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Efficacy of combined albendazol and praziquntel and their loaded solid lipid nanoparticles components in chemoprophylaxis of experimental hydatidosis

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Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 549-554页

作者： Ali Jelowdar abdollah rafiei Mohammad Reza Abbaspour Iran Rashidi Mahmood Rahdar Department of Parasitology School of MedicineAhvaz Jundishapur University of Medical Sciences Health Research Institute Infectious and Tropical Diseases Research CenterFaculty of MedicineAhvaz Jundishapur University of Medical Sciences Targeted Drug Delivery Research Center School of PharmacyMashhad University of Medical Sciences Department of Pathology School of MedicineAhvaz Jundishapur University of Medical Sciences

Objective:To evaluate the efficacy of combined ABZ and PZQ and their solid lipid nanoparticles in chemoprophylaxis of cystic echinococcosis(CE).Methods:ABZ and PZQ loaded solid lipid nanoparticles(SLNs) were prepared by high shear homogenization and microemulsion congealing techniques with some minor *** average size,polydispersity index(PDI),and particle size distribution were determined by scanning electron microscopy(SEM) and photon correlation *** females BALB/c were experimentally infected by protoscoleces(PSC) and randomly divided into four equal groups of 10 *** the end of the 3 months treatment period and 2 months rest,mice were sacrificed and the peritoneal cavity was opened for removal,counting,measuring,and histological analysis of hydatid ***:The results indicated that ABZ and PZQ chemoprophylaxis treatment reduced the wet weight and size of developed cysts 77.3% and 79%,*** corresponding result for the ABZ and PZQ loaded SLNs was 83% and 85%,***:This study for the first time demonstrated that ABZ and PZQ loaded SLNs is superior to free ABZ and PZQ for the chemoprophylaxis of CE in mice.

关键词： Echinococcosis Albendazole Praziquantel High pressure homogenization Solid lipid nanoparticles(SLNs)

Molecular characterization of Echinococcus granulosus in paraffin-embedded human tissues from Southwest Iran

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Asian Pacific Journal of Tropical Medicine 2019年第11期12卷 507-511页

作者： Elham Yousefi abdollah rafiei Iran Rashidi Shahram Khademvatan Masoud Foroutan Department of Medical Parasitology Ahvaz Jundishapur University of Medical SciencesAhvazIran Department of Pathology Ahvaz Jundishapur University of Medical SciencesAhvazIran Cellular and Molecular Research Center and Department of Medical Parasitology Urmia University of Medical SciencesUrmiaIran Cellular and Molecular Research Center Ahvaz Jundishapur University of Medical SciencesIran Department of Parasitology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran

Objective:To investigate Echinococcus(E.)granulosus genotypes as the causative agents of hydatidosis in humans in the southwest of Iran(Khuzestan province).Methods:In this study,isolates of 80 archived human paraffin embedded hydatid cysts were collected from pathology laboratories in Ahvaz city,Khuzestan *** was extracted and examined by nested-PCR of ribosomal DNA(rDNA)internal transcribed spacer 1(ITS1),and *** addition,the sequences of fragments of genes coding for Cox space1 and NADH dehydrogenase 1(ND1)were also ***:Of the 80 paraffin samples,44(55.0%)were from the liver,27(33.8%)from the lung,and the rest from other *** amplified hydatid genomic DNA showed that the cysts were *** *** results of PCR-RFLP and sequencing analysis revealed the presence of G1 genotype(sheep strain)in all human ***,no camel strain(G6)was detected among all samples in the regions ***:The molecular findings indicate that the predominant genotype involved in *** transmission in southwest of Iran is the common sheep strain(G1),which occurs in human *** results may have important implications for hydatid disease control in the studied areas.

