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Case series in Indonesia:B.1.617.2(delta)variant of SARS-CoV-2 infection after a second dose of vaccine

World Journal of Clinical Cases 2022年第36期10卷 13216-13226页

作者： Anis Karuniawati Ari F Syam Armand Achmadsyah Fera ibrahim Yulia Rosa Pratiwi Sudarmono Fadilah Fadilah Menaldi Rasmin department of Clinical Microbiology Faculty of MedicineUniversitas Indonesia/Cipto Mangunkusumo Jakarta IndonesiaJakarta 10430DKI JayaIndonesia division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversitas Indonesia/Cipto Mangunkusumo Jakarta IndonesiaJakarta PUsat 10430DKI JayaIndonesia Faculty of Medicine Universits IndonesiaJakarta Pusat 10430DKI JayaIndonesia department of Medical Chemistry Faculty of MedicineUniversitas IndonesiaJakarta IndonesiaFaculty of MedicineUniversitas IndonesiaJakarta 10430DKI JayaIndonesia department of Pulmonology and Respiratory Medicine Faculty of MedicineUniversitas Indonesia/Persahabatan HospitalJakarta IndonesiaJakarta Pusat 10430DKI JayaIndonesia

BACKGROUNd The B.1.617.2(delta)variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first discovered in Maharashtra in late 2020 and has rapidly expanded across India and *** took only 2 mo for this variant to spread in Indonesia,making the country the new epicenter of the delta variant as of July *** efforts made by accelerating massive rollouts of current vaccines to protect against infection,cases of fully-vaccinated people infected with the delta variant have been *** To describe the demographic statistics and clinical presentation of the delta variant infection after the second dose of vaccine in *** A retrospective,single-centre case series of the general consecutive population that worked or studied at Faculty of Medicine,Universitas Indonesia with confirmed delta Variant Infection after a second dose of vaccine from 24 June and 25 June *** were collected retrospectively based on a combination of author recall,reverse transcription-polymerase chain reaction(RT-PCR),and whole genome sequencing results from the Clinical Microbiology Laboratory,Faculty of Medicine,Universitas *** Between 24 June and 25 June 2021,15 subjects were confirmed with the B.1.617.2(delta)variant infection after a second dose of the *** subjects were vaccinated with CoronaVac(Sinovac)and one subject with ChAdOx1 nCoV-19(Oxford-AstraZeneca).All of the subjects remained in home isolation,with fever being the most common symptom at the onset of illness(n=10,66.67%).The mean duration of symptoms was 7.73 d(±5.444).The mean time that elapsed from the first positive swab to a negative RT-PCR test for SARS-CoV-2 was 17.93 d(±6.3464).The median time that elapsed from the second dose of vaccine to the first positive swab was 87 d(interquartile range:86-128).CONCLUSION Although this case shows that after two doses of vaccine,subjects are still susceptible to the delta variant infection,currently availab

关键词： COVId-19/SARS-CoV-2 infection B.1.617.2(delta)variant Fully vaccinated Case series

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Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 220-225页

作者： Halil ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner department of Ophthalmology Duzce University Medical Faculty department of Ophthalmology Abant Izzet Baysal University Medical School Ophthalmology Clinic Izzet Baysal State Hospital department of Pathology Duzce University Medical Faculty

AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHOdS:Thirty adult male Sprague-dawley rats weighing 250-300 g,were *** NV was induced by NaOH in the left eyes of each *** the establishment of alkali burn,the animals were randomized into five groups according to topical *** 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone *** the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea’s total area using computer-imaging *** corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by ***:A statistically significant difference in the percent area of corneal NV was found among the groups(Pd the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(Pd endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and ***:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats.

