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Chinese Journal of Natural Medicines 2017年第7期15卷 505-514页

作者： Muhammad Asif Armaghan Shafaei Aman Shah abdul Majid mohammed Oday Ezzat Saad S Dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah abdul Majid EMAN Testing and Research Laboratory Department of Pharmacology School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmaceutical Chemistry School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmacology School of Medical Sciences Quest International University Perak Malaysia Centre for Drug Research Universiti Sains Malaysia Penang 11800 Malaysia Institute for Research in Molecular Medicine (INFORMM) Universiti Sains Malaysia Penang 11800 Malaysia

Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways.

关键词： Mesua ferrea a-Amyrin Apoptotic Antimetastatic Molecular pathways

Tracking Dengue on Twitter Using Hybrid Filtration-Polarity and Apache Flume

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Computer Systems Science & Engineering 2022年第3期40卷 913-926页

作者： Norjihan Binti abdul Ghani Suraya Hamid Muneer Ahmad Younes Saadi N.Z.Jhanjhi mohammed A.Alzain Mehedi Masud Department of Information Systems Faculty of Computer Science&Information TechnologyUniversiti Malaya50603Kuala LumpurMalaysia School of Computer Science and Engineering SCE Taylor’s UniversitySubang Jaya47500Malaysia Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

The world health organization(WHO)terms dengue as a serious illness that impacts almost half of the world’s population and carries no specific *** and accurate detection of spread in affected regions can save precious *** the severity of the disease,a few noticeable works can be found that involve sentiment analysis to mine accurate intuitions from the social media text ***,the massive data explosion in recent years has led to difficulties in terms of storing and processing large amounts of data,as reliable mechanisms to gather the data and suitable techniques to extract meaningful insights from the data are *** research study proposes a sentiment analysis polarity approach for collecting data and extracting relevant information about dengue via Apache *** method consists of two main parts:the first part collects data from social media using Apache Flume,while the second part focuses on querying and extracting relevant information via the hybrid filtration-polarity algorithm using Apache *** overcome the noisy and unstructured nature of the data,the process of extracting information is characterized by pre and post-filtration *** a result,only with the integration of Flume and Hive with filtration and polarity analysis,can a reliable sentiment analysis technique be offered to collect and process large-scale data from the social *** introduce how the Apache Hadoop ecosystem–Flume and Hive–can provide a sentiment analysis capability by storing and processing large amounts of *** important finding of this paper is that developing efficient sentiment analysis applications for detecting diseases can be more reliable through the use of the Hadoop ecosystem components than through the use of normal machines.

关键词： Big data analysis data filtration text analysis sentiment analysis social media event detection

An Optimized Offloaded Task Execution for Smart Cities Applications

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Computers, Materials & Continua 2023年第3期74卷 6321-6334页

作者： Ahmad Naseem Alvi Muhammad Awais Javed Mozaherul Hoque Abul Hasanat Muhammad Badruddin Khan abdul Khader Jilani Saudagar mohammed Alkhathami Department of Electrical and Computer Engineering COMSATS University Islamabad45550Pakistan Information Systems Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

Wireless nodes are one of the main components in different applications that are offered in a smart *** wireless nodes are responsible to execute multiple tasks with different priority *** the wireless nodes have limited processing capacity,they offload their tasks to cloud servers if the number of tasks exceeds their task processing *** these tasks from remotely placed cloud servers causes a significant delay which is not required in sensitive task *** execution delay is reduced by placing fog computing nodes near these application nodes.A fog node has limited processing capacity and is sometimes unable to execute all the requested *** this work,an optimal task offloading scheme that comprises two algorithms is proposed for the fog nodes to optimally execute the time-sensitive offloaded *** first algorithm describes the task processing criteria for local computation of tasks at the fog nodes and remote computation at the cloud *** second algorithm allows fog nodes to optimally scrutinize the most sensitive tasks within their task *** results show that the proposed task execution scheme significantly reduces the execution time and most of the time-sensitive tasks are executed.

