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Aetiology and risk factors of ischaemic cholangiopathy after liver transplantation

World Journal of Gastroenterology 2014年第20期20卷 6159-6169页

作者： Moustafa Mabrouk mourad Abdullah Algarni Christos Liossis Simon R Bramhall Liver Unit Queen Elizabeth Hospital Birmingham B15 2TH United Kingdom

Liver transplantation (LT) is the best treatment for end-stage hepatic failure, with an excellent survival rates over the last decade. Biliary complications after LT pose a major challenge especially with the increasing number of procured organs after circulatory death. ischaemic cholangiopathy (iC) is a set of disorders characterized by multiple diffuse strictures affecting the graft biliary system in the absence of hepatic artery thrombosis or stenosis. it commonly presents with cholestasis and cholangitis resulting in higher readmission rates, longer length of stay, repeated therapeutic interventions, and eventually re-transplantation with consequent effects on the patient’s quality of life and increased health care costs. The pathogenesis of iC is unclear and exhibits a higher prevalence with prolonged ischaemia time, donation after circulatory death (dCd), rejection, and cytomegalovirus infection. The majority of iC occurs within 12 mo after LT. Prolonged warm ischaemic times predispose to a profound injury with a subsequently higher prevalence of iC. Biliary complications and iC rates are between 16% and 29% in dCd grafts compared to between 3% and 17% in donation after brain death (dBd) grafts. The majority of ischaemic biliary lesions occur within 30 d in dCd compared to 90 d in dBd grafts following transplantation. However, there are many other risk factors for iC that should be considered. The benefits of dCd in expanding the donor pool are hindered by the higher incidence of iC with increased rates of re-transplantation. Careful donor selection and procurement might help to optimize the utilization of dCd grafts.

关键词： ischaemic cholangiopathy Biliary complications Orthotopic liver transplantation donation after circulatory death Reperfusion injury Cold ischaemia time

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Oil-source correlation and Paleozoic source rock analysis in the Siwa Basin,Western desert:insights from well-logs,Rock-Eval pyrolysis,and biomarker data

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Energy Geoscience 2024年第3期5卷 313-327页

作者： Moham.d i.abdel-Fattah Moham.d Reda Moham.d Fathy diaa A.Saadawi Fahad Alshehri Moham.d S.Ahmed Petroleum Geosciences and Remote Sensing Program Department of Applied Physics and AstronomyCollege of SciencesUniversity of SharjahSharjah27272United Arab Emirates Geology department Faculty of ScienceSuez Canal UniversityIsmailiaEgypt Faculty of Science Geology DepartmentAl-Azhar UniversityP.O.Box 11884Nasr CityCairoEgypt Abdullah Alrushaid Chair for Earth Science Remote Sensing Research Geology and Geophysics DepartmentCollege of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Understanding the origins of potential source rocks and unraveling the intricate connections between reservoir oils and their source formations in the Siwa Basin(Western desert,Egypt)necessitate a thorough oil-source correlation *** objective is achieved through a meticulous analysis of well-log responses,Rock-Eval pyrolysis,and biomarker *** analysis of Total Organic Carbon across 31 samples representing Paleozoic formations in the Siwa A-1X well reveals a spectrum of organic richness ranging from 0.17 wt%to 2.04 wt%,thereby highlighting diverse levels of organic content and the presence of both Type ii and Type iii *** of the fingerprint characteristics of eight samples from the well suggests that the dhiffah Formation comprises a blend of terrestrial and marine organic ***,a significant contribution from more oxidized residual organic matter and gas-prone Type iii kerogen is ***,the desouky and Zeitoun formations exhibit mixed organic matter indicative of a transitional environment,and thus featuring a pronounced marine influence within a more reducing setting,which is associated with Type ii *** analysis of five oil samples from different wells—SiWA L-1X,SiWA R-3X,SiWA d-1X,PTAH 5X,and PTAH 6X,it is evident that terrestrial organic matter,augmented by considerable marine input,was deposited in an oxidizing environment,and contains Type iii *** scrutiny confirms the coexistence of mixed terrestrial organic matter within varying redox *** is the uniformity of identified kerogen Types ii and iii across all samples,known to have potential for hydrocarbon *** discovery presented in this paper unveils captivating prospects concerning the genesis of oil in the Jurassic Safa reservoir,suggesting potential links to Paleozoic sources or even originating from the Safa Member *** revelations mark a substantial advancement in understanding source

关键词： Biomarker data Oil-source correlation Rock-Eval pyrolysis Source rocks Siwa Basin

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dirac operator on the sphere with attached wires

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Chinese Physics B 2016年第4期25卷 335-338页

作者： E N Grishanov d A Eremin d A ivanov i Yu Popov Ogarev Mordovia State University Bolshevistskaya Str. 68 Saransk Russia iTMO University Kroverkskiy pr. 49 St. Petersburg 197101 Russia

An explicitly solvable model for tunnelling of relativistic spinless particles through a sphere is suggested. The model operator is constructed by an operator extensions theory method from the orthogonal sum of the dirac operators on a semi- axis and on the sphere. The transmission coefficient is obtained. The dependence of the transmission coefficient on the particle energy has a resonant character. One observes pairs of the Breit-Wigner and the Fano resonances. it correlates with the corresponding results for a non-relativistic particle.