关键词： corneal neovascularization regorafenib tyrosine kinase inhibitor

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Evaluation of Antibiotic Prescribing in the Pediatric department of Gabriel TouréTeaching Hospital, Bamako, Mali

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Open Journal of Pediatrics 2024年第3期14卷 645-656页

作者： Pierre Togo Hawa Konaré Mariam Maïga Karamoko Sacko djénéba Konaté Abdoul Karim doumbia Adama dembélé Oumar Coulibaly Aminata Sangaré Mohamed Elmouloud Cissé Fousseyni Traoré Belco Maïga ibrahim Ahamadou Aminata doumbia Lala N’drany Sidibé Amadou Touré Yacouba Aba Coulibaly Kalirou Traoré Tati Simaga Souleymane Sagara Leyla Bagna Maïga Bory Traoré Abdoul Aziz diakité Fatoumata dicko Mariam Sylla Sounkalo dao Boubacar Togo Paediatric department Gabriel Tour&#233 Teaching Hospital Bamako Mali Pediatric department Distric VI Reference Health Center Bamako Mali Infectious diseases department Point G Teaching Hospital Bamako Mali

Objectives: The main objective was to evaluate antibiotic prescribing in the department of Pediatrics at Gabriel Touré teaching hospital. Methods: This was a prospective descriptive study conducted from September 1 to November 31, 2018, in the department of Pediatrics at Gabriel Touré teaching hospital. All children aged 0 to 15 years hospitalized for any pathology during the study period and having received at least one antibiotic had been included. Results: We collected 445 children’s records out of 1032 admissions during the study period, representing a hospital frequency of 43.1%. The sex ratio was 1.3%. The 2 - 5 age group accounted for 48.1%. Fever was the reason for consultation in 45.6% of cases. Patients’ general condition was altered in 60% of cases. The fathers were blue-collar workers in 65.4% and the mothers housewives in 85%, and had no education in 42.9% and 64.5% respectively. Hepatomegaly was present in 18.2%, splenomegaly in 9.6% and peripheral adenopathy in 3.1%. The site of infection was pulmonary in 37.6% and ENT in 9.2%. Bacterial infection was assumed on admission in 54% of cases, and meningitis in 57.7%. The discharge diagnosis was malaria in 54.6%, severe acute malnutrition in 18.6% and meningitis in 6.7%. The death rate was 3.8%. Neutrophilic leukocytosis was present in 47.3% of patients. CRP was positive in 85% of patients. Blood cultures taken in 27.6% of patients were positive in 5. CSF analysis in 30% of patients showed elevated leukocytes in 6.5%. No cultures were positive. Antibiotic prescription was justified by infectious hypotheses in 43.1% of patients. β-lactam antibiotics were prescribed in 98.6%. Antibiotic therapy was not adapted to national/international recommendations in 68.3% of cases, and was not justified in 16.3% of cases on d5 of hospitalization. Conclusion: Antibiotic use was justified in more than half of patients, but remained inadequate in almost two-thirds of cases, in line with national and international recommend

关键词： Antibiotic Prescription Hospitalization Child

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Effect of Si-addition as a grain refiner on microstructure and properties of Ti-6Al-4V Alloy

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Transactions of Nonferrous Metals Society of China 2013年第7期23卷 1863-1874页

作者： Khaled M.ibrahim abdel Hamied HUSSEIN Mohamed abdeLKAWY Central Metallurgical R&d Institute CMRDICairoEgypt Cairo University GizaEgypt

Two different Ti alloys were cast in a graphite mould using vacuum induction skull melting furnace. The first alloy was Ti-6Al-4V and the second was Ti-6Al-4V 0.5Si. Silicon as a grain refiner was added into Ti-6Al-4V alloy, and the effects of Si-addition on the microstructure and properties of the as-cast and swaged alloys were investigated. Hot swaging at 900 °C was performed on the cast samples and then two different thermal treatments were applied. The first treatment was done by heating the swaged samples at 1050 °C to produce fine lamella structure, while the second treatment was carried out at 1050 °C and then decreased the temperature to 800 °C for getting coarse lamella structure. An addition of 0.5% Si to Ti-6Al-4V alloy decreased the grain size of the as-cast sample from 627 to 337 μm. There was an increase in ultimate tensile strength of about 25 MPa for the as-cast Ti-6Al-4V 0.5Si alloy compared to Ti-6Al-4V due to the refinement effect caused by Si addition. A maximum ultimate tensile strength of 1380 MPa and a minimum corrosion rate （1.35×10 6 mm/a in Hank’s solution and 5.78×10 4 mm/a in NaCl solution） were reported for the heat treated fine lamella structure of Ti-6Al-4V 0.5Si alloy. The wear rate was decreased to about 50% by adding 0.5% Si at low sliding speeds and to about 73% at high sliding speeds.

