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Laryngeal Cancers at the Pathological Anatomical Laboratory (ACP) in Dakar about 215 Cases

Open Journal of Pathology 2023年第2期13卷 79-86页

作者： Marie Joseph Dieme Ahouidi Adama Diedhiou abdou magib gaye Dibor Niang Falilatou Seidou Ibou Thiam Cherif Mouhamed Moustapha Dial Anatomy and Pathological Cytology Laboratory Fann Hospital Dakar Sénégal Anatomy and Pathological Cytology Laboratory Aristide Le Dantec Hospital Dakar Sénégal Anatomy and Pathological Cytology Laboratory Gaston Berger University St Louis Sénégal Anatomy and Pathological Cytology Laboratory Idrissa Pouye Hospital Dakar Sénégal

Introduction: Laryngeal cancer is the first cancer of upper aerodigestive tract. Dysphonia, dyspnea and dysphagia are evocative signs. Diagnosis is histological and squamous cell carcinoma is the most common type. The objective of our study was to discuss epidemiological and anatomo-pathological characteristics of laryngeal cancers diagnosed in different pathological anatomy and cytology (ACP) laboratories of Dakar hospitals. Material and method: This was a retrospective study spanning from January 2013 to December 2018 at the pathological anatomy laboratories of Fann, Aristide Le Dantec and Idrissa Pouye hospitals. All patients with laryngeal cancer confirmed at histology were included. Data collection was based on clinical records of the patients and archives of histological reports of the pathological laboratories. Data analysis was performed under the Excel software. Results: We collected 215 cases of laryngeal cancer. The average age was 58.01 years with extremes of 07 and 94 years. The male sex was predominant with 183 patients (85.12%) against 32 women (14.88%). The most noted risk factor was tobacco which affected 14 patients, or 60.87%. Three patients (13.04%) did not present any alcohol-smoking impregnation. Clinically, dysphonia was noted in 22 patients (26.51%). It was associated with dyspnea in 0.48% of cases and dysphagia in 3.61%. Laryngoscopy was performed in 62 patients or 28.83% of cases, nasofibroscopy in 6.45% of cases. Cord arythenoid fixity was noted in two patients (3.23%) and hypo-mobility in 1 patient (1.61%). The most frequent local extension was involvement of the piriform sinus with 11.29% of cases. Palpable lymphadenopathy reported in 17 patients (20.48%). Pathological examination was performed in all patients after post endoscopic biopsy in 92 patients (42.79%), and after obtaining the operative specimen in 123 cases (57.21%). The three floors affected 76 patients (35.35%). The ulcerative budding aspect most noted concerned 108 patients

关键词： Laryngeal Cancer Carcinoma Dakar

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Rhabdomyosarcoma in Dakar: An Update on Pronostics Factors

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Open Journal of Pathology 2022年第1期12卷 37-45页

作者： abdou magib gaye Marie Joseph Dieme-Haouidi Ibou Thiam Fabrice Senghor Gabriel Nougnignon Comlan Deguenonvo Cherif Mouhamed Moustapha Dial Anatomy and Pathological Cytology Laboratory of the Aristide Le Dantec Hospital Dakar Senegal Anatomy and Pathological Cytology Laboratory of the Fann Hospital Dakar Senegal Anatomy and Pathological Cytology Laboratory of the Idrissa Pouye General Hospital Dakar Senegal

