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Prevalence of Group B Streptococcus among Pregnant Women in Bobo-Dioulasso (Burkina Faso)

Open Journal of Medical Microbiology 2019年第3期9卷 63-76页

作者： abdoul-salam Ouédraogo Yacouba Sawadogo Der Adolphe Somé An Vercoutere Soufiane Sanou Souleymane Ouattara Fernand Michodigni Armel Poda Moussa Bambara Lassana Sangaré Sylvain Godreuil Departement of Microbiology Laboratory Sour&ocirc Sanou University Hospital Bobo Dioulasso Burkina Faso Department of Obstetrics and Gynecology Sour&ocirc Sanou University Hospital Bobo Dioulasso Burkina Faso Faculty of Medecine and health Sciences Ghent University Ghent Belgium Departement of Infectiology Sour&ocirc Sanou University Hospital Bobo Dioulasso Burkina Faso Departement of Microbiology Laboratory Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso Bacteriology-Virology Laboratory Montpellier University Hospital Montpellier France

Background: Group B Streptococcus (GBS) or Streptococcus agalactiae, which asymptomatically colonizes the female genital tract, is one of the leading causes of septicemia, meningitis and pneumonia in neonates. This study was conducted in Bobo Dioulasso, Burkina Faso to determine the prevalence of GBS colonization among pregnant women. Methods: Six hundred and eleven (611) pregnant women were screened for GBS colonization between July and December 2016. Vaginal swab samples were aseptically collected from the subjects after oral informed consent. Standard microbiological methods were used to isolate and identify GBS isolates. The antibiotic susceptibility profile of GBS isolates was assessed using the Kirby-Bauer disk diffusion method. Results: Colonization prevalence was 6.05%. No risk factors associated with the carriage rate was statistically identified. All isolates were susceptible to Amoxicillin, Ampicillin, Cefotaxime, Levofloxacin, Vancomycin and Nitrofurantoin. Resistance to antibiotics was found for erythromycin (35.14%), lincomycin (16.22%) and penicillin G (10.81%). Conclusion: Although a low carriage (6.05%) rate and isolates were susceptible to many antibiotics found in this study, a policy of systematic screening of pregnant women at least in the third trimester must be promoted.

关键词： Group B Streptococcus Prevalence GBS Carriage Burkina Faso

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Seroepidemiological Study of Dengue Virus Infection Suspected Cases in Burkina Faso

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Journal of Biosciences and Medicines 2023年第1期11卷 47-56页

作者： Kima Donatien Yeri Esther Hien Sawadogo salam Nebié K. Yacouba Ilboudo P. Denise abdoul Rahamani Nikièma Diallo Mariam Kafando Eléonore Yves Traoré Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle Ouagadougou Burkina Faso Laboratoire de Biochimie et d’Immunologie Appliquée (LaBIA) Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Université de Fada N’Gourma Fada N’Gourma Burkina Faso Institut de Recherche en Science de la Santé (IRSS) Ouagadougou Burkina Faso

Dengue fever is a mosquito-borne disease caused by four related but antigenically distinct dengue viruses. In the last half-century, the prevalence of dengue fever has increased dramatically (up to 30%) worldwide, especially in Sub-Saharan Africa. In Burkina Faso, the last dengue epidemic occurred in 2016, and the epidemiological situation is still poorly documented at the national level. Therefore, the present study aimed to conduct a sentinel seroepidemiology of suspected dengue virus infections from 2017 to 2020 at Charles de Gaulle University Pediatric Hospital Center of Ouagadougou. This investigation was designed to be a descriptive and analytical study. Patients with suspected cases of dengue fever were recruited from January 2017 to December 2020 during general medicine consultation and referred to Charles de Gaulle University Pediatric Hospital Center of Ouagadougou for the serological diagnosis of dengue. Venous blood was collected in dry or EDTA tubes and tested for DENV NS1 antigen, anti-dengue IgM, and anti-dengue IgG using SD Bioline Dengue Duo Rapid Detection Kit (Standard Diagnostic Inc., Korea). A total of 3400 blood samples from clinically suspected dengue cases were analyzed, of which 1784 (52.5%) were males, and 1616 (47.5%) were females. Among the 3400 patients included in the study, 661 (19.4%) were tested at least positive for NS1 antigen, anti-dengue IgM or anti-IgG. Among them, individuals positive for IgG suggesting past dengue virus infection were found in more than a third of 262 (7.7%) of the cases. Approximately, 80.0% (2705/3400) dengue suspected cases and 85.5% (341/399) early or primary dengue infections were recorded in the last four months of the study (September to December 2020), with a peak in mid-October and mid-November. There was no statistically significant difference in seroprevalence between males and females (p = 0.7), but an increasing seropositivity trend with age, from 11.6% for the patient under 5 years group to 39.7%

