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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa abd el-Salam el-Sayed Mohamed Z.Sayed-ahmed Shaimaa ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

Efficient energy harvesting from PV Panel with reinforced hydrophilic nano-materials for eco-buildings

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Energy and Built Environment

Energy and Built Environment 2024年第3期5卷 393-403页

作者： ahmed elnozahy Heba abd-elbary Farag K.Abo-elyousr Department of electrical Engineering Faculty of EngineeringAssiut UniversityAssiut 71516Egypt

The main target of this research is to allow solar PV to contribute economically to an on-grid energy-efficient building where the dust accumulation is a significant ***-cleaning coatings such as hydrophobic or hy-drophilic materials have recently been introduced to reduce dust deposition on building-integrated PV(BIPV)*** hydrophilic Nano-coated material is examined as a solution to decrease the impact of the dust on the BIPV panels and harvest more solar *** impartial comparison of the BIPV panels performance under natu-ral dust conditions,manual cleaning,and hydrophilic nanomaterial coating is *** an exhaustive and qualitative experimental analysis,the anti-reflection and anti-static properties of the utilized Nano-coated material are *** experimental results show that the hydrophilic Nano-coated material significantly improves the gathered maximum output power by 18%compared to the manually wiped *** calculated efficiencies of the Nano-coated,manual cleaning,and dusty panels are 11%,9%,and 6%,respectively,which highlights the futureproofing of the Nano-coated solar *** to the dusty panels,the ecological and economical results show that the BIPV carbon emissions are desirably dropped by 11%while using Nano-coated PV panels and the payback period is reduced to 3.9 years,which is approximately 12.8%faster.

关键词： Hydrophilic Self-cleaning BIPV panels Nano-coating Techno-economic

Assessment of groundwater suitability for different activities in Toshka district,south Egypt

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Journal of Groundwater Science and Engineering 2024年第1期12卷 34-48页

作者： Marwa M Aly Shymaa AK Fayad ahmed MI abd elhamid Faculty of Engineering Mataria Helwan UniversityCairo 11718Egypt Division of Engineering International Academy for Engineering and Media Science(IAEMS)6th of October City 15515Egypt Hydraulics Research Institute National Water Research CenterMWRICairo 13621Egypt

Globally,groundwater has globally emerged as a crucial freshwater source for domestic,irrigation,and industrial *** evaluation of groundwater quality in the Toshka region is imperative to ensure its suitability for the extensive agricultural and industrial activities underway in this promising,groundwater-dependent development *** is particularly significant as Egypt increasingly relies on groundwater reserves to address freshwater deficits and to implement mega-development projects in barren *** this study,fifty-two samples were collected from the recently drilled wells tapping into the Nubian Sandstone Aquifer(NSA)in the Toshka *** quality was assessed through hydrochemical analysis,Piper diagram,and various indicators such as Na%,SAR,RSC,KR,MH and *** hydrochemical analysis revealed improved groundwater quality characteristics,attributed to continuous recharge from Lake *** Piper diagram categorised most of the water samples as"secondary salinity"water *** all wells proved suitable for irrigation with only two wells unsuitable based on MH values and six wells based on KR *** Total Hardness(TH)values,all samples were classified as"Soft",indicating their suitability for domestic and industrial *** Quality Index(WQI)results concluded that all samples met WHO and FAO guidelines for drinking and irrigation,*** distribution maps,constructed using GIS,facilitate the interpretation of the *** monitoring of quality parameters is essential to detect any deviation from permissible limits.

关键词： Nubian Sandstone Aquifer Water Quality Assessment Hydro-chemical Analysis Irrigation Quality Indicators Domestic Use Water Quality Index

Does dutasteride reduce the bleeding in transurethral resection of the prostate in patients on antiplatelet drugs?

