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Anti-inflammatory and analgesic properties of Moroccan medicinal plants:Phytochemistry,in vitro and in vivo investigations,mechanism insights,clinical evidences and perspectives

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Journal of Pharmaceutical Analysis 2022年第1期12卷 35-57页

作者： Abdelhakim Bouyahya Fatima-Ezzahrae Guaouguaou Nasreddine El Omari Naoual El Menyiy abdelaali balahbib Mohamed El-Shazly Youssef Bakri Laboratory of Human Pathologies Biology Department of BiologyFaculty of Sciencesand Genomic Center of Human PathologiesFaculty of Medicine and PharmacyMohammed Ⅴ University in Rabat4014Morocco Mohammed Ⅴ University in Rabat LPCMIOMaterials Science Center(MSC)Ecole Normale SuperieureRabat1014Morocco Laboratory of Histology Embryology and CytogeneticFaculty of Medicine and PharmacyMohammed Ⅴ University in Rabat10100Morocco Department of Biology Faculty of Sciences Dhar El MahrazUniversity Sidi Mohamed Ben AbdellahFez30003Morocco Laboratory of Zoology and General Biology Faculty of SciencesMohammed Ⅴ University in RabatRabat1014Morocco Department of Pharmacognosy Faculty of PharmacyAin-Shams UniversityCairo11566Egypt Department of Pharmaceutical Biology Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt

Moroccan medicinal plants exhibit several pharmacological properties such as antimicrobial,anticancer,antidiabetic,analgesic,and anti-inflammatory effects,which are related to the presence of numerous bioactive compounds,including phenolic acids,flavonoids,and *** the present review,we systematically evaluate previously published reports on the anti-inflammatory and analgesic effects of Moroccan medicinal *** in vitro investigations revealed that Moroccan medicinal plants inhibit several enzymes related to inflammatory processes,whereas in vivo studies noted significant anti-inflammatory and analgesic effects as demonstrated using different experimental *** bioactive compounds exhibiting in vitro and in vivo anti-inflammatory and analgesic effects,with diverse mechanisms of action,have been *** plants and their bioactive compounds reveal specific secondary metabolites that possess important anti-inflammatory effects in clinical *** review proposes the potential applications of Moroccan medicinal plants as sources of anti-inflammatory and analgesic agents.

关键词： Inflammation Medicinal plants Bioactive compounds Anti-inflammatory Analgesic

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Selecting accurate post-elimination monitoring tools to prevent reemergence of urogenital schistosomiasis in Morocco:a pilot study

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Infectious Diseases of Poverty 2017年第1期6卷 664-672页

作者： abdelaali balahbib Fatima Amarir Paul L.A.M.Corstjens Claudia Jde Dood Govert Jvan Dam Amina Hajli Meryem Belhaddad Bouchra El Mansouri Abderrahim Sadak Mohamed Rhajaouim El Bachir Adlaoui National Reference Laboratory for Schistosomiasis and Malacology National Institute of HygieneAgdalRabatMorocco Faculty of Science Laboratory of Zoology and General BiologyAgdalRabatMorocco Laboratory of Parasitology and Malacology Institute of Nursing Professions and Health TechniquesCasablancaMorocco Department of Molecular Cell Biology Leiden University Medical CenterLeidenThe Netherlands Department of Parasitology Leiden University Medical CenterLeidenThe Netherlands