关键词： Echinococcus granulosus Human Genotype Iran

Pneumococcal meningitis in Iran: a systematic review and meta-analysis

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Journal of Acute Disease 2019年第3期8卷 99-105页

作者： Sedigheh rafiei Tabatabaei Ahmad Reza Shamshiri Mohammad Javad Nasiri Masoud Dadashi abdollah Karimi Pediatric Infections Research Center Research Institute for Children HealthShahid Beheshti University of Medical SciencesTehranIran Department of Epidemiology and Biostatistics School of Public HealthTehran University of Medical SciencesTehranIran Department of Microbiology School of medicineShahid Beheshti University of Medical SciencesTehranIran Department of Epidemiology of Microbial Diseases Yale School of Public HealthNew HavenUSA Department of Microbiology School of medicineAlborz University of Medical SciencesKarajIran

Objective: To estimate the frequency of pneumococcal meningitis among patients with bacterial meningitis in Iran. Methods: PubMed, Embase, Web of Science and Scientific Information Database (www. ***) were searched from 2000 to 2016 to identify studies on the frequency or prevalence of pneumococcal meningitis in Iran. Stata 14.0 (StataCorp, College Station, Texas, USA) was used to analyze the data. Results: Of the 131 records identified from the databases, 21 studies fulfilled the eligibility criteria. The analyses showed that 25.0% (95% CI: 19.0-32.0;I2=71%) of the confirmed bacterial meningitis (including children and adults) cases were caused by pneumococcus. Conclusions: The large fraction of meningitis cases caused by pneumococcus demonstrates that pneumococcal meningitis is a major public health problem in Iran, and the introduction of pneumococcal vaccines merits further attention from health authorities.

关键词： Streptococcus pneumoniae Meningitis Systematic review Meta-analysis Iran

Clinical features, management and outcomes of pediatric pleural empyema: A retrospective, multicenter cross sectional study

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Journal of Acute Disease 2020年第6期9卷 253-256页

作者： Shahnaz Armin abdollah Karimi Fatemeh Fallah Roxana Mansour Ghanaei Sedighe rafieiTabatabaei Seyed Alireza Fahimzad Seyedeh Mahsan Hoseini-Alfatemi Maryam Rajabnejad Hamid Eshaghi Gholamreza Soleimani Hosein Heydari Pediatric Infections Research Center Research Institute for Children’s HealthShahid Beheshti University of Medical SciencesTehranIran Department of Infectious Disease Pediatric Center of Excellence Children’s Medical CentersTehran University of Medical SciencesTehranIran Department of Pediatrics Zahedan University of Medical SciencesAli e-bne Abitaleb HospitalZahedanIran Department of Infectious Diseases Qom University of Medical Science and Health ServicesQomIran

Objectives:To evaluate clinical features,treatment strategies,and outcomes of pleural empyema for children who were treated at referral pediatric hospitals in 8 provinces of ***:In this retrospective,multicenter cross sectional study,we retrospectively retrieved patients'data from 8 teaching hospitals during 2010 and 2017.A questionnaire was applied and filled,and all data were statistically and descriptively ***:In total,191 children(109 males and 82 females)were *** mean age was 4.95 years and ranged from 11 months to 16 *** majority of cases(45.1%)were 1-4 years ***(70.3%),cough(65.6%),tachypnea(53.1%),chest pain(14.6%),and abdominal pain(12%)were the most common manifestations at *** mean length of admission in hospital was 16.4 ***,27 patients(14.1%)were admitted into the pediatric intensive unit because of severe illness,and 15 patients(7.9%)*** regression analysis showed that younger age(less than 12 months)and presence of underlying diseases(such as cardiovascular disease,immune deficiencies,malignancies,and neuro-developmental delay)significantly increased the mortality rate of patients with pleural empyema(P=0.004 and P=0.001,respectively).Conclusions:Pleural empyema children of younger age and with underlying diseases are at higher risks of *** addition,guidelines for treating pleural empyema should be developed.

关键词： Pleural empyema Pediatric Diagnosis Treatment Outcome