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Dapagliflozin and Spironolactone Improved Clinical Symptoms and CV Outcomes in Patient with HF Preserved Ejection Fraction (HFpEF) in Hard-to-Reach Rural African Population: A Case Series

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Case Reports in Clinical Medicine 2022年第11期11卷 465-473页

作者： Dominick Mkombozi Raphael abdu hussein mogella Elias Edrick Mtalemwa Beatrice Kabuka Internal Medicine Department St. Francis Referral Hospital Ifakara Tanzania Cardiology Department Heart and Lung Clinic St. Francis Referral Hospital Ifakara Tanzania Hematology Department Muhimbili National Hospital Dar Es salaam Tanzania Pathology Department Bugando Medical Centre Mwanza Tanzania Pathology Department St. Francis University College of Health and Allied Science Ifakara Tanzania

Objective: To observe the benefit of mineralocorticoid receptor antagonist and sodium-glucose co-transport 2 inhibitor (SGLT2 inhibitor) in heart failure preserved ejection (HFpEF) in rural Tanzania. Background and Result: The use of spironolactone and dapagliflozin was shown to be effective in improving the clinical outcome and reducing CV hospitalization rate and CV mortality in patients with heart failure preserved left ventricular ejection fraction (HFpEF). This is the case presentation of one patient with HFpEF with diastolic dysfunction grade 3, obesity grade 3, Type 2 Diabetes, and Atrial Fibrillation (permanent). In the case of a 76-year-old female after previous ineffective treatment, the initiation of Spironolactone and Dapagliflozin led to a rapid and marked improvement in the clinical conditions. Diastolic dysfunction was improved from stage III to stage I. Moreover, the initiation of spironolactone and dapagliflozin therapy avoided a referral for surgical intervention and interrupted a long series of hospitalizations for acute HF and prevented CV death. Conclusion: Based on our experience, we conclude that the treatment with spironolactone and dapagliflozin allows for better treatment optimization with a positive impact on the control of clinical outcomes and preventing CV death and CV hospitalization in HFpEF and related comorbidities in the African population, which is underrepresented in most of the trials.

关键词： HFpEF Spironolactone Dapagliflozin Africans Population

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coinfection with Malaria in Selected States in Nigeria

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Advances in Infectious Diseases 2024年第2期14卷 442-455页

作者： Oluwagbemiga Olanrewaju Aina Olufemi Samuel Amoo Kazeem Adewale Osuolale Adewale Kayode Ojogbede Azuka Patrick Okwuraiwe David Ayoola Oladele Adesola Zaidat Musa Tajudeen Akanji Bamidele Celestina Onyinye Okoyenta Abideen Olurotimi Salako Toyosi Yekeen Raheem Ifeoma Eugenia Idigbe Fehintola Anthonia Ige Joseph Ojonugwa Shaibu Gregory Aigbe Ohihoin Kikelomo Wright Bisola Adebayo hussein abdu-Razzaq abdulrahman Ahmad Mustapha Imam Bashir Bello Tambuwal Muhammad Shuaibu Gobir Richard Ikwuogu Christian Tetsola Gloria Patrick-Ferife Nathaniel Enamuotor Mildred Okowa William Nwachukwu Cornelius Ohonsi Magdalene Egede Chinwe Ochu Ehimario Igumbor Oliver Chukwujekwu Ezechi Babatunde Lawal Salako Rosemary Ajuma Audu Biochemistry and Nutrition Department Nigerian Institute of Medical Research Lagos Nigeria Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Lagos Nigeria Monitoring and Evaluation Unit Nigerian Institute of Medical Research Lagos Nigeria Public Health and Epidemiology Department Nigerian Institute of Medical Research Lagos Nigeria Clinical Sciences Department Nigerian Institute of Medical Research Lagos Nigeria Molecular Biology and Biotechnology Department Nigerian Institute of Medical Research Lagos Nigeria Department of Community Health & Primary Health Care Lagos State University College of Medicine Lagos State University Teaching Hospital Lagos Nigeria Research Unit Lagos State Ministry of Health Lagos Nigeria Sokoto State Ministry of Health Sokoto Nigeria Department of Medical Biochemistry Usmanu Danfodiyo University Sokoto Nigeria Centre for Advanced Medical Research and Training Usmanu Danfodiyo University Sokoto Nigeria Delta State Ministry of Health Asaba Nigeria Nigeria Centre for Disease Control Abuja Nigeria Center for Infectious Disease Research Nigerian Institute of Medical Research Lagos Nigeria

