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Combinatory effect of hesperetin and mesenchymal stem cells on the deteriorated lipid profile,heart and kidney functions and antioxidant activity in STZ-induced diabetic rats

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BIOCELL 2020年第1期44卷 27-39页

作者： Osama m.AHmED mohamed A.HASSAN Ablaa S.saleh Experimental Obesity and Diabetes Research Lab(EODRL) Physiology DivisionZoology DepartmentFaculty of ScienceBeni-Suef UniversityPO 62521Beni-SuefEgypt Biochemistry Department Faculty of ScienceBeni-Suef UniversityPO 62521Beni-SuefEgypt

This study aimed to assess the effect of hesperetin and/or bone marrow-derived mesenchymal stem cells(Bm-mSCs)on disturbed lipid profile,heart and kidney functions,oxidative stress and antioxidant defense system in streptozotocin(STZ)-induced diabetic *** 1 diabetes mellitus(T1Dm)was induced in male Wistar rats by injecting 40 mg/kg body weight(b.w.)STZ dissolved in citrate buffer(pH 4.5).The diabetic rats were treated with hesperetin orally administered at dose 20 mg/kg b.w.,Bm-mSCs intravenously injected at a dose of 1 x 106 cells/rat/week and their combination for 6 *** diabetic rats exhibited lipid abnormalities manifested by elevated serum levels of total cholesterol,triglycerides,LDL-cholesterol and VLDL-cholesterol and lowered HDL-cholesterol as well as elevated liver cholesterol and triglycerides content in association with the resultant fasting and postprandial hyperglycemia and insulin *** heart function biomarkers including CK-mB,AST and LDH activities as well as levels of kidney function parameters,creatinine,and urea,were significantly raised in the serum of diabetic *** changes were concomitant with abnormal redox balance represented by elevated lipid peroxidation,decreased glutathione content,and suppressed antioxidant enzyme activities in both heart and kidney of diabetic *** previous deleterious alterations were significantly ameliorated after the treatment of diabetic rats with hesperetin and Bm-mSCs singly or in combination;the treatment with hesperetin together with Bm-mSCs was the most *** on these findings,it can be concluded that the use of hesperetin with Bm-mSCs may have more additive therapeutic value than their uses singly in *** addition,the ameliorative effects of hesperetin and Bm-mSCs on lipid profile and heart and kidney functions in diabetic rats may be mediated,at least in part,via their suppressive effects on oxidative stress and ameliorative effects on the antioxidant defense system

关键词： Bm-mSCs Hesperetin Streptozotocin-induced diabetes

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Synthesis of amyl ester grafted on carbon-nanopolymer composite as an inhibitor for cleaner shale drilling

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Petroleum 2022年第4期8卷 529-537页

作者： Tawfik A.saleh mukaila A.Ibrahim Department of Chemistry King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Department of Chemistry and Biochemistry University of Lethbridge4401University DriveLethbridgeAlbertaT1K 3M4Canada

Wellbore instability in oil and gas industry well drillings is a significant challenge that is linked to shale swelling when shale interacts with free water molecules in the water-based drilling *** design of environmentally benign,biodegradable,and effective shale hydration inhibitors is a prominent objective of contemporary exploration in well-drilling fluids as a replacement for the common KCl which is detrimental to aquatic *** work reports the synthesis and potential of novel green acrylic polymer-amyl ester activated carbon(-C)nanocomposite to hinder shale hydration in formations during *** less hydrophobic acrylic acid-acrylamide-activated carbon-amyl ester(AA-AAm-C-Amyl)and more hydrophobic acrylic acid-acrylamide-octadecene-activated carbon-amyl ester(AA-AAm-OD-CAmyl)composites were synthesized,characterized,and tested with standard methods as a cleaner fluid additive for shale swelling inhibition,and their results compared with that of *** polymer matrixes displayed remarkable thermal *** also indicate that AA-AAm-C-Amyl and AA-AAm-OD-CAmyl composites could stabilize wellbore effectively with 95.2%and 93.7%anti-swelling ratio,and shale recovery capacity of 97%and 95.2%*** surface evaluation of the composite fluidtreated bentonite revealed that the mechanism of inhibition could be based on the collaborative action of nanopore plugging of carbon core and strong adsorption of the polymer component of the materials on clay surfaces via encapsulation and hydrogen bonding to form an impressive filter cake which could actively prevent water invasion into ***,AA-AAm-C-Amyl and AA-AAm-OD-C-Amyl composites could be a sustainable substitute for the conventional KCl as a shale inhibitor for welldrilling.