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Current Urology 2024年第3期18卷 194-198页

作者： ahmed M.Rammah Alaa Meshref Ebram Soliman Islam Nasser abd elaziz Enmar Habib ahmed Yehia abdelaziz ahmed H.Abozamel Department of Urology Kasr Alainy HospitalFaculty of MedicineCairo UniversityCairoEgypt el Sahel Teaching Hospital CairoEgypt

Background The aim of this study was to assess the effect of a 4-week dutasteride treatment on reducing the intraoperative and postoperative bleeding,as well as the amount and duration of irrigation required to clear the urine after transurethral resection of the prostate(TURP)≥50 g in men receiving the antiplatelet drug(APD).Materials and methods This double-blind randomized clinical trial included patients with a prostate size≥50 g who were indicated for TURP and were already receiving *** study was conducted in the Urology Department of Cairo University over a 12-month *** preoperative laboratory investigations were performed in all ***,baseline prostate size,serum prostate-specific antigen level,and International Prostate Symptom Score were *** patients were randomly divided into 2 equal groups(groups A and B).Group A,the dutasteride group,received dutasteride(0.5 mg)once daily for 4 *** B,the placebo group,received a placebo capsule once daily for 4 *** groups underwent bipolar *** patients were excluded from the study;9 patients from group A and 6 patients from group B,either due to drug intolerability or loss *** The mean blood loss was insignificant between the 2 groups immediately after and 24 hours after surgery(Δhemoglobin:1.41±0.63 g/dL vs.1.48±0.54 g/dL,2.12±0.70 g/dL vs.2.31±0.78 g/dL,respectively,p=0.631,p=0.333;Δhematocrit:2.97%±1.51%vs.3.16%±1.36%,4.96%±1.87%vs.5.73%±4.39%,respectively,p=0.610,p=0.380).However,there were significant differences in duration of indwelling urethral catheter(5.10±0.55 days vs.5.80±1.79 days,p=0.048),duration of bladder irrigation(13.60±2.85 hours vs.16.33±6.62 hours,p=0.044),and the amount of saline used for bladder irrigation(11.03±2.30 L vs.13.87±6.13 L,p=0.046)between group A and group *** Treatment with dutasteride for 4 weeks before TURP in men receiving APD did not significantly reduce intraoperative or postoperativ

关键词： Dutasteride Transurethral resection of the prostate Postprostatectomy bleeding Antiplatelet drugs

Transient elastography and diffusion-weighted magnetic resonance imaging for assessment of liver fibrosis in children with chronic hepatitis C

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World Journal of Virology 2024年第3期13卷 89-97页

作者： Mohamed A el-Guindi Alif A Allam ahmed A abdel-Razek Gihan A Sobhy Menan E Salem Mohamed A abd-Allah Mostafa M Sira Pediatric Hepatology Gastroenterology and NutritionNational Liver InstituteMenoufia UniversityShebin El-Koom 32511MenoufiaEgypt Department of Diagnostic Radiology Mansoura Faculty MedicineMansoura 13551Egypt

BACKGROUND Chronic hepatitis C(CHC)is a health burden with consequent morbidity and *** biopsy is the gold standard for evaluating fibrosis and assessing disease severity and prognostic purposes *** altern-atives for liver biopsy such as transient elastography(TE)and diffusion-weighted magnetic resonance imaging(DW-MRI)are critical *** To evaluate TE and DW-MRI as noninvasive tools for predicting liver fibrosis in children with *** This prospective cross-sectional study initially recruited 100 children with CHC virus ***-four children completed the full set of investigations including liver stiffness measurement(LSM)using TE and measurement of apparent diffusion coefficient(ADC)of the liver and spleen using *** biopsies were evaluated for fibrosis using Ishak scoring *** and liver and spleen ADC were compared in different fibrosis stages and correlation analysis was performed with histopathological findings and other laboratory *** Most patients had moderate fibrosis(73.5%)while 26.5%had mild *** had severe fibrosis or *** majority(68.8%)had mild activity,while only 7.8%had moderate *** scores had a significant direct correlation with LSM(P=0.008)and were negatively correlated with both liver and spleen ADC but with no statistical significance(P=0.086 and P=0.145,respectively).Similarly,histopatho-logical activity correlated significantly with LSM(P=0.002)but not with liver or spleen ADC(P=0.84 and 0.98 respectively).LSM and liver ADC were able to significantly discriminate F3 from lower fibrosis stages(area under the curve=0.700 and 0.747,respectively)with a better performance of liver *** TE and liver ADC were helpful in predicting significant fibrosis in children with chronic hepatitis C virus infection with a better performance of liver ADC.

