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Mitigating diabetes-related complications:Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats

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World Journal of Diabetes 2024年第8期15卷 1778-1792页

作者： Mai S attia Fadwa Ayman Mohamed S attia Galal Yahya Mansour H Zahra Magdi Mohamed Ibrahim Khalil abdel Aziz A Diab Department of Zoology Faculty of ScienceZagazig 44519Egypt Department of Pharmaceutics Faculty of PharmacyZagazig 44519Egypt Department of Microbiology and Immunology Faculty of PharmacyZagazig UniversityZagazig 44519Egypt Department of Biochemistry Faculty of MedicineZagazig 44519Egypt

BACKGROUND Type 2 diabetes is one of the most prevalent chronic diseases worldwide,significantly impacting patients'quality of *** treatment options like metformin(MET)effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy,neuropathy,nephropathy,hepatopathy,and cardiovascular *** To propose the supplementation of cholecalciferol(CHO)and taurine(TAU)to enhance MET efficacy in controlling diabetes while minimizing the risk of associated *** The study involved sixty rats,including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by *** experimental rats were further subdivided into positive control and treatment *** four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either CHO,TAU,or *** Diabetic rats exhibited elevated levels of glucose,insulin,Homeostasis Model Assessment of Insulin Resistance(HOMA-IR),glycated hemoglobin percentage,lipid markers,aspartate aminotransferase,and malondialdehyde,along with reduced levels of antioxidant enzymes(catalase and superoxide dismutase).The administration of CHO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet *** antioxidative,anti-inflammatory,and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned *** The supplementation of CHO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative,anti-inflammatory,and antiapoptotic effects.

关键词： Diabetes complications Metformin Cholecalciferol Taurine Glycated hemoglobin% Antioxidant

Protectivity of Freeze Dried Inactivated Rift Valley Fever Vaccine

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Open Journal of Veterinary Medicine 2024年第2期14卷 21-37页

作者： Diana M. Abulmagd Mohamed Hassan Atwa Noha Ezz Aldin Marwa Yehia Hammad Taradi abdel fattah Said Rift Valley Fever Vaccine Research Department Veterinary Serum and Vaccine Research Institute Agriculture Research Center (ARC) Cairo Egypt

Background: Vaccinations for animals are crucial for food production, animal welfare, public health, and animal health. They are an affordable way to stop animal sickness, increase food production efficiency, and lessen or stop the spread of zoonotic diseases to humans. Animal vaccines that are both safe and efficacious are vital to modern culture. The vaccine should induce a strong, protective and prolonged immune response against the antigenic factor. In order to achieve these goals, novel vaccination techniques and an efficient adjuvant are required to render the vaccine immunogenically protective and trigger a strong immune response. Aim: Our study aims to promote and enhance the immunogenicity against RVF virus disease through lyophilized inactivated RVF vaccine through induction of early cellular, high and prolonged humeral immunity in vaccinated animals using cabopol as stabilizer and Saponin or normal saline as a diluent at time of vaccination. Moreover, manufacturing of these vaccines is easy to be done. Results: The gained results revealed that RVF freeze-dried vaccine with Carbopol that reconstituted using Saponin elicited better immune response than that reconstituted using normal saline (NaCl). The cell mediated immune response as represented by lymphocyte blastogenesis and phagocytic activity were markedly increased with high levels when we used Saponin as a diluent than that in group vaccinated with vaccine diluted with NaCl, on the other side the humeral immune response in group vaccinated using the Saponin as diluent is more detected and stayed within the protective level till the end of 11th month post vaccination (1.5 TCID50) while the immune response induced after using normal saline as a diluent stayed within the protective level till the end of 10th month post vaccination (1.8 TCID50). Conclusion: The use of Saponin as a diluent for reconstitution of the freeze dried RVF vaccine is preferable than the

关键词： Rift Valley Fever Saponin Cabopol Binary Ethylenemine Serum Neutralization Test