关键词： Clean shale drilling Sustainable materials Advanced technology Amyl ester activated carbon Polymer composite

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Effects of different land-use systems (grazing and understory cultivation) on growth and yield of semi-arid oak coppices

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Journal of Forestry Research 2020年第6期31卷 2235-2244页

作者： Ali Soltani Hamdollah Sadeghi Kaji saleh Kahyani Department of Forest Science Faculty of Natural Resources and Earth SciencesShahrekord UniversityP.O.Box 115ShahrekordIran

The present study examines the extent of negative eff ects of traditional multiple land-use systems on oak coppices,from a forest management point of *** study area was located in approximately 10,000 ha of hilly Brant’s oak(Quercus brantii Lindl.)woodlands in the central Zagros *** the same site-quality class,three land-use systems were compared:simple coppice(Co),coppice in conjunction with small ruminant grazing(CoG),and coppice with understory rain-fed wheat cultivation plus grazing(CoCG).Data on total wood volume of trunk and major branches,and annual ring growth,were collected and analyzed from 74 stands in 15 coppiced woodland *** results showed the advantage of Co over CoG and CoCG land-uses by 43 and 60 m 3 of mean accumulated wood volume per hectare,*** diameter growth analysis also revealed an annual increase in wood production of trees in Co land-uses over 43 years,with an exception of the recent decade,when growth coincided with a severe *** a back-extrapolation method,the minimum rotation age of woodlands in Co land-use was found to be 23.6 years,5 and 7 years shorter than those of CoG and CoCG land-uses,*** CoCG,woodlands located in Co and CoG land-use systems demonstrated a high level of agreement with self-thinning rule of−3/*** for the stand density index for coppiced oak woodlands were between more than 1000 for the least disturbed(Co)and less than 400 for the most disturbed woodlands(CoCG).The structure and growth rate of the coppiced oak woodlands were irreversibly disrupted by understory tillage plus grazing and in less extent by grazing *** was concluded that ending undergrowth cultivation in semi-arid oak coppices should be addressed as a priority by adopting minimum regulations.

关键词： Coppicing Land-use impact assessment Diameter growth multi-purpose land-use Self-thinning rule Stand density index

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Ocellar lamprophyre dyke bearing mineralization,Wadi Nugrus,Eastern Desert,Egypt:Geology,mineralogy and geochemical implications

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Chinese Journal Of Geochemistry 2010年第4期29卷 383-392页

作者： Ibrahim m.E. saleh G.m. Dawood N.A. Aly G.m. Nuclear materials Authority P.O.Box 530El-MaadiCairoEgypt

The ocellar lamprophyre dyke(ENE-WSW) is recorded at Wadi Nugrus,Eastern Desert,*** cuts porphyritic biotite granites and varies in thickness from 0.5 to 1.5 m and up to 3 km in *** lamprophyre dyke has been altered,and it is characterized by porphyritic and panidiomorphic textures with plagioclase,olivine,and augite constituting the porphyritic phase in a fine groundmass of the same ***,titanite,apatite,fluorite,graphite,calcite,allanite,autunite and Fe-Ti oxides are accessory ***,chlorite and epidote are secondary *** and hematitization are *** to sub-rounded porphyritic and zoned ocelli with radiate or brush-like shapes are generally common and represent physical traps for *** ocellar features are interpreted to represent the late stage of magmatic segregation or magmatic crystallization involving two immiscible magmatic *** studies of altered lamprophyre samples,based on X-ray diffraction(XRD) and environmental scanning electron microscopy(ESEm),indicate the presence of secondary uranium minerals(autunite and uranophane),associated with gold,silver,nickel,atacamite,molybdenum,pyrite and *** presence of kaolinite indicates a high temperature *** mixing of volatile fluids with meteoric water and fluid-wall rock interaction result in changes of pH and oxygen activity and deposition of base metals in reducing environs(graphite and pyrite).Precipitation of hematite probably decreased the pH of the solution and rose acidic *** sudden change in pH and temperature of the fluids would lead to destabilization of base metal complexes favoring their *** magma source of the Nugrus lamprophyre is determined to be between calc-alkaline and alkaline and it has HKCAB and shoshonitic nature and may be derived from decomposition melting of such a metasomatised lithospheric *** is a major fractional phase to account for a rapid

关键词：煌斑岩脉矿物学地球化学沙漠埃及地质学黑云母花岗岩矿化

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R-IDPS: Real Time SDN-Based IDPS System for IoT Security

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Computers, materials & Continua 2022年第11期73卷 3099-3118页

