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Identifying the stability of housekeeping genes to be used for the quantitative real-time PCR normalization in retinal tissue of streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 794-805页

作者： Muhammad Zulfiqah Sadikan Nurul Alimah abdul nasir Mohammad Johari Ibahim Igor Iezhitsa Renu Agarwal department of Pharmacology Faculty of MedicineManipal University College Malaysia(MUCM)Bukit BaruMelaka 75150Malaysia Centre for Neuroscience Research(NeuRon) Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia department of Medical Education Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia department of Biochemistry and Molecular Medicine Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia department of Pharmacology and Bioinformatics Volgograd State Medical UniversityVolgograd 400131Russia

AIM:To investigate the stability of the seven housekeeping genes:beta-actin(ActB),glyceraldehyde-3-phosphate dehydrogenase(GAPdH),18s ribosomal unit 5(18s),cyclophilin A(CycA),hypoxanthine-guanine phosphoribosyl transferase(HPRT),ribosomal protein large P0(36B4)and terminal uridylyl transferase 1(U6)in the diabetic retinal tissue of rat ***:The expression of these seven genes in rat retinal tissues was determined using real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)in two groups;normal control rats and streptozotocininduced diabetic *** stability analysis of gene expression was investigated using geNorm,NormFinder,BestKeeper,and comparative delta-Ct(ΔCt)***:The 36B4 gene was stably expressed in the retinal tissues of normal control animals;however,it was less stable in diabetic *** 18s gene was expressed consistently in both normal control and diabetic rats’retinal *** this gene was the best reference for data normalisation in RT-qPCR studies that used the retinal tissue of streptozotocin-induced diabetic ***,there was no ideal gene stably expressed for use in all experimental ***:Identifying relevant genes is a need for achieving RT-qPCR validity and reliability and must be appropriately achieved based on a specific experimental setting.

关键词： housekeeping genes stability real-time reverse transcription polymerase chain reaction retinal tissue streptozotocin-induced diabetic rats

Hybrid Effects on MHd Mixed Convective Boundary Layer Flow through a Sloped Plate in Existence of Nanofluid-Saturated Porous Medium

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Journal of Applied Mathematics and Physics 2024年第9期12卷 3037-3052页

作者： Md. nasir Uddin abdul Halim Bhuiyan Zahurul Islam Tahmina Tahrim department of Mathematics Bangladesh Army University of Engineering & Technology Natore Bangladesh department of Mathematics Bangladesh University of Engineering and Technology Dhaka Bangladesh department of Computer Science and Engineering Jagannath University Dhaka Bangladesh

This study examines the effects of heat, mass, and boundary layer assumptions-based nanoparticle characteristics on the hybrid effects of using MHd in conjunction with mixed convective flow through a sloped vertical pore plate in the existence of medium of porous. Physical characteristics such as thermo-diffusion, injection-suction, and viscous dissipation are taken into consideration, in addition to an equally distributed magnetic force utilized as well in the completely opposite path of the flow. By means of several non-dimensional transformations, the momentum, energy, concentration, and nanoparticle volume fraction equations under investigation are converted in terms of nonlinear boundary layer equations and computationally resolved by utilizing the sixth-order Runge-Kutta strategy in combination together with the iteration of Nachtsheim-Swigert shooting procedure. By contrasting the findings produced for a few particular examples with those found in the published literature, the correctness of the numerical result is verified, and a rather good agreement is found. Utilizing various ranges of pertinent factors, computing findings are determined not only regarding velocity, temperature, and concentration as well as nanoparticle fraction of volume but also concerning with local skin-friction coefficient, local Nusselt and general Sherwood numbers associated with nanoparticle Sherwood number. The findings of the study demonstrate that increasing the fluid suction parameter decreases the velocity and temperature of the flow field in conjunction with concentration and has a variable impact on the nanoparticle fraction of volume, despite an increasing behavior in the local skin friction coefficient and local Nusselt as well as general Sherwood numbers and an increasing behavior in the local nanoparticle Sherwood number. Furthermore, enhancing a Schmidt number leads to a reduction in the local nanoparticle Sherwood number and a rise in the nanoparticle proportion of vo

