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Modified thin manual Descemet stripping endothelial keratoplasty with air-guided, non-pachymetric donor lenticule dissection: outcomes of graft thickness and complication rate

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 342-345页

作者： abdo karim tourkmani Andrew M J Turnbull Parwez N Hossain Aristides Konstantopoulos David F Anderson Cornea and External Eye Disease Service Department of OphthalmologyUniversity Hospital SouthamptonSouthampton SO166YDUK.

●AIM:To describe a modified technique of donor lenticule dissection for thin manual Descemet stripping endothelial keratoplasty(TM-DSEK).●METHODS:Donor material was soaked in balanced salt solution(BSS)for 30 min,before being mounted on an artificial anterior chamber(AAC).Rather than BSS,the AAC was filled with filtered air,resulting in a visible reflection at the corneal endothelium-air *** reflection served as a landmark for the depth of the dissection,facilitating the creation of a thin lenticule with low risk of *** was commenced at a standardized depth of 500 microns,with no initial pachymetry *** 29 donor corneas were dissected by a novice TM-DSEK *** time,central graft thickness at 2 mo and complications were analysed.●RESULTS:Results were similar to other endothelial keratoplasty techniques,despite the cases being performed by a novice DSEK *** dissection time was 7 min(range 6-10).One graft perforation occurred(3.45%),but the air tamponaded the break and enabled dissection to be restarted and completed from a different *** central graft thickness after at least two months follow-up was 106 microns(range 25-170).●CONCLUSION:A problem with manual DSEK is the risk of graft perforation by attempting to dissect too thin a lenticule,or creating a thick graft due to fear of *** modified air-guided technique addresses this problem,and is recommended for surgeons either embarking on the learning curve,or who wish to achieve more consistently thin grafts while reducing perforation rates.

关键词： Descemet stripping endothelial keratoplasty manual donor lenticule dissection graft thickness

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Simultaneous tectonic Descemet stripping endothelial keratoplasty and tectonic Bowman layer transplant for the management of corneal perforation

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1549-1554页

作者： abdo karim tourkmani Colm McAlinden David F.Anderson Jorge L.Alio del Barrio Jorge L.Alió Royal Gwent Hospital NewportWales NP202UBUK Ophthalmology Department Universidad Miguel HernándezAlicante 03202Spain Ulster University Northern IrelandBelfast BT151EDUK Southampton General Hospital Southampton SO166YDEnglandUK Cornea Cataract&Refractive Surgery UnitVissum(Miranza Group)Alicante 03106Spain

AIM:To report the outcomes of three cases of corneal perforation managed with simultaneous tectonic Descemet stripping endothelial keratoplasty(t-DSEK)and tectonic Bowman layer transplant(t-BLT)as an alternative to tectonic penetrating keratoplasty(t-PKP).METHODS:Three eyes of three patients receiving simultaneous t-DSEK and t-BLT for corneal perforation were *** technique for DSEK was modified depending on individual *** t-BLT technique was standardised using an 8 mm graft and fixated with a running *** was measured by the ability of this procedure to close a corneal ***:All three cases achieved tectonic eye globe restoration and remained stable during the minimum 3-month observation *** were relatively common:2 cases required amniotic membrane transplant for persistent epithelial *** case required DSEK *** case developed angle closure glaucoma requiring surgical peripheral ***:Simultaneous t-DSEK and t-BLT may be a useful strategy for the management of corneal perforation as an alternative management to t-PKP for selected cases.

关键词： tectonic corneal graft Descemet stripping endothelial keratoplasty Bowman layer transplant penetrating keratoplasty

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Weighing of risk factors for penetrating keratoplasty graft failure：application of Risk Score System

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 372-377页

作者： abdo karim tourkmani Valeria Sánchez-Huerta Guillermo De Wit Jaime D.Martínez David Mingo Ignacio Mahillo-Fernández Ignacio Jiménez-Alfaro Asociación Para Evitar la Ceguera en México Hospital Luis Sáinchez Bulnes Mexico City 04030 México Hospital Fundación Jiménez Diaz Madrid 28040 Spain