关键词： Ti-6Al-4V alloy silicon casting grain refinement heat treatment wear

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An investigation into the effects of particle texture,water content and parallel plates' diameters on rheological behavior of fine sediment

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International Journal of Sediment Research 2016年第2期31卷 120-130页

作者： Masoumeh Moayeri Kashani Lai Sai Hin Shaliza Binti ibrahim Nik Meriam Binti Nik Sulaiman Fang Yenn Teo department of Civil Engineering Faculty of EngineeringUniversity of Malaya department of Chemical Engineering Faculty of EngineeringUniversity of Malaya Research Development and Innovation DivisionNational Water Services Commission

Siltation,a phenomenon resulted from the presence of fine particles in an aqueous environment,dominated by silt and clay,is a known and common environmental issue *** accumulation of fine sediments engenders murky water with low oxygen levels,which leads to the death of aquatic ***,investigating the physical and mechanical properties of fine sediment by rheological methods has *** is the science of deformation and flow of matter in *** survey investigates the rheological behavior of six samples of soil as the fine particles structure(d different regions of Malaysia by using a rotational rheometer with a parallel-plate measuring(using two sizes:25 mm and 50 mm) device to explore the flow and viscoelastic properties of fine *** samples were examined in two rheological curve and amplitude sweep test methods to investigate the effect of water content ratio,texture,and structure of patticles on rheological *** was found that the content of fine sand,clay,and silt had an effect on the stiffness,structural stability,and shear ***,the pseudoplastic and viscoelastic behaviot are respectively ***,the amount of fine sediments present in water *** concentration of these particles,has a direct effect on the rheological curve.A reduction in viscosity of samples with higher concentrations of water has been *** a consequence,a considerable quantity of fine sediments are distributed within the water body and remain suspended over the *** a result,the sedimentation rate slows *** needs to be asserted that the stotage modulus G′,loss modulus G″,and yield point can vary depending on particle *** G′ and G″were instigated for samples(70%and 45%concentrations) that demonstrated viscoelastic characteristics using the same rotational rheometer with a parallel-plate measuring device.

关键词： Fine sediment Rheology Siltation Soil texture Stiffness degradation

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digestive fungal flora in asymptomatic subjects in Bobo-dioulasso,Burkina Faso

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Asian Pacific Journal of Tropical Biomedicine 2014年第8期4卷 659-662页

作者： Bamba Sanata Ouédraogo Abdoul Salam Sangaré ibrahim Zida Adama Cissé Mamoudou Karou d.Simplice Simpore Jacques Guiguemdé T.Robert Hennequin Christophe department of Parasitology-Mycology University Hospital Sanou SouroBobo-DioulassoBurkina Faso department of Parasitology-Mycology Higher Institute of Health SciencesPolytechnic University of Bobo-DioulassoBurkina Faso department of Bacteriology-Virology Higher Institute of Health SciencesPolytechnic University of Bobo-DioulassoBurkina Faso Faculty of Health Sciences University of OuagadougouBurkina Faso Biomolecular Research Center Pietro Annigoni(CERBA/LABIOGENE) OuagadougouBurkina Faso Service of Parasitology-Mycology Saint Antoine de Paris HospitalFrance

