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Phytochemical Characterization and Evaluation of the Antibacterial Activity of Leaf Extracts of Mitragyna inermis (Willd.) O. Ktze on the in Vitro Growth of Clinical Strains Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa Involved in Gastro Enteritis

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Journal of Biosciences and Medicines 2024年第6期12卷 101-113页

作者： Monon Kone youssouf Zanga Traore Tidiane Kamagate Ahmont Landry Claude Kablan abdoulaye Toure Karamoko Ouattara Adama Coulibaly Department of Biochemistry-Genetics Training and Research Unit Biological Sciences Peleforo Gon Coulibaly University Korhogo Cte dIvoire Department of Mathematics-Physics-Chemistry Training and Research Unit Biological Sciences Peleforo Gon Coulibaly University Korhogo Cte dIvoire Department of Biology and Health Training and Research Unit of Bioscience University of Flix Houphout-Boigny Abidjan Ivory Coast Department of Microbiology and Molecular Biology Training and Research Unit of Agriculture Fisheries Resources and Agro-Industry University of San Pedro San Pedro Cte dIvoire

Gastroenteritis constitutes a group of diarrheal diseases of infectious origin, responsible for absenteeism from work, morbidity and mortality, especially among aged people. This study aimed to evaluate the antibacterial activity of Mitragyna inermis extracts on the in vitro growth of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa involved in gastroenteritis. Phytochemical screening was carried out using two distinct methods. The detection of phytochemical compounds by tube coloring and chromatography on a thin layer of silica gel. The sensitivity of organisms was evaluated by the agar well method. The dilution method in liquid medium coupled with spreading on Mueller Hinton agar helped determine the CMB/MIC activity ratios. The investigations show that the extract has the best extraction yield (75.86% ± 0.20%) compared to the aqueous macerated (61.8% ± 0.08%) and decocted (66.6% ± 0.12%). These extracts contain several phytochemical compounds such as flavonoids, polyphenols, tannins, alkaloids, saponosides, coumarins and sterols and terpenes. These substances are endowed with biological activities and could be at the origin of antibacterial activity observed with M. inermis extracts. The analysis of antibacterial activity showed that the germs are sensitive to the extracts with inhibition diameters ranging from 8.30 ± 0.53 to 17.87 ± 0.58 mm. The ethanolic extract was the most active with diameters varying from 15.07 ± 0.62 to 17.87 ± 0.58 mm on all the germs tested. E. coli and S. aureus were the most sensitive germs to the extracts. P. aeruginosa was the least sensitive germ. Activity reports indicate that the extracts exert bactericidal activity on E. coli and S. aureus but bacteriostatic activity on P. aeruginosa. These results justify the use of M. inermis leaves in a traditional environment to treat gastroenteritis.

关键词： Phytochemical Characterization Antibacterial Activity Mitragyna inermis Gastro Enteritis

Serological Profile of Hepatitis D Virus (Hepatitis Delta) in the Hepato-Gastro-Enterology Department of Chu Gabriel Toure

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Open Journal of Gastroenterology 2024年第3期14卷 93-98页

作者： Sanra Déborah Sanogo Kadiatou Doumbia Hourouma Sow Moussa Younoussou Dicko youssouf Oumarou abdoulaye Berthé Sabine Drabo Luc Sidibé Makan Siré Tounkara abdoulaye Maiga Ouatou Mallé Ganda Soumaré Anselme Konaté Moussa Tièmoko Diarra Hepato-Gastroenterology Department CHU Point G Bamako Mali Hepato-Gastroenterology Department CHU Gabriel Touré Bamako Mali Department of Internal Medicine Centre Hospitalier Universitaire Communautaire de Bangui Bangui Central African Republic

Infection with the defective hepatitis D virus (HDV) co-infects or superinfects a patient carrying hepatitis B virus (HBV). Delta virus infection is relatively common. The seriousness of infection with the hepatitis D virus (HDV), a virus defective in a patient carrying the hepatitis B virus (HBV), lies in its aggravating effect on the associated viral hepatitis B. Our aim was to study the serological profile of HDV in HBsAg-positive patients. As this study was fragmentary, we initiated this study with the aim of investigating the serological profile of HDV in HBsAg-positive patients. This was a descriptive and analytical cross-sectional study that ran from March 2019 to February 2020, a 12-month period. It focused on the population of patients seen and screened positive for HBsAg. We obtained a frequency of 10%. The mean age of our patients was 41.8 ± 13.09 years. The sex ratio was 4.5. VHD RNA was detected in 50% of patients. In 100% of cases, the presence of VHD RNA was associated with advanced fibrosis according to the APRI score, but without any statistically significant link. All HBV-infected patients should be screened for anti-HDV Ac. HDV infection leads to rapid progression to complications of liver disease.