AIM：To analyze the relationship between the score obtained in the Risk Score System（RSS）proposed by Hicks et al with penetrating keratoplasty（PKP）graft failure at 1y postoperatively and among each factor in the RSS with the risk of PKP graft failure using univariate and multivariate ***：The retrospective cohort study had 152 PKPs from 152 patients. Eighteen cases were excluded from our study due to primary failure（10 cases）,incomplete medical notes（5 cases）and follow-up less than 1y（3cases）. We included 134 PKPs from 134 patients stratified by preoperative risk score. Spearman coefficient was calculated for the relationship between the score obtained and risk of failure at 1y. Univariate and multivariate analysis were calculated for the impact of every single risk factor included in the RSS over graft failure at 1y. RESULTS：Spearman coefficient showed statistically significant correlation between the score in the RSS and graft failure（P〈0.05）. Multivariate logistic regression analysis showed no statistically significant relationship（P〉0.05）between diagnosis and lens status with graft failure. The relationship between the other risk factors studied and graft failure was significant（P〈0.05）,although the results for previous grafts and graft failure was unreliable. None of our patients had previous blood transfusion,thus,it had no impact. CONCLUSION：After the application of multivariate analysis techniques,some risk factors do not show the expected impact over graft failure at 1y.

关键词： penetrating keratoplasty graft failure score

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Stem cell transplantation in cerebrovascular accidents:A global bibliometric analysis(2000-2023)

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World Journal of Stem Cells 2024年第9期16卷 832-841页

作者： Jad El Masri Ahmad Afyouni Maya Ghazi karim Hamideh Israe Moubayed abdo Jurjus Hanine Haidar Ruzanna Petrosyan Pascale Salameh Hassan Hosseini École Doctorale Sciences de la Vie et de la Santé UniversitéParis-Est CréteilCréteil 94010France INSERM U955-E01 Institut Mondor de Recherche BiomédicaleUniversitéParis-Est CréteilCréteil 94000France Faculty of Medical Sciences Lebanese UniversityBeirut 1533Lebanon Department of Anatomy Cell Biology and Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 1107Lebanon Department of Neurology Faculty of MedicineLebanese American UniversityBeirut 1102Lebanon Department of Pathology Faculty of MedicineLebanese American UniversityBeirut 1102Lebanon Faculty of Pharmacy Lebanese UniversityBeirut 1102Lebanon Faculty of Medicine Lebanese American UniversityBeirut 1102Lebanon Department of Primary Care and Population Health University of Nicosia Medical SchoolNicosia 2408Cyprus Institut National de SantéPublique d'Épidémiologie Clinique et de Toxicologie-Liban Beirut 1103Lebanon Department of Neurology Henri Mondor HospitalAP-HPCréteil 94000France

BACKGROUND Cerebrovascular accident(CVA)is a major global contributor to death and *** part of its medical management,researchers have recognized the importance of promising neuroprotective strategies,where stem cell transplantation(SCT)is thought to confer advantages via trophic and neuroprotective *** To evaluate the current state of research on SCT in patients with CVA,assess key trends and highlight literature *** PubMed was screened for SCT in CVA-related articles in October 2023,for each country during the period between 2000 and *** the World Bank data,total population and gross domestic product were collected for ***_1.6.19 was used to create the VOS figure using the results of the same *** and tables were obtained using Microsoft Office *** A total of 6923 studies were identified on SCT in CVA,making 0.03%of all published studies ***,68%were conducted in high-income countries,with a significant focus on mesenchymal stem *** journal“Stroke”featured the largest share of these articles,with mesenchymal SCT having the highest rate of inclusion,followed by hematopoietic *** time,there has been a noticeable shift from in vitro studies,which assess stem cell proliferation and neurogenesis,to in vivo studies aimed at evaluating efficacy and ***,the number of reviews increased along this *** This bibliometric analysis provides a comprehensive guide for physicians and researchers in the field through an objective overview of research activity,and highlights both current trends and *** a potential therapeutic role in CVA,more research is needed in the future to focus on different aspects of SCT,aiming to reach a better treatment strategy and improve life quality in patients.

关键词： Bibliometric analysis PubMed Stem cell transplantation Cerebrovascular accidents Stroke

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