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Clinical, virologic and phylogenetic features of hepatitis B infection in Iranian patients

World Journal of Gastroenterology 2008年第35期14卷 5448-5453页

作者： Golnaz Bahramali Majid Sadeghizadeh Samad Amini-Bavil-Olyaee Seyed-Moayed Alavian abbas behzad-behbahani Ahmad Adeli Mohammad-Reza Aghasadeghi Safieh Amini Fereidoun Mahboudi Department of Genetics Faculty of Basic SciencesTarbiat Modares UniversityTehran 14115-175Iran Biotechnology Department Pasteur Institute of IranTehran 13164IranMohammad-Reza AghasadeghiSafieh AminiHepatitis and HIV DepartmentPasteur Institute of IranTehran 13164Iran Baqiyatallah Research Center for Gastroenterology and Liver Diseases Tehran Hepatitis CenterTehran 14155-3651Iran Medical Technology Research Center School of Paramedical SciencesShiraz University of Medical SciencesShiraz ***Iran Biotechnology Department Pasteur Institute of IranTehran 13164Iran Hepatitis and HIV Department Pasteur Institute of IranTehran 13164Iran

AIM： To characterize the clinical, serologic and virologic features of hepatitis B virus （HBV） infection in Iranian patients with different stages of liver disease.METHODS： Sixty two patients comprising of 12 inactive carriers, 30 chronic hepatitis patients, 13 patients with liver cirrhosis and 7 patients with hepatocellular carcinoma （HCC） were enrolled in the study. The HBV S, C and basal core promoter （BCP） regions were amplified and sequenced, and the clinical, serologic, phylogenetic and virologic characteristics were investigated.RESULTS： The study group consisted of 16 HBeAgpositive and 46 HBeAg-negative patients. Anti-HBepositive patients were older and had higher levels of ALT, ASL and bilirubin compared to HBeAg-positive patients. Phylogenetic analysis revealed that all patients were infected with genotype D （mostly ayw2）. The G1896A precore （PC） mutant was detected in 58.1% patients. HBeAg-negative patients showed a higher rate of PC mutant compared to HBeAg-positive patients （2,2 = 9.682, P = 0.003）. The majority of patients with HCC were HBeAg-negative and were infected with PC mutant variants. There was no significant difference in the occurrence of BCP mutation between the two groups, while the rate of BCP plus PC mutants was higher in HBeAg-negative patients （2,2 = 4.308, P = 0.04）. In the HBV S region, the genetic variability was low, and the marked substitution was P120T/S, with a rate of 9.7% （n = 6）.CONCLUSION： In conclusion, HBV/D is the predominant genotype in Iran, and the nucleotide variability in the BCP and PC regions may play a role in HBV disease outcome in HBeAg-negative patients.

关键词： Hepatitis B virus Clinical and virologic features Genetic variability Phylogenetic analysis

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Hepatitis B virus genotypes in southwest Iran: Molecular, serological and clinical outcomes

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World Journal of Gastroenterology 2008年第10期14卷 1510-1513页

作者： Anahita Mojiri abbas behzad-behbahani Mehdei Saberifirozi Maryam Ardabili Mahmood Beheshti Marjan Rahsaz Mehrdad Banihashemi Negar Azarpira Bita Geramizadeh Baharak Khadang Afsaneh Moaddeb Mojgan Ghaedi Tahereh Heidari Ardeshir Torab Alireza Salah Saeid Amirzadeh Zahra Jowkar Davood Mehrabani Samad Amini-Bavil-Olyaee Mohammad Ali Dehyadegari Gastroenterology and Hepatology Research Center Namazi Hospital Shiraz University of Medical Sciences Shiraz Iran Organ Transplant Research Center Namazi Hospital Shiraz University of Medical Sciences Shiraz Iran Department of Microbiology School of Medicine Shiraz University of Medical Sciences Shiraz Iran Iranian Blood Transfusion Organization Shiraz Iran Biotechnology Department PasteurInstitute of Iran Tehran Iran Professor Alborzi Clinical Microbiology Research Center Shiraz University of Medical Sciences Shiraz Iran

AIM: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. METHODS: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed. RESULTS: Genotype D was the only type of HBV foundin different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV- infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and -negative individuals (P = 0.24). CONCLUSION: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease.

