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Simultaneous nephrectomy during kidney transplantation for polycystic kidney disease does not detrimentally impact comorbidity and graft survival

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World Journal of Transplantation 2022年第5期12卷 100-111页

作者： Tom Darius Sébastien Bertoni Martine De Meyer Antoine Buemi Arnaud Devresse Nada Kanaan Eric Goffin Michel mourad Surgical and Abdominal Transplantation Unit University Clinics Saint LucBrussels 1200Belgium Division of Nephrology University Clinics Saint LucBrussels 1200Belgium

BACKGROUND The lack of space,as an indication for a native unilateral nephrectomy for positioning a future kidney graft in the absence of other autosomal dominant polycystic kidney disease-related symptoms,remains *** To evaluate the surgical comorbidity and the impact on graft survival of an associated ipsilateral native nephrectomy during isolated kidney transplantation in patients with autosomal dominant polycystic kidney *** One hundred and fifty-four kidney transplantations performed between January 2007 and January 2019 of which 77 without(kidney transplant alone(KTA)group)and 77 with associated ipsilateral nephrectomy(KTIN group),were retrospectively *** and surgical variables were analyzed and their respective impact on surgical comorbidity and graft *** Creation of space for future graft positioning was the main reason(n=74,96.1%)for associated ipsilateral *** significant difference in surgical comorbidity(lymphocele,wound infection,incisional hernia,wound hematoma,urinary infection,need for blood transfusion,hospitalization stay,Dindo Clavien classification and readmission rate)was observed between the two study *** incidence of primary nonfunction and delayed graft function was comparable in both groups[0%and 2.6%(P=0.497)and 9.1%and 16.9%(P=0.230),respectively,in the KTA and KTIN group].The 1-and 5-year graft survival were 94.8%and 90.3%,and 100%and 93.8%,respectively,in the KTA and KTIN group(P=0.774).The 1-and 5-year patient survival were 96.1%and 92.9%,and 100%and 100%,respectively,in the KTA and KTIN group(P=0.168).CONCLUSION Simultaneous ipsilateral native nephrectomy to create space for graft positioning during kidney transplantation in patients with autosomal dominant polycystic kidney disease does not negatively impact surgical comorbidity and short-and long-term graft survival.

关键词： Autosomal dominant polycystic kidney disease Complications Kidney transplantation Graft survival Unilateral nephrectomy Surgical comorbidity

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The pulse vaccination effects in mammary carcinoma

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International Journal of Biomathematics 2017年第3期10卷 103-123页

作者： Chahinez Aboura Tarik Mohamed Touaoula mourad Aribi Laboratoire d'Analyse Non Lineaire et Mathematiques Appliqudes University of Abou Bekr Belkaid Tlemcen 13000 Algeria Department of Mathematics University of Abou Bekr Belkaid Tlemcen 13000 Algeria Department of Biology and Immunology University of Abou Bekr Belkaid Tlemcen 13000 Algeria

Induction of antitumor immunity by vaccination is one of the major current immunotherapy strategies. We present a mathematical model of the competition between immune cells and mammary carcinogenesis under the effect of Triplex vaccine. The model describes both humoral and cell-mediated immune responses against cancer cells. The control of the cancer cells growth occurs through the application of the pulse vaccination. Here we determine the relationship between the strength of the vaccine and the time required to eradicate cancer cells, and we present some simulations to illustrate our theoretical results, namely, the total cancer cells depletion, which is influenced by competition occurs among the immune and cancer cells.

关键词： Global stability periodic solution impulsive differential equations mammary carcinoma tumor-immune interaction

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Decentralized Networked Control System Design Using Takagi-Sugeno(TS) Fuzzy Approach

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International Journal of Automation and computing 2015年第2期12卷 125-133页

作者： Chedia Latrach mourad Kchaou abdelhamid Rabhi Ahmed El Hajjaji Laboratory of Modelisation Information and SystemUniversity of Picardie Jules Verne Electrical Engineering Department National Engineering School of SfaxUniversity of Sfax

This paper proposes a new method for control of continuous large-scale systems where the measures and control functions are distributed on calculating members which can be shared with other applications and connected to digital network *** first, the nonlinear large-scale system is described by a Takagi-Sugeno(TS) fuzzy model. After that, by using a fuzzy LyapunovKrasovskii functional, sufficient conditions of asymptotic stability of the behavior of the decentralized networked control system(DNCS),are developed in terms of linear matrix inequalities(LMIs). Finally, to illustrate the proposed approach, a numerical example and simulation results are presented.