MAFLD Not NAFLD is Associated with Impairment of Health-related Quality of Life

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 4-5页

作者： Dina attia Nadia abdel Aty Ahmed Shawket Ebada Said Yasser Fouad Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineBeni-Suef UniversityEgypt Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineAin Shams UniversityEgypt Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineAssiut UniversityEgypt Depart-ment of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineBenha UniversityEgypt Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineMinia UniversityEgypt

Citation of this article:attia D,Aty NA,Shawket A,Said E,Fouad *** Not NAFLD is Associated with Impairment of Health-related Quality of Life.J Clin Transl Hepatol 2022;10(1):***:10.14218/*** the Editor,We read with great interest the article by Yu et al.1 who reported that the metabolic dysfunction-associated fatty liver disease(MAFLD)criteria are more practical and im-prove the identification of high-risk patients with fatty liver disease compared with the previous nonalcoholic fatty liver disease(NAFLD)criteria.

关键词： NAFLD Quality MAF

The Effect of Sun Elevation on the Twilight Stages in Malaysia

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International Journal of Astronomy and Astrophysics 2022年第1期12卷 7-29页

作者： Yasser abdel-fattah abdel-Hadi Amir Hussein Hassan Solar and Space Research Department National Research Institute of Astronomy and Geophysics (NRIAG) Helwan Cairo Egypt

This study is concerned with determining the altitude of the sun under the horizon to the beginning and the end of the true and pseudo dawn and dusk. In 2007 and 2008, the Sky Quality Meter (SQM) was used in four regions in Malaysia to measure the brightness at night, pseudo dawn, true dawn, true dusk and pseudo dusk. The measurements were taken when the device was directed to the position of sunrise and sunset at the horizontal angle of the sunrise or sunset and at five degrees above the horizon during the entire monitoring period. The altitude of the sun for the true dusk was found to be -14.38°± 0.91°and for the beginning of the pseudo dusk was found to be -14.86°± 0.91°and the end of the pseudo dusk is -17.8°± 0.7°, while for the beginning of the true dawn it was found to be -14.19°± 0.52°(for high confidence -14.71°) and for the pseudo dawn was found to be -18.62°± 0.82°. The light magnitude of the full night after the pseudo dusk was found to be 20.77 ± 0.93 mag./arcsec2, while it was found to be 22.17 ± 0.1 mag./arcsec2 before the pseudo dawn.

关键词： Twilight Light Magnitude Altitude of the Sun Beginning of the True Dusk Beginning of the True Dawn Pseudo Dusk Pseudo Dawn Full Night SQM

Formation and Biomimetic Deposition of Bone-like Hydroxyapatite on Wollastonite-gypsum Composites

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Journal of Bionic Engineering 2018年第5期15卷 894-906页

作者： Yaser Greish Nuha attia abdel-Hamid Mourad Department of Chemistry College of Science United Arab Emirates University AI Ain UAE Department of Ceramics National Research Centre Cairo Egypt Department of Mechanical Engineering College of Engineering United Arab Emirates University Al Ain UAE Mechanical Design Department Faculty of Engineering at Mataria Helwan University Cairo Egypt

Bone cements are often used for bone repair and fixation. The main objective of formulating a bone cement is to achieve structure and properties similarity to bone. In addition, bioactivity of a bone cement provides a major advantage that helps achieving better binding and interaction with the surrounding tissues. In the current study, gypsum was used as a matrix for a composite that comprises highly crys- talline prestine and acid-treated wollastonite （CaSiO3） fibers. Composites made by mixing their powder precursors with deionized water at room temperature, were investigated for their composition using X-ray diffraction （XRD） and Thermogravimetric Analysis （TGA）, for their microstructure using Scanning Electron Microscopy （SEM）, for their compressive strengths and modulus of elasticity, and for setting time measurements. In addition, cement composites were evaluated for their preliminary bioactivity in a protein-free Simulated Body Fluid （SBF） for up to 14 days. Results show the improvement of mechanical properties and bioactivity of the composites using acid-treated wollastonite fibers. This was attributed to the formation of hydrated silica layer on the surface of the acid-treated fibers which improved the binding with the gypsum matrix and provided nucleating sites for the deposition of bone-like apatite spherolites from SBF media.