关键词： Hepatitis B virus-D Cirrhosis Iran Anti-HBe Polymerase chain reaction

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Heat transfer analysis in particle-laden flows using the immersed boundary method

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Particuology 2024年第7期90卷 394-403页

作者： Ali abbas Zaidi Department of Mechanical Engineering University of Manitoba75A Chancellors CircleWinnipegR3T 5V6Canada

This paper investigates an efficient immersed boundary method(IBM)for multiple-core CPU machines with local grid refinement for the calculation of heat transfer between fluids and finite-sized *** fluid momentum equations are solved by using the fractional step method,while the energy equation is solved by employing the second-order Adams-Bashforth *** efficient load balancing between the CPU cores,the coupling between particles and fluid is obtained by applying the body force in the fluid equations,which depends on the solid volume fraction of particles contained in each grid cell,and then by linearly interpolating the particle temperature and velocity on the fluid grid cell(in place of the delta function commonly used in literature).Several test cases from the literature are studied,and good agreement is observed between the simulation results and the ***,a scaling study on multiple core machines is performed,demonstrating the proposed IBM's capabilities for a significant reduction in processing time.

关键词： Heat transfer Immersed boundary method Particle resolved direct numerical simulations Fluid solid interactions

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Determination of uncertainties of geomechanical parameters of metamorphic rocks using petrographic analyses

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 345-364页

作者： behzad Dastjerdy Ali Saeidi Shahriyar Heidarzadeh Department of Applied Sciences University of Quebec at ChicoutimiSaguenayQCCanada SNC-Lavalin MontrealCanada

Geomechanical parameters of intact metamorphic rocks determined from laboratory testing remain highly uncertain because of the great intrinsic variability associated with the degrees of *** aim of this paper is to develop a proper methodology to analyze the uncertainties of geomechanical characteristics by focusing on three domains,*** treatment process,schistosity angle,and ***,the variabilities of the geomechanical laboratory data of Westwood Mine(Quebec,Canada)were examined statistically by applying different data treatment techniques,through which the most suitable outlier methods were selected for each parameter using multiple decision-making criteria and engineering *** indicated that some methods exhibited better performance in identifying the possible outliers,although several others were unsuccessful because of their limitation in large sample *** well-known boxplot method might not be the best outlier method for most geomechanical parameters because its calculated confidence range was not acceptable according to engineering ***,several approaches,including adjusted boxplot,2MADe,and 2SD,worked very well in the detection of true ***,the statistical tests indicate that the best-fitting probability distribution function for geomechanical intact parameters might not be the normal distribution,unlike what is assumed in most geomechanical ***,the negative effects of schistosity angle on the uniaxial compressive strength(UCS)variabilities were reduced by excluding the samples within a specific angle range where the UCS data present the highest ***,a petrographic analysis was conducted to assess the associated uncertainties such that a logical link was found between the dispersion and the variabilities of hard and soft minerals.

关键词： Intact rock parameters Natural variabilities Outlier detection methods Uncertainties Westwood mine Mineralogy

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Habitat preferences and nest site selection by sympatric populations of Middle Spotted Woodpecker(Dendrocoptes medius) and Syrian Woodpecker(Dendrocopos syriacus) in natural mountain forests of Southwest Iran

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Avian Research 2024年第1期15卷 81-90页

作者： Arya Shafaeipour Jerzy Michalczuk behzad Fathinia Department of Biology Yasouj UniversityYasujIran Department of Nature Conservation and Landscape Ecology University of RzeszowZelwerowicza 435-601RzeszowPoland

We examined habitat preferences and nesting requirements of sympatric populations of Middle Spotted Woodpecker(Dendrocoptes medius) and Syrian Woodpecker(Dendrocopos syriacus).We carried out our study in 2015–2018 in natural mountain forests of Southwest *** compared selected features of nesting,territory,and outside territory tree stands of the studied *** Middle Spotted Woodpecker occupied only oak forests,but the Syrian Woodpecker inhabited heterogenic forests that included the preferred tree of this species,the Mount Atlas *** recorded that in the breeding territories of the Middle Spotted Woodpecker,a greater area covered by tree crowns,as well as a larger number of trees,and a larger trunk basal area were observed in comparison to the territories occupied by the more plastic Syrian *** habitat preferences demonstrated by both species could be a result of the selection of tree stands that provide the necessary food resources for each woodpecker *** of Syrian Woodpecker to use heterogenic forest stands including tree species that produce fruits and as Mount Atlas Mastic trees,which likely allowed this species to colonise in Asia and Europe non-forest tree stands as orchards or *** results showed that poor tree condition and large tree trunk dimensions had a positive impact on the selection of nesting sites by both *** presence of trees with large trunk dimensions was associated with multiple years of use of woodpecker breeding sites in the studied *** habitats in suitable condition for both studied woodpeckers can be achieved by preserving natural forests in the mountain regions of Iran.