关键词： Hybrid Effects Mixed Convection MHd Nanofluid Viscous dissipation

design of a Novel Robotic Fish Structure Utilizing PVC Gel Actuators

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Modern Mechanical Engineering 2024年第3期14卷 57-72页

作者： Ruyhan Nazia Bibi Sara Rahman abdullah Al Hossain Newaz abdul Kadir nasir Uddin School of Mechanical Engineering Xian Jiaotong University Xian China School of Mechanical Engineering University of Bridgeport Bridgeport USA

In this research work, it has been designed a bionic robot fish structure, can swim underwater. The active compact body is powered by eight sets of symmetric PVC gel actuators with a caudal fin. The robot’s 200 mm-long, fish structure design incorporates a 55.52 angle to optimize the fish dynamics movement. It’s a fast and smooth operation and can swim. The robot can swim fast and quietly by using the right positions and the appropriate actuators on PVC gel actuators. This design entails a unique architecture that enables the robot to move safely and unobtrusively at the same time, which makes it suitable equipment for different exploration and surveillance missions in the water with speed and silent operation as the foremost concern.

关键词： Biomimetic Robotics Structural design PVC Gel Actuators Swimming Mechanisms

Highly Efficient Back‑End‑of‑Line Compatible Flexible Si‑Based Optical Memristive Crossbar Array for Edge Neuromorphic Physiological Signal Processing and Bionic Machine Vision

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Nano-Micro Letters 2024年第11期16卷 323-339页

作者： dayanand Kumar Hanrui Li dhananjay d.Kumbhar Manoj Kumar Rajbhar Uttam Kumar das abdul Momin Syed Georgian Melinte Nazek El‑Atab Smart Advanced Memory Devices and Applications(SAMA)LaboratoryElectrical and Computer EngineeringComputer Electrical Mathematical Science and EngineeringKing Abdullah University of Science and Technology(KAUST)23955‑6900 ThuwalSaudi Arabia

The emergence of the Internet-of-Things is anticipated to create a vast market for what are known as smart edge devices,opening numerous opportunities across countless domains,including personalized healthcare and advanced *** 3d integration,edge devices can achieve unprecedented miniaturization while simultaneously boosting processing power and minimizing energy ***,we demonstrate a back-end-of-line compatible optoelectronic synapse with a transfer learning method on health care applications,including electroencephalogram(EEG)-based seizure prediction,electromyography(EMG)-based gesture recognition,and electrocardiogram(ECG)-based arrhythmia *** experiments on three biomedical datasets,we observe the classification accuracy improvement for the pretrained model with 2.93%on EEG,4.90%on ECG,and 7.92%on EMG,*** optical programming property of the device enables an ultralow power(2.8×10^(-13) J)fine-tuning process and offers solutions for patient-specific issues in edge computing ***,the device exhibits impressive light-sensitive characteristics that enable a range of light-triggered synaptic functions,making it promising for neuromorphic vision *** display the benefits of these intricate synaptic properties,a 5×5 optoelectronic synapse array is developed,effectively simulating human visual perception and memory *** proposed flexible optoelectronic synapse holds immense potential for advancing the fields of neuromorphic physiological signal processing and artificial visual systems in wearable applications.

关键词： Neuromorphic computing Electrophysiological signal Artificial vision system Image recognition Memristor

Effect of Sweptback Angle of a delta Wing on Surface Pressure distribution at Supersonic Mach Numbers

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Fluid dynamics & Materials Processing 2024年第10期20卷 2353-2376页

作者： Shamitha Shetty Asha Crasta Sher Afghan khan abdul Aabid Muneer Baig Mathematics department Mangalore Institute of Technology and EngineeringVisvesvaraya Technological UniversityNear MoodabidreMangaluruKarnataka574225India Nitte Meenakshi Institute of Technology Visvesvaraya Technological UniversityBangalore560064India department of Mechanical and Aerospace Engineering Faculty of EngineeringInternational Islamic University MalaysiaKuala Lumpur53100Malaysia department of Engineering Management College of Engineering Prince Sultan UniversityP.O.Box 66833Riyadh11586Saudi Arabia

The purpose of this work is to shed light on the effect of the pivot position on the surface pressure distribution over a 3d wing in different flight *** study is intended to support the design and development of aerospace vehicles where stability analysis,performance optimization,and aircraft design are of primary *** following parameters are considered:Mach numbers(M)of 1.3,1.8,2.3,2.8,3.3,and 3.8,angle of incidence(θ)in the range from 5°to 25°,pivot position from h=0.2 to *** results of the CFd numerical simulations match available analytical data,thereby providing evidence for the reliability of the used *** findings provide valuable insights into the relationship between the surface pressure distribution,the Mach number and the angle of incidence.