关键词： gypsum wollastonite bone cement biomimetic SBF microstructure

Nanoscale electropolishing of high-purity nickel with an ionic liquid

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International Journal of Minerals,Metallurgy and Materials 2019年第5期26卷 649-656页

作者： Jon Derek Loftis Tarek M.abdel-fattah Applied Research Center at Thomas Jefferson National Accelerator Facility and Department of Molecular Biology and Chemistry at Christopher Newport University Department of Physical Sciences Virginia Institute of Marine Science College of William and Mary Faculty of Sciences Alexandria University

High purity(>99.9% composition) nickel metal specimens were used in electropolishing treatments with an acid-free ionic liquid electrolyte prepared from quaternary ammonium salts as a green polishing solution. Voltammetry and chronoamperometry tests were conducted to determine the optimum conditions for electrochemical polishing. Atomic force microscopy(AFM) revealed nanoscale effectiveness of each polishing treatment. Atomic force microscopy provided an overall observation of the material interface between the treated and unpolished regions. Surface morphology comparisons summarized electrochemical polishing efficiency by providing root-mean-square roughness averages before and after electrochemical polishing to reveal a mirror finish six times smoother than the same nickel metal surface prior to electropolishing. This transition manifested in a marked change in root-mean-squared roughness from 112.58 nm to 18.64 nm and producing a smooth mirror finish. Finally, the mechanism of the ionic liquid during electropolishing revealed decomposition of choline in the form of a transient choline radical by acceptance of an electron from the nickel-working electrode to decompose to trimethylamine and ethanol.

关键词： electrochemical polishing ionic liquid Ni 2EG:1VB4

Antioxidant, hepatoprotective and nephroprotective activities of Gazania rigens against carbon tetrachloride-induced hepatotoxicity and nephrotoxicity in rats

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Traditional Medicine Research 2022年第5期7卷 29-39页

作者： Alshymaa abdel-Rhman Gomaa Mamdouh Nabil Samy Eman Zekry attia Mina Ezzat Attya Michael Atef Fawzy Samar Yehia Desoukey Mohamed Salah Kamel Department of Pharmacognosy Faculty of PharmacyMinia UniversityMinia 61519Egypt Department of Pathology Faculty of MedicineMinia UniversityMinia 61519Egypt Department of Biochemistry Faculty of PharmacyMinia UniversityMinia 61519Egypt

Objective:The current study investigated the efficacy of total ethanolic extract and various fractions of Gazania rigens to protect against carbon tetrachloride-induced liver and kidney damage in rats and evaluated their antioxidant ***:The antioxidant activity of the total extract and fractions(petroleum ether,ethyl acetate,and aqueous)of Gazania rigens was examined using 2,2’-diphenyl-1-picrylhydrazyl radical scavenging and phosphomolybdate assays,and their total phenolic and flavonoid contents were *** hepatoprotective and nephroprotective potentials were studied at a dose of 300 mg/kg for six consecutive days followed by induction of hepatorenal injury using carbon tetrachloride single dose(1.5 mL/kg,1:1 v/v in olive oil,intraperitoneal)the next ***:The results revealed the potent hepato and nephroprotective effects of ethyl acetate and aqueous fractions by significantly(P<0.01 or P<0.001)reducing the serum levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin,creatinine,urea,triglycerides,cholesterol,and lactate dehydrogenase,along with elevated serum albumin *** improvement of hepatic and renal antioxidant capacities and catalase activities,together with the prominent reduction of hepatic and renal malondialdehyde contents,were confirmed by histopathological ***:The potent hepatoprotective and nephroprotective effects of the total extract and different fractions of Gazania rigens may be attributed to the presence of highly phenolic and flavonoid compounds along with their complementary antioxidant scavenging properties.