关键词： Apparent diffusion coefficient Chronic hepatitis C Diffusion-weighted magnetic resonance imaging Liver fibrosis Liver stiffness Transient elastography

Magnetoresistive properties of Ni-doped La_(0.7)Sr_(0.3)MnO_3 manganites

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Rare Metals 2016年第7期35卷 551-558页

作者： ahmed Mohamed ahmed abd el-Moez ahmed Mohamed Medhat abdelrady abdellateef hassan ahmed abd el-Ghanny Physics Department Faculty of ScienceSohag University

Lao.7Sr0.3Mnl_xNixO3 （x = 0, 0.025, 0.050 and 0.075） ceramics were prepared by the conventional solid-state reaction method. The partial substitution of Mn by Ni2＋ leads to a decrease in cell volume as well as a structural transition from the rhombohedral to the orthorhombic structure. Ni2＋ doping increases the electrical resistivity, decreases the semiconductor-metal transition temperature （Tms） and relatively enhances the room temperature magnetoresistance （MR）, especially in x = 0.025 and around Tins. With respect to conduction mechanism, the small polaron hopping （SPH） and the variable range hopping （VRH） models were used to ex- amine conduction in the semiconducting region.

关键词： Manganites X-ray diffraction Structure electrical resistivity Magnetoresistance

A Comparative Analysis on Surgical Outcomes and Complications of Endoscopic and Open Vein Harvesting Techniques

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Open Journal of Thoracic Surgery 2024年第2期14卷 29-39页

作者： Mohammed Fawzy eltaweel Ismail N. el-Sokkary ahmed Alherazi Mohamed Wael Badawi Mohammed G. abdellatif Bahaa A. elkhonezy Ibrahim K. Gamil Haytham Mohamed abd el Moaty Sarra Sadmi Mahmoud Khalil Department of Cardiothoracic Surgery Faculty of Medicine Menoufia University Shibin El Kom Egypt Department of Cardiovascular & Thoracic Surgery Faculty of Medicine Al-Azhar University Cairo Egypt Department of Cardiothoracic Surgery Faculty of Medicine Alexandria University Alexandria Egypt Faculty of Medicine University of Algiers Algiers Algeria Department of Cardiac Surgery Sabah Al-Ahmed Cardiac Center Al-Amiri Hospital Kuwait City Kuwait

Objective: The great saphenous vein (GSV) is commonly used as a conduit for grafting during CABG surgery, and open GSV harvesting (OVH), commonly used with long incision to expose the vein. However, endoscopic vein harvesting (EVH) is an alternative approach, utilizing specialized instruments and small incisions to harvest the vein. Methods: A retrospective analysis was conducted on a cohort of patients who underwent Coronary artery bypass graft (CABG) requiring great saphenous vein (GSV) harvesting which was done by EVH or OVH procedures. Demographic variables, including age and gender, were assessed for both groups. Intraoperative variables such as the number of grafts, cardiopulmonary bypass time, X clamp time, and type of procedure were analyzed. Postoperative variables, including infection and bleeding rates, were also evaluated. Results: The study included 30 patients each undergoing Coronary artery bypass graft (CABG) with need of great saphenous vein harvesting which was done by EVH and OVH. Demographic variables were well-matched between the two groups in terms of age, while a significant difference in gender distribution was observed. Obesity and smoking were more prevalent in the OVH group, and EVH was associated with a higher mean number of grafts compared to OVH. Conversion to an open technique occurred in a portion of the EVH cases, and infection rates did not significantly differ between the EVH and OVH groups. However, the incidence of postoperative bleeding was significantly higher in the EVH group. Conclusion: This study provides valuable insights into the demographic, intraoperative, and postoperative variables associated with EVH and OVH techniques. EVH demonstrated advantages in terms of reduced infection rates compared to OVH. However, the higher incidence of postoperative bleeding associated with EVH raises concerns about potential risks.

