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Human-water interactions associated to cercarial emergence pattern and their influences on urinary schistosomiasis transmission in two endemic areas in Mali

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Infectious Diseases of Poverty 2024年第4期13卷 103-104页

作者： Bakary Sidibe Privat Agniwo Assitan Diakite Boris Agossou Eyaton-olodj Segnito Savassi Safiatou Niare Doumbo Ahristode Akplogan Hassim Guindo Moudachirou Ibikounle Laurent Dembele abdoulaye Djimde Jerome Boissier abdoulaye Dabo Department of Epidemiology of Infectious Diseases Faculty of Pharmacy University of Sciences Techniques and Technologies of Bamako Bamako Mali Centre de Recherche Pour La Lutte Contre Les Maladies Infectieuses Tropicales (CReMIT/TIDRC) Université d’Abomey-Calavi Abomey-Calavi Bénin IHPE Univ. Montpellier CNRS Ifremer Univ. Perpignan Via Domitia Perpignan France

Background Mali is known to be a schistosomiasis-endemic country with a limited supply of clean *** has forced many communities to rely on open freshwater bodies for many human-water contact(HWC)***,the relationship between contact with these water systems and the level of schistosome infection is cur-rently receiving limited *** study assessed human-water interactions including cercarial emergence pat-tern and their influences on urinary schistosomiasis transmission in two communities in the Kayes district of *** We carried out a parasitological study frst in children in September 2021,then a cross-sectional study of quantitative observations of human-water contact activities in the population,and finally a study of snail infectiv-ity at contact points in September *** study took place in two communities,Fangoune Bamanan and Diakalel in the Kayes region of western *** chronobiological study focused on cercarial release from naturally infected *** cercariae were molecularly genotyped by targeting the cox1 region,and the ITS and 18S ribosmal DNA gene(18S rDNA)regions of the *** between sociodemographic parameters,human water-contact points and hematuria were established using multivariate statistical analysis or the logistic regression *** The main factor predisposing the 97 participants to water contact was domestic activity(62.9%).Of the 378 snails collected at 14 sampling sites,27(7.1%)excreted schistosome cercariae,with 15.0%(19/126)at Fangoune Bamanan and 3.3%(8/252)at *** release of Schistosoma cercariae shows three different patterns in Fangoune Bamanan:(i)an early release peak(6:00-8:00 AM),(i)a mid-day release peak(10:00 AM-12:00 PM)and(ili)a double peak:(6:00-8:00 AM)and(6:00-8:00 PM)cercariae release;and two release patterns in Diakalel:early release(6:00-8:00 AM)and(il)mid-day release(12:00-2:00 PM).All cercariae released during early diurnal(6:00-8:00 AM)or nocturnal

关键词： Schistosomiasis Chronobiology Cercarial emission Snail Water contact Mali

Neurobiology of Neuronal Network Alteration in Intellectual Disability Related to Fetal Alcohol Spectrum Disorders

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Journal of Behavioral and Brain Science 2022年第3期12卷 43-81页

作者： abdoulaye Bâ Université Félix Houphouë t-Boigny UFR Biosciences Abidjan C&ocirc te d’Ivoire

The molecular and cellular mechanisms by which alcohol produces its deleterious effects on neuronal networks are only now beginning to be understood. This review focused on alcohol-induced neurobiological alterations on neuronal network components underlying information processing, for further understanding of intellectual disability related to FASD. Abnormal neurodevelopmental events related to alcohol-damaged fetal brain included neurogenesis inhibition, aberrant migration, impaired differentiation, exacerbated apoptosis, impaired axon outgrowth and branching altering synaptogenesis and synaptic plasticity, abnormal GABAergic interneurons triggering synaptic inhibitory/excitatory imbalance, reduced myelinogenesis causing injured white matter in prefrontal lobe and atrophied corpus callosum compromising interhemispheric information transfer, the whole compromising neuronal network scaffolding which may lead to biased information processing with deficits in executive function. What added to these abnormalities are smaller gray matter and reduced hippocampus, resulting in cognition and memory failures. As a whole, these developmental disorders may underlie intellectual disability related to FASD. In rodents, these neuronal network components matured mainly during the second and third trimesters equivalents of human gestation. Transferability of results from animal to human was also discussed. It was hoped that the understanding of alcohol-induced neuronal networks failure mechanisms during the developing brain may lay a foundation for prospective new treatments and interventions.

关键词： Fetal Alcohol Spectrum Disorders Intellectual Disability Neuronal Network Axogenesis Synaptogenesis Myelinogenesis

Chemical characterization of essential oil from the leaves of Callistemon viminalis(D.R.) and Melaleuca leucadendron(Linn.)