关键词： Dengue Seroepidemiology Ouagadougou Burkina Faso

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Study of the Management of Children with Major Sickle Cell Disease in Pediatric Emergencies at the Gabriel Toure University Hospital

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Open Journal of Pediatrics 2023年第2期13卷 244-252页

作者： Mohamed Elmouloud Cissé abdoul Aziz Diakité Adama Dembélé Belco Maiga Fatoumata Nampomo diarra Oumar Coulibaly Hawa Diall Pierre Togo abdoul Karim Doumbia abdoulaye Barry Karamoko Sacko Fousseyny Traore Djeneba Konaté Kalirou Traoré Lala N’Drainy Sidibé Ibrahim Ahamadou Amadou Touré Fatoumata Dicko Boubacar Togo Mariam Sylla Department of Pediatrics Gabriel Toure University Hospital Bamako Mali

Objective: To study the epidemiological, clinical and therapeutic aspects of sickle cell disease in children admitted to the pediatric emergency department of the Gabriel Toure University Hospital. Materials and methods: This was a prospective study over 12 months in sickle cell children aged 6 months to 15 years. Results: The frequency of sickle cell disease was 4.67% with 71.1% of SS form. The age range of 60 - 120 months predominated with 43.4% and the sex ratio 1.4. Vaso-occlusive crises (VOC) were the most frequent reason for consultation (50.6%) and osteoarticular pain was the main symptom followed by fever and pallor with respectively 67.5%, 60.2%, 39.8%. The pain subsided in less than 72 hours in 39.8% and hyper hydration was performed in 85.1% of patients. Analgesic treatment was given in 90.4%, antibiotic therapy in 51.8% and phenotyped red blood cells transfusion was performed in 36.1%. The average duration of treatment was 10 days. Conclusion: Vaso-occlusive crisis remains the main reason for consultation in sickle cell disease children at Gabriel Toure University Hospital. The management consisted, in addition to the correction of the triggering factors, of hyper hydration and the administration of analgesics and blood products.

关键词： Sickle Cell Disease Pediatrics Emergencies

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Mortality of HIV-Infected Patients on Antiretroviral Therapy in a Large Public Cohort in West Africa, Burkina Faso: Frequency and Associated Factors

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Advances in Infectious Diseases 2013年第4期3卷 281-289页

作者： Armel Poda Arsène Hema Jacques Zoungrana Nongodo Firmin Kaboré Bebar Euloges Kamboulé Ibrahim Soré Guillaume Bado abdoul-salam Ouédraogo Nicolas Meda Adrien Bruno Sawadogo Day Care Hospital for HIV-Patients of Bobo Dioulasso Department of Infectious Diseases Souro Sanou Teaching Hospital Bobo Dioulasso Burkina Faso Day Care Hospital for HIV-Patients of Bobo Dioulasso Department of Infectious Diseases Souro Sanou Teaching Hospital Bobo Dioulasso Burkina Faso Department of Virology and Bacteriology Souro Sanou Teaching Hospital Bobo Dioulasso Burkina Faso School of Medicine University of Bobo Dioulasso Bobo Dioulasso Burkina Faso Day Care Hospital for HIV-Patients of Bobo Dioulasso Department of Infectious Diseases Souro Sanou Teaching Hospital Bobo Dioulasso Burkina Faso School of Medicine University of Bobo Dioulasso Bobo Dioulasso Burkina Faso Department of Virology and Bacteriology Souro Sanou Teaching Hospital Bobo Dioulasso Burkina Faso School of Medicine University of Ouagadougou Ouagadougou Burkina Faso Muraz Center Bobo Dioulasso Burkina Faso

