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Intestinal glucagon-like peptide-1:A new player associated with impaired counterregulatory responses to hypoglycaemia in type 1 diabetic mice

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World Journal of Diabetes 2024年第8期15卷 1764-1777页

作者： Fang-Xin Jin Yan Wang Min-ne Li Ru-Jiang Li Jun-Tang Guo Department of Histology and Embryology Key Laboratory of Universities in Shandong ProvinceShandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Pathological Physiology Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina

BACKGROUND Impaired hypoglycaemic counterregulation has emerged as a critical concern for diabetic patients who may be hesitant to medically lower their blood glucose levels due to the fear of potential hypoglycaemic ***,the pathogenesis of hypoglycaemic counterregulation is still ***-like peptide-1(GLP-1)and its analogues have been used as adjunctive therapies for type 1 diabetes mellitus(T1DM).The role of GLP-1 in counterregulatory dysfunction during hypoglycaemia in patients with T1DM has not been *** To explore the impact of intestinal GLP-1 on impaired hypoglycaemic counterregulation in type 1 diabetic *** T1DM was induced in C57BL/6J mice using streptozotocin,followed by intraperitoneal insulin injections to create T1DM models with either a single episode of hypoglycaemia or recurrent episodes of hypoglycaemia(DH5).Immunofluorescence,Western blot,and enzyme-linked immunosorbent assay were employed to evaluate the influence of intestinal GLP-1 on the sympathetic-adrenal reflex and glucagon(GCG)*** GLP-1 receptor agonist GLP-1(7-36)or the antagonist exendin(9-39)were infused into the terminal ileum or injected intraperitoneally to further investigate the role of intestinal GLP-1 in hypoglycaemic counterregulation in the model *** The expression levels of intestinal GLP-1 and its receptor(GLP-1R)were significantly increased in DH5 *** instances of excess of intestinal GLP-1 weakens the sympathetic-adrenal reflex,leading to dysfunction of adrenal counterregulation during ***5 mice showed increased pancreaticδ-cell mass,cAMP levels inδcells,and plasma somatostatin concentrations,while cAMP levels in pancreaticαcells and plasma GCG levels ***,GLP-1R expression in islet cells and plasma active GLP-1 levels were significantly increased in the DH5 *** experiments involving terminal ileal infusion and intraperitoneal injection in the model mice demonstra

关键词： Glucagon-like peptide-1 Impaired hypoglycaemic counterregulation Type 1 diabetes Intestine Pancreas

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Crosstalk between androgen signaling and the chemokine receptor CXCR4:a novel strategy to promote myelin regeneration

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neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-Lagarde Narimène Asbelaoui Abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

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The Life and Political Leadership of Gra?a Machel

心理传记与质性心理学

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心理传记与质性心理学 2024年第1期 126-154页

作者： Claude-Hélène Mayer University of Johannesburg South Africa

This article focuses on the life and political leadership of an extraordinary woman leader, Gra?a Machel. Gra?a Machel was born in very poor circumstances in rural Mozambique, became a fighter against colonialism, and married to Presidents: firstly, she married Samora Machel, later she married nelson Mandela. At the same time, she followed her own political career, always promoting a political agenda of education, peace and distribution of wealth. Her political leadership is an extraordinary example for leaders in Southern Africa and the world. This psychobiography contributes to expanding the psychobiographies on extraordinary women in political leadership in Southern Africa. Its aim is to present new insights into the life of Gra?a Machel and her political leadership as a woman leader in pan-African contexts from a psychobio-graphical perspective.

