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Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells

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World Journal of Stem Cells 2016年第3期8卷 106-117页

作者： hanaa h Ahmed Ahmed M Salem hazem M Atta Emad F Eskandar abdel razik h farrag Mohamed A Ghazy Neveen A Salem hadeer A Aglan Department Medical Research Division National Research Centre Biochemistry Department Faculty of Science Ain Shams University Clinical Biochemistry Department Faculty of Medicine King Abdulaziz University Medical Biochemistry and Molecular Biology Department Faculty of Medicine Cairo University Pathology Department Medical Research Division National Research Centre Narcotics Ergogenic aids and Poisons Department Medical Research Division National Research Centre

AIM: To explore the approaches exerted by mesenchymal stem cells (MSCs) to improve Parkinson’s disease (PD) ***: MSCs were harvested from bone marrow of femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group (1) was control, Groups (2) and (3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group (2) was left untreated, while Group (3) was treated with single intravenous dose of bone marrow derived MSCs (BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1 (TGF-β1), monocyte chemoattractant protein-1 (MCP-1) and brain derived neurotrophic factor (BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase (Th) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. histopathological investigation of brain tissues was also ***: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1 (489.7 ± 13.0 vs 691.2 ± 8.0, P h significant increase in serum BDNF (3663 ± 17.8 vs 2905 ± 72.9, P h (1.18 ± 0.004 vs 0.54 ± 0.009, P he number of positive cells for survivin (293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histologica

关键词： Parkinson’s disease Pathophysiology Bone marrow derived mesenchymal stem cells Rotenone Anti-inflammatory action Ovariectomy Anti-apoptotic effect Neurogenic potential

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hepatoprotective activity of Dypsis lutescens against D-galactosamine-induced hepatotoxicity in rats and its phytoconstituents

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Asian Pacific Journal of Tropical Biomedicine 2019年第11期9卷 467-473页

作者： Mai M.El-Ghonemy Walaa A.El-Kashak Tahia K.Mohamed Enayat A.Omara Jihan hussein abdel-razik h.farrag Mahmoud I.Nassar Mohamed Y.El-Kady Chemistry of Natural Compounds Department National Research Centre33 El-Bohouth St.Dokki12622CairoEgypt Department of Pathology National Research Centre33 El Bohouth St.Dokki12622CairoEgypt Medical Biochemistry Department National Research Centre33 El Bohouth St.Dokki12622CairoEgypt Chemistry Department Faculty of ScienceAin Shams UniversityCairoEgypt

Objective:To isolate and identify the polyphenolic constituents of Dypsis lutescens,and evaluate the hepatoprotective activity of the ethanolic extract of Dypsis lutescens ***:hepatoprotective,antioxidant and anti-inflammatory effects of two doses of Dypsis lutescens ethanolic leaf extract were investigated in five groups of six rats each administered with the ethanolic extract of Dypsis lutescens *** function parameters were assessed,histopathological study was carried out,the anti-inflammatory mediators and the antioxidant potential in the liver tissues were *** addition,the total ethanolic extract of Dypsis lutescens leaves was subjected to different chromatographic separation techniques to yield ten phenolic *** isolated compounds structures were spectroscopically ***:hepatoprotective activity of Dypsis lutescens ethanolic extract was estimated for the first time and showed significant activity against histopathological changes induced by D-galactosamine in *** extract improved the liver *** to the D-galactosamine group,the architecture of the liver in the treated groups was improved in the histopathological *** results proved the hepatoprotective activity of Dypsis lutescens and its ability in attenuating liver oxidative damage and *** investigations of the total extract afforded ten compounds from the genus ***:The alcoholic extract of Dypsis lutescens exerted potential hepatoprotective action,maintaining liver health and functions.

关键词： Dypsis lutescens Flavonoid glycosides Phenolic acids hepatoprotective Antioxidant Anti-inflammatory

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SYNThESIS, ChARACTERIZATION AND SPECTROSCOPIC INVESTIGATION OF PYRAZINOPORPhYRAZINE NETWORK POLYMER-SUPPORTED METAL (Ⅱ)-BASED CATALYSTS

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Chinese Journal of Polymer Science 2013年第2期31卷 242-250页

作者： h.h. abdel-razik B.h. Asghar E. Kenawy Chemistry Department Faculty of Science Mansoura University Chemistry Department Faculty of Science Taif University Chemistry Department Faculty of Applied Sciences Umm Al-Qura University Chemistry Department Polymer Research Group Faculty of Science Tanta University

