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Intraocular pressure before and after capsulorhexis using two viscoelastic substances and two surgical approaches in enucleated porcine eyes

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1156-1160页

作者： Chiraz ben abdallah Walter Sekundo Markus SLadewig Daniel M.Handzel Augenzentrum Osthessen Fulda 36037Germany University Eye Hospital Philipps-University Marburg 35043Germany University Eye Hospital Philipps-University Campus FuldaFulda 36043Germany

AIM:To investigate the influence of ophthalmic viscoelastic devices(OVDs)and different surgical approaches on the intraocular pressure(IOP)before and after creation of the curvilinear circular capsulorhexis(CCC)as a measure for anterior chamber stability during this ***:Prospective experimental WetLab study carried out on enucleated porcine *** was measured before and after CCC with the iCare Rebound tonometer(iCare ic200;iCare Finland Oy,Vantaa,Finland).The OVDs used were a cohesive one[Z-Hyalin,Carl Zeiss Meditec AG,Germany;hyaluronic acid(HA)]and a dispersive[Z-Celcoat,Carl Zeiss Meditec AG,Germany;hydroxy propylmethylcellulosis(HPMC)].The CCC was created using Utrata forceps or 23 g microforceps in different combinations with the ***:Using the Utrata forceps the IOP dropped from 63.65±6.44 to 11.25±3.63 mm Hg during the *** use of different OVDs made no *** the 23 g microforceps the IOP dropped from 65.35±8.15 to 36.55±6.09 mm *** difference between IOP drop using either Utrata forceps or 23 g microforceps was highly significant regardless of the OVD ***:Using the sideport for the creation of the capsulorhexis leads to a lesser drop in IOP during this maneuver compared to the main incision in enucleated porcine *** use of different OVD has no significant influence on IOP drop.

关键词： cataract surgery ophthalmosurgical viscoelastic device intraocular pressure capsulorhexis enucleated porcine eye

Calculation and application of partition coefficients of light hydrocarbons in oil-based mud system

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Petroleum Exploration and Development 2022年第4期49卷 906-918页

作者： ben abdallah Bacem Rabie AHMADI Riadh LYNEN Frederic REKHISS Farhat Laboratoire LR3E.Ecole Nationale d’Ingénieurs de Sfax Rte Soukra km 3SfaxTunisia Separation Science Group Department of Organic and Macromolecular ChemistryGhent UniversityKrijgslaan 281-S4B-9000 GhentBelgium

To find out the relationship between the oil-based mud,the formation fluid and the extracted gas,we use a thermodynamic approach based on static headspace gas chromatography technique to calculate the partition coefficients of 47 kinds of light hydrocarbons compounds between nC5 and nC8 in two kinds of oil-based mud-air systems,and reconstruct the original formation fluid composition under thermodynamic *** oil-based drilling mud has little effect on the formation fluid compositions in the range of nC5-nC8(less than 1%for low-toxicity oil-based mud and less than 10%for oil-based mud).For most light hydrocarbon compositions,the partition coefficients obtained by vapor phase calibration and the direct quantitative methods have errors of less than 10%,and the partition coefficients obtained by direct quantitative method are more *** reconstructed compositions of the two kinds of crude oil have match degrees of 91%and 89%with their real compositions,proving the feasibility and accuracy of reconstructing the composition of original formation fluid by using partition coefficients of light hydrocarbon compositions between nC5 and nC8.

关键词： oil-based mud drilling mud gas light hydrocarbon compositions partition coefficients reservoir fluid

Pulmonary cavitary disease due to Mycobacterium xenopi

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Infectious Medicine 2022年第1期1卷 63-66页

作者： Yousri ben abdallah Nabil Belfeki Timothée Klopfenstein Souheil Zayet Pneumology Department Hôpital Nord Franche-Comté(HNFC)BelfortFrance Internal Medicine Department Groupe Hospitalier Sud Ile de FranceMelunFrance Infectious Diseases Department Hôpital Nord Franche-Comté(HNFC)BelfortFrance

Non-tuberculous mycobacteria are a significant cause of pulmonary infections worldwide and can be clinically *** xenopi(***)has a low pathogenicity and usually requires immunosuppression or lung *** describe herein a scarce case of pulmonary cavitary disease attributed to *** in a 57-year-old Caucasian patient with underlying structural lung disease successfully treated with rifampicin,ethambutol,clarithromycin,and amikacin.