关键词： Endoscopic Vein Harvesting (EVH) Open Vein Harvesting (OVH) Coronary Artery Bypass Grafting (CABG) Great Saphenous Vein (GSV) Surgical Outcomes

Response of seed yield and fatty acid compositions for some sunflower genotypes to plant spacing and nitrogen fertilization

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Information Processing in Agriculture 2017年第3期4卷 241-252页

作者： Mohamed Ali abd el-Satar Asmaa abd-el-Halime ahmed Tamer hassan Ali hassan Oil Crops Research Department Field Crops Research InstituteAgricultural Research Center9 El-Gamaa St.GizaEgypt

A field experiment was conducted at the experiment Farm of Kafr-el-Hamam Research Station,Zagazig,Sharkia Governorate,Agricultural Research Center,Egypt during the two successive summer seasons of 2015 and 2016 to achieve the highest yield and good oil quality of three tested sunflower *** both seasons,the experiment was conducted using the split split plot design in randomized complete block design with three replicates arrangement keeping plant spaces(15,20 and 25 cm apart between hills)in main plots,nitrogen fertilization levels(15,30 and 45 N fad.^-1)in sub plots and sunflower genotypes(Giza 102,Sakha 53 and promising line of L120)in sub sub *** and quality traits were significantly influenced by plant spaces,nitrogen fertilization levels and genotypes as well as interactions in both seasons and their combined *** wider plant spacing of 25 cm seems to be a good compromise between the highest seed yield fad.^-1 and good acid composition of *** increasing of nitrogen fertilization level had a positive reflected on yield and desirable acid composition of *** 53 was ranked in the first order in stem diameter,head diameter,100-seed weight,seed weight plant^-1,flowered late and hence seed yield fad.^-1 as well as seed oil content whereas,Giza 102 characterized with its contained the highest proportion of oleic and linoleic unsaturated fatty *** highest values of head diameter,100-seed weight,seed weight plant^-1 and hence seed yield fad.^-1 as well as the highest proportion of oleic and linoleic unsaturated fatty acids composition were obtained by grown sunflower *** 53 at wider spacing of 25 cm with application of nitrogen fertilization levels of 45 N fad.^-*** and path analyses revealed that 100-seed weight and head diameter had the highest direct and indirect influence on seed weight plant1,at the same time also,oleic acid content and linoleic acid content had the highest direct and indirect effect inf

关键词： Sunflower Plant spacing Nitrogen fertilization Genotypes Seed yield Fatty acids

Micropunch grafting for healing of refractory chronic venous leg ulcers

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Chinese Journal of Plastic and Reconstructive Surgery 2022年第4期4卷 166-170页

作者： Aya Mohamed Samy Mostafa abd el-Halim ahmed hassan el-Sabbagh Department of Plastic and Reconstructive Surgery Mansoura University HospitalMansoura 35516Egypt Plastic Surgery Center Faculty of MedicineMansoura UniversityMansoura 35516Egypt

Background: Chronic venous ulcers are a serious problem for both patients and physicians. The CEAP classification(clinical manifestations(C), etiologic factors(E), anatomic distribution of disease(A), and underlying pathophysiologic findings(P)) for chronic venous disorders(CVD) was developed in 1994. Published papers on CVD use all or part of the CEAP. Micropunch grafts, which are a variation of skin grafts, have been used with great success in plastic surgery for both esthetic and reconstructive purposes. This study aimed to assess the outcomes of micropunch grafting in the treatment of chronic refractory venous ***: Patients with chronic venous ulcers who did not respond to conservative treatment for more than 6months were included in the study. All patients underwent ulcer coverage by micropunch skin grafts using a micrometer. The patients were discharged on the same day as the surgery. Micropunch skin grafts were manually counted per square centimeter intraoperatively and during follow-up using Dermlite DermatoschopeTM II Pro *** satisfaction was assessed by using a ***: Twenty patients underwent the surgery. Most of the patients were middle-aged males. The ulcers were predominantly small-and medium-sized. The mean operation time was 167.00 ± 86.01 min. After 6 months, the survival rate of the planted micrografts was 84%. Three ulcers had graft loss and two patients had an infection at the ulcer site, which was managed conservatively. The patients were followed-up for 14 ***: Micropunch grafting is a useful and convenient method for the treatment of difficult venous ulcers and can be performed on an outpatient basis.

关键词： Venous ulcer Micropunch grafting