Background: In sub Saharan Africa, small size surveys have demonstrated early high mortality among infected patients on antiretroviral therapies (ART). Few studies have been conducted in large cohorts of HIV-patients in public health care system in West Africa. Objectives: Our study aims to determine mortality rate and its predictors in a cohort of patients on ART in a public daycare hospital in Burkina Faso. Methods: We have carried out a retrospective cohort study. All HIV-infected patients on ART between January 1st 2008 and December 31st 2011 were included in the study. Survival probability was estimated by the Kaplan-Meier method. Cox regression analysis was used to identify associated factors to mortality. Results: A total of 2243 HIV-infected patients were included in the study. During the follow-up, 218 patients representing 9.7% were lost. About 104 patients representing 4.6% were transferred and 1691 representing 75.4% were still in the therapeutic cohort. There were 230 death cases for a total of 4282 persons-years, (5.4 deaths for 100 persons-years;95% CI: 4.8 -6.3). The survival probabilities after 6 months, 1 year and 2 years were 92.6%, 91% and 88.9% respectively. For the multivariate analysis, the following factors were independently associated to death: male gender, BMI .5 kg/m2, WHO stage 3 and 4, HIV-2, T-CD4 lymphocytes < 200/μl, haemoglobin rate g/dl and creatinine clearance 2. Conclusions: Our study provides for the first time mortality rates and its predictors among HIV-patients on antiretroviral treatment in a large cohort in public health sector in Burkina Faso. It highlights the importance of early HIV screening to limit ART initiation at advanced HIV infection stages.

关键词： Antiretroviral Therapy Burkina Faso HIV Mortality West Africa

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Tonsillitis and Their Complications: Epidemiological, Clinical and Therapeutic Profiles

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International Journal of Otolaryngology and Head & Neck Surgery 2019年第3期8卷 98-105页

作者： abdoul Wahab Haidara Youssouf Sidibé Djibril Samaké Amady Coulibaly Mamadou Karim Touré Bréhima Bolonpé Coulibaly Siaka Soumaoro Boubacary Guindo Kassim diarra Kalifa Coulibaly Boubacar Sanogo Mohamed Kéï ta Alhousseini Ag Mohamed ENT and Head and Neck Surgery Department CHU Mother-Child “Luxembourg” Bamako Mali ENT and Head and Neck Surgery Department Reference Health Center Bamako Mali Department of Stomatology and Maxillofacial Surgery CHU-CNOS Bamako Mali Department of Anesthesia Resuscitation CHU Mother-Child “Luxembourg” Bamako Mali ENT and Head and Neck Surgery Department CHU Gabriel Toure Bamako Mali

Tonsillitis or angina, is considered as an inflammation of the palatine tonsils most often of infectious origin. It can be acute or chronic. The germs in question are mostly viruses and bacteria. Objectives: The objective of this work was to study the epidemiological and therapeutic profile of tonsillitis and their complications in the ENT Department and Head and Neck Surgery of the Mother-Child University Hospital in Luxembourg. Patients and Methods: This is a prospective study over a 12-month period from January 2018 to December 2018, including all patients who presented with tonsillitis and/or their complications. Results: Three hundred and fifteen (315) patients were collected during this period. The average age in our study was 14.25 years with extremes ranging from 2 years to 61 years. The sex ratio was 0.65 in favor of the female sex. During this period we recorded 80.95% of cases of uncomplicated tonsillitis including 60.50% for acute tonsillitis, 24.5% for chronic tonsillitis 5% for adenoid tonsillitis and 19.05% for complications. Complications included peritonsillar phlegmon 42.22%, heart disease 33.33%, cervical cellulitis 8.89%, adeno-phlegmon 6.67%, para-pharyngeal abscess 4.44%, and sepsis 4.44%. The exclusive medical treatment was performed in 44.31%. Surgical treatment (drainage incision and tonsillectomy) was performed in 55.69%. Conclusion: Tonsillitis and its complications represent an important pathology in ENT. Feynophagy febrile is the pair-origin symptom that can lead to the diagnosis. The prevention of complications is the guarantor of the reduction of its morbidity. We recommend that in the absence of RDT (Rapid Diagnostic Test), it is necessary to systematize antibiotic therapy to prevent serious complications.