Objective::To identify Candida species in asymptomatic subjects in Bobo-dioulasso(Burkina Faso) by the matrix—assisted laser desortption ionization—time of flight mass ***:A cross-sectional study was conducted from January to February 2013 in Bohodioulasso to coiled fecal and urine specimens from voluntary *** strains were isolated on Sabouraud dextrose agar and analyzed using matrix—assisted laser desorption ionisation—time-of—flight mass ***:A total of 135 samples including stools(78.5%,106/135) and urine(21.5%,29/135) were *** results revealed that fecal specimens contained mainly Candida krusei(***)(42.5%) followed by Candida albicans(29.3%),Candida glabrata(18.0%) and Candida tropicalis(***)(4.7%).***(34.6%) was also found to be the most frequently identified in urine samples followed by Candida albicans(27.0%).***(15.4%) and Candida parapsilosis,However,uncommon species such as Candida *** *** norvegensis,Candida *** lusitaniae and Candida robusta were also identified from fecal and urines ***:This study noted the emergence of species such as ***,Candida glabrata,Candida parapsiolosis,***,Candida nivariensis,Candida norvegensis,and *** is an imperative to take into account the existence of these species in the therapeutic management of patients in Bobo—dioulasso.

关键词： Candida Mass spectrometry Matrix—assisted laser desorption ionization—time of flight Bobodioulasso

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Age distribution,polyps and rectal cancer in the Egyptian population-based cancer registry

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World Journal of Gastroenterology 2012年第30期18卷 3997-4003页

作者： darlene Veruttipong Amr S Soliman Samuel F Gilbert Taylor S Blachley Ahmed Hablas Mohamed Ramadan Laura S Rozek ibrahim A Seifeldin department of Epidemiology University of Michigan School of Public HealthAnn ArborMI 48109United States department of Biostatistics University of Michigan School of Public HealthAnn ArborMI 48109United States Tanta Cancer Center and the Gharbiah Population-Based Cancer Registry Tanta 31512Egypt department of Environmental Health Science University of Michigan School of Public HealthAnn ArborMI 48109United States

AIM:To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based ***:The Gharbiah cancer registry is the only population-based cancer registry in Egypt since *** analyzed the data of all colorectal cancer patients included in the registry for the period of *** medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted:age,residence,diagnosis date,grade,stage,topology,clinical characteristics,and histology *** census data for 1996 and 2006 were used to provide the general population's statistics on age,sex,residence and other related demographic *** addition to age-and sex-specific incidence rate analyses,we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the *** also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results(SEER) data of the United ***:Over the 9 year-period,1364 colorectal cancer cases were *** disease incidence under age 40 years was relatively high(1.3/10 5) while the incidence in the age groups 40 and over was very low(12.0/10 5,19.4/10 5 and 21.2/10 5 in the age groups 40-59 years,60-69 years and > 70 years,respectively).The vast majority of tumors(97.2%) had no polyps and 37.2% of the patients presented with primary lesions in the *** cancer was more common in patients from urban(55%) than rural(45%) *** differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this *** registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 *** results also shows significantly lower incidence of colorectal cancer in subjects over age

关键词： Colorectal cancer Young-onset Polyps developing countries Egypt

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Sodium-glucose co-transporter 2 inhibitors induced euglycemic diabetic ketoacidosis within four days of initiation

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World Journal of diabetes 2022年第3期13卷 272-274页

作者： Almurtada Razok Fateen Ata Sara Mohamed ibrahim Ahmed dabia Hamad S H Al Mohanadi department of Internal Medicine Hamad Medical CorporationDoha 3050Qatar department of Endocrinology Hamad Medical CorporationDoha 3050Qatar

Euglycemic diabetic ketoacidosis(EdKA)is a well-known complication of sodium-glucose co-transporter 2 inhibitors,and many cases with variable onset following the initiation of these agents are reported before,with a median onset of approximately 2 *** letter discusses a 45-year-old lady who initially presented with ischemic stroke but developed EdKA 4 d after starting empagliflozin,a rare *** patient had severe metabolic acidosis that necessitated admission into the intensive care *** discontinuation of empagliflozin and dKA management resulted in clinical recovery.