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Plasmodium species are the causative agents of coronavirus disease 2019 (COVID-19) and malaria respectively with similar clinical presentations. The objective of this study is to determine the burden of co-infection of SARS-CoV-2 and malaria in the general population. Five (5 mLs) of blood samples were collected for SARS-CoV-2 and malaria parasite test. The malaria test was performed using a commercially available one-step malaria antigen Plasmodium falciparum histidine-rich protein 2 (Pf HRP-II) rapid test kit. The results of the study showed that the participants that were coinfected with SARS-CoV-2 IgG and malaria were 13 (2.5%) in Lagos, 1114 (39.1%) in Delta and 49 (2.3%) in Sokoto States. The prevalence of coinfection of SARS-CoV-2 and malaria in urban areas in Lagos, Delta and Sokoto States were 7 (2.2%), 1373 (48.1%), and 5 (0.2%) respectively. In rural areas, the prevalence of coinfection of SARS-CoV-2 and malaria in Lagos, Delta and Sokoto States were 6 (0.3%), 365 (12.8%), and 44 (2.1%) respectively in this study. This suggests that participants in the urban areas were more prone to co-infections than the rural areas in Lagos and Delta states, while it was otherwise in Sokoto State. In conclusion, the co-infection of SARS-CoV-2 and malaria was very high in Delta State compared to the other States. It is important for clinics to screen for both diseases when patients present with symptoms of malaria. This is because the infections have similar symptoms and the public is quick to assume malaria infection without diagnosing for COVID-19 and vice versa.

关键词： SARS-CoV-2 Malaria Coinfection

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Detection of Left Ventricular Cavity from Cardiac MRI Images Using Faster R-CNN

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Computers, Materials & Continua 2023年第1期74卷 1819-1835页

作者： Zakarya Farea Shaaf Muhammad Mahadi abdul Jamil Radzi Ambar Ahmed abdu Alattab Anwar Ali Yahya Yousef Asiri Faculty of Electrical and Electronic Engineering Universiti Tun Hussein Onn MalaysiaParit RajaBatu Pahat86400JohorMalaysia Department of Computer Science College of Science and ArtsSharurahNajran UniversityNajran61441Saudi Arabia Department of Computer Science Faculty of Computer Science and Info.SystemsThamar UniversityDhamar87246Yemen Department of Computer Science College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia

The automatic localization of the left ventricle(LV)in short-axis magnetic resonance(MR)images is a required step to process cardiac images using convolutional neural networks for the extraction of a region of interest(ROI).The precise extraction of the LV’s ROI from cardiac MRI images is crucial for detecting heart disorders via cardiac segmentation or ***,this task appears to be intricate due to the diversities in the size and shape of the LV and the scattering of surrounding tissues across different ***,this study proposed a region-based convolutional network(Faster R-CNN)for the LV localization from short-axis cardiac MRI images using a region proposal network(RPN)integrated with deep feature classification and *** was trained using images with corresponding bounding boxes(labels)around the LV,and various experiments were applied to select the appropriate layers and set the suitable *** experimental findings showthat the proposed modelwas adequate,with accuracy,precision,recall,and F1 score values of 0.91,0.94,0.95,and 0.95,*** model also allows the cropping of the detected area of LV,which is vital in reducing the computational cost and time during segmentation and classification ***,itwould be an ideal model and clinically applicable for diagnosing cardiac diseases.

关键词： Cardiac short-axis MRI images automatic left ventricle localization deep learning models faster R-CNN

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A Compact Size 5G Hairpin Bandpass Filter with Multilayer Coupled Line

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Computers, Materials & Continua 2021年第12期69卷 4025-4042页

作者： Qazwan abdullah Ömer Aydogdu Adeeb Salh Nabil Farah Md Hairul Nizam Talib Taha Sadeq Mohammed A.A.Al-Mekhalfi abdu Saif Faculty of Electrical and Electronic Engineering Selçuk UniversityKonyaTurkey Faculty of Engineering and Natural Sciences Konya Technical UniversityKonyaTurkey Faculty of Engineering Technology Universiti Tun Hussein Onn MalaysiaPagohMuarJohorMalaysia Faculty of Electrical Engineering Universiti Teknikal Malaysia MelakaMelakaMalaysia Faculty of Engineering and Science Universiti Tunku Abdul RahmanSungai Long CampusSelangor43000Malaysia Faculty of Electrical Engineering Department University of MalayaKuala LumpurMalaysia

The multilayer structure is a promising technique used to minimize the size of planar microstrip *** the flexible design and incorporation of other microwave components,multilayer band-pass filter results in better and enhanced *** paper introduces a microstrip fifth-generation(5G)low-frequency band of 2.52–2.65 GHz using a parallel-coupled line(PCL)Bandpass filter and multilayer(ML)hairpin Bandpass *** targeted four-pole resonator has a center frequency of 2.585 GHz with a bandwidth of 130 *** filters are designed with a 0.1 dB passband ripple with a Chebyshev *** hairpin-line offers compact filter design ***,they can be obtained by bending half-wavelength resonator resonators with parallel couplings into a“U”*** proposed configuration of the parllel-coupled line resonator is used to design the ML band-pass *** FR4 substrate with a dielectric constant(Er)of 4.3 and 1.6 mm thickness was used.A comparative analysis between the simulated insertion loss and the reflection cofficient of substrates RO3003 and FR4 was performed to validate the eficiency of the proposed filter *** of PCL filter is accom-plished using computer simulation technology(CST)and an advanced design system(ADS)*** PCL Bandpass filter was experimentally validated and a total tally between simulation results and measured results were achieved demonstrating a well-measured reflection *** simulated results obtained by the hairpin ML bandpass filter show that the circuit performs well in terms of Scattering(S)parameters and the filter size is significantly reduced.

关键词： Band-pass filter 5G hairpin multi-layer size reduction parallelcoupled line

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