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Neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-Lagarde Narimène Asbelaoui abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

Synthesis and characterization of poly(2,5-diyl pyrrole-2-pyrrolyl methine)semiconductor copolymer

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Journal of Semiconductors 2018年第10期39卷 10-16页

作者： hammou Gherras Ahmed Yahiaoui Aicha Hachemaoui abdelkader Belfedal abdelkader dehbi abdel-ham.d i.mourad Laboratoire de chimie Organique Macromoleculaire et des Materiaux(LCOMM)Universite de MascaraFaculte des Sciences ExactesBP 763 Mascara 29000Algeria Laboratoire de Chimie Physique des Macromolecules et interfaces Biologiques Universite de Mascara Algeria Laboratoire de Genie Physique Universite d'Ibn KhaldounTiaret BP 78 14000 TiaretAlgeria Mechanical Engineering department College of EngineeringUnited Arab Emirates UniversityAl-AinUAE On leave from Mechanical design department Faculty of EngineeringHelwan UniversityCairoEgypt

The proposed technique to synthesise poly {（2,5-diyl pyrrole）（2-pyrrolyl methine）}（PPPM） copolymer by condensation of pyrrole and pyrrole-2-carboxaldehyde monomers catalyzed by Maghnite-H＋ is *** protons are exchanged with Maghnite-H＋, which is available in the form of a montmorillonite silicate clay sheet. The effect of several parameters such as time and temperature of copolymerization, [pyrrole]/[pyrrole-2-carboxaldehyde] molar ratio, amount of Maghnite-H＋, and solvent on the produced poly（2,5-diyl pyrrole-2-pyrrolyl methine） semiconductor copolymer material（yield%） was investigated. The synthesized PPPM copolymer was characterized using nuclear magnetic resonance, Fourier transform infrared, and ultraviolet-visible *** results show that the synthesized copolymer using the copolymerization technique is a real organic copolymer consisting of two monomers units（i.e, pyrrole and pyrrole-2-carboxaldehyde）. Also, the synthesized copolymer is more soluble than polypyrrole in most of the commonly used organic solvents. Hence, copolymerization of pyrrole with pyrrole-2-carboxaldehyde will overcome the insolubility of polypyrrole. in addition, the resultant copolymer exhibits good film formability. The produced copolymer has several potential applications in the field of rechargeable batteries, sensors, capacitors, light emitting diodes, optical displays, and solar cells.

关键词： proposed technique Maghnite-H^+ catalyst conducting PPPM copolymer pyrrole pyrrole-2-carboxaldehyde

Self-phase modulation via similariton solutions of the perturbed NLSE Modulation instability and induced self-steepening

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Communications in Theoretical Physics 2022年第8期74卷 41-50页

作者： H i abdel-Gawad department of Mathematics Faculty of Science Cairo University Egypt

The perturbed nonlinear Schrodinger equation(PNLSE)describes the pulse propagation in optical fibers,which results from the interaction of the higher-order dispersion effect,self-steepening(SS)and self-phase modulation(SPM).The challenge between these aforementioned phenomena may lead to a dominant one among *** is worth noticing that the study of modulation instability(Mi)leads to the inspection of dominant phenomena(dPh).indeed,the Mi triggers when the coefficient of dPh exceeds a critical value and it may occur that the interaction leads to wave *** PNLSE is currently studied in the literature,mainly on finding traveling wave ***,we are concerned with analyzing the similarity solutions of the *** exact solutions are obtained via introducing similarity transformations and by using the extended unified *** solutions are evaluated numerically and they are shown *** is observed that the intensity of the pulses exhibits self steepening which progresses to shock soliton in ultrashort time(or near t=0).Also,it is found that the real part of the solution exhibits self-phase modulation in *** study of(Mi)determines the critical value for the coefficients of SS,SPM,or high dispersivity to occur.

关键词： Perturbed NLSE steepening self–phase modulation extended unified method

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Rapid Magnetic 3d Printing of Cellular Structures with MCF-7 Cell inks

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Research 2019年第1期2019卷 1183-1195页

作者： S.Mishriki A.R.abdel Fattah T.Kammann R.P.Sahu F.Geng i.K.Puri School of Biomedical Engineering McMaster UniversityHamiltonOntarioCanada department of Mechanical Engineering McMaster UniversityHamiltonOntarioCanada Faculty of Biological Sciences Friedrich-Schiller-University JenaGermany