关键词： Smart cities fog computing task offloading knapsack

The stellar system HIP 101227:is it a binary,a triple or a quadruple system?

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Research in Astronomy and Astrophysics 2021年第5期21卷 121-129页

作者： Zahra Talal Yousef Adlyka Annuar Abdallah Mohammad Hussein Hamid Al-Naimiy MashhoorAl-Wardat Nurul Shazana abdul Hamid mohammed Fadil Talafha Department of Applied Physics Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Department of Physics Al al-Bayt UniversityMafraq 25113Jordan Department of Applied Physics and Astronomy University of SharjahP.O.Box 27272 SharjahUnited Arab Emirates Sharjah Academy for Astronomy Space Sciences and Technology SAASSTUniversity of SharjahP.O.Box 27272 SharjahUnited Arab Emirates

In this paper,we present the analysis of the stellar system HIP 101227 to determine the actual number of components in the system,and their *** use dynamical modeling and complex spectrophotometric(involving atmospheric modeling)techniques with recent data,to determine the physical properties and orbital solution for the system,respectively,with better accuracy than past *** on our analysis,we found that the system is more consistent with being a quadruple rather than a binary or a triple system as suggested by previous *** total mass of the system determined from our SED analysis is 3.42±0.20 M,which is distributed almost equally between the four *** stars are found to be zero-age main sequence stars;i.e.,at the last stage of pre-main sequence,with age less than 200 Myr and spectral types *** four stars have very similar physical characteristics,suggesting that the fragmentation process is the most likely theory for the formation and evolution of the system.

关键词： stars:binaries:close stars:binaries:visual stars:individual:HIP 101227

Platelet indices in evaluation of patients with recurrent pregnancy loss

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Asian pacific Journal of Reproduction 2018年第1期7卷 15-18页

作者： Abeer abdul-Rahman Al-Aghbary mohammed abdul Wahid Almorish Dikra Waheeb Mohamed Jaffar Waiel Mohmed Al-Kahiry Department of Gynecology and Obstetrics Taiz UniversityYemen Department of Hematology Sanaa UniversityYemen Department of Gynecology and Obstetrics Aden UniversityYemen Department of Hematology Oncology Aden UniversityYemen

Objective: To explore the change of platelet indices namely plateletcrit, platelet distribution width and mean platelet volume among patients with recurrent pregnancy loss (RPL). Methods: The medical records of 45 women with a history of RPL and 45 women who gave birth without RPL were reviewed retrospectively from three governmental hospitals in Yemen. The personal, obstetric and complete blood count reports were analyzed. Results: Platelets' count and indices were significantly higher among RPL patients when compared to the control and the receiver operating characteristic curve for each platelet index showed significant area under the curve, with higher area for plateletcrit followed by platelet distribution width and then mean platelet volume. While the multiple logistic regression analysis for all platelets indices revealed that the platelet distribution width was the significant predictor for RPL in this study. Conclusions: The use of platelet indices may help gynecologists in predicting high risk pregnancy (pregnancy loss) in the low resources areas inYemen.

关键词： Pregnancy loss Platelets Platelet distribution width Mean platelet volume Plateletcrit

Convergence Track Based Adaptive Differential Evolution Algorithm(CTbADE)

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Computers, Materials & Continua 2022年第7期72卷 1229-1250页

作者： Qamar Abbas Khalid Mahmood Malik abdul Khader Jilani Saudagar Muhammad Badruddin Khan Mozaherul Hoque Abul Hasanat abdullah AlTameem mohammed AlKhathami Department of Computer Science and Software Engineering International Islamic UniversityIslamabad44000Pakistan Department of Computer Science and Engineering Oakland UniversityRochesterMIUSA Information Systems Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)RiyadhSaudi Arabia