关键词： Tonsillitis Complication Mali

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Tuberculosis in Children: Epidemio-Clinical Aspects in the Paediatric Department of the Gabriel TouréUniversity Hospital Center

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Open Journal of Pediatrics 2022年第2期12卷 376-388页

作者： Adama Dembélé abdoul Aziz Diakité Mohamed Elmouloud Cissé Bassirou diarra Belco Maïga Issa Sanou Pierre Togo abdoul Karim Doumbia Oumar Coulibaly Karamoko Sacko Djéneba Konaté Hawa Diall Lala Ndrainy Sidibé Bréhima Dégoga Fatoumata Léonie Diakité Guédiouma Dembélé Fatoumata Dicko Mariam Sylla Boubacar Togo Department of Paediatrics University Teaching Hospital of Gabriel Touré Bamako Mali University Clinical Research Center University of Sciences Techniques and Technologies of Bamako Bamako Mali Department of Pediatrics CHU Gabriel Touré Bamako Mali

Introduction: Globally, tuberculosis is the leading cause of death from a single infectious agent ahead of HIV/AIDS. Approximately 10 million people contracted TB in 2017, 10% of whom were children aged 0 - 15 years, or about 1 million with 250,000 deaths in 2016 (including children with HIV-associated TB). The signs of TB in children are not always specific and diagnosis remains difficult unlike in adults. According to a study conducted in 2011 in the paediatric department of the CHU-Gabriel Touré, only seventeen cases of all forms of tuberculosis were found, or approximately 0.2% of hospitalised children. The objective of our study was to investigate the epidemiological and clinical aspects of tuberculosis in children. Materials and Method: This was a prospective, cross-sectional and descriptive study that took place from 24 October 2017 to 23 October 2018, or 12 months in children aged 0-15 years. Data were collected from an individual medical record opened for each patient and an individual survey form established for each child. Results: During the study period, 40,434 children were consulted. Tuberculosis was suspected in 91 children, with a frequency of 0.22%. The age range of 1 to 4 years was 36.3% with a median age of 72 months. The sex ratio was 1.8. Chronic cough with 84.6% and malnutrition with 24.17% were the most frequent symptoms. Chest X-ray revealed bilateral pulmonary lesions in 52.7% and mediastinal adenopathy in 12.1%. TST was positive in 10.9% of patients, microscopy in 26.4%, Gene Xpert in 18.7%, and culture in 16.5%. The biological diagnosis of tuberculosis was retained in 48.4% of the patients, the pulmonary form represented 93.2%. The therapeutic regime (2RHZE/4RH) was used in 81.6% of cases and the evolution was favourable in 65.9% of patients. Conclusion: The diagnosis of tuberculosis in children remains difficult in our context. The clinical signs are not always specific, and further studies are needed to further elucidate this disease.

关键词： Child Clinic Epidemiology Gabriel Touré University Hospital Center Tuberculosis

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Can the Urine Dipstick Test Be an Alternative in the Screening of Urinary Tract Infections for Inpatients in the Context of a Low-Income Country?

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Advances in Infectious Diseases 2023年第4期13卷 627-640页

作者： André Nagalo Odilon D. Kaboré Senkaye-Lagom Aimée Kissou Hervé Kafando Boukary Kabré Emmanuel Zongo Cheick Ahmed Ouattara Yacouba Sawadogo Aoua Semdé Jacques Zoungrana Armel Poda Sylvain Godreuil abdoul-salam Ouédraogo Bacteriology-Virology Laboratory Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Biomedical Analysis Laboratory Regional University Hospital of Ouahigouya Ouahigouya Burkina Faso Department of Medical Pediatrics Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Bacteriology-Virology Laboratory Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso Department of Urology-Andrology Regional Hospital of Tenkodogo Tenkodogo Burkina Faso Information Epidemiology Research and Planning Department Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Department of Nephrology-Hemodialysis Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Department of Infectious Diseases Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Laboratory of Bacteriology of the Arnaud de Villeneuve University Hospital Montpellier France