Background:After alleged stop of transmission of schistosomiasis and further down the line in post elimination settings,sensitive tools are required to monitor infection status to prevent potential *** Rahala,where transmission cycle of Schistosoma haematobium is interrupted since 2004 but where 30%of snails are still infected by ***,potential human *** infection can’t be *** methods based on egg-counts do not provide the required sensitivity,antibody or antigen assays are envisaged as the most appropriate tools for this type of ***:In this pilot study,the performances of three assays were compared:two commercially available antibody tests(ELISA and haemagglutination format)indicating exposure,and an antigen test(lateral flow strip format)demonstrating active *** 37 recruited study participants resided in Rahala(Akka,province Tata,Morocco).Participants had been diagnosed and cured from schistosomiasis in the period between 1983 and *** 2015 these asymptomatic participants provided fresh clinical samples(blood and urine)for analysis with the aforementioned diagnostics ***:No eggs were identified in the urine of the 37 *** haemagglutination test indicated 6 antibody positives whereas the ELISA indicated 28 antibody positives,one indecisive and one false *** and haemagglutination results matched for 18 individuals,amongst which 5 out of 6 haemagglutination *** the antigen test(performed on paired serum and urine samples),serum from two participants(cured 21 and 32 years ago)indicated the presence of low levels of the highly specific Schistosoma circulating anodic antigen(CAA),demonstrating low worm level infections(less than 5 pg/ml corresponding to probably single worm pair).One tested also CAA positive with *** indicated the presence of human anti-Schistosoma antibodies in these two CAA positive cases,haemagglutination results were ***:To pre

关键词： Schistosomiasis Transmission stop Elimination Monitoring Antibody test Antigen test Circulating Anodic Antigen(CAA) Active infection

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Prediction of elastic and acoustic behaviors of calcarenite used for construction of historical monuments of Rabat, Morocco

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第1期9卷 74-83页

作者： abdelaali Rahmouni Abderrahim Boulanouar Abderrahim Samaouali Mohamed Boukalouch Yves Géraud Jamal Sebbani Laboratory of Thermodynamics Department of Physics Faculty of Science Mohammed V University P.O. Box 1014 Rabat Morocco University of Lorraine ENSG UMR 7359-GeoRessources Nancy Cedex France

Natural materials(e.g. rocks and soils) are porous media, whose microstructures present a wide *** generally consist of a heterogeneous solid phase and a porous phase which may be fully or partially saturated with one or more fluids. The prediction of elastic and acoustic properties of porous materials is very important in many fields, such as physics of rocks, reservoir geophysics, civil engineering, construction field and study of the behavior of historical monuments. The aim of this work is to predict the elastic and acoustic behaviors of isotropic porous materials of a solid matrix containing dry, saturated and partially saturated spherical pores. For this, a homogenization technique based on the Morie Tanaka model is presented to connect the elastic and acoustic properties to porosity and degree of water saturation. Non-destructive ultrasonic technique is used to determine the elastic properties from measurements of P-wave velocities. The results obtained show the influence of porosity and degree of water saturation on the effective properties. The various predictions of Morie Tanaka model are then compared with experimental results for the elastic and acoustic properties of calcarenite.

关键词： Calcarenite Porous media Homogenization Morie Tanaka model Porosity Elastic properties Acoustic properties Degree of water saturation

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Impacts of anisotropy coefficient and porosity on the thermal conductivity and P-wave velocity of calcarenites used as building materials of historical monuments in Morocco

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1687-1699页

作者： abdelaali Rahmouni Abderrahim Boulanouar Younes El Rhaffari Mohammed Hraita Aziz Zaroual Yves Géraud Jamal Sebbani Abdellah Rezzouk Bassem S.Nabawy Laboratory of Solid State Physics Department of PhysicsFaculty of Science Dhar El MahrazSidi Mohamed Ben Abdellah UniversityFezMorocco Laboratory of Applied Sciences National School of Applied SciencesAbdelmalek Essaadi UniversityAl HoceimaMorocco Laboratory of Civil Engineering and Environment Higher School of Technology of SaléMohammed V UniversityRabatMorocco Department of Physics Higher Normal SchoolMohammed V UniversityRabatMorocco Laboratory of Materials Nanotechnologies and EnvironmentFaculty of ScienceMohammed V UniversityRabatMorocco University of Lorraine ENSGUMR 7359-GeoRessourcesNancyFrance Mechanics and Materials Team Faculty of ScienceMohammed V UniversityRabatMorocco Geophysical Sciences Department National Research CentreCairoEgypt

