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Evaluation of the 8th AJCC staging system for pathologically versus clinically staged pancreatic adenocarcinoma: A time to revisit a dogma?

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 64-69页

作者： Omar abdel-rahman Clinical Oncology Department Faculty of Medicine Ain Shams University

Background: The 8 th edition of the American Joint Committee on Cancer(AJCC) staging system for pancreatic exocrine adenocarcinoma has been released. The current study seeks to assess the 7 th and 8 th editions among patients registered within the surveillance, epidemiology and end results(SEER) ***: SEER database(2010–2013) has been accessed through SEER*Stat program and AJCC 8 th edition stages were reconstructed utilizing the collaborative stage descriptions. Kaplan–Meier analysis of overall survival and pancreatic cancer-specific survival analyses(according to both 7 th and 8 th editions and according to whether pathological or clinical staging were conducted) has been performed. Multivariate analysis of factors affecting pancreatic cancer-specific survival was also conducted through a Cox proportional hazard ***: A total of 18 948 patients with pancreatic adenocarcinoma were identified in the period from 2010–2013. Pancreatic cancer-specific survival among pathologically staged patients and according to the 8 th edition showed significant differences for all pair wise comparisons among different stages(P < 0.0001) except for the comparison between stage IA and stage IB(P = 0.307) and the comparison between stage IB and stage IIA(P = 0.116). Moreover, P value for stage IA vs IIA was 0.014; while pancreatic cancer-specific survival according to the 7 th edition among pathologically staged patients showed significant differences for all pair wise comparisons among different stages(P < 0.0001) except for the comparison between IA and IB(P = 0.072), the comparison between stage IIA and stage IIB(P = 0.065), the comparison between stage IIA and stage Ⅲ(P = 0.059) and the comparison between IIB and Ⅲ(P = 0.595).Among clinically staged patients(i.e. those who did not undergo initial radical surgery), the prognostic performance of both 7 th and 8 th stages for both overall survival and pancreatic cancer-specific survival was ***: Th

关键词： Pancreatic cancer AJCC SEER Prognosis

Outcomes of liver transplantation as an oncologic surgery for different primary liver cancers:A real-world,population-based study

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 88-91页

作者： Omar abdel-rahman Department of Oncology Cross Cancer Institute and the University of AlbertaEdmontonCanada

To the Editor:Although liver transplantation is likely used to treat individuals with end-stage liver disease because of non-neoplastic reasons,the adoption of liver transplantation in the management of primary liver cancer has been expanding in the past decades[1-3].Prior population-based studies for liver transplantation,in the cancer sphere,focused on delineating the outcomes of patients with hepatocellular carcinoma(HCC)treated with transplantation versus other locoregional treatments[4-6].

关键词： liver cancer surgery

Asian Americans have better outcomes of non-metastatic gastric cancer compared to other United States racial groups: A secondary analysis from a randomized study

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World Journal of Gastrointestinal Oncology 2019年第12期11卷 1151-1160页

作者： Omar abdel-rahman Department of Oncology University of Alberta and Cross Cancer Institute

BACKGROUND It has been recognized for a long time that gastric cancer behavior and outcomes might be different between patients living in Asian countries vs patients living in Western *** is not clear if these differences would persist between patients of Asian ancestry and patients of other racial subgroups within the multiethnic communities of North *** current study hypothesizes that these differences will present within North American multiethnic *** To evaluate the impact of race on survival outcomes of non-metastatic gastric cancer patients in the United *** This is a secondary analysis of a randomized controlled trial(CALGB 80101 study)that evaluated two adjuvant chemoradiotherapy schedules following resection of non-metastatic gastric ***-Meier analysis and log-rank testing were utilized to explore the overall and disease-free survival differences according to the race of the *** and multivariate Cox regression analyses were then used to explore factors affecting overall and disease-free *** A total of 546 patients were included in the current *** which,73.8%have white race(vs 12.8%black Americans and 8.2% Asian Americans).Using Kaplan-Meier analysis/log-rank testing,Asian Americans appear to have better overall and disease-free survival outcomes compared to other United States racial groups(White Americans,Black Americans,and other racial groups)(P=0.011;P=0.010;respectively).Moreover,in an adjusted multivariate model,Asian American race seems to be associated with better overall and disease-free survival(hazard ratio:0.438;95% confidence interval:0.254-0.754),P=0.003;(hazard ratio:0.460;95% confidence interval:0.280-0.755,P=0.002;respectively).CONCLUSION Asian American patients with non-metastatic gastric cancer have better overall and disease-free survival compared to other racial groups in the United *** preclinical and clinical research is needed to clarif

关键词： Race Asian Americans Survival Prognosis Outcomes

A ROUGH SET APPROACH TO FEATURE SELECTION BASED ON SCATTER SEARCH METAHEURISTIC

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Journal of Systems Science & Complexity 2014年第1期27卷 157-168页

作者： WANG Jue ZHANG Qi abdel-rahman Hedar abdel-MONEM M Ibrahim Center for Forecasting Science Academy of Mathematics and System Science Chinese Academy of ScienceBeijing 100190 China. Department of Computer Science Faculty of Computers and Information Assiut University Assiut 71516Egypt.