Background: Urinary Tract Infection (UTI), a prevalent bacterial infection in adults, heavily relies on cytobacteriological examination of urine (CBEU) for diagnosis. However, in resource-limited countries, accessibility to CBEU remains hindered by cost and availability. This study aims to assess the utility of the Urinary Dipstick Test (UDT) in diagnosing UTIs among hospitalized patients in the context of limited resources. Methods: A cross-sectional study was conducted from February to May 2019, encompassing hospitalized patients who underwent CBEU at the bacteriology unit of Sour? Sanou University Hospital. UDT and CBEU were concurrently performed, and UDT’s analytical and diagnostic performance was evaluated against CBEU, considered the gold standard. Results: A total of 274 CBEU requests were registered, involving 274 patients (159 males) with a mean age of 45.8 ± 21.3 years (ranging from 1 to 90 years). UTI was confirmed in 90 patients, yielding a frequency of 32.85%. The UTI bacteriological profile was dominated by Enterobacteriaceae (75.23%), primarily Escherichia coli (60.55%). Nitrite and Leukocytes were positive in 54 (19.8%) and 157 (53.6%) of the samples tested. Among patients with confirmed UTI, Nitrite, and Leukocytes were positive in 30 (33%) and 71 (79%) patients respectively. UDT demonstrated variable performance based on nitrite and leukocyte combination: Sensitivity (57%-82%), Specificity (7%-98%), Positive Predictive Value (PPV) (43%-57%), Negative Predictive Value (NPV) (43%-67%). UDT performed slightly better in women (NPV = 88%) and inpatients without urinary catheters (NPV = 75% and PPV = 80%). Conclusion: This study underscores UDT’s potential utility in excluding UTIs among women, younger patients, and inpatients without urinary catheters, albeit with limited confidence. The UDT emerges as a complementary tool for UTI screening, particularly in resource-limited settings.

关键词： Urine Dipstick Test Urinary Tract Infection LMICs Burkina Faso

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Congenital Heart Disease in Newborns: Epidemiological and Clinical Particularities in a Neonatology Department in Mali

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Open Journal of Pediatrics 2022年第5期12卷 857-866页

作者： abdoul Karim Doumbia Oumou Koné Adama Dembélé Noumou Sidibé Noel Banou Hawa Gouro Diall Pierre Togo Oumar Coulibaly Karamoko Sacko Djéneba Konaté Tati Simaga Lala Ndrainy Sidibé Fatoumata Léonie Diakité Boubacar diarra Guédiouma Dembélé Belco Maïga Mohamed Elmouloud Cissé Hawa Konaré Aminata Doumbia Ibrahim Ahamadou abdoul Aziz Diakité Fatoumata Dicko Traoré Boubacar Togo Department of the CHU Gabriel Touré Bamako Mali

Introduction: Congenital heart disease is an important cause of mortality, chronic morbidity, and disability in children in poor countries. The objective of this study was to highlight the diversity of congenital heart defects in the neonatology department. Methodology: This work had taken place in a neonatology service over a period of six months from January 2019 to June 2019. It was a prospective descriptive study with information collected from the medical records of newborns with congenital heart disease. Results: Of 1478 neonates hospitalized during the study period, 41 had congenital heart disease, for a hospitalization rate of 2.77%. CHD accounted for 2.77% of neonatal hospitalizations. The sex ratio was 1.73 (26 boys/15 girls). Consanguinity was found in 19% of cases. The average time to consultation was 11 days. The main clinical signs were heart murmur (58%), respiratory distress (56%) and extracardiac malformations (54%). The main cardiac malformations found were atrial septal defect (46%), patent ductus arteriosus (44%), ventricular septal defect (17%), complete atrioventricular canal (15%), and transposition of the great vessels (5%). The case fatality rate was 29%. Conclusion: Delayed diagnosis, generally related to the long delay in consultation, and lack of surgical management partly explain this high case fatality.