Chloranil through condensation reaction with vicinal diamine such as diaminomaleonitrile produced heterocyclic monomer, p-benzoquinonebis[2,3-b; 2＇,3＇-b＇]pyrazine-5,6-dinitrile. The tetranitrile monomer was cyclo-tetramerised using lithium/pentanol and acetic acid affording the corresponding tetrap-benzoquinone bis[2,3-b; 2＇,3＇-b＇]pyrazinoporphyrazine）]- based network polymer （2h-Pz）. The tetranitril monomer was cyclo-tetramerised using metal salt and quinoline affording the corresponding porphyrazinato-metal II-based network polymers （M-Pz）, M = Co, Ni or Cu. Elemental analytical results, IR and NMR spectral data of the prepared molecules are consistent with their assigned formulations. Molecular masses and metal contents of the synthesized polymers proved to be of high molecular masses which confirm the efficiency of tetramerization polymerization and complexation reactions. The prepared pyrazinoporphyrazines were used as efficient catalysts for the oxidation of thiophenol and benzylthiol to their disulfides in the presence of air atmosphere. The results of oxidation of thiophenol and benzylthiol show that after 15 min the maximum yield of the corresponding disulfides reached 95%, 91%, respectively.

关键词： Pyrazinoporphyrazine Polymer-supported metal (II)-based catalysts Chloranil.

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NANOPOROUS MATERIALS BASED ON SPIROKETAL AND SPIROThIOKETAL POLYMERS FOR SEPARATING METhANOL-TOLUENE MIXTURE

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Chinese Journal of Polymer Science 2011年第4期29卷 450-455页

作者： hamada hamada abdel-razik Zeinhom Mohamed El-Bahy Chemistry Department Faculty of Science and Education(Alkhurma Branch)Taif UniversitySaudi Arabia

Organic microporous materials based on spiroketal and spirothioketal polymers were synthesized through 1,3- dioxol-forming polymerization reaction between pentaerythritol or pentaerythritol tetrathiol and different types of cyclohexa- 1,4-dione derivatives. The structure of the prepared polymers was confirmed by NMR spectroscopy and molecular mass measurements. Nitrogen adsorption/desorption isotherms of the prepared polymers show a large amount of nitrogen adsorbed at low relative pressure indicating microporosity. These polymers have Brunauer Emmitt and Teller （BET） surface areas in the range from 492 （m^2g^-1） to 685 （m^2 g^-1）. The prepared polymers were found to be useful for pervaporation separation of methanol-toluene mixture with a separation factor up to 12.5 and fluxes, varying between 6.7×10-3 kg/（m^2 h） and 13.4 × 10^-3 kg/（m^2 h）.

关键词： Spiroketal polymers Nanoporous materials Separation membranes.

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Intermittent fasting and the liver: Focus on the Ramadan model

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World Journal of hepatology 2024年第8期16卷 1070-1083页

作者： Mohamed h Emara hanan Soliman Ebada M Said hassan Elbatae Mostafa Elazab Shady Elhefnawy Tarik I Zaher Ahmed abdel-razik Mohamed Elnadry Department of hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Medicine Alyousif HospitalAlkhobar 34622Saudi Arabia Department of Tropical Medicine and Infectious Diseases Tanta UniversityTanta 31512Egypt Department of hepatology Gastroenterology and Infectious DiseasesBenha UniversityBenha 13511Egypt Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Tropical Medicine Mansoura UniversityMansoura 35516Egypt Department of hepato-Gastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt

Intermittent fasting(IF)is an intervention that involves not only dietary modific-ations but also behavioral changes with the main core being a period of fasting alternating with a period of controlled *** duration of fasting differs from one regimen to *** fasting(RF)is a religious fasting for Muslims,it lasts for only one month every one lunar *** this model of fasting,observers abstain from food and water for a period that extends from dawn to *** period of daily fasting is variable(12-18 hours)as Ramadan rotates in all seasons of the ***,longer duration of daily fasting is observed during the *** fact,RF is a peculiar type of *** is a dry IF as no water is allowed during the fasting hours,also there are no calorie restrictions during feeding hours,and the mealtime is exclusively *** three variables of the RF model are believed to have a variable impact on different liver *** was evaluated by different observational and interventional studies among patients with non-alcoholic fatty liver disease and it was associated with improve-ments in anthropometric measures,metabolic profile,and liver biochemistry regardless of the calorie restriction among lean and obese *** situation is rather different for patients with liver *** was associated with adverse events among patients with liver cirrhosis irrespective of the underlying etiology of *** patients developed new ascites,ascites were increased,had higher serum bilirubin levels after Ramadan,and frequently developed hepatic encephalopathy and acute upper gastrointestinal *** complications were higher among patients with Child class B and C cirrhosis,and some fatalities occurred due to *** transplant recipients as a special group of patients,are vulnerable to dehydration,fluctuation in blood immunosuppressive levels,likelihood of deterioration and hence observing RF without special precautions

关键词： Intermittent fasting Ramadan fasting Non-alcoholic fatty liver disease Liver cirrhosis Peptic ulcer Liver transplantation Gilbert syndrome

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