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Suppression of NLRP3 inflammasome by ivermectin ameliorates bleomycin-induced pulmonary fibrosis

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第8期24卷 723-733页

作者： Mai A.abd-elMAWLA Heba R.GHAIAD Enas S.GAD Kawkab A.ahmed Maha abdelMONEM Department of Biochemistry Faculty of PharmacyCairo UniversityCairo 11562Egypt Department of Pharmaceutical Sciences Faculty of PharmacyKing Faisal UniversityAl-Ahsa 31982Saudi Arabia Department of Pharmacology and Toxicology Faculty of PharmacySinai UniversityIsmailia 45511Egypt Department of Pathology Faculty of Veterinary MedicineCairo UniversityCairo 12211Egypt

Ivermectin is a US Food and Drug Administration(FDA)-approved antiparasitic agent with antiviral and anti-inflammatory *** recent studies reported the possible anti-inflammatory activity of ivermectin in respiratory injuries,its potential therapeutic effect on pulmonary fibrosis(PF)has not been *** study aimed to explore the ability of ivermectin(0.6 mg/kg)to alleviate bleomycin-induced biochemical derangements and histological changes in an experimental PF rat *** can provide the means to validate the clinical utility of ivermectin as a treatment option for idiopathic *** results showed that ivermectin mitigated the bleomycin-evoked pulmonary injury,as manifested by the reduced infiltration of inflammatory cells,as well as decreased the inflammation and fibrosis ***,ivermectin decreased collagen fiber deposition and suppressed transforming growth factor-β1(TGF-β1)and fibronectin protein expression,highlighting its anti-fibrotic *** study revealed for the first time that ivermectin can suppress the nucleotide-binding oligomerization domain(NOD)-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome,as manifested by the reduced gene expression of NLRP3 and the apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),with a subsequent decline in the interleukin-1β(IL-1β)*** addition,ivermectin inhibited the expression of intracellular nuclear factor-κB(NF-κB)and hypoxia‑inducible factor‑1α(HIF-1α)proteins along with lowering the oxidative stress and apoptotic ***,this study revealed that ivermectin could ameliorate pulmonary inflammation and fibrosis induced by *** beneficial effects were mediated,at least partly,via the downregulation of TGF-β1 and fibronectin,as well as the suppression of NLRP3 inflammasome through modulating the expression of HIF‑1αand NF-κB.

关键词： Intra-tracheal instillation Immunohistochemistry Transforming growth factor-β1(TGF-β1) Nuclear factor-κB(NF-κB) Lung fibrosis

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Limiting the Migration of Bisphenol A from Polycarbonate Using Dielectric Barrier Discharge

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Open Journal of Synthesis Theory and Applications 2014年第3期3卷 27-36页

作者： Emad A. Soliman ahmed Samir Ali M. A. hassan Mohamed S. Mohy-eldin Gamal abd el-Naim Center of Plasma Technology Al-Azhar University Nasr City Cairo Egypt Department of Chemistry Faculty of Science Al-Azhar University Nasr City Cairo Egypt Department of Polymer Materials Research Advanced Technology and New Materials Research Institute SRTA-City New Bourg El-Arab City Alexandria Egypt

Dielectric barrier discharge is used as a cheap technique for surface treatment of polycarbonate. The discharge system is working in open air at atmospheric pressure. The treatments are carried out at low discharge powers (1.5 and 2 W) for treatment time (2.5 - 15 min). The treated samples show decrease in the contact angle and increase in the crystallinity, thermal stability and surface roughness. The effect of ozone on the increase in the oxygen containing functional groups is discussed. The treatment process shows effective limitation of the migration of bisphenol A from the surface of polycarbonate due to the cross linking. Zero migration of bisphenole A is recorded as the sample is treated for 7.5 min. The treatment process is found to be very efficient with very low cost.

