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Feasibility of Upfront Debulking Surgery versus Neoadjuvant Chemotherapy Followed by Interval Debulking Surgery for Advanced Ovarian Cancer

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Journal of Cancer Therapy 2018年第2期9卷 145-155页

作者： Amen Hamdy Zaky Adel Gabr Doaa Wadie Maximous Ahmed A. S. Salem Amr Farouk mourad Haisam Atta Marwa ismail Medical Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Surgical Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Radiadiagnosis Department South Egypt Cancer Institute Assiut University Assiut Egypt Clinical Oncology Department Faculty of Medicine Assiut University Assiut Egypt

Background: Inappropriately ovarian cancer cannot be detected until an advanced stage. Radical debulking surgery is considered the cornerstone in the management of advanced ovarian cancer pointing to complete tumor resolution. Unless optimal debulking cannot be achieved, these patients gain little benefit from surgery. Neoadjuvant chemotherapy (NACT) has been recommended as a novel therapeutic modality to a diversity of malignant tumors when the disease is not willing to optimal surgical resection at the time of diagnosis or the patient who unfit for aggressive debulking surgery. The purpose of this study is to compare survival in the patient with advanced ovarian cancer (stage III/IV) underwent primary debulking surgery followed by adjuvant chemotherapy (PDS-ACTR) to those who received neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS). Results: Neoadjuvant chemotherapy (NACT-IDS) showed significant complete cytoreduction and decreased in surgical morbidity in comparison to primary debulking surgery (PDS-ACTR). NACT-IDS showed significant improvement in progression-free survival (P-value 0.002) and overall survival (P-value 0.03) in comparison to PDS-ACTR. Response to NACT and residual volume were the two independent prognostic factors for overall survival. Conclusion: NACT-IDS for advanced ovarian cancer (III/IV) resulted in higher frequency of complete resection with no residual tumor, less post-operative surgical morbidity and significant increase progression-free survival and overall survival. Both responses to NACT and residual tumor volume were the two independent prognostic factors for survival in ovarian cancer.

关键词： Advanced Ovarian Cancer Debulking Surgery Neoadjuvant Chemotherapy

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Exploration and Mapping of Metalliferous Black Shales in the Saghro Temporary Subsidence Zones (Anti-Atlas, Morocco)

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Open Journal of Geology 2023年第7期13卷 740-762页

作者： Ali Bouayachi Saida Alikouss Zouhir Baroudi Youssef Zerhouni Lahcen Rakhis Mohammed Zouhair Assia Idrissi mourad Essalhi Barzouk abdelhafed Department of Geology Faculty of Sciences Ben M’Sik University Hassan II Casablanca Morocco MANAGEM Group 191 bd Med Zerktouni Twin Center Tour A. 20100 Casablanca Morocco Department of Geology Faculty of Sciences University Mohamed V Rabat Morocco Faculty of Sciences and Techniques University Molay Ismail Errachidia Morocco Faculty of Sciences Semlalia Caddi Ayyad University Marrakech Morocco

The Saghro massif constitutes a vast metallogenic province with numerous deposits and shows of base metals (lead, zinc, copper) and precious metals (gold and silver), besides various useful substances (talc, pyrophyllite, barite, fluorite). Silver/lead occurrences are concentrated along the Cryogenian Imiter series and moderately at Boumalne and Sidi Flah. Copper occupies the plutonic intrusions and intrusive rocks of the East-Central Saghro while barite deposits are widespread throughout the Cambrian cover of the East Saghro in contact with the Ediacaran basement. To justify this distribution, the new contributions of the cartography and the organic geochemistry of the black shales of Jbel Saghro have clearly shown the particularity of the Imiter black shales in terms of the richness in organic matter (TOC = 0.18%), the blackish color and the friability. The Boumalne and Sidi Flah groups present some similarities with the Imiter group, such as the sub-equatorial structuring, the friable pelites and the richness in organic matter (Boumalne TOC = 0.11% and SidiFlah TOC = 0.16%), which is a quite good show that requires to reinforce the exploration works. For Western Saghro in the Iknioun and Qalaa’t M’Gouna groups, the variations in the thickness of the volcanic cover show an irregular paleotopography with hard, greenish, organic-poor pelitic sediments (TOC = 0.01 to 0.04%). We can conclude that the formation of Imiter-type silver concentrations requires the combination of the sedimentological, the volcanic and structural factors. For Imiter-type silver these factors are: a fine pelitic and argillic casing deposited in a confined environment, a basic volcanism source of metals and other intermediate to acid generated by the hydrothermalism and heat, a convenable paleotopography and a network of fracturations to trap the mineralizations.

关键词： Saghro Metallic Shales Silver TOC Exploration Cryogenic Polymetallic Imiter

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