Rhabdomyosarcoma (RMS) belongs to the soft tissue sarcomas that have striated muscle differentiation. It is most common in young children under 5 years of age and adolescents. The definite diagnosis of rhabdomyosarcoma is based on histology and the positivity of striated muscle markers in immunohistochemistry. Our objective was to describe the prognostic characteristics of RMS diagnosed in Dakar. MATERIAL AND METHODS: This was a retrospective and descriptive study spread over nine (09) years from 1 January 2011 to 31 December 2019. It was conducted from the histological report archives of the anatomy and pathology laboratories of Dakar. Paraffin blocks were reread and immunohistochemically studied by manual method. Antidesmin and antimyogenin antibodies were used. RESULTS: We collected 44 patients with rhabdomyosarcoma out of 228 cases of soft tissue cancers, i.e. 19.29% of all malignant soft tissue tumours. The mean age of the patients was 25.41 ± 23.95 (standard deviation) years with a median age of 16 years and extremes of 6 months and 81 years. Patients were less than or equal to 17 years of age in 61.4% of cases. A clear male predominance was observed with 29 men (65.9%) against 15 women (34.1%). Rhabdomyosarcomas were located in the limbs in 34.1% of cases, in the head and neck in 29.5% of cases and in the genitourinary tract in 25% of cases. The average tumour size was 7.45 cm ± 4.64 (standard deviation) with a minimum of 2 cm and a maximum of 17 cm. It was greater than or equal to 5 cm in 15 patients (68.2%). Embryonal rhabdomyosarcoma (ERMS) was the most frequent histological type with 34 cases (77.3%), followed by pleomorphic rhabdomyosarcoma 7 cases (15.9%) and alveolar rhabdomyosarcoma 3 cases (6.8%). The histological subtypes of ERMS consisted of conventional ERMS (91.18%);botryoid RMS (5.88%) and spindle cell RMS (2.94%). The correlation between histological type and age was statistically significant (p = 0.039). A relationship was also observ

关键词： Rhabdomyosarcoma Prognosis Histology Dakar

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Epidermal Inclusion Cyst: A Rare Benign Breast Lesion

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Open Journal of Pathology 2022年第2期12卷 64-69页

作者： abdou magib gaye Modukpè Colette Nadine Odah Moussa Guira Fabrice Senghor Gabriel Nougnignon Comlan Deguenonvo Amadou Ndiade Ibou Thiam Marie Joseph Dieme-Ahouidi Cherif Mouhamed Moustapha Dial Anatomy and Pathological Cytology Laboratory Aristide Le Dantec Hospital Dakar Senegal Public Care Center of Richard Toll Saint-Louis Senegal Anatomy and Pathological Cytology Laboratory Idrissa Pouye General Hospital Dakar Senegal Anatomy and Pathological Cytology Laboratory Fann Hospital Dakar Senegal

Epidermal inclusion cyst in the breast is an uncommon condition. It may be congenital, originating from hair follicles or occurring after trauma (breast reduction or breast cytology puncture) or consists of squamous metaplasia of the regular columnar epithelium within an ectatic ductus galactophorus. We report the case of a 22-year-old woman, with two pregnancies and with no particular pathological history, who presented with a 3 cm nodule of the right breast at the union of the upper quadrants, firm, mobile and painless. The skin, areola and nipple were unaffected. The axillary areas and the contralateral breast were unremarkable. The breast ultrasound showed a heterogeneous and well circumscribed hypoechoic mass classified as ACR3. Macroscopic examination revealed a unilocular cyst with a discretely thickened wall, abundant yellowish contents and measuring 2 cm on a long axis. Histologically, it was a cystic cavity whose wall was lined with a pseudo stratified keratinized squamous epithelium with a granular layer and whose lumen contained keratin lamellae. This cyst is surrounded by a more or less fibrous pallial tissue containing regular, sometimes dilated or even cystic milk ducts. The diagnosis of epidermal inclusion cyst of the breast on a background of fibrocystic mastopathy was thus concluded. The importance of this benign lesion lies in the differentiation between other non-neoplastic and neoplastic breast lesions.

