infection in a low-risk women attended in Obstetrics and Gynaecology Clinic, Universiti Kebangsaan Malaysia Medical Centre

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 702-705页

作者： Norhayati Moktar Nor Liyana ismail Phoy Cheng Chun Mohamad Asyrab Sapie Nor Farahin abdul Kahar Yusof Suboh Noraina abdul rahim Nor Azlin Mohamed ismail Tengku Shahrul Anuar Department of Parasitology and Medical Entomology Universiti Kebangsaan Malaysia Medical Centre Department of Obstetrics and Gynaecology Universiti Kebangsaan Malaysia Medical Centre Department of Medical Laboratory Technology Faculty of Health Sciences Universiti Teknologi MARAPuncak Alam Campus

Objective: To investigate the presence of trichomoniasis among women attending the Obstetrics and Gynaecology Clinic, Universiti Kebangsaan Malaysia Medical ***: A total of 139 high vaginal swabs were taken from the subjects and sent to the laboratory in Amies gel transport media. The specimens were examined for the presence of Trichomonas vaginalis using wet mount, Giemsa staining and cultured in Diamond's medium. Sociodemographic characteristics and gynaecological complaints were obtained in private using structured questionnaire applied by one ***: The median age was 32 years, with an interquartile interval of 9.96. Most of the subjects were Malays(76.9%) and the remaining were Chinese(15.1%), Indians(2.2%)and other ethnic groups(5.8%). One hundred and thirty eight(99.3%) of the women were married and 98.6% had less than 6 children. More than half(75.5%) of the women's last child birth was less than 6 years ago. Forty seven percent of them were involved in supporting administrative work and 64.7% of the women gave a history of previous or current vaginal ***: The present study reported zero incidence rate of trichomoniasis. The low incidence rate was postulated due to all women who participated in this study were categorized into a low-risk group.

关键词： Trichomoniasis Incidence rate Wet mount Giemsa staining Culture

Integration of CityGML and Oracle Spatial for implementing 3D network analysis solutionsand routing simulation within 3D-GIS environment

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Geo-Spatial Information Science 2013年第4期16卷 221-237页

作者： Umit ATILA ismail Rakip KARAS Alias abdul-RAHMAN Department of Computer Engineering Karabuk UniversityKarabukTurkey Department of Geoinformatics Universiti Teknologi MalaysiaJohorMalaysia

3D navigation within a 3D-GIS environment is increasingly getting more popular and spreading to various *** thelast decade,especially after the 9/11 disaster,evacuating the complex and tall buildings of today in case of emergencyhas been an important research area for *** of the current navigation systems are still in the 2D environmentand that is insufficient to visualize 3D objects and to obtain satisfactory solutions for the 3D ***,there is currently still a lack of implementation of 3D network analysis and navigation for indoor spaces in respect *** objective of this paper is to investigate and implement 3D visualization and navigation techniques andsolutions for indoor spaces within *** realizing this,we have proposed a GIS implementation that is capable ofcarrying out 3D visualization of a building model stored in the CityGML format and perform analysis on a networkmodel stored in Oracle *** proposed GUI also provides routing simulation on the calculated shortest paths withvoice commands and visual instructions.

关键词： 3D-GIS 3D network analysis indoor navigation evacuation

Numerical Solution for Neutral Delay Differential Equation of Constant or Proportional Type using Hybrid Block Method

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Advances in Applied Mathematics and Mechanics 2022年第5期14卷 1138-1160页

作者： Nur Inshirah Naqiah ismail Zanariah abdul Majid Norazak Senu Institute for Mathematical Research Universiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Department of Mathematics and Statistics Faculty of ScienceUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia

Neutral Delay Differential Equation(NDDE)is a differential problem that has regularly existed in numerous occurrences and has represented a significant role in dealing with real-life phenomena,especially on their application in biological and physiological processes.A fifth-order two-point hybrid implicit multistep block method(2PIH5)has been formulated in this research for the numerical solution of Neutral Delay Differential Equation(NDDE).A Taylor series interpolation polynomial has been implemented in the formulation of the proposed *** order,consistency,and zero-stability for 2PIH5 have been *** analyses of convergence and stability test have been performed and *** initial value problems for the first-order NDDE with constant or proportional delay have been solved using the proposed block *** numerical results for the proposed method have been presented to prove the adaptability and applicability of the proposed method in solving *** proposed method is proved to be comparable with the other existing *** is assumed to be reliable and efficient for solving the first-order NDDE with constant or proportional delay.

关键词： Constant delay hybrid method multistep block method neutral delay differential equation proportional delay