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Brain Amyloidoma: Case Report and Literature Review

Open Journal of Modern Neurosurgery 2020年第4期10卷 403-421页

作者： Abd El Kader Moumouni Daniel Memia Zolo Essossinam Kpelao Pascal Compaore Dabou Abiba Tamou Tabe Latevi Lawson Pwerew Rodolphe Plante Edem Kossi Gueouguede Benedicte Souho abderrahmane hamlat Department of Neurosurgery CHU Martinique Martinique France Department of Neurosurgery CHU Kara Kara Togo Department of Neurosurgery CHU Sylvanus Olympio Lomé Togo Departments of Radiology CHR Kara Kara Togo

Introduction: Primary deposition of amyloid can take several forms including amyloidoma organ restricted among which is brain. Brain amyloidoma can mimic several lesions and offers a diagnostic challenge to the physician. The present work reports an additional case and summarizes the salient characteristics of previously published cases. Case Report: A 61-year-old, woman experienced paroxystic auditory hallucinations followed at times by generalized tonico-clonic seizures. Examination revealed a mild left pyramidal weakness. Head CT scan and MRI revealed a lobular lesion of the right atrium with contrast enhancement. The diagnosis of amyloidoma Lambda light chain (λLC) type was performed by means of a stereotactic biopsy. The patient was treated by 3 cures of high dose methotrexate (15 mg/m2). At 24 months follow up the patient remains stable clinically and biologically. The 2 years follow-up MRI showed the same findings. Conclusion: No guidelines can be suggested for brain amyloidoma treatment;the “wait and see” was the mind-set in the literature. However, a non-tumour like pattern of a cerebral mass developing near the ventricle with a fine, irregular radiating margin enhancement and lack of oedema, and mass effect are important MRI clues for brain amyloidoma diagnosis. The diagnosis is histological after biopsy or excision.

关键词： Amyloidoma Brain Literature Review

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Intradural Extra Medullary Cervical Anaplastic Ependymoma. Case Report and Review of the Literature

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Open Journal of Modern Neurosurgery 2018年第4期8卷 414-423页

作者： Daniel Memia Zolo Abd el Kader Moumouni Anabi Daouda Diakhate Dabou Abiba Tamoutabe Abderrahman hamlat Department of Neurosurgery CHU Martinique France Department of Neurosurgery CHU Kara Togo Department of Neurosurgery CHU Sylvanus Olympio Lomé Togo Department of Radiology HIA Parakou Benin

Introduction: Intra-dural and extramedullary ependymomas are rare lesions. We report a clinical case confirmed by the histology supported by the neurosurgery department of Martinique University Hospital. Clinical, paraclinical and therapeutic data will be compared to a literature review. Observation: A 38-year-old patient was admitted for tetraparesthesia evolving since 3 months, associated with a left hemiparesis. The clinical examination revealed deterioration of the general condition and a tetrapyramidal syndrome. MRI of the cervical spine revealed extensive cervical extra-medullary intradural lesion of C3 to C5. The treatment had been an excisional surgery that had been subtotal in two stages, supplemented by craniospinal radiotherapy because the pathological examination had found a grade III anaplasic ependymoma. Conclusion: Because of their rarity, the treatment of these forms of ependymoma is not yet well codified.

关键词： Intradural Extramedullary Anaplasic Ependymoma Surgery Radiotherapy

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Impact of glucotoxicity induced in vivoand in vitroin Psammomys obesus

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Journal of Diabetes Mellitus 2012年第1期2卷 59-71页

作者： Berdja Sihem Smail Leila Othmani Kheira Neggazi Samia hamlat Nadjiba Boumaza Saliha Sahraoui Abdelhamid Kacimi Ghouti Haffaf El Mahdi Benazzoug Yasmina Aouichat Bouguerra Souhila Laboratory of Cellular and Molécular Physiopathology Institute of Natural Sciences University of Technological Sciences Houari Boumediene Algiers Algeria