It is essential to study the porosity,thermal conductivity,and P-wave velocity of calcarenites,as well as the anisotropy coefficients of the thermal conductivity and P-wave velocity,for civil engineering,and conservation and restoration of historical *** study focuses on measuring the thermal conductivity using the thermal conductivity scanning(TCS)technique and measuring the P-wave ve-locity using portable *** was applied for some dry and saturated calcarenite samples in the horizontal and vertical directions(parallel and perpendicular to the bedding plane,respectively).The calcarenites were selected from some historical monuments in *** physical properties were measured in the laboratory to find a reliable relationship between all of these *** a result of the statistical analysis of the obtained data,excellent linear relationships were observed between the porosity and both the thermal conductivity and *** relationships are characterized by relatively high coefficients of determination for the horizontal and vertical *** on the thermal conductivity and P-wave velocity values in these two directions,the anisotropy coefficients of these two properties were *** internal structure and the pore fabric of the calcarenite samples were delineated using scanning electron microscopy(SEM),while their chemical and mineral compositions were studied using the energy dispersive X-ray analysis(EDXA)and X-ray diffraction(XRD)techniques.

关键词： Moroccan historical monuments Calcarenite Thermal conductivity P-wave velocity Porosity Anisotropy coefficient Water saturation

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Electrical Analysis of Indium Deep Levels Effects on Kink Phenomena of Silicon NMOSFETs

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World Journal of Nano Science and Engineering 2014年第1期4卷 7-15页

作者： abdelaali Fargi Neila Hizem Adel Kalboussi Abdelkader Souifi Department of Physics Faculty of Sciences of Monastir Monastir Tunisia

Several methods of characterization of trap levels like I-V, C-V and transient spectroscopy (DLTS) were used to determine the accurate values of the activation energies of traps present in N+P junctions obtained after retrograde profile implantation of indium and boron on silicon. Four main traps located at Ev + 0.15 eV, Ev + 0.21 eV, Ev + 0.28 eV and Ev + 0.46 eV are reported. Shallow levels are also calculated from I-V characteristics. Concurrently, indium channel doped NMOSFETs are investigated showing the kink phenomenon. In order to discuss the relationship between the kink effect and the active indium trap level situated at 0.16 eV, the transient effects are studied by varying the integration time and the temperature. The effects of substrate polarization are also carried out showing the reduction of the kink with the bulk positive polarization.

关键词： Electrical Characterization MOSFET Indium Deep Traps Kink Effect Impact Ionization

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Identification of Hammerstein-Wiener model with discontinuous input nonlinearity

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Science China(Information Sciences) 2023年第12期66卷 33-47页

作者： A.BROURI F.Z.EL MANSOURI F.Z.CHAOUI C.abdelaali F.GIRI ENSAM Moulay Ismail University ENSAM University Mohammed V Normandie Universite

This paper deals with the identification of Hammerstein-Wiener models with an irregular function in the input block. These models comprise a set of linear segments. The linear time invariant(LTI) block may be parametric or nonparametric. The nonlinearity of the output can be any continuous function of arbitrary shape; it is not necessarily assumed to be invertible. Subsequently, sine inputs will be used to identify the system parameters. First, the output nonlinearity is determined by filtering the system output and varying the phase of a given reference sine signal; second, the parameters of the linear block can be determined for any frequency; and finally, the input nonlinearity can be obtained by changing the offset and amplitude of the input sine signal.

关键词： nonlinear systems nonlinear systems identification Hammerstein-Wiener models discontinuous nonlinearities hard nonlinearities

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Determination of Thermal Conductivity and Porosity of Building Stone from Ultrasonic Velocity Measurements

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Geomaterials 2013年第4期3卷 138-144页

作者： Abderrahim Boulanouar abdelaali Rahmouni Mohamed Boukalouch Abderrahim Samaouali Yves Géraud Mimoun Harnafi Jamal Sebbani Department of Earth Science Scientific Institute Mohamed V University Rabat Morocco Laboratory of Thermodynamics Department of Physics Faculty of Science Mohammed V University Rabat Morocco University of Strasbourg EOST Institute of Global Physics Strasbourg France

Ultrasonic velocity measurement, a non-destructive and easy method to apply in both field and laboratory conditions, has increasingly been conducted to determine the physical properties of rock materials. This paper presents an experimental study of the measurement of P-wave velocity, thermal conductivity and porosity of several types of sedimentary, metamorphic, and magmatic rocks. The aim of this study is to predict the rocks properties including their thermal conductivity and porosity using P-wave velocity. For this purpose, the physical properties are determined in the laboratory to obtain correlations between P-wave velocity and physical properties. Consequently, good linear relationships are found between all the determined physical properties and the P-wave velocity measurements.

