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New trends in pharmacological treatment of acute kidney injury

Asian Pacific Journal of Tropical Biomedicine 2021年第7期11卷 285-297页

作者： Heba M.I.abdallah Department of Pharmacology Medical Research DivisionNational Research CentreGiza 12622Egypt

Acute kidney injury,previously known as acute renal failure(AKI),is defined as an abrupt decrease in kidney function that occurs within hours or *** new nomenclature opens a new door for possibility of treatment of developing renal injury before progression to unresolved renal *** arises due to diverse etiologic factors that rely mainly on three categories namely,prerenal,intrinsic renal,and post-renal factors with different clinical pictures,and confers a spectrum of injury ranging from mild to severe and sometimes leads to end-stage renal *** of pathogenesis and other factors generate barriers to developing effective treatments despite a large number of experimental and clinical *** this review,recent advances in the potential of the currently used drugs for renoprotection,novel pharmacological targets,and prospective therapeutics for AKI are *** information in this review was extracted from electronic resources(Pub med,Google Scholar,Wiley,Science Direct,Springer),and English scientific books by using keywords including kidney,injury,recent therapy,and pharmacological *** articles were carefully checked for their relevance to the current *** targets of cellular repair or regenerative processes involved in AKI such as autophagy,ferroptosis inhibition,and p53 antagonism seem to be effective in disease *** may help researchers and clinicians to understand how to target the interrelated molecular and cellular mechanisms underlying the pathogenesis of AKI.

关键词： Acute kidney injury Recent therapy Promising pharmacological targets

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Spinal cord injury regeneration using autologous bone marrowderived neurocytes and rat embryonic stem cells:A comparative study in rats

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World Journal of Stem Cells 2020年第12期12卷 1591-1602页

作者： Mir Sadat-Ali Dakheel A Al-Dakheel Ayesha Ahmed Haifa A Al-Turki abdallah S Al-Omran Sadananda Acharya Methal I Al-Bayat Department of Orthopedic Surgery Imam Abdulrahman Bin Faisal University and King Fahd Hospital of the UniversityDammam 31952Saudi Arabia Department of Orthopedic Surgery Imam Abdulrahman Bin Faisal UniversityAlKhobar 31952Saudi Arabia Department of Pathology Imam Abdulrahman Bin Faisal UniversityDammam 31952Saudi Arabia Department of Obstetrics and Gynecology Imam Abdulrahman Bin Faisal UniversityDammam 31142Saudi Arabia Department of Orthopedic Surgery Imam Abdulrahman Bin Faisal University and King Fahd Hospital of the UniversityAlKhobar 31952Saudi Arabia Department of Public Health College of Public HealthImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

BACKGROUND Spinal cord injury(SCI)is an important cause of traumatic paralysis and is mainly due to motor vehicle ***,there is no definite treatment for spinal cord *** To assess the outcome of rat embryonic stem cells(rESC)and autologous bone marrow-derived neurocytes(ABMDN)treatment in iatrogenic SCI created in rats,and to compare the efficacy of the two different cell *** The study comprised 45 male Wistar rats weighing between 250 and 300 g,which were divided into three groups,the control,rESC and ABMDN *** anesthetized animals underwent exposure of the thoracic 8th to lumbar 1st vertebrae.A T10-thoracic 12th vertebrae laminectomy was performed to expose the spinal cord.A drop-weight injury using a 10 g weight from a height of 25 cm onto the exposed spinal cord was *** wound was closed in *** urinary bladder was manually evacuated twice daily and after each evacuation Ringer lactate 5 mL/100 g was administered,twice daily after each bladder evacuation for the first 7 postoperative *** the 10th day,the rats underwent nerve conduction studies and behavioral assessment[Basso,Beattie,Brenham(BBB)]to confirm *** embryonic stem cells,ABMDN and saline were injected on the 10th *** animals were euthanized after 8 wk and the spinal cord was isolated,removed and placed in 2%formalin for histopathological analysis to assess the healing of neural tissues at the axonal *** All the animals tolerated the procedure *** BBB scale scoring showed that at the end of the first week no recovery was observed in the ***-injection,there was a strong and significant improvement in rats receiving rESC and ABMDN as compared to the control group based on the BBB scale,and the Trainof-four-Watch SX acceleromyography device exhibited statistically significant(P<0.0001)regeneration of neural tissue after *** evaluation of the spinal cord showed maximum vacuolization and least gliosis i

关键词： Spinal cord injury Regeneration Embryonic stem cells Autologous bone marrow-derived neurocytes Iatrogenic Stem cells

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Geographic integration of hepatitis C virus: A global threat

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World Journal of Virology 2016年第4期5卷 170-182页

作者： moh.med A Daw abdallah.a.El-Bouzedi moh.med O Ahmed Aghnyia A Dau moh.med M Agnan Aisha M Drah Department of medical Microbiology and Immunology Faculty of Medicine Clinical Microbiology and Microbial Epidemiology Acting Physician Internal Medicine Scientific Coordinator of Libyan National Surveillance Studies of Viral Hepatitis and HIV Department of Laboratory medicine Faculty of Biotechnology Department of Microbiology and Parasitology Faculty of Veterinary Medicine Department of Surgery Tripoli Medical Centre Faculty of Medicine Department of Pharma-cology Faculty of Medical Technology Alga-bal Algarbi University and Faculty of Medicine

AIM To assess hepatitis C virus(HCV) geographic integration, evaluate the spatial and temporal evolution of HCV worldwide and propose how to diminish its burden. METHODS A literature search of published articles was performed using Pub med, medLINE and other related databases up to December 2015. A critical data assessment and analysis regarding the epidemiological integration of HCV was carried out using the meta-analysis method. RESULTS The data indicated that HCV has been integrated immensely over time and through various geographical regions worldwide. The history of HCV goes back to 1535 but between 1935 and 1965 it exhibited a rapid, exponential spread. This integration is clearly seen in the geo-epidemiology and phylogeography of HCV. HCV integration can be mirrored either as intra-continental or trans-continental. Migration, drug trafficking and HCV co-infection, together with other potential risk factors, have acted as a vehicle for this integration. Evidence shows that the geographic integration of HCV has been important in the global and regional distribution of *** HCV geographic integration is clearly evident and this should be reflected in the prevention and treatment of this ongoing pandemic.

关键词： Geo-epidemiology Integration Hepatitis C virus genotypes Geography Phylogeography

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