关键词： Euglycemic diabetic ketoacidosis Sodium-glucose co-transporter 2 inhibitors Type 2 diabetes mellitus Empagliflozin

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New stem cell autophagy surrogate diagnostic biomarkers in earlystage hepatocellular carcinoma in Egypt:A pilot study

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World Journal of Hepatology 2021年第12期13卷 2137-2149页

作者： Tarek Yosef Wesam Ahmed ibrahim Marwa Matboli Amina Ahmed Swilam Sarah El-Nakeep Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11591Egypt department of Biochemistry Faculty of MedicineAin Shams UniversityCairo 11591Egypt department of Internal Medicine Health Affair DirectorateMinistry of Health and PopulationCairo 11591Egypt

BACKGROUNd Stem cell autophagy disruption is responsible for the development of hepatocellular carcinoma(HCC).Many non-coding RNAs are linked to the activation and inhibition of certain *** SQSTM1 gene controls stem cell autophagy as shown in previous *** upregulation of SQSTM1 is associated with the inhibition of autophagy in cancerous stem cells in patients with *** To determine whether serum microRNA,hsa-miR-519d,is linked to SQSTM1 gene and whether they could be used as diagnostic biomarkers for early-stage *** In silico analysis was performed to determine the most correlated genes of autophagy with ***1 and hsa-miR-519d were validated through this pilot clinical *** study included 50 Egyptian participants,who were classified into three subgroups:Group 1 included 34 patients with early-stage HCC,Group 2 included 11 patients with chronic liver disease,and Group 3(control)included 5 healthy *** patients were subjected to full laboratory investigations,including viral markers and alpha-fetoprotein(AFP),abdominal ultrasound,and clinical assessment with the Child–Pugh score ***,the patients with HCC underwent triphasic computed tomography with contrast to diagnose and determine the tumor site,size,and *** real-time polymerase chain reaction was used to assess hsa-miR-519d-3p and SQSTM1 in the serum of all the study *** Hsa-miR-519d-3p was significantly upregulated in patients with HCC compared with those with chronic liver disease and healthy subjects with an area under the curve(AUC)of 0.939,with cutoff value 8.34,sensitivity of 91.2%,and specificity of 81.8%.SQSTM1 was upregulated with an AUC of 0.995,with cutoff value 7.89,sensitivity of 97.1%,and specificity of 100%.AFP significantly increased in patients with HCC with an AUC of 0.794,with cutoff value 7.30 ng/mL,sensitivity of 76.5%,and specificity of 72.7%.CONCLUSION This study is the first to show a direct re

关键词： Autophagy Hepatocellular carcinoma miRNA miR-519d Stem cell SQSTM1

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Heavy Metals Contents of Municipal Solid Waste dumpsites in Potiskum, Yobe State Nigeria

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Journal of Environmental Protection 2020年第9期11卷 709-717页

作者： G. d. ibrahim E. O. Nwaichi G. O. Abu Centre for Occupational Health Safety and Environment University of Port Harcourt Port Harcourt Nigeria department of Preliminary Studies Umar Suleiman College of Education Gashu’a Nigeria department of Biochemistry Faculty of Science University of Port Harcourt Port Harcourt Rivers State Nigeria department of Microbiology Faculty of Science University of Port Harcourt Port Harcourt Rivers State Nigeria

The concentrations of As, Cd, Cr, Cu, Ni, Pb, Fe and Zn in selected dumpsites in Potiskum were determined with Buck Scientific 210VGB Atomic Absorption Spectrometer (AAS) AVG 210. One-way ANOVA was deployed at p d triplicate values. It was found that the concentration (mg·kg-1) of studied heavy metals in Potiskum dumpsites ranged from 0.108 ± 0.02 - 262.536 ± 0.68 with pattern of accumulation Pb (262.536 ± 0.02) > Zn (183.369 ± 0.58) > Fe (159.453 ± 0.50) > Cu (111.382 ± 0.62) > Cr (43.523 ± 0.36) > Ni (6.419 ± 0.26) > Cd (0.679 ± 0.01) > As (0.108 ± 0.02) mg·kg-1. The concentrations of As, Cr, Ni, Fe and Zn fell below the WHO standards while those of Pb, Cd and Cu were above set limits by WHO. High acidity corresponds markedly with high levels of Cd, Cu, Cr and Zn and requires urgent attention as this trend is capable of groundwater contamination that will cause public health concern in affected areas.

关键词： Heavy Metals Concentration Uptake Pattern dumpsites Municipal Solid Wastes

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