关键词： HBsAg VHD RNA Liver Disease

Evolution of Mother-to-Child HIV-1 Transmission Rate in Mali from 2009 to 2018

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Advances in Microbiology 2024年第5期14卷 256-267页

作者： Alou Sanogo Mohamed Ag Baraïka Maïga Aminata Demba Koita Mahamadou Abdou Mamadou Guindo Clémentine N’Diaye Fatoumata Namoudou Traoré abdoulaye Bagayoko youssouf Diallo Flabou Bougoudogo Ibrehima Guindo National Institute for Public Health Bamako Mali Faculty of Pharmacy (FAPH) University of Science of Technical and Technology de Bamako Bamako Mali University Hospital Center (CHU)-Point G Bamako Mali Faculty of Medecine and Odonto-Stomatology University of Science of Technical and Technology de Bamako Bamako Mali Sector Unit for the Fight against AIDS Tuberculosis and Hepatitis Bamako Mali UNICEF (United Nations Children’ s Fund) Bamako Mali

Despite enormous efforts to achieve the goal of eliminating mother-to-child transmission of HIV-1, it remains a major challenge for many countries in sub-Saharan Africa, particularly Mali. Our objective is to assess changes in the rate of mother-to-child transmission of HIV-1. We conducted a cross-sectional study between January 1, 2009 to December 31, 2018 (10 years) of early diagnosis activity in newborns and children born to HIV-1-positive mothers at the National Institute for Public Health (INSP). The samples came from health and referral centers in mali. All samples were received at the Laboratory of Molecular Biology at the INSP. Proviral DNA extraction was performed from a blood spot sample with a Roche DNA kit, Cobas AmpliPrep/Cobas TaqMan HIV-1 qualitative Test, V2.0 (Roche Molecular System, Inc, USA) following the company procedures. Molecular diagnosis was performed using the same kits using an algorithm of three identical PCRs. The Epi Info version 7 software was used for data analysis with a significance threshold of 5%. A total of 10,714 samples of infants and children born to HIV-positive mothers were analyzed by PCR. Ninety-six percent of mothers were on ARV prophylaxis (AZT 3TC NVP and AZT NVP) and 60% of newborns received the same ARV prophylaxis. Of these children, 956 tested positive with an overall transmission rate of 8.92%, varying between 7.27% in 2009 and 08.01% in 2018. This rate was relatively low among children receiving prophylaxis at 2.04% and remained high for children who received breastfeeding at 5.62%. However, the transmission rate remains low for those who have benefited from mixed and artificial breastfeeding at 1.58% and 1.27% respectively. A significant proportion of children remained infected by their mothers during pregnancy, childbirth or breastfeeding. This study shows the importance of early diagnosis of HIV in children using molecular technology.

关键词： Early Diagnosis Mothers-to-Child Newborns PCR DNA HIV-1

Evaluating the Influence of the Prostate Weight on the Morbidity and Mortality of Transvesical Open Prostatectomy: Prospective Analysis of 108 Cases in the Urology-Andrology Department of the Ignace Deen National Hospital in Conakry

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Open Journal of Urology 2024年第4期14卷 252-261页

作者： Thierno Oumar Diallo alimou Diallo Alpha Oumar Barry Thierno Mamadou Oury Diallo Alseny Bah youssouf Keita Daouda Kanté Mamadou Bissiriou Bah Demba Cissé Ibrahima Bah abdoulaye Bobo Diallo Oumar Raphiou Bah Urology Department National Hospital of Ignace Deen Conakry University Conakry Guinea Urology Department Sino-Guinean Friendship Hospital Conakry University Conakry Guinea