One of the challenging problems with evolutionary computing algorithms is to maintain the balance between exploration and exploitation capability in order to search global optima.A novel convergence track based adaptive differential evolution(CTbADE)algorithm is presented in this research *** crossover rate and mutation probability parameters in a differential evolution algorithm have a significant role in searching global optima.A more diverse population improves the global searching capability and helps to escape from the local optima *** the convergence path over time helps enhance the searching speed of a differential evolution algorithm for varying *** adaptive powerful parameter-controlled sequences utilized learning period-based memory and following convergence track over time are introduced in this *** proposed algorithm will be helpful in maintaining the equilibrium between an algorithm’s exploration and exploitation capability.A comprehensive test suite of standard benchmark problems with different natures,i.e.,unimodal/multimodal and separable/non-separable,was used to test the convergence power of the proposed CTbADE *** results show the significant performance of the CTbADE algorithm in terms of average fitness,solution quality,and convergence speed when compared with standard differential evolution algorithms and a few other commonly used state-of-the-art algorithms,such as jDE,CoDE,and EPSDE *** algorithm will prove to be a significant addition to the literature in order to solve real time problems and to optimize computationalmodels with a high number of parameters to adjust during the problem-solving process.

关键词： Differential evolution function optimization convergence track parameter sequence adaptive control parameters

Lipopeptides in promoting signals at surface/interface of micelles:Their roles in repairing cellular and nuclear damages

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Food Bioscience 2022年第2期46卷 73-90页

作者： Sami Saadi Nazamid Saari Hasanah Mohd Ghazali abdulkarim Sabo mohammed Azizah abdul-Hamid Nor Elhouda Nacer Farooq Anwar Institut de la Nutrition de l’Alimentation et des Technologies Agro-alimentaires INATAA 25017Universit´e Fr`eres Mentouri Constantine 1Algeria Faculty of Food Science and Technology University Putra Malaysia43400SerdangSelangorMalaysia Department of Microbiology and Biotechnology Federal University DutseNigeria D´epartement de Biologie Universit´e de Batna 2Algeria Institute of Chemistry University of SargodhaSargodha40100Pakistan

Lipopeptides are recognized as a structurally diverse group of functional *** possess multiple biological,biotechnological and therapeutic applications and are able to affect cell membrane integrity and *** is widely accepted that suppressing the interaction of redooxidation is mainly aimed by inserting functional biopeptides on form alpha-helical peptides or on form *** types of structured biomaterials have great potential in promoting signal transductions to the most organelles having geometrical and spacial structures similar to endogenous liposome forms such as lysosomes,ribosomes,mitochondria and platelets..Thus,inserting radioactive trace-elements along with biopeptides is necessary in tracing the trajectory of those radioactive micelles that are destined in targeting further complicated disease and growth factor *** techniques are important in determining structure-symmetry and asymmetry leading to meso-spherical crystal-packing modes or to copolymer *** main objective of this review is to highlight and elucidate the potential role of lipopeptides in promoting signals at surface/interface of micelles along with their functionalities in repairing cellular and nuclear ***,state-of-the-art scientific knowledge is reviewed regarding bioconjugation and structuring charged-mono-layer and/or bi-layer phospholipidic membranes in adherent to signal-biopeptides using some advanced techniques such as ultra-sound probe based polydispersity of radioactive trace-elements assisted microdialysis as micro-separating techniques in between those miscible and immiscible compounds.

关键词： Lipopeptides Biopeptides Biomaterials Spacial structure Transduction signal

Interaction of cetyltrimethylammonium bromide with drug in aqueous/electrolyte solution:A combined conductometric and molecular dynamics method study

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Chinese Journal of Chemical Engineering 2018年第1期26卷 159-167页

作者： Md.Anamul Hoque Md.Masud Alam Mohammad Robel Molla Shahed Rana Malik abdul Rub Mohammad A.Halim mohammed abdullah Khan Farida Akhtar Department of Chemistry Jahangirnagar UniversitySavarDhaka 1342Bangladesh Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Excellence for Advanced Materials Research King Abdulaziz UniversityJeddah 21589Saudi Arabia Division of Quantum Chemistry BICCBThe Red-Green Computing Centre218 Elephant RoadDhaka 1205Bangladesh Institut Lumière Matière Université Lyon 1-CNRSUniversitéde Lyon69622 Villeurbanne CedexFrance

