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spinal cord injury regeneration using autologous bone marrowderived neurocytes and rat embryonic stem cells:A comparative study in rats

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World Journal of stem Cells 2020年第12期12卷 1591-1602页

作者： Mir sadat-ali Dakheel A al-Dakheel Ayesha Ahmed Haifa A al-Turki abdallah s al-omran sadananda Acharya Methal I al-Bayat Department of Orthopedic surgery Imam Abdulrahman Bin Faisal University and King Fahd Hospital of the UniversityDammam 31952Saudi Arabia Department of Orthopedic surgery Imam Abdulrahman Bin Faisal UniversityAlKhobar 31952Saudi Arabia Department of Pathology Imam Abdulrahman Bin Faisal UniversityDammam 31952Saudi Arabia Department of Obstetrics and Gynecology Imam Abdulrahman Bin Faisal UniversityDammam 31142Saudi Arabia Department of Orthopedic surgery Imam Abdulrahman Bin Faisal University and King Fahd Hospital of the UniversityAlKhobar 31952Saudi Arabia Department of Public Health College of Public HealthImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

BACKGROUND spinal cord injury(sCI)is an important cause of traumatic paralysis and is mainly due to motor vehicle ***,there is no definite treatment for spinal cord *** To assess the outcome of rat embryonic stem cells(rEsC)and autologous bone marrow-derived neurocytes(ABMDN)treatment in iatrogenic sCI created in rats,and to compare the efficacy of the two different cell *** The study comprised 45 male Wistar rats weighing between 250 and 300 g,which were divided into three groups,the control,rEsC and ABMDN *** anesthetized animals underwent exposure of the thoracic 8th to lumbar 1st vertebrae.A T10-thoracic 12th vertebrae laminectomy was performed to expose the spinal cord.A drop-weight injury using a 10 g weight from a height of 25 cm onto the exposed spinal cord was *** wound was closed in *** urinary bladder was manually evacuated twice daily and after each evacuation Ringer lactate 5 mL/100 g was administered,twice daily after each bladder evacuation for the first 7 postoperative *** the 10th day,the rats underwent nerve conduction studies and behavioral assessment[Basso,Beattie,Brenham(BBB)]to confirm *** embryonic stem cells,ABMDN and saline were injected on the 10th *** animals were euthanized after 8 wk and the spinal cord was isolated,removed and placed in 2%formalin for histopathological analysis to assess the healing of neural tissues at the axonal *** all the animals tolerated the procedure *** BBB scale scoring showed that at the end of the first week no recovery was observed in the ***-injection,there was a strong and significant improvement in rats receiving rEsC and ABMDN as compared to the control group based on the BBB scale,and the Trainof-four-Watch sX acceleromyography device exhibited statistically significant(Pal tissue after *** evaluation of the spinal cord showed maximum vacuolization and least gliosis i

关键词： spinal cord injury Regeneration Embryonic stem cells Autologous bone marrow-derived neurocytes Iatrogenic stem cells

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An Attention-Based Approach to Enhance the Detection and Classification of Android Malware

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Computers, Materials & Continua 2024年第8期80卷 2743-2760页

作者： abdallah Ghourabi Department of Computer science College of Computer and Information SciencesJouf UniversitySakaka72388Saudi Arabia

The dominance of Android in the global mobile market and the open development characteristics of this platform have resulted in a significant increase in *** malicious applications have become a serious concern to the security of Android *** address this problem,researchers have proposed several machine-learning models to detect and classify Android malware based on analyzing features extracted from Android ***,most existing studies have focused on the classification task and overlooked the feature selection process,which is crucial to reduce the training time and maintain or improve the classification *** current paper proposes a new Android malware detection and classification approach that identifies the most important features to improve classification performance and reduce training *** proposed approach consists of two main ***,a feature selection method based on the Attention mechanism is used to select the most important ***,an optimized Light Gradient Boosting Machine(LightGBM)classifier is applied to classify the Android samples and identify the *** feature selection method proposed in this paper is to integrate an Attention layer into a multilayer perceptron neural *** role of the Attention layer is to compute the weighted values of each feature based on its importance for the classification *** evaluation of the approach has shown that combining the Attention-based technique with an optimized classification algorithm for Android malware detection has improved the accuracy from 98.64%to 98.71%while reducing the training time from 80 to 28 s.