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Effects of Prandtl and Jacob Numbers and Dimensionless Thermal Conductivity on Velocity Profiles in Media (Porous and Liquid)

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Journal of Modern Physics 2024年第10期15卷 1603-1614页

作者： Momath Ndiaye Madialène Sene Goumbo Ndiaye Department of Hydraulics Rural Engineering Machinery and Renewable Energy UFR Fundamental and Engineering Sciences University of Sine Saloum El Hadj Ibrahima NIASS Kaolack Senegal

In this present study, we analyzed the effects of Prandtl and Jacob numbers and dimensionless thermal conductivity on the velocity profiles in media (porous and liquid). The transfers in the porous medium and the liquid film are described respectively by the improved Wooding model and the classical boundary layer equations. The mesh of the digital domain is considered uniform in the transverse and longitudinal directions. The advection and diffusion terms are discretized with a back-centered and centered scheme respectively. The coupled systems of algebraic equations thus obtained are solved numerically using an iterative line-by-line relaxation method of the Gauss-Seidel type. The results show that the parameters relating to the thermal problem (the dimensionless thermal conductivity, the Prandtl (Pr) and Jacob (Ja) numbers) have no influence on the dimensionless speed, although the thermal and hydrodynamic problems are coupled. Via the heat balance equation. The results obtained show that the parameters relating to the thermal problem have no influence on the dimensionless speed, although the thermal and hydrodynamic problems are coupled via the heat balance equation. So, at first approximation with the chosen constants, we can solve the hydrodynamic problem independently of the thermal problem.

关键词： Condensation Implicit Finite Difference Thin Film Porous Material Model Wooding Vertical Wall

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Potential of contemporary earth-sheltered buildings to achieve Plus Energy status in various European climates during the heating season

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Building Simulation 2024年第1期17卷 41-52页

作者： Aleksandar nesovic nebojsa Jurisevic Robert Kowalik lvana Terzic Faculty of Engineering University of KragujevacSestre Janjic 634000 KragujevacSerbia Faculty of Environmental Geomatic and Energy EngineeringKielce University of TechnologyTysigclecia Panstwa Polskiego725-314 KielcePoland

This study investigates the potential of contemporary Earth-Sheltered Buildings to contribute to sustainable societies by achieving Plus Energy Building status during the heating *** buildings analyzed are intended to house a four-member family(102.5 m^(2)).The house is equipped with a ground source heat pump,geothermal vertical probes,floor heating panels,an energy recovery ventilator,and building-integrated photovoltaic panels installed on the exposed building *** numerical analysis(using EnergyPlus software)was carried out for nine European sites covering five different climatic zones(namely:southern,Atlantic,continental,alpine,and northern climate)and three latitude belts spanning Europe from south to *** above 65°N(northern and alpine climate)could not achieve Plus Energy status with 20% efficient *** 15% efficient BIPVs,the building above 59°N(northern climate)was incapable of achieving this as *** the monthly time step,the buildings in the southern and Atlantic climates with 15% efficient BiPVs were able to produce an energy surplus every month,as was the building in theAlps with 20% efficientBIPVs.

关键词： civil engineering earth-sheltered buildings renewable energy sustainable societies Plus Energy Buildings Energy Plus software

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Local Application of Combined Drugs of Natural Essential Oils for the Prevention of Acute Pharyngitis

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International Journal of Otolaryngology and Head & neck Surgery 2024年第5期13卷 311-320页

作者： Diāna Katoviča Marks Ronis Beāte Rundāne Pauls Stradins Clinical University Hospital Riga Latvia Childrens Clinical University Hospital Riga Latvia Faculty of Medicine Rga Stradi University Riga Latvia

Objective: Viral pharyngitis, commonly known as a sore throat, is a widespread condition affecting people of all ages globally. This study aimed to assess the effectiveness of a medical device containing the combined drugs of natural essential oils (CDneO) formulation in managing throat pain in patients with acute viral pharyngitis. With the growing resistance to traditional antibacterial treatments, essential oils have attracted interest for their potential analgesic, anti-inflammatory, and antibacterial properties. Results: The study involved 81 patients randomly divided into two groups: those taking a medical device containing combined drugs of natural essential oils (CDneO) and those taking a placebo. A questionnaire was used to assess throat pain among the participants, with 45 receiving the CDneO and 36 the placebo. The CDneO group experienced a significant reduction in throat pain, with the average VAS score decreasing from 5.36 to 1.09, compared to the placebo group, which saw a decrease from 4.97 to 2.19. This difference, with p Conclusion: By using a double-blind research method, it was possible to evaluate the effectiveness of the oils more objectively, since there was also a control placebo group. The study shows that CDneO significantly reduces throat pain and decreases the need for additional pain relief medication in patients with acute viral pharyngitis. The findings suggest that natural essential oils could serve as an alternative treatment for pharyngitis, particularly in efforts to minimize NSAID use and combat antibiotic resistance.