作者： Noman mazhar Rosli saleh Reza Zaba muhammad Zeeshan m.muzaffar Hameed Nauman Khan Faculty of Computer Science and Information Technology University of MalayaKuala Lumpur50603Malaysia Centre for Research in Industry 4.0 University of MalayaKuala Lumpur50603Malaysia mImOS Berhad National Applied R&D CentreKuala Lumpur57000Malaysia School of Electrical Engineering and Computer Science National University of Sciences and TechnologyIslamabad44000Pakistan

The advent of the latest technologies like the Internet of things(IoT)transforms the world from a manual to an automated way of ***,IoT sector open numerous security *** traditional networks,intrusion detection and prevention systems(IDPS)have been the key player in the market to ensure *** challenges to the conventional IDPS are implementation cost,computing power,processing delay,and ***,online machine learning model training has been an *** these challenges still question the IoT network *** has been a lot of research for IoT based detection systems to secure the IoT devices such as centralized and distributed architecture-based detection *** centralized system has issues like a single point of failure and load balancing while distributed system design has scalability and heterogeneity *** this study,we design and develop an agent-based hybrid prevention system based on software-defined networking(SDN)*** system uses lite weight agents with the ability to scaleup for bigger networks and is feasible for heterogeneous IoT *** baseline profile for the IoT devices has been developed by analyzing network flows from all the IoT *** profile helps in extracting IoT device *** features help in the development of our dataset that we use for anomaly *** anomaly detection,support vector machine has been used to detect internet control message protocol(ICmP)flood and transmission control protocol synchronize(TCP SYN)flood *** proposed system based on machine learning model is fully capable of online and offline *** than detection accuracy,the system can fully mitigate the attacks using the software-defined technology SDN *** major goal of the research is to analyze the accuracy of the hybrid agent-based intrusion detection systems as compared to conventional centralized only solutions,especially under the flood attac

关键词： machine learning Internet of things software defined networking distributed denial of service attacks

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Awareness and knowledge about glaucoma among patients visiting the screening clinic in Jeddah Eye Hospital,Saudi Arabia

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 887-895页

作者： saleh m.Alqahtani marwan A Bakarman Ahmed Almanjoumi Sami H.Alzahrani ministry of Health Jeddah 23545Saudi Arabia Department of Family and Community medicine Faculty of Medicine in RabighKing Abdul Aziz UniversityJeddah 21589Saudi Arabia Ophthalmology Department Faculty of MedicineKing Abdulaziz UniversityJeddah 22234Saudi Arabia Family medicine Department Faculty of MedicineKing Abdulaziz UniversityJeddah 22431Saudi Arabia

AIm:To explore levels and determinants of awareness and knowledge about glaucoma among ***:This was a cross-sectional study that included adult patients from October to the end of December 2018.A semi-structured questionnaire was designed by the researchers to measure the levels of awareness and knowledge about 18 basic information about *** sheet was divided into 4 domains:types of glaucoma,risk factors,clinical features,and management.A knowledge score(KS,range=0-18)was calculated,with higher scores indicating higher ***:A total of 383 patients responded to the questionnaire,61.9%males,mean±SD age was 38.5±12.94 years old,and 61.6%had a university degree or *** them,6.3%and 23.2%reported personal and family history of glaucoma,*** most frequently reported source of information about glaucoma was another person with glaucoma(28.2%),followed by physicians(24.8%)and TV(19.6%).Knowledge by item ranged from 3.1%to 82.5%correctness rate,while KS showed mean=5.91 and median=5;and reliability testing of the knowledge scale showed Cronbach’s alpha=*** KS were found among respondents with higher educational level(P=0.036),diabetes history(P=0.025),and personal(Pmily(Pma among the attendees of a local eye care hospital,where several misconceptions about disease risk factors,clinical features,and management are identified.

关键词： awareness knowledge glaucoma Saudi Arabia

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Dielectric response and electric properties of organic semiconducting phthalocyanine thin films

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Journal of Semiconductors 2012年第8期33卷 15-21页

作者： A.m.saleh S.m.Hraibat R.m-L.Kitaneh m.m.Abu-Samreh S.m.musameh Physics Department Al-Quds UniversityJerusalemPalestine physics Department An-Najah UniversityNablusPalestine