关键词： Android malware malware detection feature selection attention mechanism LightGBM mobile security

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sodium nitroprusside as a signal molecule for up-regulating membrane characteristics,antioxidant defense system to improve flax productivity under water stress

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Oil Crop science 2024年第3期9卷 160-169页

作者： N.M.al-Ashkar B.A.Bakry H.M.s.El-Bassiouny M.M.s.abdallah M.s.sadak Botany Department Agricultural and Biological Research InstituteNational Research Centre33 El Bohouth Street P.O.12622DokkiGizaEgypt Field Crops Research Department Agricultural and Biological Research InstituteNational Research Centre33 El Bohouth Street P.O.12622DokkiGizaEgypt

Water stress is a critical environmental adversity that significantly impacts the growth,development,and yield of flax *** this study,flax seeds were cultivated under different water irrigation requirements(WIR)(100%,75%,and 50%)to investigate the effects of exogenously supplied nitric oxide(NO)donor sodium nitroprusside(sNP)as foliar treatments at concentrations of 0.0 mmol/L,0.5 mmol/L,1.0 mmol/L,and 2.0 mmol/*** stress led to a significant decrease in plant growth,photosynthetic pigments,yield components such as oil and total carbohydrate *** also resulted in an increase in leaf H2O2 production,lipid peroxidation levels and activities of enzymatic antioxidants including polyphenol oxidase,superoxide dismutase,and nitrate reductase ***,foliar application of sNP improved photosynthetic pigments and antioxidant defense system which mitigated the negative impact of water stress on growth and yield productivity by reducing oxidative damage caused by reactive oxygen species *** use of sNP also decreased H_(2)O_(2) accumulation levels,lipid peroxidation levels,and improved membrane *** treatment at concentration of 2 mmol/L showed superior results compared to other concentrations with extremely significant increases observed in yield characteristics such as oil content,total carbohydrate percentages,and unsaturated fatty acids to saturated fatty acids ratio.

关键词： Flax Fatty acid sodium nitroprusside Antioxidant enzymes Yield

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search for production of dark fermion candidates in association with heavy neutral gauge boson decaying to dimuon in proton-proton collisions at√s=8 TeV using CMs open data

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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.Mahmoud H.abdallah M.T.Hussein s.Elgammal Centre for theoretical physics The British University in EgyptEgypt Physics Department Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark matter using a part of the data recorded by the CMs experiment during run-I of the LHC in 2012 with a center of mass energy of 8 TeV and an integrated luminosity of 11.6 fb−*** data were gathered from the CMs open *** matter,in the framework of the simplified model(mono-Z′),can be produced from proton-proton collisions in association with a new hypothetical gauge boson,Z′.Thus,the search was conducted in the dimuon plus large missing transverse momentum *** benchmark scenario of mono-Z′,which is known as light vector,was used for interpreting the CMs open *** evidence of dark matter was observed,and exclusion limits were set on the masses of dark matter and Z′at 95%confidence level.