关键词： dirac operator nanostructure tunnelling solvable model

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A diRECT SEARCH FRAME-BASEd CONJUGATE GRAdiENTS METHOd

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Journal of Computational Mathematics 2004年第4期22卷 489-500页

作者： i.d.Coope C.J.Price departmentofMathematicsandStatistics UniversityofCanterburyPrivateBag4800ChristchurchNewZealand

A derivative-free frame-based conjugate gradients algorithm is presented. Convergence is shown for C^1 functions, and this is verified in numerical trials. The algorithm is tested on a variety of low dimensional problems, some of which are ill-conditioned, and is also tested on problems of high dimension. Numerical results show that the algorithm is effective on both classes of problems. The results are compared with those from a discrete quasiNewton method, showing that the conjugate gradients algorithm is competitive. The algorithm exhibits the conjugate gradients speed-up on problems for which the Hessian at the solution has repeated or clustered eigenvalues. The algorithm is easily parallelizable.

关键词： Conjugate gradients derivative-free Frame-based methods Numerical results

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Evaluation of redox-sensitive metals in marine surface sediments influenced by the oxygen minimum zone of the Humboldt Current System, Northern Chile

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international Journal of Sediment Research 2019年第2期34卷 178-190页

作者： Alexis Castillo Jorge Valdés abdel Sifeddine Sue-Ellen Vega Javier díaz-Ochoa Yery Marambio Phd Program in Applied Sciences Mention Marine Coastal Systems Faculty of Marine Sciences and Biological Resources University of Antofagasta Laboratory of Sedimentology and Palaeoenvironments Alexander von Humboldt InstituteFaculty of Marine Sciences and Biological Resources University of Antofagasta international Joint Laboratory PALEOTRACES (Research institute for development Federal Fluminense University University of Antofagasta Peruvian University Cayetano Heredia) Network for Extreme Environments Research (University of Antofagasta University of the Frontera University of Magallanes) department of Geochemistry Federal Fluminense University iRd-Sorbonne University (UPMC CNRS-MNHN) department of Sciences and Natural Resources Faculty of SciencesUniversity of Magallanes

Upwelling coastal systems can be used to understand how dissolved oxygen and biological productivity control the accumulation of redox-sensitive metals in marine *** aluminium(Al),cadmium(Cd),iron(Fe),nickel(Ni),molybdenum(Mo),vanadium(V),total organic carbon(TOC),total nitrogen(TN)and total sulfur(TS)contents in surficial sediment collected from different water depths(30,70,and 120 m)in three northern Chilean bays influenced by coastal upwelling and oxygen minimum zones(OMZs)were *** component analysis(PCA),cluster analysis,and Spearman’s rank correlation were used to identify the mechanisms responsible for the redox-sensitive metal *** content of redox-sensitive metals and organic components in sediment increased with increasing water column depth,whereas lithogenic metals *** the Mejillones del Sur and Caldera bays,the enrichment factors of the redox-sensitive metals showed enrichment for all metals with *** Cd and V enrichments are mainly the product of biogenic flow to the seabed,and the Mo and Ni enrichments are due to preservation under low subsurface oxygen *** reduction is not an important mechanism in the accumulation of redox-sensitive metals in the sediment of the three *** PCA showed that the behaviors of the redox-sensitive metals and organic components reflect differences in the effects of the OMZ in sediment along the coast of northern Chile,with a more intense OMZ in Mejillones del Sur bay and weaker OMZs in Caldera and inglesa ***,the high degree of enrichment in redox-sensitive metals in Caldera Bay can be attributed to the intense activity of the mining industry near the bay,a situation that produces geochemical behavior similar to that observed in Mejillones del Sur Bay.