关键词： Habitat conservation Nesting requirements Primary cavity nesters Species co-occurrence

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An Overview of PRP-Delivering Scaffolds for Bone and Cartilage Tissue Engineering

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Journal of Bionic Engineering 2024年第2期21卷 674-693页

作者： Somayeh Baghersad behzad Bolandi Rana Imani Shabnam Afaghi Samira Davoudinia Department of Textile Engineering Amirkabir University of Technology(Tehran Polytechnic)Tehran159163-4311Iran Department of Biomedical Engineering Amirkabir University of Technology(Tehran Polytechnic)Tehran159163-4311Iran

Tissue engineering is nowadays an emerging approach that aims to replace or regenerate diseased or damaged organs with engineered constructs. Considering the key role of growth factors (GFs) in the tissue regeneration process, these biomolecules are considered an important part of the tissue engineering process, so the presence of growth factors in engineered scaffolds can accelerate tissue regeneration by influencing the behavior of cells. Platelet-rich plasma (PRP), as an autologous source of a variety of growth factors, is considered a therapeutic agent for the treatment of degenerative diseases. Regarding its ability to promote the healing process and tissue regeneration, PRP therapy has attracted great attention in bone and cartilage tissue engineering. Incorporating PRP and its derivatives into engineered scaffolds not only bioactivates the scaffold, but the scaffold matrix also acts as a sustained and localized growth factor release system. In addition, the presence of a scaffold can promote the bioactivity of GFs by providing an environment that facilitates their interaction, leading to enhanced effects compared to their free form. This review presents a brief overview of PRP's role in bone and cartilage tissue regeneration with the main focus on scaffold-mediated PRP delivery. In addition, the classification of platelet-rich products, current extraction techniques, terminology, and scaffold bioactivation methods are presented to provide a better understanding of the basics and the key aspects that may affect the effectiveness of therapy in bone and cartilage tissue engineering.

关键词： Platelet-rich plasma Growth factors delivery Scaffold Bone Cartilage

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Seismic performance evaluation of hybrid coupled shear wall system with shear and flexural fuse-type steel coupling beams

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 691-712页

作者： Zahra Ramezandoust abbas Tajaddini Panam Zarfam Department of Civil Engineering Science and Research branchIslamic Azad UniversityTehran 14778-93855Iran Department of Civil Engineering Karaj BranchIslamic Azad UniversityKaraj 31485-313Iran

Replaceable flexural and shear fuse-type coupling beams are used in hybrid coupled shear wall(HCSW)systems,enabling concrete buildings to be promptly recovered after severe *** study aimed to analytically evaluate the seismic behavior of flexural and shear fuse beams situated in short-,medium-and high-rise RC buildings that have *** building groups hypothetically located in a high seismic hazard zone were studied.A series of 2D nonlinear time history analyses was accomplished in OpenSees,using the ground motion records scaled at the design basis earthquake *** was found that the effectiveness of fuses in HCSWs depends on various factors such as size and scale of the building,allowable rotation value,inter-story drift ratio,residual drift quantity,energy dissipation value of the fuses,*** results show that shear fuses better meet the requirements of rotations and *** contrast,flexural fuses dissipate more energy,but their sectional stiffness should increase to meet other *** was concluded that adoption of proper fuses depends on the overall scale of the building and on how associated factors are considered.

