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Rating of CCR5-Delta 32 Homozygous Mutation in Sudanese HIV Patients and Sex Workers

World Journal of AIDS 2022年第2期12卷 55-64页

作者： Mawaib Hassan Fath-Elrahman Mubarak Alkarsany Bakri Yousif Mohammed Nour Adam Dawoud Abakar abdelrahman eldaw mhammed Salaheldein Gumma Elzaki Eman Osman Mubarak Elshafia Elhadi Abdalla Ahmed Department of Virology National Public Health Laboratory Khartoum Sudan Department of Medical Laboratory Sciences Karary University Khartoum Sudan Department of Medical Parasitology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Medical Microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Molecular Biology Laboratory Department of Epidemiology Tropical Medicine Research Institute Khartoum Sudan National Tuberculosis Reference Laboratory National Public Health Laboratory Khartoum Sudan Department of Haematology and Immunohaematology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan

Background: Prevention against human immunodeficiency virus (HIV) includes natural resistance in the population;mainly frequency of cysteine-cysteine chemokine receptor type-5 (CCR5-delta 32 mutation). By knowing the frequency of this resistance in the community, the proportion of the population susceptible to infection can be determined. This study aimed to detect for the first time the rate of CCR5-delta 32 mutation in Sudanese individuals with HIV and sex workers. Methods: Cross-sectional study was followed in the parade from 2019 through 2021, study groups were Sudanese with HIV and sex workers. Sero-negativity of sex workers was confirmed by a rapid immunochromatography test (ICT). A blood sample was targeted for DNA isolation. PCR amplification was accomplished for CCR5 wild type and CCR5-delta 32 mutation genes using specific primers. Result: Among HIV patients, males, basic education level and ages below 60 years were commonly recorded while ages below 40 years, secondary education level and single marital status were predominated in sex workers. All HIV patients were positive for CCR5 wild type and negative for CCR5-delta 32 genotype. The sex workers group showed a frequency of 3.5% (97/200) for homozygous CCR5-delta 32 mutation. Conclusion: The rating of homozygous CCR5-delta 32 genotype in studied Sudanese sex workers was relatively more than other results obtained from African countries, and the mutation was significantly detected among sex workers group (P value = 0.008) when compared to the studied HIV group.

关键词： CCR5-Delta 32 HIV Sex Workers Rating Sudan

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