关键词： Congenital Heart Disease Neonates Management

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Improving Postpartum Haemorrhage Management Using Simulation in Senegal: Midterm Results

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Open Journal of Obstetrics and Gynecology 2017年第13期7卷 1292-1299页

作者： Mamour Gueye Moussa Diallo Mame diarra Ndiaye Gueye Omar Gasama abdoul Aziz Diouf Mouhamadou Mansour Niang Mohamed Diadhiou Astou Coly Niassy Serigne Modou Kane Gueye Marie Edouard Faye Dieme Magatte Mbaye Philippe Marc Moreira Alassane Diouf Jean Charles Moreau Gynecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Cheikh Anta Diop University Dakar Senegal

Objective: To assess a training approach in Emergency Obstetric and Neonatal Care (EmONC) to strengthen skills of healthcare providers and reduce maternal mortality. Materials and methods: The approach was based on the skills training using the so-called “humanist” method and “life saving skills”. Simulated practice took place in the classroom through thirteen clinical stations summarizing the clinical skills on EmONC. The evaluation was done in all phases and the results were recorded in a database to document the progress of each learner. Results: We trained 432 providers in 10 months. The increase in technical achievements of each participant was documented through a database. The combination of training based on the model “learning by doing” has ensured learning and mastering all EmONC skills particularly postpartum haemorrhage management and reduced missed learning opportunities. Conclusion: The impact of training on postpartum haemorrhage management and maternal mortality is a major challenge in terms of prospects.

关键词： Emergency Obstetric Care Postpartum Haemorrhage Training Simulation

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Association between Polymorphisms of Glutathione S-Transferase and Progression to Cervical Cancer in Women from Burkina Faso and Mali

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Journal of Biosciences and Medicines 2020年第4期8卷 12-25页

作者： Teega-Wendé Clarisse Ouedraogo Florencia Wendkuuni Djigma Théodora Mahoukèdè Zohoncon Boureima Idani abdoul Karim Ouattara Pegdwendé Abel Sorgho Dorcas Obiri-Yeboah Prosper Bado Mah Alima Esther Traore Birama diarra Albert Théophane Yonli Charlemagne Ouedraogo Jacques Simpore Laboratory of Molecular Biology and Genetics (LABIOGENE) University Joseph Ki-Zerbo Ouagadougou Burkina Faso Pietro Annigoni Biomolecular Research Centre (CERBA) Ouagadougou Burkina Faso University Saint Thomas d’Aquin Faculty of Medicine Ouagadougou Burkina Faso Department of Microbiology and Immunology School of Medical Sciences University of Cape Coast PMB Cape Coast Ghana University Joseph Ki-Zerbo UFR/SDS Ouagadougou Burkina Faso

Although persistence of high-risk human papillomavirus infection is the main risk factor, Glutathione S-Transferase highly polymorphic enzyme involved in the metabolism of xenobiotics, is a good candidate gene. The objective of this study was to compare the polymorphisms of Glutathione S-Transferase M1-null in women with cancerous lesions and without lesions. This study consisted of 322 uterine cervix samples of women from Mali and Burkina Faso with Cervical Intra-epithelial Neoplasia 2 and 3, adenocarcinoma and squamous cell carcinoma and 100 women with no lesions. Human Papillomavirus genotyping was performed by Real-time multiplex Polymerase Chain Reaction. Glutathione S-Transferase gene polymorphisms were determined using conventional Polymerase Chain Reaction followed by migration on agarose gel. A statistically significant association with high relative risks of 10.77 for the development of High grade Superficial or Squamous Intra-epithelial Lesion (95% CI = 5.59 - 20.72;p < 0.001), and 13.20 for cancer development (95% CI = 6.79 - 25.63;p < 0.001) was found in women with the null genotype of Glutathione S-Transferase M1 in the study population. In Burkina Faso and Mali, Glutathione S-Transferase M1-null presented relative risks of 9 and 11.05 for high-grade lesions, 15 and 11.40 for cancer. Similarly, significant results had been observed in women with human papillomavirus positive and human papillomavirus negative. The results of the present study support the idea that the deletion of Glutathione S-Transferase M1 plays a crucial role in the progression of high-grade lesions and cervical cancer.

关键词： Glutathione S-Transferase M1-Null Cervical Cancer Burkina Faso Mali

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