Introduction: Open transvesical prostatectomy remains today one of the most effective approaches for the management of benign prostatic hyperplasia despite the fact that, this method is associated with multiple complications. The objective of this study was to evaluate the influence of prostate weight on the morbidity and mortality of transvesical prostatectomy for adenoma in the urology-andrology department of the Ignace Deen National Hospital. Materials and Methods: This was a prospective, longitudinal and analytical study lasting 6 months, from March 1, 2022 to August 31, 2022 including patients admitted and operated on by open transvesical prostatectomy by assessing the influence of prostate weight on the morbidity and mortality of transvesical adenomectomies. Results: 108 patients were included in our study, the average age of our patients was 70 ± 7.7 years, cultivators were the most represented profession with 38.89%, and hypertension was the most represented comorbidity with 75%. 33.06% of cases became complicated and surgical wound infection was the main complication with a frequency of 17.40%. Statistical analysis did not conclude that, the prostate weight does not have a statistically significant influence on the morbidity and mortality of transvesical open prostatectomy for benign prostatic hyperplasia. Conclusion: Prostate weight has no influence on the morbidity and mortality of transvesical prostate adenoma.

关键词： Benign Prostatic Hyperplasia (BPH) Adenomectomy Prostate Weight Complication

Prostatic Adenomectomy and Comorbidities: Frequency and Management at the Urology Department of the Ignace Deen National Hospital in Conakry

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Open Journal of Urology 2024年第4期14卷 217-226页

作者： Demba Cisse Alpha Oumar Barry Morlaye Fatoumata Bangoura alimou Diallo Mamadou Dian Bah youssouf Keita Daouda Kanté Thierno Mamadou Oury Diallo Mamadou Bissiriou Bah Mamadou Diawo Bah abdoulaye Bobo Diallo Oumar Raphiou Bah Maitre-Assistant à la Facult&#233 des Sciences et Techniques de la Sant&#233 Universit&#233 Gamal Abdel Nasser de Conakry Conakry Guin&#233e

Goal: To determine the type of comorbidity and highlight the complications of adenomectomy and comorbidities. Material and Methods: This is a prospective, descriptive, cross-sectional study lasting six (6) months, from July 1, 2022 to December 31, 2022. Patients with BPH on comorbidity condition taken care of during the study period AND have agreed to participate in the study. Results: During our study, 49 cases of benign prostatic hypertrophy with comorbidities were collected, representing a frequency of 29%. The average age ranges for the patients were 43 - 70 years. The age group most affected was 70 to 79 years old (38.80%). Nocturnal urinary frequency was the main reason for consultation present in all our patients. The most frequent comorbidity was hypertension, i.e. 83.70%. The PSA rate between 4 and 10 was the most represented, i.e. 42.86%. The prostate volume was between 61 and 100 ml in 40.82% of patients. Histology showed that it was a benign adenomatous hypertrophy of the prostate in 85.70% and a prostatic adenomyoma in 14.29%. Trans-bladder adenomectomy alone was the most performed technique, i.e. 49%, followed by trans urethral resection of the prostate, i.e. 38.80%. Retention of urine after removal of the catheter was the most observed complication, i.e. 12.20%. Conclusion: Benign prostatic hypertrophy with comorbidities constitutes a frequent association. Because their presence can affect effectiveness and lead to complications.

关键词： Prostatic Hypertrophy Comorbidities Conakry University Hospital

Postpartum Family Planning at the Timbuktu Hospital in Mali

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 1074-1082页

作者： Kassogué Djibril Samaké Alou Dolo Akoro Sogoba Seydou Touré Lahaou Cissouma Assetou Kassogué abdoulaye Maiga Mariam Mariko Souleymane Kantako Karamoko Ongoiba Oumar Sanogo Ooumar Traoré Bassirima Sidibé Idrissa Mandé Kassambara youssouf Traoré Halima Timbuktu Hospital Bamako Mali Commune VI Bamako District Hospital Bamako Mali CHU Point G Bamako Bamako Mali Sikasso Hospital Bamako Mali Nianankoro Fomba Sgou Hospital Bamako Mali