Rough set theory is an effective method to feature selection, which has recently fascinated many researchers. The essence of rough set approach to feature selection is to find a subset of the original features. It is, however, an NP-hard problem finding a minimal subset of the features, and it is necessary to investigate effective and efficient heuristic algorithms. This paper presents a novel rough set approach to feature selection based on scatter search metaheuristic. The proposed method, called scatter search rough set attribute reduction （SSAR）, is illustrated by 13 well known datasets from UCI machine learning repository. The proposed heuristic strategy is compared with typical attribute reduction methods including genetic algorithm, ant colony, simulated annealing, and Tabu search. Computational results demonstrate that our algorithm can provide efficient solution to find a minimal subset of the features and show promising and competitive performance on the considered datasets.

关键词： Attribute reduction computational intelligence metaheuristics rough set scatter search.

Non-alcoholic fatty liver disease:Epidemiology,pathophysiology and an update on the therapeutic approaches

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Asian Pacific Journal of Tropical Biomedicine 2022年第3期12卷 99-114页

作者： Rehab F.abdel-rahman Department of Pharmacology Medical Research and Clinical Studies InstituteNational Research Centre12622-DokkiGizaEgypt

Non-alcoholic fatty liver disease(NAFLD)denotes a spectrum of fatty liver disease in individuals without significant alcohol *** is set to be the most common etiology of serious liver diseases in numerous nations when accompanied by obesity and type 2 *** is further histologically categorized into the non-alcoholic fatty liver(NAFL;steatosis without hepatocellular injury)and non-alcoholic steatohepatitis(NASH)which is characterized by the coexistence of hepatic steatosis and inflammation and is accompanied by hepatocyte injury(ballooning),either with or without *** is considered the benign and reversible stage arising from the excessive accumulation of triglycerides in ***,NASH is a more progressive stage of NAFLD,due to the increased risks of evolving more serious diseases such as cirrhosis,hepatocellular *** concept,however,has been lately challenged by a hypothesis of multiple parallel hits of NAFLD,in which steatosis and NASH are separate entities rather than two points of the NAFLD spectrum,not only from a set of histological patterns but also from a pathophysiological *** current review highlights the epidemiology and pathophysiology of NAFLD,and its progression towards steatohepatitis,with special focus on the novel imminent therapeutic approaches targeting the molecular aspects and the pathogenic pathways involved in the development,and progression of NAFLD.

关键词： Non-alcoholic fatty liver disease Steatosis Insulin sensitizers Glucagon-like peptide-1 analogues Dipeptidyl peptidase-4 inhibitors Farnesoid X receptor agonists

Effect of Heat Input on the Microstructure and Properties of Dissimilar Weld Joint Between Incoloy 28 and Superaustenitic Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2014年第2期27卷 259-266页

作者： M.S.abdel rahman N.A.abdel Raheem M.R.El Koussy Department of Metallurgy Faculty of EngineeringCairo University

Abstract This work focuses on studying the effect of welding heat input within the range from 1 to 5 kJ/mm on the microstructure and the corresponding mechanical and corrosion properties of dissimilar joint between superaustenitic stainless steel （UNS S31254） and Incoloy 28 （UNS N08028）. The two materials were butt-welded with ER NiCrMo3. The metallurgical changes associated with welding of SASS and Incoloy 28 were studied using optical microscope, SEM, and EDX. The mechanical and corrosion properties were investigated using tensile test, Vickers hardness test, and pitting and crevice corrosion tests. The weld metal microstructure showed precipitates with needle-like shape at 3 and 5 kJ/mm. Also, the microstructure showed unmixed zone （UMZ） at the fusion line of both SASS and Incoloy 28 sides at all the investigated heat inputs. The Mo microsegregation within UMZ at Incoloy 28 side increased as the heat input increased from 1 to 5 k J/ram but that in SASS increased with increasing heat input from 1 to 3 kJ/mm and then decreased with increasing from 3 to 5 kJ/mm. The ultimate tensile strengths for all specimens at all the investigated heat inputs are acceptable. The average hardness noticeably changed in weld metal as the heat input increased from 1 to 5 kJ/mm. Other zones such as HAZ or UMZ did not demonstrate marked changes in the average hardness. The pitting and crevice corrosion rates of the weld joint were found significant at l and 3 kJ/mm but insignificant at 5 kJ/mm according to ASTM G48.