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Asian Pacific Journal of Tropical Biomedicine 2017年第4期7卷 347-351页

作者： Rokhaya Fall Saliou Ngom Dienaba Sall Mbacke Sembène abdoulaye Samb Laboratory of Natural Products Department of ChemistryFaculty of Science and TechnologyCheikh Anta Diop University Center for the Development of Horticulture Senegalese Institute of Agricultural Research Laboratory of Entomology Department of Animal BiologyFaculty of Science and TechnologyCheikh Anta Diop University

Objective: To isolate and identify the compounds in the essential oils from the leaves of Callistemon viminalis(D.R.) and Melaleuca leucadendron(Linn.) collected in Dakar,***: The essential oils from the leaves of these two myrtaceaes were extracted by steam distillation and analyzed by gas chromatograph and gas chromatography–mass ***: A total of 34 constituents were identified in the oil of Callistemon viminalis and the major compounds were 1.8-cineole(58.12%), limonene(9.72%), a-terpineol(9.56%),geranial(6.02%), d-elemene(3.53%), myrcene(2.96%) and a-pinene(2.49%).For the essential oil of Melaleuca leucadendron, 43 constituents were identified, and 1.8-cineole(28.87%), epiglobulol(23.06%), a-pinene(12.22%), limonene(11.65%) and a-terpineol(7.06%) were major ***: Considering properties of the identified major compounds, essential oils of both studied myrtaceae could be used in the medicine field including the food, pharmaceutical and cosmetic industry.

关键词： Callistemon viminalis Melaleuca leucadendron Essential oil Chemical composition

Experimental adsorption equilibrium study and comparison of zeolite with water and ethanol for cooling systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 216-220页

作者： MAIGA abdoulaye Siddeye, CHEN Guang-ming, WANG Qin (Institute of Refrigeration and Cryogenics, Zhejiang University, Hangzhou 310027, China) Institute of Refrigeration and Cryogenics Zhejiang University Hangzhou 310027 China Ph.D student at Zhejing University from Mali

Two adsorption refrigeration working pairs of zeolite with water and ethanol were studied and the parameters of Dubinin-Astakhov model were regressed using the experimental data of equilibrium. The coefficient of heterogeneity varied from 1.305 to 1.52 for the zeolite-water pair and from 1.73 to 2.128 for zeolite-ethanol pair. The maximum adsorption capacity varied from 0.315 to 0.34 for zeolite-water and 0.23 to 0.28 for zeolite-ethanol, respectively. The results showed that the zeolite-water pair is suitable for solar energy cooling not only because of the high latent heat of vaporization of water but also because of the better equilibrium performance. On the other hand, zeolite-ethanol gives a high adsorption capacity at high regeneration tem-perature, which means it can be used in heat engine systems like buses and cars.

关键词： Adsorption refrigeration Zeolite Ethanol Water Equilibrium

High Urine Retention: Experience in a Series of Patients with Renal Failure Patients

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Open Journal of Urology 2024年第1期14卷 1-10页

作者： Cyrille Ze Ondo abdoulaye Ndiath Amath Thiam Alioune Sarr Ndiaga Seck Ndour Ousmane sow Babacar Sine Babacar Diao Alain Khassim Ndoye Urology Department Aristide Le Dantec Hospital Dakar Senegal Urology Department Ouakam Military Hospital Dakar Senegal

Purpose: High urinary retention (HUR) can negatively impact renal function. Our study aimed to present the epidemiological, diagnostic, and therapeutic aspects of HUR in a Senegalese academic hospital. Patients and Methods: We conducted a retrospective study of 70 patients with HUR associated with renal failure from January 2017 to December 2020. Parameters examined included: age, sex, coexisting conditions affecting renal function, clinical symptoms, diagnostic tests, causes of HUR, urinary diversion, and patient outcomes. Results: The average age was 66, with a majority of male patients (87%). Twenty-three patients had pre-existing medical conditions. Oligo-anuria was the most common reason for detecting HUR (70%). Half of the patients had an ECOG score ≥ 2. The mean creatinine level was 50.7 mg/l. Nineteen patients exhibited hydroelectrolytic disorders. Bacterial colonization was observed in 25 patients. Ultrasound and computed tomography were the most frequently performed imaging tests (100% and 62.8%, respectively). Sixty-seven patients had ureterohydronephrosis (UHN), with bilateral UHN in 88.6% of cases. Pelvic cancers (47.1%) were the primary cause of HUR, primarily bladder cancers (27.1%). Nephrostomy was the most common urinary drainage method (50%), particularly for obstructions due to pelvic cancer (88.6%). The majority of patients (52.8%) regained normal renal function after drainage. Nineteen deaths occurred among elderly patients with compromised general health. Conclusion: Urinary drainage significantly improved renal function for most patients. Pelvic cancer emerged as the leading cause of HUR. Nephrostomy was the predominant drainage method.

