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The effect of bi-annual community-directed treatment with ivermectin on the incidence of epilepsy in onchocerciasis endemic villages in South Sudan:a study protocol

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Infectious Diseases of Poverty 2018年第1期7卷 1177-1184页

作者： Gasim abd-elfarag Makoy Yibi Logora Jane YCarter Morrish Ojok Jackson Songok Sonia Menon Ferdinand Wit Richard Lako Robert Colebunders Department of Global Health Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Amsterdam Institute for Global Health and Development AmsterdamThe Netherlands Neglected Tropical Diseases Unit Ministry of HealthJubaRepublic of South Sudan Amref International University NairobiKenya Amref Health Africa JubaSouth Sudan Global Health Institute University of AntwerpAntwerpBelgium Policy PlanningBudgeting and ResearchMinistry of HealthJubaRepublic of South Sudan Global Health Institute University of AntwerpKinsbergen CentrumDoornstraat 3312610 AntwerpBelgium

Background:Nodding syndrome(NS)is a devastating epileptic illness of unknown aetiology mainly affecting children 5-15 years of *** nodding distinguishes NS from other forms of *** manifestations of the illness include mental and physical growth *** children die as a result of falling in fires or ***,it was shown that NS is only one of the phenotypic presentations of onchocerciasis associated epilepsy(OAE).Despite the strong epidemiological association between epilepsy and onchocerciasis,the causal mechanism is *** implementation of bi-annual community directed treatment with ivermectin(CDTi)and larviciding of rivers in northern Uganda,new cases of NS have ceased,while new cases continue to emerge in South Sudanese onchocerciasis-endemic areas with an interrupted CDTi *** study is designed to evaluate the potential effects of bi-annual CDTi on reducing the incidence of NS/OAE in onchocerciasisendemic areas in South ***:A pre-intervention door-to-door population-based household survey will be conducted in selected onchocerciasis-endemic villages in Mundri and Maridi Counties,which have a high prevalence of *** a validated questionnaire,the entire village will be screened by community research assistants for suspected epilepsy *** cases will be interviewed and examined by a trained clinical officer or medical doctor who will confirm or reject the diagnosis of ***-annual CDTi will be implemented in the villages and a surveillance system for epilepsy set *** implementing an epilepsy onchocerciasis awareness campaign we expect to obtain>90%CDTi coverage of eligible *** door-to-door survey will be repeated two years after the baseline *** incidence of NS/OAE will be compared before and after bi-annual ***:Our study is the first population-based study to evaluate the effect of bi-annual CDTi to reduce the incidence of NS/*** the study

关键词： Onchocerciasis Epilepsy Nodding syndrome South Sudan Ivermectin Community directed treatment Mundri Maridi

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Intraday Lead-Lag Relationship between Index Futures and Stock Index Markets:Evidence from Malaysia

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Journal of Modern Accounting and Auditing 2018年第10期14卷 561-569页

作者： Jude W. Taunson Mohd. Fahmi Bin Ghazali Minah Japang abd. Kamal Bin Char Universiti Malaysia Sabah SabahMalaysia

This paper investigates the lead-lag relationship between the stock index futures(known as FKLI)and its underlying index,the Kuala Lumpur Composite Index(KLCI)in the emerging Malaysian *** 15-second interval data,cross-correlation,and the partial adjustment model,we find a bi-directional asymmetric lead-lag relationship and that the KLCI’s lead over FKLI is much *** evidence also suggests that the KLCI returns over-react to information,more so once thin trading effects are ***,the evidences suggest that traders prefer to exploit stock specific information in the underlying market despite the advantages of trading the index futures.

关键词： lead-lag relations index futures emerging market

Clinical approach to diarrheal disorders in allogeneic hematopoietic stem cell transplant recipients

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World Journal of Hematology 2016年第1期5卷 23-30页

作者： Shadi Hamdeh abd Almonem M abdelrahman Osama elsallabi Ranjan Pathak Smith Giri Kailash Mosalpuria Vijaya Raj Bhatt Department of Internal Medicine Creighton University School of Medicine Department of Medicine Reading Health System Reading Department of Medicine University of Tennessee Health Science Center Department of Internal Medicine Division of Hematology-Oncology University of Nebraska Medical Center

Diarrhea is a common complication of allogeneic hematopoietic stem cell transplant(HSCT), with an average incidence of approximately 40%-50%. A wide variety of etiologies can contribute to diarrhea in HSCT patients, including medication-induced mucosal inflammation, infections, graft-vs-host disease and cord colitis syndrome in umbilical cord blood transplant. Clinical manifestations can vary from isolated diarrheal episodes, to other organ involvement including pneumonia or myocarditis, and rarely multiorgan failure. The approach for diagnosis of diarrheal disorders in HSCT patients depends on the most likely cause. Given the risk of life-threatening conditions, the development of clinically significant diarrhea requires prompt evaluation, supportive care and specific therapy, as indicated. Serious metabolic and nutritional disturbances can happen in HSCT patients, and may even lead to mortality. In this review, we aim to provide a practical approach to diagnosis and management of diarrhea in the post-transplant period.