关键词： Dielectric Barrier Discharge Polycarbonate Bisphenole A Surface Treatment

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Determination of Full Energy Peak Efficiency of NaI(Tl) Detector Depending on Efficiency Transfer Principle for Conversion Form Experimental Values

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World Journal of Nuclear Science and Technology 2012年第3期2卷 65-72页

作者： Mohamed abd-elzaher Mohamed Salem Badawi ahmed el-Khatib Abouzeid ahmed Thabet Department of Basic and Applied Science Faculty of Engineering Arab Academy for Science Technology and Maritime Transport Alexandria Egypt Physics Department Faculty of Science Alexandria University Alexandria Egypt

In this work we calibrated the NaI(Tl) scintillation detectors (5.08 × 5.08 cm2 and 7.62 × 7.62 cm2) and the Full Energy Peak Efficiency (FEPE) for these detectors have been calculated for point sources placed at different positions on the detector axis using the analytical approach of the effective solid angle ratio. This approach is based on the direct mathematical method reported by Selim and Abbas [1,2] and has been used successfully before to calibrate the cylindrical, parallelepiped, and 4π NaI(Tl) detectors by using point, plane and volumetric sources. In addition, the present method is free of some major inconveniences of the conventional methods.

关键词： Full Energy Peak Efficiency NaI(Tl) Scintillation Efficiency Transfer

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Effects of Nephrolithiasis on Serum DNase(Deoxyribonuclease Ⅰ and Ⅱ) Activity and E3 SUMO-Protein Ligase NSE2(NSMCE2) in Malaysian Individuals

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Biomedical and Environmental Sciences 2015年第9期28卷 660-665页

作者： Faridah Yusof Atheer Awad Mehde Wesen Adel Mehdi Raha ahmed Raus Hamid Ghazali Azlina abd Rahman Department of Biotechnology Engineering College of EngineeringInternational Islamic University Malaysia Department of Medical Analysis Health and Medical Technical College Department of Chemistry College of Sciences for WomenUniversity of Baghdad Department of Urology Hospital Tengku Ampuan Afzan Department of Pathology Hospital Tengku Ampuan Afzan

Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase Ⅰ/Ⅱ activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage. Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase Ⅰ/Ⅱ activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by elISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria. Results The result indicated that mean levels of sera NSMCE2 have a significantly increase（P〈0.01） in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase Ⅰ and Ⅱ were significantly elevated in nephrolithiasis patients（P〈0.01）. Conclusion This study suggests that an increase in serum concentrations of DNase Ⅰ/Ⅱ and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis.

关键词： Nephrolithiasis DNase Ⅰ DNase Ⅱ E3 SUMO-protein ligase NSE2 NSMCE2

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Physiological Role of Humic Acid and Nicotinamide on Improving Plant Growth, Yield, and Mineral Nutrient of Wheat (<i>Triticum durum</i>) Grown under Newly Reclaimed Sandy Soil

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Agricultural Sciences 2014年第8期5卷 687-700页

作者： Hala Safwat Mohamed el-Bassiouny Bakry ahmed Bakry Amany abd el-Monem Attia Maha Mohamed abd Allah Agronomy Department Agriculture and Biology Division National Research Center Cairo Egypt Botany Department Agriculture and Biology Division National Research Center Cairo Egypt

Humic acid is not a fertilizer as it does not directly provide nutrients to plants, but is a compliment to fertilizer. Nicotinamide (Vitamin pp) is a stress-associated compound that can induce and regulate secondary metabolic accumulation and/or the manifestation of defense metabolism in plants. A field experiment was conducted at the experimental station of National Research center at el-Nubaria region, Egypt, to study the role of foliar application of humic acid (as soil conditioner 13 cm/l) and/or priming grains in nicotinamide (vitamin pp 5 mg/l) in saving irrigation water, decreasing fertilizer dose of NPK and at the same time increasing durum wheat (Triticum durum) cultivars’ (Beni Sweif-1 and Beni Sweif-3) productivity grown under newly reclaimed sandy soil exposed to drought for three weeks continuously. The results showed that plant treated with humic acid or nicotinamide increased significantly all morphological criteria (plant height, leaves number, fresh and dry weights of shoots), metabolism (photosynthetic pigment, total soluble sugar, total carbohydrates, total amino acids and proline), mineral contents (N, P, K, Ca and Mg) and yield (grain, straw and biology) of both cultivars amended with either recommended or half recommended doses of NPK. Foliar application of humic acid to plant priming in Vitamin pp induced significant increases in all studied parameters (morphology, chemical and yield) of plants amended with recommended or half recommended doses of NPK as compared with control plants. The maximum yields of grain, straw and biology of both cultivars were obtained in response to triple treatment (humic acid + nicotinamide + recommended dose of NPK) or (humic acid + nicotinamide + half recommended dose of NPK) respectively.