Interaction between beta-lactum antibiotic drug ciprofloxacin hydrochloride(CFH)and cationic surfactant cetyltrimethylammonium bromide(CTAB)was performed conductometrically in aqueous as well as in the occurrence of different salts(NaCl,KCl as well as NH_4Cl)over the temperature range of 298.15–323.15 K at the regular interval of 5 *** drug has been suggested for the treatment of bacterial infections such as urinary tract infections and acute sinusitis.A clear critical micelle concentration(CMC)was obtained for pure CTAB as well as(CFH+CTAB)mixed *** decrease in CMC values of CTAB caused by the addition of CFH reveals the existence of the interaction between the components and therefore it is the indication of micelle formation at lower concentration of CTAB and their CMC values further decrease in attendance of salts.A nonlinear behavior in the CMC versus T plot was observed in all the *** ΔG_m^0 values are found to be negative in present study systems demonstrated the stability of the *** values of ΔH_m^0 and ΔS_m^0 reveal the existence of hydrophobic and electrostatic interactions between CFH and *** thermodynamic properties of transfer for the micellization were also evaluated and discussed in *** dynamic simulation disclosed that environment of water and salts have impact on the hydrophobic interaction between CFH and *** water and salts,CTAB adopts spherical micelle in which charged hydrophilic groups are interacted with waters whereas hydrophobic tails form the core of the *** hydrophobic core region is highly conserved and *** addition,micelle formation is more favorable in aqueous Na Cl solution than other solutions.

关键词： Ciprofloxacin hydrochloride Cetyltrimethylammonium bromide Molecular dynamics Flydrophobic interaction Salt effect

Prevalence and associated factors of stress, anxiety and depression among emergency medical officers in Malaysian hospitals

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World Journal of Emergency Medicine 2018年第3期9卷 178-186页

作者： Siti Nasrina Yahaya Shaik Farid abdull Wahab Muhammad Saiful Bahribin Yusoff Mohd Azhar Mohd Yasin mohammed Alwi abdul Rahman Emergency and Trauma Department School of Medical Sciences University Sains Malaysia Kelantan Malaysia Department of Medical Education School of Medical Sciences University Sains Malaysia Kelantan Malaysia Department of Psychiatry School of Medical Sciences University Sains Malaysia Kelantan Malaysia Emergency and Trauma Department Selayang Hospital Selangor Darul Ehsan Malaysia

BACKGROUND： Demanding profession has been associated with poor psychological health due to multiple factors such as overworking hours and night shifts. This study is to determine prevalence and associated factors of depression, anxiety and stress among medical officers working at emergency department in Malaysian ***： A cross-sectional study was conducted on 140 emergency department medical officers working at general hospitals from seven Malaysia regions. They were randomly selected and their depression, anxiety and stress level were measured by the 21-item Depression, Anxiety, Stress Scale. RESULTS： The highest prevalence was anxiety （28.6%） followed by depression （10.7%） and stress （7.9%）. Depression, anxiety and stress between seven hospitals were not significantly different （P〉0.05）. Male medical officers significantly experienced more anxiety symptoms than female medical officers （P=0.0022）, however depression and stress symptoms between male and female medical officers were not signi？ cantly different （P〉0.05）. Depression, anxiety and stress were not associated with age, working experience, ethnicity, marital status, number of shifts and type of system adopted in different hospitals （P〉0.05）. CONCLUSION： The prevalence of anxiety was high, whereas for depression and stress were considerably low. Gender was the only factor significantly associated with anxiety. Other factors were not associated with depression, anxiety and stress. Future research should aim to gain better understanding on unique factors that affect female and male medical officers’ anxiety level in emergency setting, thus guide authorities to chart strategic plans to remedy this condition.

关键词： Medical officers Emergency department Depression Anxiety Stress