关键词： dark matter large hadron collider CMs open data search for new physics dark fermion

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Adaptive segmentation for Unconstrained Iris Recognition

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Computers, Materials & Continua 2024年第2期78卷 1591-1609页

作者： Mustafa alRifaee sally almanasra Adnan Hnaif Ahmad althunibat Mohammad abdallah Thamer alrawashdeh Faculty of Architecture and Design Al-Zaytoonah University of JordanAmman11733Jordan Faculty of Computer studies Arab Open UniversityRiyadh11681Saudi Arabia Faculty of science and Information Technology Al-Zaytoonah University of JordanAmman11733Jordan

In standard iris recognition systems,a cooperative imaging framework is employed that includes a light source with a near-infrared wavelength to reveal iris texture,look-and-stare constraints,and a close distance requirement to the capture *** these conditions are relaxed,the system’s performance significantly deteriorates due to segmentation and feature extraction ***,a novel segmentation algorithm is proposed to correctly detect the pupil and limbus boundaries of iris images captured in unconstrained ***,the algorithm scans the whole iris image in the Hue saturation Value(HsV)color space for local maxima to detect the sclera *** image quality is then assessed by computing global features in red,green and blue(RGB)space,as noisy images have heterogeneous *** iris images are accordingly classified into seven categories based on their global RGB *** the classification process,the images are filtered,and adaptive thresholding is applied to enhance the global contrast and detect the outer iris ***,to characterize the pupil area,the algorithm scans the cropped outer ring region for local minima values to identify the darkest area in the iris *** experimental results show that our method outperforms existing segmentation techniques using the UBIRIs.v1 and v2 databases and achieved a segmentation accuracy of 99.32 on UBIRIs.v1 and an error rate of 1.59 on UBIRIs.v2.

关键词： Image recognition color segmentation image processing localization

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Accuracy and precision of dried urine spot method for the detection of schistosoma mansoni circulating cathodic antigens in resource-limited settings

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Infectious Diseases of Poverty 2024年第1期13卷 103-104页

作者： abdallah Zacharia Clemence Kinabo Twilumba Makene Huda Omary George Ogweno Faraja Lyamuya Billy Ngasala Muhimbili University of Health and allied sciences Dar es Salaam Tanzania National Institute for Medical Research Mwanza Tanzania Neglected Tropical Diseases Control Program Ministry of Health Dodoma Tanzania

Background The World Health Organization recommends the use of schisto point-of-care circulating cathodic anti-gens(schisto POC-CCA)for screening of schistosoma mansoni as it offers better sensitivity than ***,there are limitation facing the use of this method including timely availability of the test *** aim of this study was to determine the reliability of dried urine spot(DUs)method for collection of urine and detection of *** using schisto POC-CCA cassettes in a resource-limited *** A cross-sectional study was conducted between October and November 2022 among 250 primary school children in sengerema District,northwestern *** CCA was detected in filter paper-based DUss,liquid urine using DUs schisto POC-CCA(index),and direct urine schisto POC-CCA(comparator)methods *** eggs in stool were detected using duplicate Kato-Katz(KK)*** measures of accuracy were com-puted and compared between the index and comparator *** strength of agreement between inter-raters precisions was tested using Cohen's kappa(k).Results This study revealed *** prevalence rates of 28.8%,54.0%and 50.8%by duplicate KK,direct urine schisto POC-CCA and DUs schisto POC-CCA methods *** mean intensity of infection among infected participants Was 86.3 eggs per gram of stool(EPG)ranging from 12.0 EPG to 824.0 *** sensitivity of DUs schisto POC-CCA and direct urine schisto POC-CCA Was 94.44%(95%CI:89.15-99.74%)and 97.22%(95%CI:93.43-100.00%)*** DUs schisto POC-CCA method had slightly higher specificity(66.85%)than direct urine schisto POC-CCA method(63.48%).The accuracy of the DUs schisto POC-CCA Was found to be slightly high(74.80%,95%CI:68.94-79.06%)compared to that of direct urine schisto POC-CCA(73.20%,95%CI:67.25-78.59%).There was good agreement between two laboratory technologists who performed the DUs schisto POC-CCA method on similar samples(k=0.80,95%CI:0.59-0.95).Con

关键词： Accuracy Point-of-care circulating cathodic antigen Dried urine spot schistosoma mansoni sensiti specificity