Introduction: Postpartum family planning is the prevention of pregnancies during the 12 months following childbirth. Few studies have been devoted to postpartum family planning in Mali. Our work will contribute to reducing unmet need for family planning. Objective: To study the use of contraceptive methods in the postpartum period in the obstetrics and gynecology unit of Timbuktu hospital. Materials and Methods: This was a descriptive and analytical cross-sectional study with prospective collection of data from January 1, 2022 to December 31, 2023. All women who gave birth having chosen and benefited from a contraceptive method were included. The statistical test used was the Fisher test with a significance threshold fixed at 5%. Results: The frequency of contraception in the postpartum period was 17.03%. The average age of clients was 26.14% with extremes of 14 and 45 years. They were paupiparous at 56.4% with an inter-birth interval of less than 12 months at 12.3%. More than half of the counseling (58.5%) was done during postnatal visits. The methods chosen were implants at 48.1%, injectable progestins at 21.3%, intrauterine device at 14.7%, miro-progestin pills at 13.5%, tubal ligation at 1 .4% and condoms at 1%. The regular follow-up rate was 51.1% of cases and 25.6% had no follow-up. Conclusion: The overall rate of postpartum family planning of 17.08% remains low. Improving FP staff skills will reduce unmet needs and contribute to increasing contraceptive prevalence in Timbuktu.

关键词： Family Planning Postpartum Counseling Contraceptive Methods Timbuktu Hospital

Ethnobotanical Investigation of Insecticidal Plants and Evaluation of the Insecticidal Activity of Capsicum chinense on Sitophilus zeamaïs of Maize and Aphis craccivora of Groundnuts: Case of Boffa, BokéRegion (Republic of Guinea)

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Journal of Agricultural Chemistry and Environment 2022年第2期11卷 132-142页

作者： Aboubacar Diallo Adama Moussa Sakho Namory Keita Lansana Abou Bangoura Amadou youssouf Bah abdoulaye Keita Department of Chemistry Gamal Abdel Nasser University Conakry Republic of Guinea Department of Laboratory Techniques Mamou Superior Institute of Technology Mamou Republic of Guinea Department of Biology Kindia University Kindia Republic of Guinea

The present study, which aims to contribute to the valorization of Capsicum chinense, focuses on ethnobotanical investigations and evaluation of insecticidal activity on Sitophilus zeamaïs and Aphis craccivora, as well as the germination power of infected maize and peanut grains treated and not treated with Capsicum chinense leaf powder. To do this, the moisture content of corn and peanuts was determined by the techniques: drying in the sun and in the oven. The insecticidal effect of the powder was tested on maize and peanut kernels infected by the AGRAR (2013) method, followed by a test of the germination potency of these treated grains. The average moisture values of corn and groundnut kernels are 14.51% and 12.25% respectively. The results show, a higher insecticidal efficacy of Capsicum chinense leaf powder on Sitophilus zeamaïs and Aphis craccivora with doses (2, 4 and 8 g). The average germination rates of maize and peanut kernels infected and treated with this powder are: (16.5%;63%;99.5%) and (21.25%;96.5%;99.75%), respectively. This study could be a bio-insecticide alternative for the peasant community in the conservation of cereal and legume products.

关键词： Corn Groundnut Ethnobotany And Insecticidal Activity of Capsicum chinense

Isolated Congestive Reactional Non-Specific Retro-Peritoneal Adenitis Mimicking a Choledocal Cyst in a Case at the “Luxembourg” Hospital Center in Bamako

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Open Journal of Radiology 2022年第4期12卷 189-196页

作者： Camara Mamoudou Camara Toumin Keita Aboubacar Sidiki Mariko Mahamane Koné Achomba abdoulaye Konaté Moussa Tounkara youssouf Sidibé Siaka Center for Medical Imaging Exploration and Diagnosis (CIMED) Conakry Guinea Medical Imaging Department CH Mother-Child “Luxembourg” Bamako Mali Internal Medicine Department of The Siguiri Prefectural Hospital Gamal Abdel Nasser University Conakry Guinea Medical Imaging Department North Franche Comté Hospital Trevenans France Medical Imaging Department CHU Point G Bamako Mali