关键词： hybrid coupled shear wall steel fuse coupling beam shear and flexural fuse nonlinear dynamic analysis seismic performance

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Global export flow of Chilean copper:The role of environmental innovation and renewable energy transition

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Geoscience Frontiers 2024年第3期15卷 336-345页

作者： Shujaat abbas Najia Saqib Umer Shahzad Graduate School of Economics and Management Ural Federal UniversityRussian Federation Brandenburg University of Technology Chair of Energy EconomicsGermany Adnan Kassar School of Business Lebanese American UniversityBeirutLebanon MEU Research Unit Middle East UniversityAmmanJordan Department of Finance College of Business AdministrationPrince Sultan UniversityRiyadhSaudi Arabia Department of Trade and Finance Faculty of Economics and ManagementCzech University of Life Sciences Prague

Copper is one of the most important minerals that has extensive use in environment-friendly technologies and renewable energy *** global urgency for environmental and ecological conservation through renewable energy transition has considerably enhanced the importance of copper and articles *** is a major producer of *** contributes more than one-third to global ***,this study explores the export flow of Chilean copper in response to increasing demand side conditions in major 24 trading partners from 2002 to *** objective is realized by constructing an augmented model for import demand that incorporates bilateral real exchange rate along with real GDP,environmental innovation,and renewable energy transition in major import *** estimated results of panel quantiles via moments techniques reveal a significant positive impact with increasing coefficients at higher quantiles,while environmental innovation and renewable energy transition in trading partners show significant positive impact with decreasing values of coefficients at higher *** findings urge Chile to enhance production capacity of copper and other critical mineral and improve participation in global value chain to meet sharply increasing copper demand from environmental innovation and renewable energy transition.

关键词： Copper Export flow Renewable energy Environmental innovation Panel data Quantiles via moments

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Feedback Mechanism-driven Mutation Reptile Search Algorithm for Optimizing Interpolation Developable Surfaces

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Journal of Bionic Engineering 2024年第1期21卷 527-571页

作者： Gang Hu Jiao Wang Xiaoni Zhu Muhammad abbas Department of Applied Mathematics Xi'an University of TechnologyXi'an 710054China School of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China Department of Mathematics University of SargodhaSargodha 40100Pakistan

Curvature lines are special and important curves on *** is of great significance to construct developable surface interpolated on curvature lines in engineering *** this paper,the shape optimization of generalized cubic ball developable surface interpolated on the curvature line is studied by using the improved reptile search ***,based on the curvature line of generalized cubic ball curve with shape adjustable,this paper gives the construction method of SGC-Ball developable surface interpolated on the ***,the feedback mechanism,adaptive parameters and mutation strategy are introduced into the reptile search algorithm,and the Feedback mechanism-driven improved reptile search algorithm effectively improves the solving *** IEEE congress on evolutionary computation 2014,2017,2019 and four engineering design problems,the feedback mechanism-driven improved reptile search algorithm is compared with other representative methods,and the result indicates that the solution performance of the feedback mechanism-driven improved reptile search algorithm is *** last,taking the minimum energy as the evaluation index,the shape optimization model of SGC-Ball interpolation developable surface is *** developable surface with the minimum energy is achieved with the help of the feedback mechanism-driven improved reptile search algorithm,and the comparison experiment verifies the superiority of the feedback mechanism-driven improved reptile search algorithm for the shape optimization problem.

关键词： Reptile search algorithm Feedback mechanism Adaptive parameter Mutation strategy SGC-Ball interpolation developable surface Shape optimization

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A Stochastic Model to Assess the Epidemiological Impact of Vaccine Booster Doses on COVID-19 and Viral Hepatitis B Co-Dynamics with Real Data

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2973-3012页

作者： Andrew Omame Mujahid abbas Dumitru Baleanu Department of Mathematics Federal University of TechnologyOwerri460114Nigeria Abdus Salam School of Mathematical Sciences Government College UniversityLahore54000Pakistan Department of Mathematics Government College UniversityLahore54000Pakistan Department of Computer Science and Mathematics Labanese American UniversityBeirutLebanon Institute of Space Sciences Magurele-BucharestRomania Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402Taiwan

A patient co-infected with COVID-19 and viral hepatitis B can be atmore risk of severe complications than the one infected with a single *** study develops a comprehensive stochastic model to assess the epidemiological impact of vaccine booster doses on the co-dynamics of viral hepatitis B and *** model is fitted to real COVID-19 data from *** proposed model incorporates logistic growth and saturated incidence *** analyses using the tools of stochastic calculus,are performed to study appropriate conditions for the existence of unique global solutions,stationary distribution in the sense of ergodicity and disease *** stochastic threshold estimated from the data fitting is given by:R_(0)^(S)=*** assessments are implemented to illustrate the impact of double-dose vaccination and saturated incidence functions on the dynamics of both *** effects of stochastic white noise intensities are also highlighted.

关键词： Viral hepatitis B COVID-19 stochastic model extinction ergodicity real data

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