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自主机器人使能技术在制造业中的应用（英文）

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期 403-431页

作者： ERd?S Gábor ABAI Kristóf BEREGI Richárd CSEmPESZ János CSERTEG Tamás GOdó Gábor HAJóS mátyás HáY Borbála HORVáTH dániel HORVáTH Gergely JUNIKI ádám KEméNY Zsolt KOVáCS András NACSA János PANITI Imre PEdONE Gianfranco TAKáCS Emma TIPARY Bence ZAHORáN László VáNCZA József 匈牙利研究网络计算机科学与控制研究所布达佩斯经济与技术大学制造科学与技术系 EPIC非盈利创新实验室厄特沃什·罗兰大学

自主制造系统的研究既受益于信息物理融合系统这一新技术的推动，也响应工业实际需求的号召。目前，先进的传感器技术、数字孪生、人工智能和新型通信技术可以支持半结构化工业环境中的自主操作，可实现对生产过程的实时监控、情况识别... 详细信息

自主制造系统的研究既受益于信息物理融合系统这一新技术的推动，也响应工业实际需求的号召。目前，先进的传感器技术、数字孪生、人工智能和新型通信技术可以支持半结构化工业环境中的自主操作，可实现对生产过程的实时监控、情况识别和预测、自动和自适应（重新）规划、团队合作，以及通过学习提高性能。本文总结了实现自主工业机器人技术的主要需求，提出了实现此类系统的通用工作流程，并介绍了HUN-REN SZTAKI最近在装配、焊接、打磨、拾取和放置以及机械加工等多个应用领域的广泛实践。这些解决方案的共同点是以通用的数字孪生概念为核心。最后，本文提出实现工业自主机器人解决方案的一般建议，并讨论了未来要研究的一些开放性问题。

关键词：工业机器人自动化数字孪生使能技术

Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia déri dóra Tihanyi Edit Várkondi EnikőKispéter Róbert dóczi dóra Lakatos Anna dirner mátyás Vidermann Péter Filotás Réka Szalkai-dénes István Szegedi Katalin Bartyik Krisztina míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss miklós Garami István Peták Oncompass medicine Hungary Kft Retek Str.34Budapest 1024Hungary division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology department Velkey LászlóPaediatric Health CentreMiskolcHungary department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology department Heim Pál Children’s HospitalBudapestHungary department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(ddA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of ddA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(d in our precision oncology program,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the ddA algorithm for therapeutic decision ***,a molecular tumor board(mTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a ddA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** ddA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

Evaluation of stress concentration for planar tubular joints

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中国有色金属学会会刊：英文版 2006年第B1期16卷 1-10页

作者： m.F.GHANAmEH d.THE VENET A.ZEGHLOUL Laboratory of mechanics and Physics of materials - U.m.R.CNRS N° 7554 University of MetzLPMM57045 MetzFrance Laboratory of mechanics of Naval Structures ENSIETA29806 BrestFrance Received 10 April 2006 accepted 25 April 2006

In offshore tubular structures, a typical tubular joint may be subjected to three different types of basic loadings: axial, in-plane bending and out-of-plane bending, through its brace members. Each type will cause a different stress distribution at the joint intersection of structures. moreover, the actual load condition of a tubular joint can be any combination of the above three basic load cases, for this reason, a combined loading was investigated in addition to these three basic loadings. This load is composed of an axial loading combined with a continuation of rotational bending loading obtained while rotate center of the brace around a circle. different types of planar joints such as T, Y, X, K, dT, dY, dX, ty, TK, dTX, dTdY, and dTdK, with braces subjected to combined loading, were numerically analyzed to study the effect of those different cases of loading and different types of joints, on the stress concentration zone and values.

关键词：管子接头焊接应力集中评价应力分布有限元法海洋平台

Is alcoholic pancreatitis associated with enteroviral infection?

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World Journal of Gastroenterology 2013年第24期19卷 3819-3823页

作者： Jahangir Khan Isto Nordback Hanna Seppnen Riitta Lappalainen-Lehto Satu Jrvinen Sami Oikarinen Sisko Tauriainen Sari Rty Heikki Hyty Juhani Sand department of Gastroenterology and Alimentary Tract Surgery Tampere University Hospital department of Virology School of Medicine University of Tampere department of microbiology Center of Laboratory Medicine Tampere University Hospital