The aim of our work was to establish the diagnostic difficulty of isolated nonspecific retroperitoneal congestive adenitis on medical imaging. Patient: This is a 27-year-old patient from a district located 660 km from Bamako with no known medical history or notion of travel. The onset of the disease dates back to 3 years marked by pain in the right hypochondrium and the epigastrium radiating to the back in the form of torsion, of medium intensity associated with periodic vomiting and jaundice. She was referred to the medical imaging department for pain in the right hypochondrium and cholestatic jaundice. The abdominal CT scan with and without contrast injection showed an oval retroperitoneal mass, with regular contours sitting behind the head of the pancreas and in front of the right kidney with its hypo-dense center of density equal to 23 HU measuring 44 × 28 mm, with a thick wall enhanced after injection of contrast product. It was associated with a distended gallbladder with a thin wall and hypo-dense content and a moderate dilation of the intrahepatic bile ducts. Following these examinations, the diagnostic hypothesis of cystic dilation of the common bile duct was retained. Surgery made it possible to cure the retroperitoneal lesion, discectomy of the gallbladder and biopsy of the lesions. The histological examination made it possible to make the diagnosis of isolated nonspecific reactive congestive adenitis. Conclusion: Isolated nonspecific congestive retropancreatic adenitis with a necrotic center poses a diagnostic problem for imaging in our environment because of its similarity to the bile duct cyst. This study, which is a very illustrative case, showed us a diagnostic discrepancy between the result of cross-sectional imaging and that of surgery and pathology.

关键词： Adenitis Cyst Imaging Luxembourg

Epidemiological, Clinical and Radiological Study of Patients Operated on for Spondylolisthesis in the Neurosurgery Department of CH “the Luxembourg” in Bamako

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Open Journal of Medical Imaging 2022年第3期12卷 109-122页

作者： abdoulaye Kone Moussa Traore Mamoudou Camara youssouf Kone Moussavou-Imounga Jacqueline Ouncoumba Diarra Mamadou Diarra youssouf Diawara Oumar Abba Ata Ibrahima Coulibaly Moussa Konate Kassim Sidibe Toumin Camara Cheick Oumar Touré abdoulaye Mody Camara Salia Coulibaly Mahamadou Diallo Adama Diaman Keita Siaka Sidibé Faculty of Medicine and Odontostomatology Bamako Mali Medical Imaging Department of the University Hospital of Point G Bamako Mali Medical Imaging Department of the Pasteur Polyclinic Bamako Mali Medical Imaging Department of GABRIEL TOURE Hospital Bamako Mali Medical Imaging Service Mother Child Hospital Luxembourg Bamako Mali Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinee Radiology Department of the Jacques Boutard Hospital Saint-Yrieix-la-Perche France Neurosurgery Department of the Mère-enfant le Luxembourg Hospital Bamako Mali Radiology Department of CSREF Commune III Bamako Mali DCSSA Bamako Mali Internal Medicine Department of the Prefectural Hospital of Siguiri Siguiri Guinea Medical Imaging Service Health Center of Ref Commune IV Bamako Mali Medical Imaging Department of Mali Hospital Bamako Mali Medical Imaging Department of KATI Hospital Kati Mali

Introduction: Spondylolisthesis is defined as a permanent anterior sliding of the vertebral body accompanied by the pedicles, the transverse processes and the posterior joints in relation to the underlying vertebra. The prevalence of spondylolisthesis varies between 4% and 9%, according to different authors in France, China and Japan. In Africa, some African authors find a spondylolisthesis rate of 9.93%. The objective of this study was to study the clinical and radiological aspects of spondylolisthesis at the Mother-Child Hospital of Bamako. Methods: Prospective and retrospective descriptive study carried out in the neurosurgery department of CH Mother-Child Luxembourg in Bamako from 2010 to 2018. Result: We collected 42 patients operated on for spondylolisthesis out of 145 patients, i.e., 29% of the department’s activities. The average age of our patients was 51 years old, with extremes of 20 and 75 years old. The sex ratio was 0.81 in favor of women. 61.9% of our patients performed work requiring physical strength. Neurogenic claudication was the predominant clinical sign with 88.1% of cases. CT was the most common way of exploration in 57.1% of cases and CT myelo in 47.6% of cases. Disc herniation was associated with spondylolisthesis in 23% of cases. Spondylolisthesis was grade 1 in 59.6% of cases and was responsible for mixed stenosis in 73.82% of cases. All our patients underwent laminectomy. The evolution at 6 months postoperative was favorable in 64.3% of cases. Conclusion: The diagnosis of spondylolisthesis is radiological and makes it possible to define the type of lesion according to its etiology and its severity, but also to highlight the conflicts with the nervous system which will have to be cured. Field and household work, pregnancy, carrying loads or children on the back could be incriminated.

关键词： Spondylolisthesis Radiology Operated