关键词： Continuous large-scale systems decentralized static output feedback fuzzy control networked control systems(NCS) Takagi-Sugeno(T

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Prevalence and Predictive Factors of Severe Coronary Lesions in Algerian Patients Undergoing Coronary Angiography

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Open Journal of Pathology 2023年第4期13卷 184-194页

作者： mourad Boukheloua Mohamed Berrehal Aziza Baali Souad Chelghoum Djamaleddine Nibouche Service de Cardiologie Centre Hospitalier Universitaire Nafissa Hamoud Algiers Algeria Service de Cardiologie Centre Hospitalier Universitaire Sétif Algeria Service de Radiologie Centre Hospitalier Universitaire Nafissa Hamoud Algiers Algeria Service de Néphrologie Centre Hospitalier Universitaire Mustapha Bacha Algiers Algeria

Background: The severity of coronary lesions in patients with coronary artery disease (CAD) has important prognostic and therapeutic consequences. Clinical symptoms not always reflect the disease severity and this study aimed to evaluate coronary lesions in the Algerian population where these data are scarce. Methods: It was a prospective cross-sectional study conducted in consecutive patients with an age ≥20 years who underwent clinically-indicated coronary angiography in our center. The objective of the study was to determine the prevalence of severe coronary lesions assessed with the Gensini score. The predictive factors of severity were evaluated in a multivariate analysis. Results: A total of 507 patients were included (male, 79.7%;mean age, 58.8 years). Coronary angiography was prescribed most frequently for ST-segment elevation myocardial infarction (STMI) (46.9%) and non-STMI (38.1%). The prevalence of severe coronary lesions was 69.6% (95% CI 65.5 - 73.5). In multivariate analysis, the independent predictive factors of severe coronary lesions were male sex (odds ratio [OR] 2.00;p = 0.0141), diabetes (OR 1.92;p = 0.0070), left ventricular dysfunction (OR 1.81;p = 0.0059), age (OR 1.72;p = 0.0297) and no lipid-lowering treatment (OR, 0.47;p = 0.0388). Conclusions: Severe coronary lesions were present in two out three patients in this cohort of Algerian patients undergoing coronary angiography. Independent predictive factors of severe coronary lesions were male sex, diabetes, age, left ventricular dysfunction and no lipid-lowering treatment. It is important to identify these at-risk patients, as they should be explored at an asymptomatic stage before a cardiovascular event and receive prompt treatment with angioplasty or surgery.

关键词： Coronary Artery Disease Coronary Angiography Gensini Score Cardiovascular Risk Factors

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Cardiac stem cells: Current knowledge and future prospects

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World Journal of Stem Cells 2022年第1期14卷 1-40页

作者： Radwa A Mehanna Marwa M Essawy Mona A Barkat Ashraf K Awaad Eman H Thabet Heba A Hamed Hagar Elkafrawy Nehal A Khalil Abeer Sallam Marwa A Kholief Samar S Ibrahim Ghada M mourad Medical Physiology Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Oral Pathology Department Faculty of Dentistry/Center of Excellence for Research in Regenerative Medicine and ApplicationsFaculty of MedicineAlexandria UniversityAlexandria 21500Egypt Human Anatomy and Embryology Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Histology and Cell Biology Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Medical Biochemistry Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Forensic Medicine and Clinical toxicology Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt

Regenerative medicine is the field concerned with the repair and restoration of the integrity of damaged human tissues as well as whole *** the inception of the field several decades ago,regenerative medicine therapies,namely stem cells,have received significant attention in preclinical studies and clinical *** from their known potential for differentiation into the various body cells,stem cells enhance the organ's intrinsic regenerative capacity by altering its environment,whether by exogenous injection or introducing their products that modulate endogenous stem cell function and fate for the sake of ***,research in cardiology has highlighted the evidence for the existence of cardiac stem and progenitor cells(CSCs/CPCs).The global burden of cardiovascular diseases’morbidity and mortality has demanded an in-depth understanding of the biology of CSCs/CPCs aiming at improving the outcome for an innovative therapeutic *** review will discuss the nature of each of the CSCs/CPCs,their environment,their interplay with other cells,and their *** addition,important issues are tackled concerning the potency of CSCs/CPCs in relation to their secretome for mediating the ability to influence other ***,the review will throw the light on the clinical trials and the preclinical studies using CSCs/CPCs and combined therapy for cardiac ***,the novel role of nanotechnology in cardiac regeneration will be explored.