关键词： Asteraceae Gazania rigens antioxidant hepatoprotective nephroprotective

Meta-heuristics for Feature Selection and Classification in Diagnostic Breast Cancer

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Computers, Materials & Continua 2022年第10期73卷 749-765页

作者： Doaa Sami Khafaga Amel Ali Alhussan El-Sayed M.El-kenawy Ali E.Takieldeen Tarek M.Hassan Ehab A.Hegazy Elsayed abdel fattah Eid abdelhameed Ibrahim abdelaziz A.abdelhamid Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Communications and Electronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Communications and Computers Engineering Department Faculty of EngineeringDelta University for Science and TechnologyInternational Coastal RoadGamasa CityDakhliyaEgypt Faculty of Applied Health Science Technology Delta University for Science and TechnologyMansoura35712Egypt Faculty of Medicine Head of Internal Medicine DepartmentDelta University for Science and TechnologyMansouraEgypt Computer Engineering and Control Systems Department Faculty of EngineeringMansoura University35516MansouraEgypt Department of Computer Science Faculty of Computer and Information SciencesAin Shams University11566CairoEgypt Department of Computer Science College of Computing and Information TechnologyShaqra University11961Saudi Arabia

One of the most common kinds of cancer is breast *** early detection of it may help lower its overall rates of *** this paper,we robustly propose a novel approach for detecting and classifying breast cancer regions in thermal *** proposed approach starts with data preprocessing the input images and segmenting the significant regions of *** addition,to properly train the machine learning models,data augmentation is applied to increase the number of segmented regions using various scaling *** the other hand,to extract the relevant features from the breast cancer cases,a set of deep neural networks(VGGNet,ResNet-50,AlexNet,and GoogLeNet)are *** resulting set of features is processed using the binary dipper throated algorithm to select the most effective features that can realize high classification *** selected features are used to train a neural network to finally classify the thermal images of breast *** achieve accurate classification,the parameters of the employed neural network are optimized using the continuous dipper throated optimization *** results show the effectiveness of the proposed approach in classifying the breast cancer cases when compared to other recent approaches in the ***,several experiments were conducted to compare the performance of the proposed approach with the other *** results of these experiments emphasized the superiority of the proposed approach.

关键词： Breast cancer image segmentation dipper throated optimization feature selection meta-heuristics

Antifouling evaluation of extracts from Red Sea soft corals against primary biofilm and biofouling

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 991-997页

作者： Yosry abdel Aziz Soliman Ahmed Mohammed Brahim Ahmed Hussein Moustafa Mohamed abdel fattah Hamed Marine Chemistry Lab. Marine Environment DivisionNational Institute of Oceanography and FisheriesSuezEgypt Department of Chemistry Faculty of ScienceZagazig UniversityZagazigEgypt

Objectives: To evaluate antifouling property of extracts from Red Sea soft corals against primary biofilm and ***: Seven species of soft corals Sarcophyton glaucum(a), Sinularia compressa,Sinularia cruciata(a), Heteroxenia fuscescens(a), Sarcophyton glaucum(b), Heteroxenia fuscescens(b) and Sinularia cruciata(b) were chosen to test their extracts as antibacterial and antifouling agents in Eastern Harbour of Alexandria, Mediterranean *** compounds of soft corals were extracted by using methanol and concentrated under vacuum. The residues of extracts were mixed in formulation of inert paint which consisted of rosin, chlorinated rubber and ferrous oxide against micro and macro fouling organisms. The formulated paints were then applied on PVC panels twice by brush,hanged in a steel frame and immersed in Eastern Harbour of Alexandria Mediterranean Sea followed by visual inspection and photographic ***: After 185 days of immersion in seawater, the antifouling results agreed with the antibacterial results where extracts of Sinularia compressa and Heteroxenia fuscescens(b) gave the best activity against marine fouling tubeworms and barnacles. The inhibition activity was correlated with the major functional groups(hydroxyl, amino, carbonyl,aliphatic(fatty acids), C]C of alkene or aromatic rings and CeC l of aryl halides) of the ***: The strong antifouling activity makes them promising candidates for new antifouling additives. After the screening and application of natural organic compounds from soft corals, marine organisms show activity against micro and macro fouling organisms.

关键词： Antibacterial Antifouling Paints Seawater Marine Organisms