AIm: To investigate whether enteroviral infection might trigger acute pancreatitis in patients made susceptible due to high alcohol consumption. mETHOdS: Patients with alcohol-induced acute pan-creatitis were analyzed for signs of simultaneous or preceding enteroviral infection. We studied the serum samples of 40 patients hospitalized for alcohol-induced acute pancreatitis and 40 controls recruited from an alcohol detoxification center. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect enterovirus RNA and diagnose acute viremia. Immuno-globulin G (IgG), immunoglobulin A (IgA) and immuno-globulin m (Igm) enteroviral antibodies were measured using enzyme immunoassay to detect subacute andprevious infections. The samples were considered posi-tive when the antibody titers were≥15 IU. Further-more, using RT-PCR, we studied pancreatic biopsy sam-ples obtained during surgery from nine patients with chronic pancreatitis, one patient with acute pancreatitis and ten control patients with pancreatic carcinoma for evidence of persisting enteroviral RNA in the pancreatic tissue. RESULTS: No enterovirus RNA indicating acute viremia was detected by RT-PCR in the serum samples of any patient or control. A high incidence of positive antibody titers was observed in both study groups: Igm antibod-ies had positive titers in 5/40 (13%) vs 4/40 (10%), P=0.723; IgG in 15/40 (38%) vs 19/40 (48%), P=0.366; and IgA in 25/40 (63%) vs 33/40 (83%), P=0.045, patients and controls, respectively. Ten (25%) patients had severe pancreatitis and two (5%) required treatment in intensive care. The median length of hos-pitalization was 7 d (range: 3-47 d). The severity of acute pancreatitis or the length of hospitalization was not associated with enteroviral Igm, IgG or IgA anti-bodies. Five pancreatic biopsy samples tested positive with RT-PCR, three (8%) in the control group and two (5%) in the patient group (P=0.64). CONCLUSION: The rate of enteroviral infection is not incre

关键词： Pancreatitis Alcoholic Pancreatitis Acute necrotizing Enterovirus

用于口服活菌苗的伤寒沙门氏突变菌株的体外特性

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微生物学免疫学进展 1991年第1期19卷 77-79页

作者： Evgenia m.d 贾平卢燕

通常所用的非胃肠的伤寒死菌苗,已证明具有明显的保护作用,但常有严重的不良反应。因此,发展新的低反应原性的菌苗,特别是口服活菌苗已有一段时间的进展。几株减毒的伤寒沙门氏菌株已被作为口服活菌苗的候选者。GalE ty21a用于自愿者和... 详细信息

通常所用的非胃肠的伤寒死菌苗,已证明具有明显的保护作用,但常有严重的不良反应。因此,发展新的低反应原性的菌苗,特别是口服活菌苗已有一段时间的进展。几株减毒的伤寒沙门氏菌株已被作为口服活菌苗的候选者。GalE ty21a用于自愿者和在现场试验中,没有出现任何不良反应,且显示了中等水平的保护。营养缺陷型突变株541ty和543ty,用于自愿者亦无不良反应,且可诱导体液抗体反应和介导细胞免疫。通过EX462的免疫原性突反株GalE保留了对人体的毒性。

关键词：口服菌苗伤寒菌突变株

modern comprehensive study of the W Uma system ty Boo

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Research in Astronomy and Astrophysics 2015年第4期15卷 501-516页

作者： magdy m.Elkhateeb mohamed Ibrahim Nouh Abdel-Naby S.Saad Astronomy department National Research Institute of Astronomy and Geophysics Physics department College of ScienceNorthern Border University mathematics department Preparatory YearQassim University

New three color light curves of ty Boo were acquired during five nights from February to may 2006 in the BVR bandpass using a 50-cm F/8.4 Ritchey- Chr6tien telescope （Ba50） at the Baja Astronomical Observatory （Hungary）, with a 512×512 Apogee AP-7 CCd camera. A photometric solution of these light curves was obtained by means of the Wilson-devinney code. The results showed that the less massive component is hotter than the more massive one, and the temperature difference between the components is △T -249 K. Long term investigation of the system based on all available data shows two stages of increase and a similar trend for decrease, which appears to be periodic behavior. A set of new light elements yields a new period （P = 0.3171506d） and shows a periodic decrease with the rate dP/dE -- 5.858×10^-12 d cycle-1, 6.742×10^-9 d yr-1 or 0.058 s century-1. The evolutionary status of the system is discussed.