关键词： Cardiac stem and progenitor cells Cardiac stem cells’secretome Cardiac stem cells’niche and metabolism Nanotechnology Clinical trials Combined therapy

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Application of fuzzy logic control algorithm as stator power controller of a grid-connected doubly-fed induction generator

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Frontiers in Energy 2013年第1期7卷 49-55页

作者： Ridha CHEIKH Arezki MENACER Said DRID mourad TIAR LGEB Laboratory Department of Electrical Engineering Biskra University Biskra 07000 Algeria LSPIE Laboratory Department of Propulsion-Induction Electromagnetic Electrical Engineering University of Bama Batna 05000 Algeria

This paper discusses the power outputs control of a grid-connected doubly-fed induction generator （DFIG） for a wind power generation systems. The DFIG structure control has a six diode rectifier and a PWM IGBT converter in order to control the power outputs of the DFIG driven by wind turbine. So, to supply commercially the electrical power to the grid without any problems related to power quality, the active and reactive powers （Ps, Qs） at the stator side of the DFIG are strictly controlled at a required level, which, in this paper, is realized with an optimized fuzzy logic controller based on the grid flux oriented control, which gives an optimal operation of the DFIG in sub-synchronous region, and the control of the stator power flow with the possibility of keeping stator power factor at a unity.

关键词： doubly-fed induction generator (DFIG) vector control fuzzy logic controller optimization power factor unity active and reactive power

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Mixed Convection of Bingham Fluid in a Two Sided Lid-Driven Cavity Heated From Below

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Fluid Dynamics & Materials Processing 2019年第2期15卷 107-123页

作者： Toufik Benmalek Ferhat Souidi mourad Moderres Bilal Yassad Said Abboudi Laboratoire de mécanique des fluides théorique et appliqué USTHBB.P.32El-AliaBab-Ezzouar16111 AlgerAlgérie Laboratory of Industrial Fluids Measurements and Applications(FIMA)UDBKM44225Ain DeflaAlgeria Laboratoire M3MUTBM 90010 Belfort CedexFrance

This study aims to analyze mixed convection in a square cavity with two moving vertical walls by finite volume *** cavity filled with Non-Newtonian fluid of Bingham model is heated from below and cooled by the other *** study has been conducted for certain parameters of Reynolds number(Re=1-100),Richardson number(Ri=1-20),Prandtl number(Pr=1-500),and Bingham number has been studied from 0 to *** results indicate that the increase in yield stress drops the heat transfer and the flow become flatter,while increasing Reynolds number augments *** convective transport is dominant when increasing Richardson number which leads to enhance heat transfer in the cavity for both Newtonian and Non-Newtonian fluid.A correlation of Nusselt number is given in function of different parameters.

关键词： Mixed convection heat transfer Bingham fluid lid-driven cavity

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Efficiency and degradation products elucidation of the photodegradation of mefenpyrdiethyl in water interface using TiO_2 P-25 and Hombikat UV100

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Journal of Environmental Sciences 2012年第9期24卷 1686-1693页

作者： Amina Chnirheb mourad Harir Basem Kanawati Mohammed El Azzouzi Istvan Gebefgi Philippe Schmitt-Kopplin Department of BioGeoChemistry and Analytik German Research Center for Environmental HealthHelmholtz Center MunichIngoldstdter Landstraβe 1D-85764 NeuherbergGermany University Mohammed V-Agdal Faculty of SciencesAvenue Ibn BatoutaBP 1014 RabatMorocco. Lehrstuhl fr Chemische-Technische Analyse und Chemische Lebensmitteltechnologie Technische Universitt MuenchenWeihenstephaner Steig 2385354 Freising-WeihenstephanGermany