A contactless label-free method using a diamagnetophoretic ink to rapidly print three-dimensional(3d)scafold-free multicellular structures is *** inks consist of MCF-7 cells that are suspended in a culture medium to which a paramagnetic salt,diethylenetriaminepentaacetic acid gadolinium(iii)dihydrogen salt hydrate(Gd-dTPA),is *** a magnetic feld is applied,the host fuid containing the paramagnetic salt is attracted towards regions of high magnetic feld gradient,displacing the ink towards regions with a low *** this method,3d structures are printed on ultra-low attachment(ULA)*** a tissue culture treated(TCT)surface,a 3d printed spheroid coexists with a two-dimensional(2d)cell monolayer,where the composite is termed as a 2.5d *** 3d structures can be magnetically printed within 6 hours in a medium containing 25 mM *** infuence of the paramagnetic salt on MCF-7 cell viability,cell morphology,and ability of cells to adhere to each other to stabilize the printed structures on both ULA and TCT surfaces is *** expressions of hypoxia-inducible factor 1-alpha(HiF1�)and vascular endothelial growth factor(VEGF)allow comparison of the relative stresses for the printed 3d and 2.5d cell geometries with those for 3d spheroids formed without magnetic *** magnetic printing method can be potentially scaled to a higher throughput to rapidly print cells into 3d heterogeneous cell structures with variable geometries with repeatable dimensions for applications such as tissue engineering and tumour formation for drug discovery.

关键词： structure culture dimensions

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico i.Bohnen department of Radiology University of MichiganAnn ArborMIUSA department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s disease Research University of MichiganAnn ArborMIUSA institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

Pedestrian Height Estimation and 3d Reconstruction Using Pixel-resolution Mapping Method Without Special Patterns

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international Journal of Automation and computing 2019年第4期16卷 449-461页

作者： Bing-Xing Wu Suat Utku Ay Ahmed abdel-Rahim department of Electrical and Computer Engineering University of Idaho Moscow 83844-1023 USA department of Civil Engineering University of Idaho Moscow 83844-1022 USA

Extracting the three-dimensional (3d) information including location and height of a pedestrian is important for vision-based intelligent traffic monitoring systems. This paper tackles the relationship between pixels′ actual size and pixels′ spatial resolution through a new method named pixel-resolution mapping (P-RM). The proposed P-RM method derives the equations for pixels′ spatial resolutions (XY-direction) and object′s height (Z-direction) in the real world, while introducing new tilt angle and mounting height calibration methods that do not require special calibration patterns placed in the real world. Both controlled laboratory and actual world experiments were performed and reported. The tests on 3d mensuration using proposed P-RM method showed overall better than 98.7% accuracy in laboratory environments and better than 96% accuracy in real world pedestrian height estimations. The 3d reconstructed images for measured points were also determined with the proposed P-RM method which shows that the proposed method provides a general algorithm for 3d information extraction.

关键词： Traffic monitoring application spatial resolution pixel-resolution mapping (P-RM) method 3d information pedestrian height estimation

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady international LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Privacy-preserved learning from non-i.i.d data in fog-assisted ioT:A federated learning approach

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digital Communications and Networks 2024年第2期10卷 404-415页

作者： Moham.d abdel-Basset Hossam Hawash Nour Moustafa imran Razzak Moham.d Abd Elfattah Faculty of Computers and informatics Zagazig UniversityZagazigSharqiyah44519Egypt School of Engineering and information Technology University of New South Wales@ADFACanberraACT2600Australia deakin University Geelong Waurn Ponds CampusAustralia Computer Science department Misr Higher Institute for Commerce and ComputersMansoura35511Egypt

With the prevalence of the internet of Things(ioT)systems,smart cities comprise complex networks,including sensors,actuators,appliances,and cyber *** complexity and heterogeneity of smart cities have become vulnerable to sophisticated cyber-attacks,especially privacy-related attacks such as inference and data poisoning *** Learning(FL)has been regarded as a hopeful method to enable distributed learning with privacypreserved intelligence in ioT *** though the significance of developing privacy-preserving FL has drawn as a great research interest,the current research only concentrates on FL with independent identically distributed(i.i.d)data and few studies have addressed the non-i.i.d *** is known to be vulnerable to Generative Adversarial Network(GAN)attacks,where an adversary can presume to act as a contributor participating in the training process to acquire the private data of other *** paper proposes an innovative Privacy Protection-based Federated deep Learning(PP-FdL)framework,which accomplishes data protection against privacy-related GAN attacks,along with high classification rates from non-i.i.d ***-FdL is designed to enable fog nodes to cooperate to train the FdL model in a way that ensures contributors have no access to the data of each other,where class probabilities are protected utilizing a private identifier generated for each *** PP-FdL framework is evaluated for image classification using simple convolutional networks which are trained using MNiST and CiFAR-10 *** empirical results have revealed that PF-dFL can achieve data protection and the framework outperforms the other three state-of-the-art models with 3%–8%as accuracy improvements.

关键词： Privacy preservation Federated learning deep learning Fog computing Smart cities