关键词： Redox sensitive-metals Atacama desert Enrichment factor Mejillones del Sur Bay Caldera Bay system PCA

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Composition and antimicrobial activity of Cistus munbyi essential oil: an endemic plant from Algeria

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Journal of Forestry Research 2017年第6期28卷 1127-1132页

作者： Fethi Benbelaid abdelmounaim Khadir mourad Bendahou Moham.d Amine Abdoune Alain Muselli Jean Costa Laboratory of Applied Microbiology in Food Biomedical and Environment Aboubekr Belkad UniversityP.O. Box 119 13000 Tlemcen Algeria department of Biology University of Oran 1 Ahmed Ben Bella Es Senia Oran Algeria Laboratory of Natural Products Chemistry University of Corsica UMR CNRS 6134 Campus Grimaldi BP 5220250 Corte France department of Biology Faculty of Sciences of Nature LifeEarth and Universe Aboubekr Belkad UniversityP.O. Box 119 13000 Tlemcen Algeria

The chemical composition and antimicrobial potential of Cistus munbyi essential oil were studied for the first time. GC and GC–MS analysis revealed 48 compounds representing 96.98% of the oil. Terpinen-4-ol(23.75%), meta-Cymene(17.30%), and Sabinene(12.38%)were the major constituents. Antimicrobial activity was evaluated against nine pathogens using the disc diffusion and broth micro-dilution methods. Results show that *** essential oil possesses strong antimicrobial activity against all strains, regardless if Gram-positive or Gramnegative bacteria, or yeast, with MiCs values not exceeding10(mg/ml). in addition to its efficacy, C. munbyi essential oil has an unusual antimicrobial potency which is attributed to its specific chemical composition. Thus, findings presented here suggest that endemic C. munbyi contains a very interesting essential oil that may be valuable in several areas.

关键词： Antimicrobial activity Chemical composition Cistus munbyi Essential oil

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Three-dimensional Meshfree Analysis of interlocking Concrete Blocks for Step Seawall Structure

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Computers, Materials & Continua 2021年第1期66卷 165-178页

作者： Hau Nguyen-Ngoc HNguyen-Xuan Magd abdel-Wahab Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 903B-9052ZwijnaardeBelgium University of Science and Technology The University of DanangDa Nang CityVietnam CiRTech institute Ho Chi Minh City University of TechnologyHo Chi Minh CityVietnam division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam

This study adapts the flexible characteristic of meshfree method in analyzing three-dimensional(3d)complex geometry structures,which are the interlocking concrete blocks of step *** elastostatic behavior of the block is analysed by solving the Galerkin weak form formulation over local support *** 3d moving least square(MLS)approximation is applied to build the interpolation functions of *** pre-defined number of nodes in an integration domain ranging from 10 to 60 nodes is also investigated for their effect on the studied *** accuracy and efficiency of the studied method on 3d elastostatic responses are validated through the comparison with the solutions of standard finite element method(FEM)using linear shape functions on tetrahedral elements and the well-known commercial software,*** results show that elastostatic responses of studied concrete block obtained by meshfree method converge faster and are more accurate than those of standard *** studied meshfree method is effective in the analysis of static responses of complex geometry *** amount of discretised nodes within the integration domain used in building MLS shape functions should be in the range from 30 to 60 nodes and should not be less than 20 nodes.

关键词： Meshfree method local support domain moving least square shape function 3d elastostatic behavior complex geometry

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Efficiency and degradation products elucidation of the photodegradation of mefenpyrdiethyl in water interface using TiO_2 P-25 and Hombikat UV100

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Journal of Environmental Sciences 2012年第9期24卷 1686-1693页

作者： Amina Chnirheb mourad Harir Basem Kanawati Mohammed El Azzouzi istvan Gebefgi Philippe Schmitt-Kopplin department of BioGeoChemistry and Analytik German Research Center for Environmental HealthHelmholtz Center MunichIngoldstdter Landstraβe 1D-85764 NeuherbergGermany University Mohammed V-Agdal Faculty of SciencesAvenue Ibn BatoutaBP 1014 RabatMorocco. Lehrstuhl fr Chemische-Technische Analyse und Chemische Lebensmitteltechnologie Technische Universitt MuenchenWeihenstephaner Steig 2385354 Freising-WeihenstephanGermany

The photodegradation of mefenpyrdiethyl （MFd）, an herbicide safener, was investigated in aqueous suspensions by using degussa P-25 and Hombikat UV100 titanium oxide under simulated sunlight irradiation. The effects of initial concentration of the herbicide, pH, catalysts and hydrogen peroxide doses as well as their combinations were studied and optimized. Accordingly, the kinetic parameters were determined and the effectiveness of the processes was assessed by calculating the rate constants. A pseudo first-order kinetics was observed. Under experimental conditions, the degradation rate constants were strongly influenced using P-25 and no noticeable effect was observed for Hombikat UV100. dFT calculations with B3LYP/6-311＋G（2d,p）//B3LYP/6-31＋G（d,p） level of theory were performed to check whether significant conformational changes occur when the charge state of the MFd substrate changes and whether these changes could play a role in the dependency of photodegradation rate constant on the studied pH. High resolution mass spectrometry （FT-iCR/MS） was implemented to identify the main degradation products.

关键词： photodegradation mefenpyrdiethyl P-25/Hombikat UV100 kinetic degradation products

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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George d.Bittner dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

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