关键词： Mach number angles of incidence stability analysis performance optimization

Population genetic insights into the conservation of common walnut(Juglans regia)in Central Asia

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Plant diversity 2024年第5期46卷 600-610页

作者： Linjiang Ye Robabeh Shahi Shavvon Hailing Qi Hongyu Wu Pengzhen Fan Mohammad nasir Shalizi Safiullah Khurram Mamadzhanov davletbek Yerlan Turuspekov Jie Liu CAS Key Laboratory for Plant diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Key Laboratory of Plant Resources and Biodiversity of Jiangxi Province Jingdezhen UniversityJingdezhen 333400JiangxiChina Germplasm Bank of Wild Species&Yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina department of Biology Faculty of ScienceYasouj UniversityYasouj 75918-74934Iran University of Chinese Academy of Sciences Beijing 100049China department of Forestry and Environmental Resources North Carolina State UniversityRaleighNC 27695United States department of Forestry and Natural Resources Faculty of AgricultureKabul UniversityKabul D-1006Afghanistan National Academy of Science of the Kyrgyz Republic Jalal-Abad Scientific CenterJalal-Abad 715600Kyrgyzstan Laboratory of Molecular Genetics Institute of Plant Biology and BiotechnologyAlmaty 050040Kazakhstan

The common walnut(Juglans regia)is one of the most economically important nut trees cultivated *** its importance,no comprehensive evaluation of walnut tree population genetics has been undertaken across the range where it originated,Central *** this study,we investigated the genetic diversity and population structure of 1082 individuals from 46 populations across Central *** found moderate genetic diversity of *** across Central Asia,with 46 populations clustered into three groups with a weak relationship between genetic and geographic *** findings reveal that the western Himalaya might be the core region of common walnut genetic diversity in Central Asia and that,except for two populations in Gongliu Wild Walnut Valley,humans might have introduced walnut populations to Xinjiang,*** observed distribution of the genetic landscape has probably been affected by historical climate fluctuation,breeding system,and prolonged anthropogenic *** propose the conservation of the core genetic diversity resources in the western Himalaya and pay special attention to populations from Gongliu in *** findings enhance our understanding of the genetic variation throughout the distribution range of *** in Central Asia,which will provide a key prerequisite for evidence-based conservation and management.

关键词： Central Asia Genetic diversity Germplasm management Gongliu wild walnut valley Juglans regia Western Himalaya

Base Pressure Control with Semi-Circular Ribs at Critical Mach Number

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Fluid dynamics & Materials Processing 2024年第9期20卷 2007-2028页

作者： Ambareen khan Sher Afghan khan Mohammed Nishat Akhtar abdul Aabid Muneer Baig School of Aerospace Engineering Universiti Sains MalaysiaPenang11600Malaysia department of Mechanical and Aerospace Engineering Faculty of EngineeringInternational Islamic University MalaysiaKuala Lumpur59000Malaysia department of Engineering Management College of EngineeringPrince Sultan UniversityP.O.Box 66833Riyadh11586Saudi Arabia

When better fuel-air mixing in the combustion chamber or a reduction in base drag are required in vehicles,rockets,and aeroplanes,the base pressure control is *** the base pressure and drag is necessary in both *** this work,semi-circular ribs with varying diameters(2,4,and 6 mm)positioned at six distinct positions(0.5d,1d,1.5d,2d,3d,and 4d)inside a square duct with a side of 15 mm are proposed as an efficient way to apply the passive control ***-depth research is done on optimising rib size for various rib *** to this study,the base pressure rises as rib height ***,the optimal location for the semi-circular ribs with a diameter of 2 mm is at *** 1d location appears to be optimal for the 4 mm size as *** the 6 mm size,however,the 4d position fills this function.