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Human biomonitoring of novel brominated flame retardants:A review on invasive and non-invasive biomarkers

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Emerging Contaminants 2024年第3期10卷 374-385页

作者： Oluwatoyin M.Olagoke Temilola O.Oluseyi Kelechi L.Njoku stuart Harrad Mohamed Abou-Elwafa abdallah Department of Cell Biology and Genetics Faculty of ScienceUniversity of LagosAkokaLagos101017Nigeria Department of Chemistry Faculty of ScienceUniversity of LagosAkokaLagos101017Nigeria school of Geography Earth and Environmental SciencesUniversity of BirminghamBirminghamB152TTUnited Kingdom

Novel brominated flame retardants(NBFRs)are a group of chemicals applied mainly as alternatives to the phased-out polybrominated diphenyl ethers(PBDEs).However,toxicological studies show that NBFRs may pose health risks similar to *** present study reviews available information on the biomonitoring of NBFRs and their metabolites in humans through invasive and non-invasive biomarkers,as well as the toxicological effects of these chemicals both in vivo and in *** general,higher concentrations of NBFRs were reported in tissues of occupationally exposed adults from NBFR production facilities,e-waste recycling facilities and inhabitants living close to these areas,compared to the general *** is worth noting that NBFR human biomonitoring data are limited to few countries located in North America,Europe and Asia,while data from developing countries are *** from in vivo and in vitro toxicity studies show that several NBFRs can cause adverse health effects through various modes of action,mainly:hormone disruption,genotoxicity,endocrine disruption,and behavioural *** few studies have investigated the biotransformation of NBFRs in humans,evidence suggests that the toxicity of some NBFRs may be augmented through their metabolites,as in the case of 2,3,4,5-tetrabromobenzoic acid(TBBA),which may exhibit higher toxicity than its parent compound 2-ethylhexyl-2,3,4,5-tetrabromobenzoate(EH-TBB).More research is required to assess toxicity thresholds,toxic endpoints,and tolerable intakes for various NBFRs,and their metabolites in *** epidemiological studies are highly recommended to further understand the risk arising from human exposure to different NBFRs,particularly in occupational settings.

关键词： NBFRs Human biomonitoring Human exposure Biomarkers Metabolites

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Advancing Early Detection of Colorectal Adenomatous Polyps via Genetic Data Analysis: A Hybrid Machine Learning Approach

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Journal of Computer and Communications 2024年第7期12卷 23-38页

作者： Ahmed s. Maklad Mohamed A. Mahdy Amer Malki Noboru Niki abdallah A. Mohamed Computer science Department College of Computer Science and Engineering in Yanbu Taibah University Medina Saudi Arabia Information systems Department Faculty of Computers and Artificial Intelligence Beni-Suef University Beni-Suif Egypt Computer science Department Faculty of Computers and Artificial Intelligence Beni-Suef University Beni-Suif Egypt Institute of Advanced science and Technology Tokushima University Tokushima Japan Information systems Department College of Computer Science and Engineering in Yanbu Taibah University Medina Saudi Arabia Mathematics and Computer science Department Faculty of Science Menoufia University Menoufia Egypt

In this study, a hybrid machine learning (HML)-based approach, incorporating Genetic data analysis (GDA), is proposed to accurately identify the presence of adenomatous colorectal polyps (ACRP) which is a crucial early detector of colorectal cancer (CRC). The present study develops a classification ensemble model based on tuned hyperparameters. surpassing accuracy percentages of early detection approaches used in previous studies, the current method exhibits exceptional performance in identifying ACRP and diagnosing CRC, overcoming limitations of CRC traditional methods that are based on error-prone manual examination. Particularly, the method demonstrates the following CRP identification accuracy data: 97.7 ± 1.1, precision: 94.3 ± 5, recall: 96.0 ± 3, F1-score: 95.7 ± 4, specificity: 97.3 ± 1.2, average AUC: 0.97.3 ± 0.02, and average p-value: 0.0425 ± 0.07. The findings underscore the potential of this method for early detection of ACRP as well as clinical use in the development of CRC treatment planning strategies. The advantages of this approach are highly expected to contribute to the prevention and reduction of CRC mortality.