关键词： Sore Throat Essential Oils NSAID Acute Viral Pharyngitis Natural Treatment

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Experimental Investigation of the Stability of the Performance Characteristics of a Photovoltaic Module in the Face of Environmental and Meteorological Factors

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Open Journal of Applied Sciences 2024年第2期14卷 589-608页

作者： Adingra Paul Arsène Kouassi Siaka Touré Diakaridja Traoré Laboratoire des Sciences de la Matière de l’Environnement et de l’Energie Solaire (LASMES) Unité de Formation et de Recherche des Sciences des Structures de la Matière et Technologie (UFR-SSMT) Université Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire

The explosive technological improvement of photovoltaic systems as well as the necessity of populations to come to less expensive energy sources, that have led to an implosion at the level of solar panel manufacturers. This causes a large flow of these equipments to developing countries where the need is high, without any quality control. That conducted an experimental investigation on the performance characteristics of a 250 wp monocrystalline silicon photovoltaic module in other to check the verification and quality control. Most of these PV panels which often have missing informations are manufactured and tested in places that are inadequate for our environmental and meteorological conditions. Also, their influences on the stability of internal parameters were evaluated in order to optimize their performance. The results obtained at maximum illumination (1000 w/m2) confirmed those produced by the manufacturer. The analysis of these characteristics showed that the illumination and the temperature (meteorological factors) influenced at most the stability of the internal characteristics of the module in the sense that the maximum power increased very rapidly beyond 750 w/m2 but a degradation of performance was accentuated for a temperature of the solar cells exceeding 50°C. The degradation coefficients were evaluated at -0.0864 V/°C for the voltage and at -1.6248 w/°C for the power. The 10° inclination angle of the solar panel proved to be ideal for optimizing overall efficiency in practical situations.

关键词： Renewables Energies Instruments Internal Parameters of Photovoltaic Panel Monocrystalline Photovoltaic Panel Solar Energy Production Energy Intermittence

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Study of the Biological Quality of the Water in the Manantali Dam Reservoir: Analysis of the Fish Fauna and Plankton Communities

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Journal of Agricultural Chemistry and Environment 2024年第1期13卷 100-114页

作者： Joseph Mbeur Faye Saïdou Ndao Louis Eugène Victor Sambou Laboratory of Water and Environment Sciences and Technologies (LaSTEE) Polytechnic School of Thies (EPT) Thies Senegal UFR Sciences et Technologies (SET) University Iba Der Thiam of Thies (UIDT) Thies Senegal

The aim of this study of the Manantali dam reservoir is to investigate the biological quality of the water through inventories and analysis of the ichthyofauna and planktonic communities (zooplankton and phytoplankton). Inventories of ichthyofauna and plankton communities were carried out quarterly from 2003 to 2022. The fish populations studied on the basis of bioindicators (species richness, diversity index, equitability index, diversification index) identified 29 species belonging to 10 families. The Cichlidae family is the most represented, while the Schilbeidae and Tetraodontioae families are less represented in terms of number of species. The species Hydrocynus forskalii and Brycinus nurse with relative abundances of 40.12% and 21.4% respectively, both from the family Alestidae, are the most abundant. The species H. forskalii has a frequency of occurrence of 100%. The specific diversity index of 2.9 and the equitability index of 0.6 show an average diversity of fish species. The diversification index of 2.9 indicates a theoretical number of habitats of 2 to 3. The planktonic community is made up of zooplankton and phytoplankton. The inventory of zooplankton shows the presence of 28 zooplankton species belonging to 9 families of the three zooplankton groups Rotifera, Cladocera and Copepoda. Analysis of the frequencies of occurrence of the various taxa showed that the characteristic species of Lake Manantali are the omnipresent rotifers Keratella cochlearis, Keratella quadrata and Trichocerca chattoni. For phytoplankton, the inventories carried out show the presence of 65 species belonging to 5 families (Chlorophycees, Diatomees, Dinophycees, Chrysophycees and Cyanophycees). An analysis of the frequency of occurrence of the various taxa shows that the characteristic species of Lake Manantali are Chlorophycees, with 7 species: Desmidium baileyi, Micrasterias alata, Sphaerocystis schroeteri, Spondylosium sp., Staurastrum heimii, Staurastrum subanchora, Staurodesmu