关键词： Mycobacterium xenopi Non-tuberculous mycobacteria COPD Pulmonary cavitary disease

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油基钻井液体系轻烃组分分配系数计算及应用

石油勘探与开发 2022年第4期49卷 787-797页

作者： abdallah Bacem Rabie ben AHMADI Riadh LYNEN Frederic REKHISS Farhat 突尼斯斯法克斯国家工程学院LR3E实验室斯法克斯3000突尼斯比利时根特大学有机与高分子化学系根特9000比利时

采用一种基于静态顶空气相色谱技术的热力学方法研究了油基钻井液、地层流体和钻井液气体之间的关系,计算了两种油基钻井液-空气体系nC_(5)—nC_(8)范围内47种轻烃组分的分配系数,在热力学平衡条件下开展原始地层流体组分重构。研究表明... 详细信息

采用一种基于静态顶空气相色谱技术的热力学方法研究了油基钻井液、地层流体和钻井液气体之间的关系,计算了两种油基钻井液-空气体系nC_(5)—nC_(8)范围内47种轻烃组分的分配系数,在热力学平衡条件下开展原始地层流体组分重构。研究表明,油基钻井液对钻井液气体中nC_(5)—nC_(8)范围内的地层流体组分的影响很小,对于低毒性合成油基钻井液,影响小于1%,对于柴油基钻井液,影响小于10%。对于多数轻烃组分,采用气相校准法和直接定量法确定的分配系数的误差小于10%,直接定量法计算的分配系数更准确。两种原油样品重构组分与真实组分之间的匹配度分别为91%和89%,证明利用nC_(5)—nC_(8)范围内轻烃组分分配系数通过静态顶空分析重构原始地层流体组分的可行性和准确性较高。

关键词：油基钻井液钻井液气体轻烃组分分配系数地层流体

A Generalized Stationary Algorithm for Resonant Tunneling:Multi-Mode Approximation and High Dimension

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Communications in Computational Physics 2011年第9期10卷 882-898页

作者： Naoufel ben abdallah Hao Wu Department of Mathematical Sciences Tsinghua UniversityBeijing10084China Institut de Math´ematiques de Toulouse Universite Paul Sabatier118route de Narbonne31062 Toulouse CedexFrance.

The multi-mode approximation is presented to compute the interior wave function of Schr¨odinger *** idea is necessary to handle the multi-barrier and high dimensional resonant tunneling problems where multiple eigenv... 详细信息

关键词： Schrodinger equation numerical scheme resonant tunneling multi-mode approximation high dimension.

Efficacy of Essential Trace Elements Supplementation on Mineral Composition,Sperm Characteristics,Antioxidant Status,and Genotoxicity in Testis of Tebuconazole-treated Rats

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Biomedical and Environmental Sciences 2020年第10期33卷 760-770页

作者： Hajer ben SAAD Fatma ben abdallah Intidhar BKHAIRIA Ons BOUDAWARA Moncef NASRI Ahmed HAKIM Ibtissem ben AMARA Laboratory of Enzyme engineering and Microbiology National Engineering School in SfaxUniversity of SfaxB.P.11733038 SfaxTunisia Laboratory of Human Molecular Genetics Faculty of Medicine ofSfaxUniversity of SfaxTunisia Laboratory of Anatomopathology CHU Habib BourguibaUniversity of Sfax3029 SfaxTunisia Laboratory of Pharmacology Faculty of Medicine3029 SfaxUniversity of SfaxTunisia

Objective This research was performed to evaluate the effect of tebuconazole(TBZ)on reproductive organs of male rats and to assess the protective role of combined essential trace elements in alleviating the detrimental effect of TBZ on male reproductive *** For this purpose,48 rats were exposed to 100 mg/kg TBZ,TBZ supplemented with zinc(Zn),selenium(Se),copper(Cu),and iron(Fe),TBZ+(Se+Zn);TBZ+Cu;or TBZ+*** experiment was conducted for 30 consecutive *** TBZ caused a significant perturbation in mineral levels and reduction in reproductive organs weights,plasma testosterone level,and testicular antioxidant enzyme *** TBZ-treated group also showed a significant increase in sperm abnormalities(count,motility,and viability percent),plasma follicle-stimulating hormone and luteinizing hormone concentrations,lipid peroxidation,protein oxidation,and severe DNA degradation in comparison with the ***,TBZ caused testis ***,treatment with trace elements,in combination or alone,improved the reproductive organ weights,sperm characteristics,TBZ-induced toxicity,and histopathological modifications in *** TBZ exerts significant harmful effects on male reproductive *** concurrent administration of trace elements reduces testis dysfunction,fertility,and toxicity induced by TBZ.