关键词： Epidermal Inclusion Cyst Breast Fibrocystic Mastopathy Dakar Senegal

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High-dimensional supervised classification in a context of non-independence of observations to identify the determining SNPs in a phenotype

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Infectious Disease Modelling 2023年第4期8卷 1079-1087页

作者： Aboubacry gaye abdou Ka Diongue Lionel Nanguep Komen Amadou Diallo Seydou Nourou Sylla Maryam Diarra Cheikh Talla Cheikh Loucoubar Laboratory for Studies and Research in Statistics and Development Gaston Berger University of Saint LouisSenegal Epidemiology Clinical Research and Data Science UnitInstitute Pasteur de Dakar220DakarSenegal African Institute for Mathematical Sciences(AIMS) Senegal Information and Communication Technologies for Development Alioune Diop University of BambeySenegal

This work addresses the problem of supervised classification for highly correlated highdimensional data describing non-independent observations to identify SNPs related to a *** use a general penalized linear mixed model with a single random effect that performs simultaneous SNP selection and population structure adjustment in highdimensional prediction ***,the model simultaneously selects variables and estimates their effects,taking into account correlations between *** nucleotide polymorphisms(SNPs)are a type of genetic variation and each SNP represents a difference in a single DNA building block,namely a *** research has shown that SNPs can be used to identify the correct source population of an individual and can act in isolation or simultaneously to impact a *** this regard,the study of the contribution of genetics in infectious disease phenotypes is of great *** this study,we used uncorrelated variables from the construction of blocks of correlated variables done in a previous work to describe the most related observations of the *** model was trained with 90%of the observations and tested with the remaining 10%.The best model obtained with the generalized information criterion(GIC)identified the SNP named rs2493311 located on the first chromosome of the gene called PRDM16((PR/SET domain 16))as the most decisive factor in malaria attacks.

关键词： Non independence of observations Correlated variables High-dimensional supervised classification SNP Phenotype

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Northeastern Tropical Atlantic SST and Sahel Rainfall Variability

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Atmospheric and Climate Sciences 2023年第4期13卷 431-454页

作者： Dahirou Wane abdou Lahat Dieng Coumba Niang Amadou T. gaye Laboratoire de Physique de l’Atmosphère et de l’Océan Siméon Fongang Ecole Supérieure Polytechnique Université Cheikh Anta Diop de Dakar (LPAO-SF/ESP/UCAD) Dakar Senegal

The SST variability during the summer period in the northeastern tropical Atlantic region (NTA) is characterized by an alternation of warming/cooling which represents 87% of the total variability. The aim of this paper is to study the atmospheric responses as well as the precipitation associated with these oceanic conditions. Based on Reynolds’s SST from 1982 to 2019, a normalized Northern Tropical Atlantic index (NTAI) is computed into the region between 15° - 25°W;12° - 16°N and a composite analysis is then performed. It is shown that the NTAI is significantly correlated with the SST’s first principal component mode (PC1) in this region. Moreover, the composite of SST anomalies and atmospheric parameters exhibits a strong local ocean-atmosphere interaction which highly impacts the large-scale atmospheric circulation in West Africa, particularly in the western Sahel. An in-depth analysis shows that the atmospheric response to the warm (cold) SST is a cyclonic (anticyclonic) circulation in the lower layers near the West Africa Coast. This cyclonic (anticyclonic) circulation strengthens/reduces the moisture transport towards the continent in the low levels. In the middle layers of the atmosphere (500 hPa), the warm (cold) composite is associated with a decrease (increase) in the intensity of the African Easterly Jet (AEJ) whereas, in the upper atmosphere (200 hPa), the strengthening (weakening) of the Tropical Easterly Jet (TEJ) is observed. With regard to the composite precipitation field, a positive/negative SST anomaly is associated with significantly enhanced/reduced rainfall in the western Sahelian region. It is found that this relationship (correlation) increases as we are closer to the coasts.