关键词： Building Stone Thermal Conductivity P-Wave Velocity Porosity Optical Scanning

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Prediction of Porosity and Density of Calcarenite Rocks from P-Wave Velocity Measurements

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International Journal of Geosciences 2013年第9期4卷 1292-1299页

作者： abdelaali Rahmouni Abderrahim Boulanouar Mohamed Boukalouch Yves Géraud Abderrahim Samaouali Mimoun Harnafi Jamal Sebbani Department of Earth Science Scientific Institute Mohamed V University Rabat Morocco Laboratory of Thermodynamics Department of Physics Faculty of Science Mohammed V University Rabat Morocco University of Strasbourg EOST Institute of Global Physics Strasbourg Cedex France

Petrophysical proprieties such as porosity, density, permeability and saturation have a marked impact on acoustic proprieties of rocks. Hence, there has been recently a strong incentive to use new geophysical techniques to invert such properties from seismic or sonic measurements for rocks characterization. The P-wave velocity, which is non-destructtive and easy method to apply in both field and laboratory conditions, has increasingly been conducted to determine the geotechnical properties of rock materials. The P-wave velocity of a rock is closely related to the intact rock properties, and been measuring the velocity in rock masses describes the rock structure and texture. The present work deals with the use of a simple and non-destructive technique, ultrasonic velocity, to predict the porosity and density of calcarenite rocks that are characteristic in historical monument. The ultrasonic test is based on measuring the propagation time of a P-wave in the longitudinal direction. Good correlations between P-wave velocity, porosity and density were found, which indicated them as an appropriate technique for estimating the porosity and density.

关键词： Calcarenite Rocks Porosity Density P-Wave Velocity Regression Analysis T Student

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Spatial variation of coda wave attenuation using aftershocks of the Al Hoceima earthquake of 24 February, 2004, Morocco

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Natural Science 2013年第8期5卷 72-77页

作者： Abderrahim Boulanouar Lahcen El Moudnib Mimoun Harnafi Taj-Eddine Cherkaoui abdelaali Rahmouni Mohamed Boukalouch Jamal Sebbani Earth Science Department Scientific Institute Mohammed V University-Agdal Rabat Morocco Physics Department Faculty of Science Mohammed V University-Agdal Rabat Morocco Physics Department Faculty of Science Mohammed V University-Agdal Rabat Morocco Earth Science Department Scientific Institute Mohammed V University-Agdal Rabat Morocco

On 24th February 2004 a significant earthquake (Md = 6.4) occurred in the north of Moroccocausing great damage in the vicinity of Al Hoceima region. This area is characterized by a complex faulting system as a result of compressional tectonic forces. Three short period seismic stations are set in this area of interest and recordings from these stations were used in this study. In order to complete our knowledge of attenuation, 60 local earthquakes are recorded a few days after the great earthquake with magnitude Ml 2.6 - 5.0 to estimate seismic attenuation. For this purpose, we applied the single backscattering model of Aki & Chouet 1975 inthe frequency range for 1 to 8 Hz. The study of coda waves was limited to a relatively short lapse time (20 Seconds) in order to sample the earth’s crust only. The values of Qc estimated for all the three stations show a strong frequency dependent relationship of the form Qc = Q0fn, where Q0 is Qc at 1 Hz , and n represents the degree of frequency dependence, and reflects the level of crustal heterogeneities to varying degrees. The average frequency dependent attenuation relationship has been obtained which indicates that the attenuation is high in this region. Finally to conclude our work, the values of Q0 suggest that Al Hoceima area is highly heterogeneous and the n parameter indicates a meaning frequency dependence of Qc.

关键词： Attenuation Coda Waves Single Backscattering Model Al Hoceima Morocco Seismic Earthquake

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