关键词： Zinc Selenium Iron Copper Testicular toxicity

Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide

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World Journal of Gastroenterology 2010年第28期16卷 3499-3509页

作者： Mohamed Amine Zaouali Ismail ben mosbah Eleonora Boncompagni Hassen ben Abdennebi Maria Teresa Mitjavila Ramon Bartrons Isabel Freitas Antoni Rimola Joan Roselló-Catafau Experimental Hepatic Ischemia Reperfusion Unit Institut of Biomedical Research of BarcelonaSpanish National Research Council08036BarcelonaSpain Liver Transplantation and Graft Viability Unit August Pi i Sunyer Biomedical Research Institut08036Barcelona Spain Animal Biology Department Pavia University27100PaviaItaly Laboratory of Human Physiology Faculty of PharmacyUniversity of Monastir5000Monastir Tunisia Department of Physiology Faculty of BiologyUniversity of Barcelona08028BarcelonaSpain Physiological Sciences Department Bellvitge CampusInstitut of Biomedical Research of Bellvitge-Barcelona University08907BarcelonaSpain

AIM:To examine the relevance of hypoxia inducible factor(HIF-1)and nitric oxide(NO)on the preservation of fatty liver against cold ischemia-reperfusion injury(IRI). METHODS:We used an isolated perfused rat liver model and we evaluated HIF-1αin steatotic and non-steatotic livers preserved for 24 h at 4℃in University of Wisconsin and IGL-1 solutions,and then subjected to 2 h of normothermic *** normoxic reperfusion,liver enzymes,bile production,bromosulfophthalein clearance,as well as HIF-1αand NO[endothelial NO synthase(eNOS)activity and nitrites/nitrates]were also *** factors associated with the higher susceptibility of steatotic livers to IRI,such as mitochondrial damage and vascular resistance were evaluated. RESULTS:A significant increase in HIF-1αwas found in steatotic and non-steatotic livers preserved in IGL-1 after cold *** preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function *** benefits were enhanced by the addition of trimetazidine(an antiischemic drug),which induces NO and eNOS activation, to IGL-1 *** normoxic reperfusion,the presence of NO favors HIF-1αaccumulation,promoting also the activation of other cytoprotective genes,such as hemeoxygenase-1. CONCLUSION:We found evidence for the role of the HIF-1α/NO system in fatty liver preservation,especially when IGL-1 solution is used.

关键词： Fatty liver Tissue preservation Hypoxia inducible factor-1α IGL-1 Nitric oxide Trimetazidine

Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution

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World Journal of Gastroenterology 2010年第45期16卷 5693-5700页

作者： Mohamed Amine Zaouali Susagna Padrissa-Altés Ismail ben mosbah Hassen ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-mosbahi Joan Roselló-Catafau Experimental Hepatic Ischemia-Reperfusion Unit Institut d'Investigacions Biomèdiques de BarcelonaConsejo Superior de Investigaciones Científicas08036 BarcelonaSpain Unitat de Transplantament de Fetgei Viabilitat del' Empelt Institut d'Investigacions Biomèdiques August Pii Sunyer08036 BarcelonaSpain Laboratory of Human Physiology Faculty of PharmacyUniversity of Monastir5000 MonastirTunisia Unit of Hepatic Transplantation Edouard Herriot Hospital69003 LyonFrance Biomedical Research Center Esther Koplowitz CIBER-ehdInstitute of Health Carlos Ⅲ08036 BarcelonaSpain

AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1  solution supplemented with or without IGF-1 and then perfused "ex vivo " for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein ***: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also ***: IGL-1  enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion.

关键词： AKT Institut georges lopez-1 solution Insulin like growth factor-1 Ischemia reperfusion injury Nitric oxide Oxidative stress Steatotic graft preservation

Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia

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World Journal of Gastroenterology 2010年第4期16卷 479-483页

作者： Imen Sfar Walid ben Aleya Leila Mouelhi Houda Aouadi Thouraya ben Rhomdhane Mouna Makhlouf Salwa Ayed-Jendoubi Houda Gargaoui Taoufik Najjar Taieb ben abdallah Khaled Ayed Yousr Gorgi Laboratory of Immunology Charles Nicolle HospitalTunis 1006Tunisia Department of Gastroenterology Charles Nicolle HospitalTunis 1006Tunisia

AIM:To assess the possible association between PTPN22(R620W) gene polymorphism and inflammatory bowel disease(IBD).METHODS:One hundred and sixty-four patients with IBD 105 Crohn's disease(CD) and 59 ulcerative colitis(UC) and 100 healthy controls were *** of the PTPN22 gene 1858C→T polymorphism was performed by restriction fragment length polymorphism-polymerase chain reaction with Rsa Ⅰ ***:The genotypic and allelic frequencies of(R620W) PTPN22 gene polymorphism reveal a significant association of the PTPN22 620-W allele with IBD,compared to the healthy control group(OR:17.81,95% CI:4.18-21.86,P = 0.00001).Nevertheless,nodifference in this polymorphism was found between CD and UC *** significant association was found between the frequencies of genotypes of the PTPN22 gene with either the clinical features such as sex,age,age at disease onset,and extent of colitis,or the production of serological markers(anti-Saccharomyces cerevisiae antibody in CD and perinuclear anti-neutrophil cytoplasmic antibody in UC).CONCLUSION:These observations confirm the association of IBD susceptibility with the PTPN22 1858T(620-W) allele in Tunisian patients.

关键词： Inflammatory bowel disease PTPN22 Genetic polymorphism Genetic susceptibility