Objective: Chronic hyperglycemia characteristic of type diabetes 2 is responsible for the accelerated atherosclerosis with increased cardiovascular risk. In this study, we will propose to analyze the effect of a long-term of glucotoxicity in vivo in Psammomys obesus by addition of sucrose to 30% for 11 months and in vitro study of adventitial fibroblasts in the presence of D-glucose 0.6% for 7 days. Materials and methods: Evaluation of plasma biochemical parameters was carried out at the initial time and at the end of experiment. At autopsy, a morphological study of the aorta was performed after fixation in aqueous Bouin and staining with Masson’s trichrome. The experimental glucotoxicity is induced by incubation of fibroblasts in DMEM enriched with D-glucose at 0.6% for 7 days. The impact of glucotoxicity is assessed in the intracellular compartments through dosage of total nitrite and malondialdehyde, a product of lipid peroxidation, and thanks to a morphological assay after fixation of cells with aqueous bouin and blood staining with May Grünwald Giemsa. The evaluation of cell proliferation is accomplished by cell counting. Collagens I and III of the extracellular compartment are characterized by SDS-PAGE. Results: Animals subjected to sucrose showed hyperglycemia associated with hyperinsulinemia, dyslipidemia, hyperproteinemia, increased CPK and VLDL-LDL and decreased HDL. Histology of aortas revealed endothelial cells hypertrophy, severe disorganization of intima and media. In the presence of glucose, the proliferation of fibroblasts increases very significantly (P = 2.34 × 10-5), the rate of malonaldehyde, nitrite and total density of chains α2 (I) and α1 (I + III) extra-cellular collagens I and III increased significantly. After staining, the cells showed hypertrophy, vacuolation of cytoplasm and chromatin condensation with nuclear fragmentation, indicative of apoptosis. Conclusion: The glucotoxicity induced in vivo and in vitro is responsible for major struc

关键词： Psammomys Obesus Aorta Adventitial Fibroblasts in Culture DT2 Glucotoxicity Extracellular Matrix Oxidative Stress

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伊犁黑蜂蜂胶对口腔主要致龋细菌作用的体外实验

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医学研究生学报 2014年第12期 1269-1272页

作者：于倩哈木拉提·吾甫尔林静赵今新疆医科大学第一附属医院牙体牙髓科/新疆维吾尔自治区口腔医学研究所新疆医科大学维吾尔医药学院

目的寻找天然防龋药物已成为国内外研究热点。文中研究伊犁黑蜂蜂胶对口腔常见致龋细菌毒力因子的作用,探讨其防龋效果。方法 1通过液体稀释法测定伊犁黑蜂蜂胶对口腔常见致龋菌的最小抑菌浓度(minimum inhibitory concentration,MIC);2... 详细信息

目的寻找天然防龋药物已成为国内外研究热点。文中研究伊犁黑蜂蜂胶对口腔常见致龋细菌毒力因子的作用,探讨其防龋效果。方法 1通过液体稀释法测定伊犁黑蜂蜂胶对口腔常见致龋菌的最小抑菌浓度(minimum inhibitory concentration,MIC);2以MIC以下的4个浓度配置成初始p H为7.0的含药培养基,以空白液体培养基作为对照组,加入菌液厌氧培养后测其p H值,并计算p H变化值(Δp H值)以检测不同浓度黑蜂蜂胶对测试菌产酸能力的影响;3蒽酮法测定MIC以下4个浓度(包括MIC浓度)的黑蜂蜂胶对变形链球菌、黏性放线菌产生胞外多糖的影响,空白液体培养基作为阳性对照组。结果 1伊犁黑蜂蜂胶对变形链球菌、远缘链球菌、嗜酸乳杆菌、血链球菌、黏性放线菌、内氏放线菌的MIC分别是0.78、0.39、1.56、0.39、0.2、0.2 mg/m L;最低杀菌浓度分别为1.56、0.78、3.125、0.78、0.39、0.39 mg/m L;2蜂胶可使各测试菌Δp H降低,蜂胶各组与阳性对照组相比差异均有统计学意义(P<0.05);3在MIC浓度时,蜂胶可使变形链球菌、黏性放线菌合成胞外多糖的能力降低,蜂胶组与阳性对照组相比差异均有统计学意义(P<0.05)。结论伊犁黑蜂蜂胶对口腔主要致龋细菌的生长、产酸、产糖均有不同程度的抑制作用,是具有一定防龋效果的天然药物。

关键词：蜂胶致龋菌产酸胞外多糖

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