关键词： Diarrhea Medication-induced diarrhea Allogeneic hematopoietic stem cell transplant Enteric infection Graft-vs-host disease

硫胺素及其磷酸酯与沙特阿拉伯人心血管代谢危险因素的相关性分析

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硫胺素及其磷酸酯与沙特阿拉伯人心血管代谢危险因素的相关性分析

决明子蛋白水解产物的抗氧化活性：热和胃肠稳定性，肽鉴定和计算机分析（英文）

作者： Nasser M Al-Daghri Omar S Al-Attas Khalid M Alkharfy Majed S Alokail Sherif H abd-Alrahman Shaun Sabico 刘庆春胡南摘

目前已表明硫胺素缺乏与几种胰岛素抵抗并发症有关。在本研究中,我们根据修订后的《国家胆固醇教育计划-成人治疗小组III》,随机招募沙特成年志愿者(166名男性和70名女性),并筛选出患有代谢综合征(MetS)的人员。用HPLC分析探讨循环硫胺... 详细信息

目前已表明硫胺素缺乏与几种胰岛素抵抗并发症有关。在本研究中,我们根据修订后的《国家胆固醇教育计划-成人治疗小组III》,随机招募沙特成年志愿者(166名男性和70名女性),并筛选出患有代谢综合征(MetS)的人员。用HPLC分析探讨循环硫胺素水平与心血管代谢相关参数的关系。

关键词：阿拉伯代谢综合征硫胺素

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现代食品科技 2019年第9期35卷 38-48页

作者：蔡俊泰徐芷茵徐国强李仁杰阿都马南·法希拉黄怀祖拉曼大学理学院马来西亚金宝31900 拉曼大学生物多样性研究中心马来西亚金宝31900 中国医科大学营养系台湾台中40402 马来西亚理工大学生物科学系马来西亚新山81310

决明子乃决明(Cassia obtusifolia L.)的干燥成熟种子,被中医界用于治疗各种疾病。本研究探讨决明子水解产物的抗氧化活性和稳定性,并鉴定其中的短肽。决明子蛋白经过碱性蛋白酶水解2~6 h,以超滤膜技术产生<3000 u肽组分。UF 2 h(2 h水... 详细信息

决明子乃决明(Cassia obtusifolia L.)的干燥成熟种子,被中医界用于治疗各种疾病。本研究探讨决明子水解产物的抗氧化活性和稳定性,并鉴定其中的短肽。决明子蛋白经过碱性蛋白酶水解2~6 h,以超滤膜技术产生<3000 u肽组分。UF 2 h(2 h水解产物分离出来的<3000 u组分)表现出最强的ABTS^·+清除能力(EC50=229μg/mL)和铁螯合能力(EC50=89μg/mL)。经过热处理和模拟胃肠消化后,UF 2 h的ABTS^·+清除能力都得以保留。UF 2 h仅在模拟胃肠消化胃后保留铁螯合活性。试验通过使用固相萃取,凝胶色谱和高效液相色谱对UF 2 h进行分离纯化。通过质谱分析,鉴定了四个肽:PMPVR(599.29 u),FETLPF(752.34 u),KMRDNL(775.37 u)和LDESKRF(893.50 u)。计算机分析预测,在模拟胃肠消化前,四个肽皆无毒无过敏性。胃肠消化后,四个肽释放的片段仍无毒,仅PMPVR和KMRDNL释放的肽片段无过敏性的。UF 2 h及其活性肽可作为抗氧化剂,用于开发功能性食品和营养保健品。

关键词：致敏性抗氧化肽决明胃肠稳定性热稳定性

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Residual Spray for the Control of <i>Aedes</i>Vectors in Dengue Outbreak Residential Areas

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Advances in Entomology 2019年第4期7卷 105-123页

作者： Nurulhusna Ab Hamid Siti Nurfadhlina Mohd Noor Mitra Saadatian-elahi Nur Rasyidah Isa Rohaiyu Md Rodzay Balqis Md Ruslan Topek Omar Mohd Iqbal Mohd Norsham Noor Hasmiza Amanzuri Nurliyana abd Khalil Izzah Farhah Zambari Muhammad Anwar Mohd Kassim Muhammad Khairi Kamarul Zaman Ainaa Mardia Bachtiar Effendi Afiq Ahnaf Hafisool Lee Teck Peng Brian Poong Mustafakamal Ibrahim Nurul Ashikin Roslan Lee Han Lim Medical Entomology Unit WHO Collaborating Centre for Vectors Institute for Medical Research Kuala Lumpur Malaysia Pôle Santé Recherche Risques et Vigilances Groupement Hospitalier Edouard Herriot Unité d’Hygiène Epidémiologie et Prévention Lyon France Vector Borne Disease Sector Disease Control Division Ministry of Health Malaysia Putrajaya Malaysia Bayer Co. (Malaysia) Sdn. Bhd. Petaling Jaya Malaysia Hulu Langat District Health Office Kajang Malaysia