关键词： Humic Acid Metabolism Mineral Ions Nicotinamide Wheat

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Nuclear Matrix Protein-22 and Telomerase Reverse Transcriptase Are Diagnostic Markers for Bladder Carcinoma in Egypt

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Journal of Cancer Therapy 2011年第5期2卷 646-653页

作者： Amel abd Allah Hashim Mahmoud Youns ahmed abd Al-rahman Soltan Sahar abd el-mohsen Ali 不详

Bladder carcinoma is the foremost oncologic problem among males in Egypt. Here, we evaluated the possible diagnostic value of the urinary Nuclear Matrix Protein-22 “NMP-22” and Telomerase Reverse Transcriptase “hTERT” among histological subtypes of bladder cancer. 120 males with non-muscle invasive bladder cancer, 21 non malignant bladder conditions and 21 healthy volunteers were included in this study. Estimation of hTERT and NMP-22 was done by PCR-elISA and elISA, respectively, from voided urine and results were compared to those of urine cytology. Results showed that urinary hTERT and NMP-22 were significantly higher in all cancer patients compared to control group. NMP-22 was able to discriminate between transitional cell bladder carcinoma “TCC” patients and squamous cell bladder carcinoma “SqCC” ones. Both markers succeded to discriminate between some transitional cell bladder carcinoma grades. Additionally, hTERT discriminated between some Tumor stages in both TCC and SqCC. Our results demonstrated that urinary hTERT and NMP-22 could be efficient urinary markers for the differential diagnosis of bladder cancer.

关键词： Bladder Cancer Urinary Markers NMP-22 hTERT

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Identification and Conservation State of Painted Wall Plasters at the Funerary House in Necropolis of Tuna el-Gebel, el-Minia-Upper Egypt

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Open Journal of Geology 2017年第7期7卷 923-944页

作者： Nabil A. abd el-Tawab Bader abdelkareem E. ahmed Conservation Department Faculty of Archaeology South Valley University Qena Egypt

During this study, the principal aim carried out was to obtain more information about technique and conservation conditions of the Egyptian wall paintings during the Roman period in the funerary house in necropolis of Tuna el-Gabal, el-Minia-Upper Egypt. It’s going back to 2nd century AD and involves different sites of Ptolemaic and Roman chapels;some are in the immaculate established style while others are a blend of Pharaonic-Greek style and both are secured with mural painting. Deterioration problems observed on the wall paintings of the funerary house are, loss of plaster layers, disintegration of plaster layers, loss of paint layers (blistering and peeling), discoloration and severely damaged owing to a lot of deterioration factors as weakness of mud brick support, deterioration of surface treatments and to the widespread presence of different salts. The materials used in the painting, preparation layers and the state of conservation of the mural painting at funerary house were investigated by integrated physio-chemical measurements, particularly micro-Raman spectroscopy (µRaman), light optical microscopy (LOM), scanning electron microscopy (SEM) coupled with an energy dispersive X-ray analysis system (EDX), X-ray powder diffraction (XRD) and Fourier transform infrared (FT-IR). In addition, the morphology of multilayer plaster from wall painting was investigated using atomic force microscopy (AFM). A wide color palette utilized as a part of the necropolis has been identified with mineral pigments and pigment mixtures. It is found that, the paints were based on an organic binder and traditional pigments (azurite, hematite, ochre, vegetable black) were used as colorants on plaster. The examination demonstrated that the preparatory layer is verging on made of pure lime while the plaster layer based mainly of lime and gypsum with variable amounts of quartz. The obtained results provided information about the painting technique, chemical composition, crystal st

关键词： Tuna el-Gebel Roman Mortuary Houses Pigments Raman Microscopy Atomic Force Microscope (AFM)

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An Ex-Press implant versus trabeculectomy in a fibrotic bleb with late failure after previous trabeculectomy

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 383-387页

作者： Faried Wagdy Tharwat H.Mokbel Hisham elsorogy ahmed Alnagdy Dina abd elfattah abd-elmonem A.elhesy Menofia University Hospital Menofia UniversityMenofia 32511Egypt Mansoura Ophthalmic Center Faculty of MedicineMansoura UniversityMansoura 35516Egypt