关键词： Kidney Urinary Retention Renal Failure Urinary Diversions Senegal

Respiratory Flow Rates of Metal Welders Compared to a Population Not Exposed to Metal Welding Dust

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Open Journal of Respiratory Diseases 2024年第2期14卷 51-59页

作者： Robert Faomowe Foko Abdou Khadir sow Awa Ba Mor Diaw Fatoumata Bah Mame Saloum Coly Absa Lam Cheikh Diop Aminata Toure abdoulaye Ba abdoulaye Samb Arame Mbengue Mathilde Cabral Mamadou Fall Laboratory of Toxicology and Hydrology Faculty of Medicine Pharmacy and Odontostomatology Cheikh Anta Diop University of Dakar Dakar-Fann Senegal Laboratory of Physiology and Functional Exploration Faculty of Medicine Pharmacy and Odontostomatology Cheikh Anta Diop University of Dakar Dakar-Fann Senegal Laboratory of Physiology and Functional Exploration Alioune DIOP University of Bambey Bambey Senegal Laboratory of Physiology UFR of Health Sciences Functional Exploration Department Thies Regional Hospital Center Thies Senegal

Background: The welding trade includes many industrial activities in both the formal and informal sectors. Workers in this professional environment do not have access to individual and collective means of protection adapted to the activity, which exposes them to the dust emitted during their activity and therefore contributes to increasing the risk of developing respiratory disorders in this population. Objective: Our study aimed to evaluate the ventilatory function of metal welders in the city of Dakar. Method: This was a comparative study based on the analysis of the spirometric parameters of metal welders working in the city of Dakar (Senegal) with those of a control group of the same kind, selected from the general population. Measurements of forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and maximum mid expiratory flow (MMEF) were measured. Results: A total of 75 men between the ages of 19 and 61 were recruited and divided into two groups (43 controls and 32 welders). The welding population had more frequent distal and central obstructions and pulmonary restriction compared to the control group. The metals most commonly used by welders were aluminum for welders who had an obstruction, while for those who had a restriction, iron was the most used metal. Signs of metal fever were frequently found in welders, especially those with ventilatory disorders. Conclusion: The prevalence of respiratory disorders observed is close to that observed in industrial environments, where exposure levels are the highest. The lack of personal protective equipment could also be a significant risk factor in the development of these disorders.

关键词： Welder Occupational Exposure Spirometric Disorder Metal Fever Dakar

Spirometric Abnormalities Met among Senegalese Workers Exposed to Chlorine Gas

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Journal of Pharmacy and Pharmacology 2019年第11期7卷 584-592页

作者： Houndjo Salimata Diagne Ouattara Rokia Mbengue Arame Ouedraogo Valentin Seck Aissatou sow Abdou khadre Diaw Mor Toure Maimouna Coly Mame Saloum Ba Awa Sar Fatou Bintou Ba abdoulaye Samb abdoulaye Laboratoire de Physiologie et d’Explorations Fonctionnelles Faculté de Médecine de Pharmacie et d’Odontologie-Senegal Universite Cheikh Anta Diop de Dakar Dakar BP 5005 Senegal UMI 3189 “Environnement Sante Societies” CNRS CNRST Universite Bamako-UCAD Dakar BP 5005 Senegal UFR des sciences de la sante Thies BP 221 Senegal UFR des sciences de la sante Bambey BP 21400 Senegal

Introduction: Chlorine as a disinfectant has many side effects on respiratory function. This respiratory toxicity may be related to the exposure time. Materials and Methods: Measure the impact of the duration of chlorine gas exposure on the respiratory function of Senegalese workers who work in the national water production factory: Senegalaise Des Eaux (SDE), aged 35-54 years. Twenty-four (24) male subjects exposed to chlorine gas were divided into two groups, one (35-44) and the other (45-54). Clinical examinations were performed on each employee, followed by chest x-rays and spirometry. We included all subjects whose first or last two spirometry results were normal. Results: In the 35-44 years group, 50% of subjects had disturbed spirometry including 41.6% of obstructive syndrome (OS), at the second spirometry and 8.3% had a restrictive syndrome FVC at -25%, at the 3rd spirometry 4/12 had a normal spirometry. The duration of exposure was 10 years. For subjects in 45-54 years, 8/12 had persistent OS or accentuated, then at the 3rd spirometry we had 10 subjects. The duration of exposure was 17.5 years. Conclusion: Compared with (35-44) group, older (45-54) subjects had significant OS, which may be related to duration of exposure.