The incidence of dengue in Malaysia has shown an increasing trend since the year 2000. Vector control is the primary approach for dengue control in Malaysia. There is an urgent need for new or modified approaches such as the residual spraying on the outer walls that can potentially last long enough to control the Aedes population, particularly in the outbreak-prone areas. In this field study, we conducted outdoor residual spraying (ORS) using a newly formulated polymer-enhanced suspension concentrate (SC-PE) of deltamethrin. The objectives of this study were to evaluate the efficacy of ORS using deltamethrin SC-PE and its effect on wild Aedes populations and to assess its residual bio-efficacy on painted cement walls against the pyrethroid-susceptible strains of laboratory-reared Aedes mosquitoes. Three rounds of spraying in a four-month cycle were conducted between 2014 and 2015 in four residential areas (low-rise and high-rise housing types) in Hulu Langat, Selangor. The bio-efficacy of the insecticide was evaluated by assessing its impact on vector population using ovitrap surveillance. Standard WHO wall deposit bioassay was adapted to determine bio-efficacy of deltamethrin, i.e. post 30 min knockdown and post 24 h mortality after exposure. During the treatment period, we observed significant reductions in the population of Ae. albopictus in the sprayed low-rise housing in both semi-indoor and outdoor environments, while in the high-rise housing, there was also a significant decline in Ae. aegypti population in the semi-indoor environment. The evaluation of the residual bio-efficacy of deltamethrin SC-PE against laboratory-reared Aedes mosquitoes showed that the insecticide lasted longer in the high-rise housing compared to the low-rise housing with >80% mortality achieved continuously for 16 weeks. We provide initial evidence on residual efficacy of deltamethrin SC-PE in reducing Aedes population size in the low-rise and high-rise housing. Our results showed tha

关键词： Indoor Residual Spraying Outdoor Residual Spraying Aedes Deltamethrin SC-PE Dengue Vector Control Ovitrap Index Malaysia

应用扩散张量成像评价腕管综合征:各向异性分数和表观扩散系数的价值

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国际医学放射学杂志 2018年第3期 363-363页

作者： A.S.Klauser M.abd ellah C.Kremser M.Taljanovic G.Schmidle M.Gabl 贺思健 Department of Radiology Medical University of Innsbruck

摘要目的应用扩散张量成像(DTI)技术定量评价腕管综合征(CTS),并采用2种方法确定阈值。方法纳入40例经神经传导检查确诊的腕管综合征病人和14名健康受试者

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祁连山主要植被下土壤水的时空动态变化特征

山地学报 2002年第6期20卷 723-726页

作者：牛云张宏斌刘贤德张学龙葛双兰甘肃省祁连山水源涵养林研究院甘肃省祁连山水源涵养林研究院甘肃张掖 734000

通过对祁连山青海云杉林、祁连圆柏林、亚高山灌丛林、牧坡草地等4种主要植被类型的土壤水测量数据进行分析表明,土壤水的空间垂直动态表现为随深度的增加而减少,可划分为土壤水分易变层、利用层、调节层三个层次;土壤水的时间动态可划... 详细信息

通过对祁连山青海云杉林、祁连圆柏林、亚高山灌丛林、牧坡草地等4种主要植被类型的土壤水测量数据进行分析表明,土壤水的空间垂直动态表现为随深度的增加而减少,可划分为土壤水分易变层、利用层、调节层三个层次;土壤水的时间动态可划分为土壤失水期、聚水期、退水期、稳水期四个时期。土壤水总的特征是,不同植被地类的土壤水季节变化规律基本一致,主要受降水量及其分配的影响。

关键词：祁连山土壤水分时间特征土壤水分空间特征土壤含水量

健康人白色和棕色脂肪组织的质子MRS测量：弛豫参数与不饱和脂肪酸

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国际医学放射学杂志 2021年第4期44卷 479-479页

作者： R.Ouwerkerk A.Hamimi J.Matta D,K.Z.abd-elmoniem J.F.Eary Z.A.Sater 席海蛟

摘要啮齿类动物棕色脂肪组织(BAT)活化可增加白色脂肪组织(WAT)分解,提高糖耐量。成年人可代谢性活化BAT, 其对人类糖尿病和肥胖的影响尚需要更好地显示 BAT

关键词：棕色脂肪组织 BAT 不饱和脂肪酸 MRS