关键词： Inventory Fish Zooplankton Phytoplankton Diversity Manantali

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Ovarian Tumors in Senegalese Women: Impact of D-Loop Mutations between Healthy and Cancerous Tissues

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Open Journal of Genetics 2024年第2期14卷 37-46页

作者： Rouguiyatou Ka Fatimata Mbaye Bineta Kénéme Mbacké Sembène Genomics Laboratory Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal

In Senegal in particular, ovarian cancer, which is one of the most common gynecological cancers, accounts for 2.8% of deaths. The most important risk factor is genetic, with 10% of cases occurring in a context of genetic predisposition. The sequencing of the human genome, which has led to the discovery of millions of sequence variations, makes it possible to study variations within sequences. These variations are limited to Single Nucleotide Polymorphisms (SNPs) and this common form of polymorphism occurs approximately every 1000 bases in the human genome and 1.8 million SNPs are currently listed according to [1]. The aim of this study is to gain a better understanding of the impact of mutations in the D-loop region of mtDNA on ovarian cancer in Senegalese women. This study involved searching for mutations in our study population after DNA extraction and sequencing. Mutations were found after a comparison of our sequences with the Cambridge reference sequence (NC_012920). The mutations found in the DNA studied extend from position 7 to position 16568 and most of these mutations are located in the hypervariate zones (HV1 and HV2). Heteroplasmy with three mutant alleles was also found in certain variants. Common mutations were found in both healthy and cancerous tissues, with almost identical frequencies in both types of tissue. This enabled us to understand the spread of tumor cells throughout the ovary.

关键词： Ovarian Cancer Mutations D-Loop Heteroplasmy

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Modelling and Sizing of a Floor Reinforced by Ballasted Columns Intended to Support a Tank

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Open Journal of Civil Engineering 2024年第3期14卷 405-420页

作者： Cheikh Diallo Diène Madièye Fall Souka Bidzha Harlin Sylvaire Laboratory of Modelling and Soil Mechanics Electrical and Building School (ESEBAT) Dakar Senegal

This work aims to study the modeling and sizing of a floor reinforced by ballasted columns. We are studying the system of reinforcement by ballasted columns because this technique is able to replace deep foundations that are technically difficult to realize and their cost is higher. The modelling and dimensioning of foundations on a ballasted column will be an important contribution to the state of the art of this method because it will highlight the mode of transfer of loads, and will expose the induced deformations by also allowing to verification criteria of bearing capacity and allowable settlement according to geometric information of the model. The columns on a substrate located at 9 m have a length of 9 m and a diameter of 40 cm and were obtained by incorporating ballast of granular class 0/31.5 of internal friction angle of 38˚ and a density weight of 21 kN/m3. The choice of this method is based on the geotechnical characteristics of the initial soil. Thus, identification and characterization tests were carried out to estimate the bearing capacity and the settlement giving respectively 125 kPa and 57 cm. These results show the ground does not have sufficient mechanical properties to withstand the loads transmitted by the tank. By adopting the reinforcement of the soil with ballasted columns, numerical calculations show that after applying a load equal to 265.1 KPa, 20 cm vertical settlement and 17 cm horizontal displacement were obtained. This is in the tolerable deformation range for our tank, namely, less than 20 cm. Analytically, in addition to reducing settlement, ballasted columns, Due to their high stiffness, they have effectively contributed to the increase of the permissible soil stress up to 257 kPa.

关键词： Reinforcement Ballasted Columns Reservoir Geotechnical Modeling Plaxis 2D

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