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HLA-G and single nucleotide polymorphism(sNP)associations with cancer in African populations:Implications in personal medicine

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Genes & Diseases 2022年第5期9卷 1220-1233页

作者： Ismael Chatita Adolf Amany Almars Nazima Dharsee Teddy Mselle Gokce Akan Irene Jeremiah Nguma abdolrahman s.nateri Fatmahan Atalar Mbeya College of Health and Allied sciences University of Dar es SalaamMbeyaP.O Box 608Tanzania Cancer Genetics&stem Cell Group BioDiscovery InstituteDivision of Cancer and Stem CellsSchool of MedicineUniversity of NottinghamNottinghamNG72UHUK Ocean Road Cancer Institute Department of OncologyDar es SalaamP.O Box 3592Tanzania Muhimbili University of Health and Allied sciences MUHAS Genetic LaboratoryDepartment of BiochemistryDar es SalaamP.O Box 65001Tanzania Clinical Oncology Department Mbeya Zonal Referral Hospital(MZRH)Mbeya P.O Box 419Tanzania Child Health Institute Department of Rare DiseasesIstanbul UniversityIstanbul 34093Turkey

The immune system plays an important role in protecting the body against *** cancer immunoediting,the immune system can recognize and keep checking the tumor cells by down-expression of some self-molecules or by increasing expression of some novel ***,the microenvironment created in the course of cancer development hampers the immune ability to recognize and destroy the transforming *** Leukocyte Antigen G(HLA-G)is emerging as immune checkpoint molecule produced more by cancer cells to weaken the immune response against ***-G is a non-classical HLA class I molecule which is normally expressed in immune privileged tissues as a soluble or membrane-bound ***-G locus is highly polymorphic in the non-coding 3′untranslated region(UTR)and in the 5′upstream regulatory region(5′URR).HLA-G expression is controlled by polymorphisms located in these regions,and several association studies between these polymorphic sites and disease predisposition,response to therapy,and/or HLA-G protein expression have been *** polymorphisms are demonstrated to modulate its expression and this is increasingly finding more significance in cancer *** review focuses on the relevance of the HLA-G gene and its polymorphisms in cancer *** highlight population genetics of HLA-G as evidence to espouse the need and importance of exploring potential utility of HLA-G in cancer diagnosis,prognosis and immunotherapy in the currently understudied African population.

关键词： African population Cancer HLA-G Immune system checkpoints MHC single nucleotide polymorphism

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EXIsTENCE TO FRACTIONAL CRITICAL EQUATION WITH HARDY-LITTLEWOOD-sOBOLEV NONLINEARITIEs

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Acta Mathematica scientia 2021年第4期41卷 1321-1332页

作者： Nemat NYAMORADI abdolrahman RAZANI Department of Mathematics Razi UniversityKermanshahIran Department of Pure Mathematics Faculty of ScienceImam Khomeini International University34149-16818QazvinIran

In this paper,we consider the following new Kirchhoff-type equations involving the fractional p-Laplacian and Hardy-Littlewood-sobolev critical nonlinearity:(A+B∫∫_(R^(2N))|u(x)-u(y)|^(p)/|x-y|^(N+ps)dxdy)^(p-1)(-△)_(p)^(s)u+λV(x)|u|^(p-2)u=(∫_(R^(N))|U|^(P_(μ,s)^(*))/|x-y|^(μ)dy)|u|^(P_(μ,s)^(*))^(-2)u,x∈R^(N),where(-△)_(p)^(s)is the fractional p-Laplacian with 0sps,a,b>0,λ>0 is a parameter,V:R^(N)→R^(+)is a potential function,θ∈[1,2_(μ,s)^(*))and P_(μ,s)^(*)=pN-pμ/2/N-ps is the critical exponent in the sense of Hardy-Littlewood-sobolev *** get the existence of infinitely many solutions for the above problem by using the concentration compactness principle and Krasnoselskii’s genus *** the best of our knowledge,our result is new even in Choquard-Kirchhoff-type equations involving the p-Laplacian case.

关键词： Hardy-Littlewood-sobolev inequality concentration-compactness principle variational method Fractional p-Laplacian operators multiple solutions

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