关键词： SST-Rain Sahel Rainfall Senegal Rainfall Ocean-Atmosphere Interaction

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Interest of Cardiac Rehabilitation in Patients with Heart Disease in a Cardiology Department in Senegal

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World Journal of Cardiovascular Diseases 2024年第4期14卷 217-227页

作者： Awa Ba-Diop abdou Khadir Sow Rim Mohamed Khaled Mor Diaw Mame Saloum Coly Fulgence abdou Faye Amadou Ndiadé Bamba gaye abdoulaye Ba abdoulaye Samb Laboratory of Physiology and Functional Explorations Department of Medicine Alioune Diop University of Bambey Bambey Senegal IRL3189 Environment Health Societies CNRS-UCAD Dakar Senegal The African Research Network Noncommunicable Diseases Dakar Senegal Laboratory of Physiology and Functional Explorations FMPOS UCAD Dakar Senegal Laboratory of Physiology and Functional Explorations UFR Sant&#233 UAS of Thi&#232s Thi&#232s Senegal INSERM U970 Team 4 Paris France

Cardiac rehabilitation helps improve the prognosis and quality of life for patients with heart disease. To show its interest in the African context, in the management of heart disease, a prospective study was carried out. Its objective was to evaluate the effects of physical rehabilitation on cardiac function. Methods: Patients were evaluated at the beginning and at the end of cardiovascular rehabilitation by cardiovascular, biological, and echocardiographic parameters including the size of the heart chambers, the kinetics of the walls, and the systolic function of the ventricles. Results: The study involved 12 patients, 67% of whom were men. After cardiac rehabilitation, the mean hemodynamic constants had not been significantly modified. However, a significant decrease in Total-Cholesterol, LDL-Cholesterol and triglyceride levels was noted. Mean fasting blood sugar decreased from 1.25 ± 0.48 g/L to 0.92 ± 0.18 g/L and glycated hemoglobin from 7.72% ± 0.01% to 6.45% ± 0.008%. The echocardiographic parameters studied showed an improvement in the dilation of the heart chambers in 8.33% of the patients, the normalization of the ejection fraction of the left ventricle in 16% patients, the improvement of the kinetic disorders in 16% of patients and recovery of right ventricular systolic function in all patients. Conclusion: Cardiac rehabilitation as a secondary preventive measure for cardiovascular disease has contributed significantly to improving the clinico-biological parameters of the disease.

关键词： Cardiac Rehabilitation Heart Disease Cardiovascular Disease

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Prevalence and Factors Associated with Positivity of Antinuclear Antibodies (ANA) Patterns, Native Anti-DNA and Extractable Nuclear Antigens (ENA) Antibodies: Experience from a Laboratory in Dakar

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第1期14卷 26-36页

作者： Diop abdou Diallo Thierno abdoulaye Ndiaye Babacar Mahou Chantal Diop Marième gaye Dubrous Phillippe Seck abdoulaye Medical Biology Laboratory Pasteur Institute of Dakar Dakar Senegal Cheikh Anta Diop University of Dakar Dakar Senegal

Background: Diagnosis of autoimmune diseases (AID) is challenging, due to overlapping features with other non-immune disorders. Anti-nuclear antibodies (ANA) are sensitive screening tests but anti-deoxyribonucleic acid-antibody (anti-DNA), and anti-extractable nuclear antigens (anti-ENA) are specific for AIDs. We aimed to look at ANA patterns in our patients and correlated them with anti-ENA for proper interpretation and better patient management cost-effectively. Methods: A retrospective study was conducted over 1 year from January to December 2022 who were tested for ANA at biology medical laboratory of Pasteur Institute of Dakar. Anti-ENA and anti-DNA results were also analyzed for ANA-positive patients. Statistical analysis was performed using STATA 14.0, p Results: 216 patients were analyzed. Women predominated at 79.2% and mean age was 48 years [CI 95%, 46 - 50], with extremes of 10 and 89. Most represented age group was [41 - 60] with 38%. ANA was positive in 27 (12.5%) of patients, 59.2% of whom were strongly positive (titer of 1/1000, 1/3200 or 1/6400). The most common pattern was nuclear speckled, which was found in 77.8% of samples. Anti-ENA and anti-DNA positivity in ANA-positive patients was found respectively in 63% (17/27) and 1.4% (3/27) of the samples analyzed. Most commonly identified anti-ENA was anti-Sm 29.6%, anti-SSA 29.6%, anti-Ro-52 25.9%, anti-RNP 18.5% and anti-SSB 14.8% which was associated with speckled pattern. Association results indicated a significant relationship between both tests and between ANA titer in the anti-ENA- and ANA-positive patients (p 0.001). Conclusions: ANA, Anti-ENA and anti-DNA antibodies are essential for AIDS diagnosis. However, the testing repertoire should follow an algorithm comprising of clinical features, followed by ANA results with nuclear, mitotic, and cytoplasmic patterns, anti-ENA, and anti-DNA for a more meaningful, and cost-effective diagnostic approach.