The dielectric function of some phthalocyanine compounds （ZnPc, H2Pc, CuPc, and FePc） were investigated by analyzing the measured capacitance and loss tangent data. The real part of the dielectric constant, ca, varies strongly with frequency and temperature. The frequency dependence was expressed as： ε1 = Aε^n, where the index, n, assumes negative values （n 〈 0）. In addition, the imaginary part of the dielectric constant, ε2, is also frequency and temperature dependent. Data analysis confirmed that ε2 = Bo）m with values of m less than zero. At low frequencies and all temperatures, a strong dependence is observed, while at higher frequencies, a moderate dependence is obvious especially for the Au-electrode sample. Qualitatively, the type of electrode material had little effect on the behavior of the dielectric constant but did affect its value. Analysis of the AC conductivity dependence on frequency at different temperatures indicated that the correlated barrier hopping （CBH） model is the most suitable mechanism for the AC conduction behavior. maximum barrier height, W, has been estimated for ZnPc with different electrode materials （Au and AI）, and had values between 0.10 and 0.9 eV. For both electrode types, the maximum barrier height has strong frequency dependence at high frequency and low temperatures. The relaxation time, r, for ZnPc and FePc films increases with decreasing frequency. The activation energy was derived from the slopes of r versus 1/T curves. At low temperatures, an activation energy value of about 0.01 eV and 0.04 eV was estimated for ZnPc and FePc, respectively. The low values of activation energy suggest that the hopping of charge carriers between localized states is the dominant mechanism.

关键词： organic semiconductor dielectric function evaporation relaxation time

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Energy and Thermodynamics of the Quantum-Corrected Schwarzschild Black Hole

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Chinese Physics Letters 2017年第8期34卷 21-24页

作者： mahamat saleh Bouetou Bouetou Thomas Timoleon Crepin Kofane Department of Physics Higher Teachers' Training College University of Maroua Maroua 55 Cameroon Ecole Nationale Supérieure Polytechnique University of Yaounde I Yaounde 8390 Cameroon The African Center of Excellence in Information and Communication Technologies University of Yaounde I Yaounde 8390 Cameroon The Abdus Salam International Centre for Theoretical Physics Trieste II-34014 Italy Department of Physics Faculty of Science University of Yaounde I Yaounde 812 Cameroon

Energy and thermodynamics are investigated in the Schwarzschild black hole spacetime when considering corrections due to quantum vacuum fluctuations. The Einstein and m？ller prescriptions are used to derive the expressions of the energy in the background. The temperature and heat capacity are also derived. The results show that due to the quantum fluctuations in the background of the Schwarzschild black hole, all the energies increase and the Einstein energy differs from m？ller＇s one. moreover, when increasing the quantum correction factor aa, the difference between Einstein and m？ller energies, the Unruh–Verlinde temperature as well as the heat capacity of the black hole increases while the Hawking temperature remains unchanged.

关键词： Energy and Thermodynamics of the Quantum-Corrected Schwarzschild Black Hole

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Quasi-Normal modes of Gravitational Perturbation around a Reissner-Nordstroem Black Hole Surrounded by Quintessence

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Chinese Physics Letters 2009年第10期26卷 228-231页

作者： mahamat saleh Bouetou Bouetou Thomas Timoleon Crepin Kofane Department of Physics Faculty of Science University of Yaounde I PO Box 812 Cameroon Ecole Nationale Supérieure Polytechnique University of Yaounde I PO Box 8390 Cameroon The Abdus Salam International Centre for Theoretical Physics PO Box 586 Strada Costiera Ⅱ-34014 Trieste Italy

We investigate quasi-normal （QN） modes of gravitational perturbation around a Reissner-Nordstroem black hole surrounded by quintessence. The third-order Wentzel-Kramers-Brillouin approximation is used to evaluate QN frequencies. The behavior of the gravitational perturbation is plotted for some frequencies. Due to the presence of quintessence, QN modes of the Reissner-Nordstroem black hole damp at a slower rate.

关键词： Black holes

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microwave-assisted synthesis of new pyrimido[4′,5′:4,5]thiazolo[3,2-a]benzimidazol-4(3H)-one derivatives in solvent-free condition

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Chinese Chemical Letters 2007年第11期18卷 1327-1330页

作者： A.Davoodnia m.Roshani E.saleh Nadim m.Bakavoli N.Tavakoli Hoseini Department of Chemistry School of Sciences Islamic Azad UniversityMashhad 91735-413Iran

microwave-assisted synthesis of new 2-arylpyrimido[4′,5′：4,5]thiazolo[3,2-α]benzimidazol-4（3H）-ones from 3-aminothia- zolo[3,2-α]benzimidazol-2-earboxamide and aroyl halides in solvent-free condition is described. In comparison with classical conditions the reactions are faster and the yields are higher under microwave irradiation.

关键词： Pyrimidothiazolobenzimidazoles Aroyl halides microwave irradiation Conventional heating

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