AIM: To compare the outcome of an Ex-Press implant and subscleral trabeculectomy(SST) in the management of glaucoma after previous trabeculectomy on a fibrotic ***: This randomized prospective study included 28 eyes from 28 patients(age range: 42-55 y) with primary open angle glaucoma(POAG) presented with elevated intraocular pressure(IOP) with fibrotic bleb despite previous SST for more than 4 mo. The eyes enrolled in the study were divided into two groups: group I(subjected to Ex-Press implant surgery) and group II [subjected to SST with mitomycin C(MMC)]. The follow-up continued one year after surgery to evaluate IOP, visual acuity(VA), visual field(VF), and postoperative complications. RESULTS: A significant decrease in IOP was found in both groups with a higher reduction in Ex-Press implant surgery with the mean IOP of 14.50 mm Hg(P=0.001), while the SST group recorded the mean IOP of 16.50 mm Hg(P=0.001) after one year. However, the difference between the two groups in terms of the decrease in IOP was insignificant. Fewer postoperative complications were recorded in the Ex-Press implant surgery and more cases requiring further anti-glaucomatous medications were seen in the SST group. Both groups showed stability in terms of VA and ***: Ex-Press implant surgery and SST with MMC are two surgical alternatives for controlling IOP in late failure that occurs more than 4 mo after previous SST with a fibrotic bleb. However, Ex-Press shunt is a safer surgery with fewer complications.

关键词： Ex-Press implant trabeculectomy glaucoma fibrotic bleb

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The Usefulness of Diffusion Weighted and Contrast Enhanced Magnetic Resonance Imaging in Characterization of Inconclusive Ovarian Mass

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2020年第1期9卷 24-33页

作者： Ghada Mohammed abd el Razeq Mohammad A. M. ahmed Department of Radiodiagnosis Qena Faculty of Medicine South Valley University Qena Egypt Department of Obstetrics & Gynecology Qena Faculty of Medicine South Valley University Qena Egypt

Introduction: Ovarian cancer is the commonest reason for death in females due to gynecologic malignancy around the world. In contrast to other gynecologic tumours, the definitive diagnosis is accomplished days after of the index surgery by the histopathology. Preoperative assessment based on conventional MRI is not accurate. Information is expanding increasing about the ability of new MRI modalities to assess ovarian mass. Aim of the study: To assess the ability of dynamic contrast-enhanced MRI (DCE–MRI), and Diffusion-weighted image (DWI) to describe uncertain ovarian masses. Patients and Methods: This is a retrospective study. Patients were referred from radio-diagnosis department and gynecology department of Qena faculty of medicine hospitals, South Valley University. Patients had uncertain adnexal masses at ultrasound. Magnetic resonance examination was doneutilizing 1.5 Tesla machine. The protocol included T1WI, T2WI, T1WI following contrast, and DWI. Results: We included 44 patients with different forms of complex cystic and solid ovarian masses. The final pathology of the ovarian masses was 18 benign, 4 borderline, and 22 malignant. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for DWI were 100%, 94.4%, 96.3%, 100%, and 97.7% respectively. The performance of DWI was higher than the conventional MRI and DCE-MRI. Conclusion: DCE-MRI and DWI have accepted ability to recognize malignant ovarian mass.

关键词： Ovarian Contrast Diffusion MRI

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electro Analytical Determination of Di Hydroxybenzene Isomers Using Glassy Carbon electrode

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Journal of Chemistry and Chemical Engineering 2014年第7期8卷 654-661页

作者： Mahmoud Khodari ahmed abd el-Rady Ekram Rabee Nada Nabil Chemistry Department Faculty of Science South Valley University Qena 83523 Egypt

In this study, the electrochemical oxidation of CT （catechol）, HQ （hydroquinone） and RS （resorcinol） was investigated using cyclic and linear sweep voltammetries at GCE （glassy carbon electrode）. The GCE showed an excellent electro activity and reversibility towards the oxidation of these isomers at different conditions. HQ and CT showed one defined oxidation peak and one defined reduction peak while RS showed one defined oxidation peak. These isomers were determined also in their binary and tertiary mixtures. The calibration curves for CT, HQ and RS were obtained in the ranges of 5 × 10-6 to 1 × 10-3 ***-3, 5 × 10-6 to 5 × ***-3 and 1 × 10-5 to 1× 10-3 ***-3, respectively. The detection limits were 9 ×10-7, 3 × 10-7, 6 × 10-6 ***3 for CT, HQ and RS, respectively. At the optimal experimental conditions, these isomers were determined in different water samples. Also, the removal of catechol from aqueous solution by adsorption on activated charcoal and alumina was studied. After 24 h, 88.7% and 65.9% of catechol was removed using charcoal and alumina, respectively.

关键词： Di hydroxybenzene isomers glassy carbon electrode electroanalytical chemistry removal ofcatechol adsorption.

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