关键词： Antinuclear Antibodies Extractable Nuclear antigen Autoimmune Disease Indirect Immunofluorescence

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Formation and Transport of a Saharan Dust Plume in Early Summer

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Journal of Atmospheric Science Research 2023年第2期6卷 58-74页

作者： Habib Senghor abdou L.Dieng Moussa Gueye Cheikh A.Diop Mariane D.Kane Amadou T.gaye Agence Nationale de l’Aviation Civile et de la Météorologie Dakar8184Sénégal Laboratoire de Physique de l’Atmosphère et de l’Océan Siméon-Fongang(LPAO-SF) UniversitéCheikh Anta DiopDakar10700Sénégal Département de Mathématiques et Informatiques Universitédu Sine Saloum Elhadj Ibrahima NiassKaolack BP 55Sénégal

This research studies the capability of the Weather Research and Forecasting model coupled with the Chemistry/Aerosol module(WRF-Chem)with and without parametrization to reproduce a dust storm,which was held on 27th June 2018 over Sahara *** authors use satellite observations and ground-based measurements to evaluate the WRF-Chem *** sensitivities of WRF-Chem Model are tested on the replication of haboob features with a tuned GOCART aerosol *** of simulations with satellite and ground-based observations show that WRF-Chem is able to reproduce the Aerosol Optical Depth(AOD)distribution and associated changes of haboob in the meteorological fields with temperature drops of about 9℃and wind gust 20 m·s–*** WRF-Chem Convec-tion-permitting model(CPM)shows strong 10-meter winds induced a large dust emission along the leading edge of a convective cold pool(LECCP).The CPM indicates heavy dust transported over the West African coast(16°W-10°W;6°N-21°N)which has a potential for long-distance travel on 27th June between 1100 UTC and 1500 *** daily precipitation is improved in the CPM with a spatial distribution similar to the GPM-IMERG precipitation and maxi-mum rainfall located at the right *** well as raising a large amount of dust,the haboob caused considerable dam-age along its route.

关键词： Dust storm WRF-Chem Convection-permitting Parameterization MCS

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Case Study of Coastal Fog Events in Senegal Using LIDAR Ceilometer

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Journal of Atmospheric Science Research 2023年第4期6卷 64-76页

作者： Semou Ndao Cheikh Modou Noreyni Fall Luis Duran Assie Regina Djiguene Diatta abdou lahat Dieng Badara Sane Amadou Thierno gaye Laboratory of Physics of the Atmosphere and Ocean-Siméon Fongang(LPAO-SF) Higher Polytechnic SchoolUniversity Cheikh Anta Diop(UCAD)PO BOX 5085DakarSenegal Department of Earth Physics and Astrophysics Complutense University of MadridMadrid28040Spain Meteorological Operation Service Representation of the Agency for the Safety of Air Navigation in Africa and Madagascar(ASECNA)in SenegalPO BOX 3144DakarSenegal Laboratory of Oceanography and Climate Experiments and Numerical Approaches(LOCEAN)Sorbonne University(SU)Paris75006France