The photodegradation of mefenpyrdiethyl （MFD）, an herbicide safener, was investigated in aqueous suspensions by using Degussa P-25 and Hombikat UV100 titanium oxide under simulated sunlight irradiation. The effects of initial concentration of the herbicide, pH, catalysts and hydrogen peroxide doses as well as their combinations were studied and optimized. Accordingly, the kinetic parameters were determined and the effectiveness of the processes was assessed by calculating the rate constants. A pseudo first-order kinetics was observed. Under experimental conditions, the degradation rate constants were strongly influenced using P-25 and no noticeable effect was observed for Hombikat UV100. DFT calculations with B3LYP/6-311＋G（2d,p）//B3LYP/6-31＋G（d,p） level of theory were performed to check whether significant conformational changes occur when the charge state of the MFD substrate changes and whether these changes could play a role in the dependency of photodegradation rate constant on the studied pH. High resolution mass spectrometry （FT-ICR/MS） was implemented to identify the main degradation products.

关键词： photodegradation mefenpyrdiethyl P-25/Hombikat UV100 kinetic degradation products

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Physical modeling and visualization of soil liquefaction under high confining stress

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Earthquake Engineering and Engineering Vibration 2005年第1期4卷 47-57页

作者： Lenart González Tarek Abdoun mourad Zeghal Vivian Kallou Michael K.Sharp Dept.of Civil and Environmental Engineering Rensselaer Polytechnic Inst.(RPI)TroyNYUSA Mueser Rutledge Consulting Engineers 225 W 34th StreetNew YorkNYUSA US Army Engineer Research and Development Center VicksburgMSUSA

The mechanisms of seismically-induced liquefaction of granular soils underhigh confining stresses are still not fully *** of these mechanisms is generallybased on extrapolation of observed behavior at shallow *** centrifuge model tests wereconducted at RPI's experimental facility to investigate the effects of confining stresses on thedynamic response of a deep horizontal deposit of saturated *** was observed at highconfining stresses in each of the tests.A system identification procedure was used to estimate theassociated shear strain and stress time *** histories revealed a response marked byshear strength degradation and dilative *** recorded accelerations and pore pressures wereemployed to generate visual animations of the *** visualizations revealed a liquefactionfront traveling downward and leading to large shear strains and isolation of upper soil layers.

关键词： centrifuge modeling high confining stress liquefaction system identification visualization

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Composition and antimicrobial activity of Cistus munbyi essential oil: an endemic plant from Algeria

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Journal of Forestry Research 2017年第6期28卷 1127-1132页

作者： Fethi Benbelaid abdelmounaim Khadir mourad Bendahou Mohamed Amine Abdoune Alain Muselli Jean Costa Laboratory of Applied Microbiology in Food Biomedical and Environment Aboubekr Belkad UniversityP.O. Box 119 13000 Tlemcen Algeria Department of Biology University of Oran 1 Ahmed Ben Bella Es Senia Oran Algeria Laboratory of Natural Products Chemistry University of Corsica UMR CNRS 6134 Campus Grimaldi BP 5220250 Corte France Department of Biology Faculty of Sciences of Nature LifeEarth and Universe Aboubekr Belkad UniversityP.O. Box 119 13000 Tlemcen Algeria

The chemical composition and antimicrobial potential of Cistus munbyi essential oil were studied for the first time. GC and GC–MS analysis revealed 48 compounds representing 96.98% of the oil. Terpinen-4-ol(23.75%), meta-Cymene(17.30%), and Sabinene(12.38%)were the major constituents. Antimicrobial activity was evaluated against nine pathogens using the disc diffusion and broth micro-dilution methods. Results show that *** essential oil possesses strong antimicrobial activity against all strains, regardless if Gram-positive or Gramnegative bacteria, or yeast, with MICs values not exceeding10(mg/ml). In addition to its efficacy, C. munbyi essential oil has an unusual antimicrobial potency which is attributed to its specific chemical composition. Thus, findings presented here suggest that endemic C. munbyi contains a very interesting essential oil that may be valuable in several areas.

关键词： Antimicrobial activity Chemical composition Cistus munbyi Essential oil

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