关键词： binaries: eclipsing -- stars: evolution

年龄相关性黄斑变性的放射治疗试验:初步研究的1年效果分析

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 23-24页

作者： marcus d.m. Peskin E. 秦雪娇

To assess the short term safety and efficacy of treating subfoveal choroidal neovascularization (CNV) with external beam radiation delivered in 5×4 Gy fract ions among patients having age related macular degeneration (Amd). A multicente r prospective randomized controlled pilot study. Eighty eight patients were enr olled through 10 sites and were randomized to radiotherapy (20 Gy delivered in 5 daily fractions of 4 Gy each; 6 mV [N=41]) or no radiotherapy (sham radiother ap y [N=22]or observation [N=25]). Eligibility criteria included visual acuity of a t least 20/320 and subfoveal CNV not amenable to treatment. Randomization was st ratified by lesion type (new or recurrent CNV) and blood ( mary outcome measure was loss of ≥3 lines of visual a cu ity. Secondary outcome measures were angiographic response and side effects. At baseline, patient and ocular characteristics were similar between treatment grou ps. At six months, 9 radiated eyes (26%) and 17 eyes not radiated (49%) lost ≥3 lines of visual acuity (P=. 04; stratified χ2 test). At 12 months, 13 radia ted eyes (42%) and 9 observed eyes (49%) lost ≥3 visual acuity lines (P=.60). The radiated group demonstrated smaller lesions and less fibrosis than the nonr adiated group (P=.05 and. 004, respectively) at 12 months. Radiation induced co mplications were not observed except for one radiated eye with numerous cotton w ool spots and possible radiation retinopathy. External beam radiation at 5×4 Gy may have a modest and short lived (six month) benefit in preserving visual acui ty.

关键词：放射治疗脉络膜新生血管放疗组损伤区棉絮斑中央凹照射量随机化血管造影研究机构

妇女的共享干预措施对出生结局的影响:尼泊尔一项聚群随机对照研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 2-3页

作者： manandhar P.d.S. Osrin d. Prasad S hrestha B. P.A.m.d.L.Costello 兰玲 International Perinatal Care Unit Institute of Child HealthUniversity Colleg e Lon-don30Guilford StreetLondon WC1N1EHUnited King-dom

Background Neonatal deaths in developing countries make the largest contribution to global mortality in children younger than 5years.90%of deliveries in the poorest quintile of households happen at hom *** postulated that a community -based participatory in tervention could sig-nificantly reduce neonatal mortali ty *** We pair -matched 42geopolitical clusters in makwanpur dis-trict,Nepal,selected 12pairs rand omly,and randomly assigned one of each pair to interven tion or *** each intervention cluster(average population 7000),a female facilitator convened nine womens g roup meetings every *** facilitator supported groups through an ac-tion -learning cycle in which they id entified local perinatal problems and formulated strategies to address *** monitored birth outcomes in a cohort of 28931women,of whom 8%joined the *** primary outcome was neonatal mortality *** outc omes included stillbirths and maternal deaths,uptake of anten atal and delivery ser-vices,home care practices,infant m orbidity,and health -care *** was by intent ion to *** study is registered as an International St andard Randomised Controlled Trial,number *** 2001to 2003,the neonatal morta lity rate was 26.2per 1000(76deaths per 2899livebirths)in intervention clusters compared with 36.9per 1000(119deaths per3226livebirths)in controls(adjusted odds ratio 0.7095%CI 0.53-0.94).Stillbirth rates were similar in both *** maternal mortality ratio was 69per 100000(two deaths per 2899livebirths)in intervention clusters compared with 341per 100000(11deaths per 3226livebirths)in control clusters(0.220.05-0.90).Women in intervention clusters were more likely to have antenatal care,institutional delivery,trained birth atten-dance,and hygienic care than were *** Birth outcomes in a poor rural popula tion improved greatly through a low cost,potentially sustainable and scalable,participatory intervention

关键词：新生儿死亡率护理培训循环法产前护理围生期公共医疗健康护理随机对照试验干预组随机分配

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住院医师施行的穿透角膜移植术

世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 19-20页

作者： Kutzscher E.m. Sorenson A.L. Goodman d.F 张磊 1850 Sullivan A ve 540 Daly City CA 94015 United States Dr.

Objective: To report the results of penetrating keratoplasty performed by resi dents. method: A retrospective medical record review of all patients undergoing penetrating keratoplasty performed by residents at our institution from April 19 98 to April 2002. Results: Forty penetrating keratoplasty procedures were perfor med by 8 residents. The most common indication was keratoconus (17 eyes 43%), followed by corneal scarring (14 eyes 35%). mean preoperative best-correcte d visual acuity was 20/250. No intraoperative complications were reported. mean follow-up time was 15 months. Postoperatively, mean best-corrected visual acui ty was 20/40, mean postoperative astigmatism was 3.4±2.1 diopters, and graft su rvival was 92.5%. Postoperative complications included elevated intraocular pre ssure, wound dehiscence, and endophthalmitis. main Outcome measures: Best-corre cted visual acuity, postoperative astigmatism, graft survival, and intraoperativ e and postoperative complications. Conclusion: Residents can be introduced to pe netrating keratoplasty and achieve surgical success with intraoperative and post operative complication rates similar to those previously published.

关键词：穿透角膜移植术住院医师植片矫正视力散光度术后并发症圆锥角膜手术指征角膜瘢痕眼内炎