This study aims to examine the atmospheric conditions characterising fog phenomena on the Senegalese coast focusing on two specific instances that occurred on April 3 and April 30,*** events were detected by the LIDAR Ceilometer installed at LPAOSF/ESP/UCAD and confirmed on the METARs of the meteorological stations at Dakar and Diass *** LIDAR’s backscatter signal showed that the fog of April 3 started around midnight with a vertical extension at 100 m altitude and dissipated around 10 *** April 30 event characterized by a good vertical extension from the surface up to 300 m above sea level,was triggered just after 2 *** lasted around 3 *** results showed that a decrease in temperature,accompanied by an increase in humidity and light wind,is favorable for the triggering and persistence of *** Level Pressure(SLP)anomaly fields show two distinct *** April 3 event was characterized by a zonal dipole of SLP anomalies between the Sahara and the northern Senegalese coast,while the April 30 event was characterized by a meridional dipole between the Sahara and the Gulf of Guinea area as far as the equatorial Atlantic.A weakening of the pressure around the study area was observed in both cases,allowing moisture advection to favor the onset of *** hovmoller diagrams of relative humidity and wind show that a good vertical extension of humidity associated with a westerly wind in the lower layers plays an important role in the formation and persistence of *** presence of dry air associated with a weak easterly wind in the middle layers could explain the low vertical extension of the fog on April 3.A strong wind in the lower layers would be responsible for the premature dissipation of the April 30 fog.

关键词： Coastal fog LIDAR Ceilometer Sea level pressure Relative humidity Temperature

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Peripheral Neuropathies Revealing Gougerot-Sjögren’s Syndrome: Description of 3 Cases

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Neuroscience & Medicine 2022年第3期13卷 120-125页

作者： Ndiaga Matar gaye Alassane Mamadou Diop Khalifa Ababacar Mbaye Serigne abdou Aziz Fall Mamadou Ka Momo Banda Ndiaye Maouly Fall Moustapha Ndiaye Amadou Gallo Diop Neuroscience Department Fann Hospital Dakar Senegal Neurology Department Pikine Hospital Dakar Senegal

Introduction: Sjögren’s syndrome is an autoimmune epithelitis with various extraglandular signs, among which are neurological, with a variable frequency according to studies. We report three cases of peripheral neuropathy revealing Gougerot-Sjögren’s syndrome, collected in the Neurology Department of the Fann University Hospital in Dakar (Senegal). Observations: The first patient, aged 48 years, presented with a length-dependent sensitivomotor polyneuropathy associated with retrobulbar optic neuritis, with dry eyes and dry mouth noticed by the patient for several years. The second patient, aged 28 years, was admitted to the hospital with chronic generalized paresthesia in the context of xerostomia and xerophthalmia. The results of the clinical examination and the electroeneuromyogram were in favour of pure sensory neuronopathy. The third patient was 32 years old female, with a history of thyroidectomy and acute inflammatory demyelinating polyneuropathy (AIDP), who was seen for acute ascending flaccid tetraplegia with facial diplegia, preceded by diffuse paresthesia. The diagnosis of recurrence of acute demyelinating polyradiculonueropathy was retained in view of the rapidly increasing character of the deficit, the hyperproteinorachy at the lumbar puncture, and the signs of demyelination at the ENMG. The diagnosis of Gougerot-Sjögren’s syndrome in our three patients was established on the basis of the 2016 ACR/EULAR criteria. Indeed, the anti-SSA antibodies (Ro) were positive in our 3 patients with a biopsy of the salivary glands which showed stage 3 in the first patient and stage 4 in the two others. Corticosteroid therapy and immunosuppressive treatment resulted in a favourable clinical evolution on the neurological and general levels. Conclusion: Gougerot-Sjögren’s syndrome is an autoimmune exocrinopathy that may present with peripheral neuropathy, which may precede the diagnosis of Sjögren’s syndrome, be concomitant or occur during the co

关键词： Sjögren’s Syndrome Peripheral Neuropathy Salivary Gland Biopsy Senegal

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