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Soluble Human Leukocyte Antigen-G Expression in Pregnancy Success and Early Pregnancy Loss in Korle-Bu Teaching Hospital

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Open Journal of Immunology 2016年第1期6卷 1-6页

作者： abdul-Rahman Mubarak Irene Sitsofe Blebu kareem Mumuni Yao Tettey Richard Kwasi Gyasi Andrew Anthony Adjei Michael Ofori Department of Pathology School of Biomedical and Allied Health Sciences University of Ghana Accra Ghana Department of Obstetrics and Gynaecology School of Medicine and Dentistry University of Ghana Accra Ghana Department of Immunology Noguchi Memorial Institute of Medical Research Accra Ghana

Introduction: Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex (MHC) class Ib antigen characterized by a limited polymorphism. The expression of HLA-G at immune privileged sites and its ability to inhibit the effectors functions of immune cells has set HLA-G as a molecule of immune tolerance. This expression pattern is unique among HLA genes and suggests that HLA-G may be involved in interactions that are critical in establishing and/or maintaining pregnancy. Methods: Soluble HLA-G (sHLA-G) levels were measured using a BioVendor sHLA-G ELISA kit following the manufacturer’s protocol. The study participants include women undergoing spontaneous abortion, non-pregnant women, males and an archive sample of women who had normal vaginal deliveries without any complications and any history of malaria infection from gestation to delivery. Results: Soluble HLA-G levels were higher among women undergoing spontaneous abortion as compared to women who had normal vaginal delivery and non-pregnant women. Soluble HLA-G levels were also higher in second trimester as compared to first trimester in both women who had spontaneous abortions and women who had normal delivery. Conclusion: Although sHLA-G levels were higher among women undergoing spontaneous abortion as compared to non-pregnant women and women who had normal delivery, this may be playing a role in the maintenance of maternal immune tolerance to fetal antigen, since plasma sHLA-G levels increased with increasing trimester in both women who had normal delivery and women undergoing spontaneous abortion.

关键词： Soluble Human Leukocyte Antigen G (sHLA-G) Spontaneous Abortion Maternal Immune Tolerance Implantation

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Effect of SARS-CoV-2 infection on the liver

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World Journal of Virology 2023年第2期12卷 109-121页

作者： Adekunle Sanyaolu Aleksandra Marinkovic Abu Fahad Abbasi Stephanie Prakash Risha Patidar Priyank Desai Martina Williams abdul Jan kareem Hamdy Rachael Solomon Vyshnavy Balendra Maaz Ansari Omar Shazley Nasar Khan Rochelle Annan Yashika Dixon Chuku Okorie Afolabi Antonio Department of Public Health Federal Ministry of HealthAbujaNigeriaAbuja 0000FCTNigeria Department of Basic Medical Science Saint James School of MedicineThe Quarter 26400000Anguilla Department of Internal Medicine Loyola University Medical CenterMaywoodIllinoisIL 60153United States Department of Basic Medical Science American University of Saint Vincent School of MedicineSaint Vincent and the Grenadines 0000Saint Vincent and the Grenadines Department of Basic Medical Science Windsor University School of MedicineCayon 0000Saint Kitts and Nevis Department of Basic Medical Science Caribbean Medical University School of MedicineWillemstad 0000CuraçaoNetherlands Antilles Basic Medical Science Saint James School of MedicineSaint Vincent and the Grenadines 0000Saint Vincent and the Grenadines University of Health Sciences Antigua School of Medicine PiccadillySt.John's Antigua Department of Science Union County CollegePlainfieldNew JerseyNJ 07016United States Department of Internal Medicine Lloydminster Regional HospitalLloydminster S9V 1Y5SaskatchewanCanada

There have been numerous concerns about the disease and how it affects the human body since the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic began in December *** impact of SARS-CoV-2 on the liver is being carefully investigated due to an increase in individuals with hepatitis and other liver illnesses,such as alcoholic liver ***,the liver is involved in the metabolism of numerous drugs used to treat comorbidities and coronavirus disease 2019(COVID-19).Determining how SARS-CoV-2 affects the liver and what factors place individuals with COVID-19 at a higher risk of developing liver problems are the two main objectives of this *** evaluation of the literature included research from three major scientific *** provide an update on the current impact of COVID-19 on the liver,data was collected and relevant information was incorporated into the *** more knowledge about the effect of the disease on the liver,better management and therapeutics can be developed,and education can ultimately save lives and reduce the long-term impact of the pandemic on our population.

关键词： Coronavirus COVID-19 SARS-CoV-2 Liver Hepatic complications

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