关键词： Colorectal Adenoma Detection Colorectal Cancer Diagnosis Hybrid Machine Learning Genetics Analysis

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Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in saudi Arabia:A multicenter retrospective study

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World Journal of Diabetes 2024年第3期15卷 440-454页

作者： saleh Fahad alqifari Aya K Esmail Dalal M alarifi Ghalya Y alsuliman Maram M alhati May R Mutlaq Mohammed aldhaeefi shaden A alshuaibi Palanisamy Amirthalingam Abrar abdallah Afaf s Wasel Heba R Hamad shoroq alamin Tasneem H Atia Tariq alqahtani Department of Pharmacy Practice University of TabukTabuk 71491Saudi Arabia Department of Clinical sciences Sulaiman Alrajhi UniversityQassim 52726Saudi Arabia Department of Family Medicine International Medical CenterJeddah 23214Saudi Arabia Clinical and Administrative Pharmacy sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Pharmacology King Saud Bin Abdulaziz University for Health SciencesKing Abdullah International Medical Research CenterRiyadh 11481Saudi Arabia

BACKGROUND Patients with diabetes mellitus(DM)are predisposed to an increased risk of infection signifying the importance of vaccination to protect against its potentially severe *** Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices(CDC/ACIP)issued immunization recommendations to protect this patient *** To assess the adherence of patients with DM to the CDC/ACIP immunization recommendations in saudi Arabia and to identify the factors associated with the vaccine adherence *** An observational retrospective study conducted in 2023 was used to collect data on the vaccination records from 13 diabetes care centers in saudi Arabia with 1000 eligible patients in phase I with data collected through chart review and 709 patients in phase II through online *** Among participants,10.01%(n=71)had never received any vaccine,while 85.89%(n=609)received at least one dose of the coronavirus disease 2019(COVID-19)vaccine,and 34.83%(n=247)had received the annual influenza *** 2.96%(n=21),2.11%(n=15),and 1.12%(n=8)received herpes zoster,tetanus,diphtheria,and pertussis(Tdap),and human papillomavirus(HPV)vaccines,*** patients with DM in saudi Arabia,the rate of vaccination for annual influenza and COVID-19 vaccines was higher compared to other vaccinations such as herpes zoster,Tdap,pneumococcal,and *** such as vaccine recommendations provided by family physicians or specialists,site of care,income level,DM-related hospitalization history,residency site,hemoglobin A1c(HbA1c)level,and health sector type can significantly influence the vaccination rate in patients with *** non-vaccinated patients with DM,the most reported barriers were lack of knowledge and fear of side *** signifies the need for large-scale research in this area to identify additional factors that might facilitate adherence to CDC/ACIP vaccine recommendations in patients with *** In s

关键词： Diabetes mellitus Vaccine recommendation COVID-19 vaccine Influenza vaccine Pneumococcal vaccine Immunization Retrospective study

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Planning Target Volume Margin in Linac-Based stereotactic Radiosurgery for Brain Metastases

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Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： Hany s. Attallah Radwa M. Hamed Khaled M. EL-shahat aliaa Mahmoud Mahmoud abdallah Ibraheem Haggag Emad Moustafa Adel Yassin Department of Radiation Oncology International Medical Center (IMC) Cairo Egypt Department of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Department of Medical Physics Al Azhar University Cairo Egypt Department of Medical Physics International Medical Center (IMC) Cairo Egypt Department of Medical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatment of brain metastases with radiotherapy has shifted to the use of stereotactic Radio-surgery (sRs). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. Material and Methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.

关键词： sRs Brain Metastases PTV

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