关键词： Base pressure nozzle pressure ratio base drag sonic Mach number passive control

The temporal-spatial expression and functional analysis of three gustatory receptor genes in Solenopsis invicta using sweet and bitter compounds

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Insect Science 2024年第2期31卷 448-468页

作者： Muhammad Irfan Waris Yanyuan Lei Guojun Qi Ziying Guan abdul Rashied Jie Chen Lihua Lyu Institute of Plant Protection Guangdong Academy of Agricultural SciencesGuangdong Provincial Key Laboratory of High Technology for Plant ProtectionGuangzhouChina department of Entomology College of Plant ProtectionSouth China Agricultural UniversityGuangzhouChina

The insect gustatory system participates in identifying potential food sources and avoiding toxic *** this process,gustatory receptors(GRs)recognize feeding stimulant and deterrent ***,the GRs involved in recognizing stimulant and deterrent compounds in the red imported fire ant,Solenopsis invicta,remain ***,we conducted a study on the genes SinvGR1,SinvGR32b,and SinvGR28a to investigate the roles of GRs in detecting feeding stimulant and deterrent *** this current study,we found that sucrose and fructose are feeding stimulants and the bitter compound quinine is a feeding *** fire ant workers showed significant behavior changes to avoid the bitter taste in feeding stimulant *** transcription quantitative real-time polymerase chain reaction results from developmental stages showed that the SinvGR1,SinvGR32b,and SinvGR28a genes were highly expressed in fire ant ***-specific expression profiles indicated that SinvGR1,SinvGR32b,and SinvGR28a were specifically expressed in the antennae and foreleg tarsi of workers,whereas SinvGR32b gene transcripts were also highly accumulated in the male ***,the silencing of SinvGRI or SinvGR32b alone and the co-silencing of both genes disrupted worker stimulation and feeding on sucrose and *** results also showed that SinvGR28a is required for avoiding quinine,as workers with knockdown of the SinvGR28a gene failed to avoid and fed on *** study first identified stimulant and deterrent compounds of fire ant workers and then the GRs involved in the taste recognition of these *** study could provide potential target gustatory genes for the control of the fire ant.

关键词： behavioral responses feeding assays gustatory receptors RNA interference Solenopsis invicta temporal-spatial expression

Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第5期16卷 293-305页

作者： Muhammad Ahmed Ali Fahim Afia Salman Hira Anas khan Syed Muhammad Hasan Muskan FatimaBhojani Sarah Aslam Amna Zia Ul Haq Vishal Reddy Bejugam Beena Muntaha nasir Wajiha Gul abdul Moeed Abdelrahman S Abdalla Muhammad Majid Muhammad Sohaib Asghar Md Al Hasibuzzaman department of Internal Medicine Dow University of Health SciencesKarachi 74200Pakistan department of Internal Medicine North Central Bronx HospitalBronxNY 10467United States department of Urology Center for Academic MedicineStanford University School of MedicinePalo AltoCA 33872United States department of Cardiovascular Imaging Cleveland ClinicClevelandOH 44195United States division of Nephrology and Hypertension Mayo Clinic RochesterRochesterMN 55905United States Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh

BACKGROUNd In severe cases of coronary artery disease,percutaneous coronary intervention provide promising *** stent used could be a drug-eluting stent(dES)or a titanium-nitride-oxide coated stent(TiNOS).AIM To compare the 5-year effectiveness and safety of the two stent *** The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines,and PubMed/MEdLINE,Scopus,and Cochrane Central were searched from inception till August *** outcomes were major adverse cardiac events(MACE),cardiac death,myocardial infarction(MI),cardiac death or MI,and ischemia-driven total lesion revascularization(Id-TLR).RESULTS Four randomized controlled trials(RCT),which analyzed a sum total of 3045 patients with acute coronary syndrome(ACS)after a median follow-up time of 5 years were *** statistically insignificant,an increase in the Id-TLR was observed in patients receiving TiNOSs vs *** addition,MI,cardiac death and MI,and definite stent thrombosis(dST)were significantly decreased in the TiNOS *** analysis revealed no significant results with meta-regression presenting non-ST elevated MI(NSTEMI)as a statistically significant covariate in the outcome of *** TiNOS was found to be superior to dES in terms of MI,cardiac death or MI,and dST outcomes,however,the effect of the two stent types on Id-TLR and MACE was not significant.A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and dES.

关键词： Stents drug-eluting Major adverse cardiac events All-cause death Meta-analysis