关键词： Spirometry exposure SDE

The Epidemiological, Clinical and Radiological (Echography, Mammography) Characteristics of Breast Pathologies at the Diagnostic Imaging Center (C.I.D) “Teriya” in Bamako

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Open Journal of Medical Imaging 2023年第1期13卷 30-39页

作者： Ilias Guindo Souleymane Sanogo Mamadou N’diaye Mody abdoulaye Camara Adama Dao Youssouf Goita Amadou sow Mohamed Malinke Salia Coulibaly Mahamadou Diallo Medical Imaging Department CHU Pr BSS of Kati Kati Mali Medical Imaging Department CHU Gabriel Touré Bamako Mali Medical Imaging Department Luxembourg Mother-Child Hospital Bamako Mali Imaging Service Bamako Infirmary Central Directorate of Armed Forces Health Services (DCSSA) Bamako Mali Medical Imaging Department Mali Hospital Bamako Mali TERIYA Diagnostic Imaging Center Bamako Mali

Breast pathology is varied, bringing together tumor and non-tumor lesions. Objective: To study the contribution of the ultrasound-mammography pair in the diagnosis of breast pathologies. Materials and Method: This was a retrospective descriptive study, carried out over a period of 3 years (from January 2018 to December 2020) at the Diagnostic Imaging Center (C.I.D) “TERIYA” in BAMAKO. It concerned all patients who came for a mammogram/ultrasound examination of the breast. All women admitted for mammogram or breast ultrasound who were diagnosed with a breast injury during the study period were included. Incomplete records and radiological checks were not included. The variables analyzed were age, sex, clinical data, and ultrasound and mammography aspects. The devices used are: a Voluson 730 PRO ultrasound machine and a G 600T type mammography machine. Results: At the end of our study, we collected 254 breast pathologies on a number of 382 women, i.e. a frequency of 66.49%. The average age of our patients was 41 years old. The dominant clinical data were mastodynia (41.88%) and mammary nodule (21.70%). On imaging (mammo-ultrasound) the lesions predominated on the left in 36% of cases, bilateral in 28% of cases and in the upper-outer quadrants in 31.5% of cases. Tumor pathologies represented 66.54% of which 45.27% were benign mainly composed of fibro-adenoma (20.88%) and cyst (18.50%), 11.8% of suspected cases and 9.45% of cancers. Non-tumor pathologies represented 33.46%, mainly mastitis (16.14%), galactophoric dilations (11.02%) and abscesses (5.51%). These pathologies were classified in 50.3% in ACR2, 17.75% in ACR3 and 4, and in 14.20% in ACR5. Lymphadenopathy was present in 73.21% of cases.

关键词： Breast Pathologies Ultrasound-Mammography Pair Diagnostic Imaging Center Bamako

Clinical and Anatomo-Pathological Study of Digestive Polyps at Point G Teaching Hospital

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Open Journal of Gastroenterology 2023年第3期13卷 111-116页

作者： Sanra Déborah Sanogo Marcelle Paule Tayue Ganda Soumaré Ouatou Mallé abdoulaye Maiga Luc Sidibé Hourouma sow Kadiatou Samaké Moussa Y. Dicko abdoulaye Diarra Ilias Guindo Bakarou Kamaté Cheickh B. Traoré Hepatogastroenterology Department Point G University Hospital Bamako Mali Anatomical Pathology Department Point G University Hospital Bamako Mali Hepatogastroenterology Department Gabriel Touré University Hospital Bamako Mali CHU Bocar Sidy Sall Bamako Mali

Introduction: The aim of our study was to describe the aspects clinical and pathology of digestive polyps. Methods: This was a descriptive and analytical study with retrospective and prospective collection from January 2014 to September 2020, i.e. a duration of 72 months. Our study focused on all cases of non-cancerous digestive pathologies. The data were collected from registers, medical files and reports from the anatomy and pathological cytology department of the Point G University Hospital. All of this data was entered on an individual survey form. This sheet includes demographic data, qualitative and quantitative variables. Results: We conducted a study of 131 cases of digestive polyps. The frequency of digestive polyps was 3.65%. The mean age of our patients was 44.6 ± 21 years with extremes of 2 years and 79 years, with a male predominance and a sex ratio of 1.01. The biopsy was the type of sample most represented in 77.1%. The digestive polyps were located in stomach in 37.4%;the colon in 27.5% then the rectum 21.4%. The polyp sessile accounted for 65.6%. Histological examination revealed that adenomatous polyps were predominant in 77% of cases, followed by juvenile polyps in 9.2%, then hyperplastic polyps in 6.2%. Low grade dysplasia was found in adenomatous polyps in 61.53% and high grade found in 38.4%. Gastritis due to Helicobacter pylori (Hp) was found in 16% of cases. Conclusion: Digestive polyps are common in the general population. The prognosis is linked to the risk of neoplastic degeneration of adenomas.

关键词： Digestive Polyps Clinical Anatomopathology