关键词： Superaustenitic Incoloy 28 Welding Heat input Unmixed zone Microsegregation Corrosion

Entrepreneurship training:its influences on innovation potentials among nursing students

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Frontiers of Nursing 2024年第1期11卷 85-98页

作者： Asmaa abdel rahman abdel rahman Dalia Abdallah abdelatief Medical Surgical Nursing Department Faculty of NursingAin Shams UniversityCairoEgypt

Objective:To evaluate the influences of entrepreneurship training on the innovation potential among nursing ***:A quasi-experimental design was utilized to conduct this *** study was conducted in the classroom at the faculty of nursing,and the“i Hub”center at Ain Shams University(ASU)in Cairo,Egypt.A purposive sample of 42 nursing students who participated in the“Ain Shams University-innovate”competition from the Faculty of Nursing of ASU were included in this *** collection tools included(1)Nursing students'innovation skills assessment questionnaire and(2)Innovative projects evaluation ***:There was a statistically significant difference between the mean scores of nursing students'total innovation skills pre-and post-implementation of entrepreneurship training,where P-value<***:The results of the current study support the research hypothesis because the implementation of entrepreneurship training positively affects nursing students'innovation *** entrepreneurship education in nursing and integrating it into nursing programs will stimulate creativity,innovation,and entrepreneurship among nursing students and health care services.

关键词： entrepreneurship training innovation potentials nursing students creative skills energy/motivation

Thermal noise-driven resonant sensors

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Microsystems & Nanoengineering 2024年第3期10卷 259-271页

作者： Yan Qiao Alaaeldin Elhady Mohamed Arabi Eihab abdel-rahman Wenming Zhang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghaiChina Department of Systems Design Engineering University of WaterlooWaterlooONCanada

MEMS/NEMS resonant sensors hold promise for minute mass and force ***,one major challenge is that conventional externally driven sensors inevitably encounter undesired intrinsic noise,which imposes a fundamental limitation upon their signal-to-noise ratio(SNR)and,consequently,the ***,this restriction becomes increasingly pronounced as sensors shrink to the *** this work,we propose a counterintuitive paradigm shift that turns intrinsic thermal noise from an impediment to a constituent of the sensor by harvesting it as the driving force,obviating the need for external actuation and realizing‘noise-driven’*** sensors employ the dynamically amplified response to thermal noise at resonances for stimulus *** demonstrate that lightly damped and highly compliant nano-structures with high aspect ratios are promising candidates for this class of *** overcome the phase incoherence of the drive force,three noise-enabled quantitative sensing mechanisms are *** validated our sensor paradigm by experimental demonstrating noise-driven pressure and temperature ***-driven sensors offer a new opportunity for delivering practical NEMS sensors that can function at room temperature and under ambient pressure,and a development that suggests a path to cheaper,simpler,and low-power-consumption sensors.

关键词： noise resonant overcome

Ensuring the possibility of using thorium as a fuel in a pressurized water reactor(PWR)

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Nuclear Science and Techniques 2021年第12期32卷 37-52页

作者： Mohamed Y.M.Mohsen Mohamed A.E.abdel-rahman Aabdelghafar Galahom Nuclear Engineering Department Military Technical CollegeKobry ElkobbahCairoEgypt Higher Technological Institute 10th of Ramadan CityEgypt

The possibility of utilizing thorium as a fuel in a pressurized water reactor(PWR)has been proven from the neutronic perspective in our previously published work without assessing the thermal hydraulic(TH)and solid structure ***,the TH and solid structure performances must be studied to confirm these results and ensure the possibility of using a thorium-based fuel as an excellent accident-tolerant *** TH and solid structure performances of thorium-based fuels were investigated and compared with those of UO_(2).The radial and axial power peaking factors(PPFs)for UO_(2),(^(232)Th,^(235)U)O_(2),and(^(232)Th,^(233)U)O_(2)were examined with a PWR assembly to determine the total PPF of each *** Gd_(2)O_(3)and Er_(2)O_(3)were tested as burnable absorbers(BAs)to manage the excess reactivity at the beginning of the fuel cycle(BOC)and reduce the total ***_(2)O_(3)resulted in a more significant reduction to the total PPF and,therefore,a greater reduction to the temperature distribution compared to Gd_(2)O_(3).Given these results,we analyzed the effects of adding Er_(2)O_(3)to thorium-based fuels on their TH and solid structure performances.

关键词： Thermal hydraulic(TH) Solid structure Thorium-based fuel Gd2O3 Er_(2)O_(3)