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Revolution in the diagnosis and management of hepatitis C virus infection in current era

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World Journal of Hepatology 2022年第4期14卷 647-669页

作者： Farina M Hanif Zain Majid Nasir Hassan Luck abbas ali tasneem Syed Muddasir Laeeq Muhammed Mubarak Department of Hepatogastroenterology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Histopathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

Chronic hepatitis C virus(HCV)infection is a major global public health problem,particularly in developing part of the *** advances have been made in the early diagnosis and treatment of the *** management has been particularly revolutionized during the past two *** this review,we summarize the major advances in the diagnostic and management armamentarium for chronic HCV *** focus of the present review is on the newer directly acting anti-viral agents,which have revolutionized the management of chronic HCV *** of uncomplicated chronic HCV infection and of specific complications and special at-risk populations of patients will be covered in *** the advent and approval of highly effective and well tolerable oral agents,still many challenges remain,particularly the affordability,the equitable distribution and access to later *** World Health Organization aims to eliminate viral hepatitis including HCV by 2030 since its poses a major public health *** is an urgent need to ensure uniform and early access to diagnostic and therapeutic facilities throughout the world if the later goal has to be realized.

关键词： Hepatitis C virus Interferons Diagnosis Management Directly acting antiviral agents

Radiative properties of matter based on quantum statistical method

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Chinese Physics B 2017年第7期26卷 234-243页

作者： Rukhsana Kouser G tasneem Muhammad Saleem Shahzad S Sardar Amjad ali M H Nasim M Salahuddin Department of Physics and Applied Mathematics Pakistan Institute of Engineering and Applied Sciences Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of China

We present the preliminary results of our code OPAQS（opacity calculation using quantum statistical model） that is based on the self consistent Hartree-Fock-Slater model for the average atom. The code is capable of performing robust calculations of average charge state, frequency-dependent and mean opacities. The accuracy of the atomic model is verified by comparing the calculations of average charge state with various published results. The monochromatic opacities for iron computed at different sets of temperatures and densities are compared with LEDCOP. The Rosseland and Planck opacities for iron and aluminum are validated with some state-of-the-art codes. The results are in good agreement with the published data.

关键词： self-consistent average atom model average ionization state Rosseland opacity Planck opacity

Long non-coding RNA(lncRNA):A potential therapeutic target in acute lung injury

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Genes & Diseases 2022年第5期9卷 1258-1268页

作者： Almaz Zaki M.Shadab ali Vijay Hadda Syed Mansoor ali Anita Chopra tasneem Fatma Department of Pulmonary Critical Care and Sleep MedicineAll India Institute of Medical SciencesNew Delhi 110029India Department of Biosciences Jamia Millia Islamia UniversityNew Delhi 110025India Department of Biotechnology Jamia Millia Islamia UniversityNew Delhi 110025India Lab Oncology Dr.BRA-IRCHAll India Institute of Medical SciencesNew Delhi 110029India

Acute Lung Injury(ali)and its severe form Acute Respiratory Distress Syndrome(ARDS)are the major cause of ICU death ***/ARDS is characterized by severe hypoxemia and inflammation that leads to poor lung *** many advances in understanding and management,ali/ARDS is still causing significant morbidity and *** non-coding RNA(lncRNA)is a fast-growing topic in lung inflammation and *** is a class of non-coding RNA having a length of more than 200 *** has been a center of research for understanding the pathophysiology of various diseases in the past few *** studies have shown that lncRNAs are abundant in acute lung injury/injuries in mouse models and cell *** targeting these long non-coding RNAs,many investigators have demonstrated the alleviation of ali in various mouse ***,lncRNAs show great promise as a therapeutic target in *** review provides the current state of knowledge about the relationship between lncRNAs in various biological processes in acute lung injury and its use as a potential therapeutic target.

关键词： Acute lung injury Apoptosis Inflammation Long non-coding RNA(lncRNA) Macrophage polarization

Effect of radiation on compressibility of hot dense sodium and iron plasma using improved screened hydrogenic model with𝑙splitting

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Chinese Physics B 2021年第3期30卷 225-236页

作者： Amjad ali G Shabbir Naz Rukhsana Kouser Ghazala tasneem M Saleem Shahzad Aman-ur-Rehman M H Nasim Department of Physics and Applied Mathematics Pakistan Institute of Engineering and Applied SciencesIslamabad 45650Pakistan Department of Nuclear Engineering Pakistan Institute of Engineering and Applied SciencesIslamabad 45650Pakistan

High pressure investigations of matter involve the study of strong shock wave dynamics within the materials which gives rise to many thermal effects leading to dissociation of molecules,ionization of atoms,and radiation emission,*** response of materials experiencing a strong shock can be determined by its shock Hugoniot calculations which are frequently applied in numerical and experimental studies in inertial confinement fusion,laboratory astrophysical plasma,*** studies involve high energy density plasmas in which the radiation plays an important role in determining the energy deposition and maximum compressibility achieved by the shock within *** this study,we present an investigation for the effect of radiation pressure on the maximum compressibility of the material using shock Hugoniot *** shock Hugoniot calculations,an equation of state(EOS)is developed in which electronic contributions for EOS calculations are taken from an improved screened hydrogenic model with−l splitting(I-SHML)[High Energy Density Physics(2018)2648]under local thermodynamic equilibrium(LTE)*** thermal ionic part calculations are adopted from the state of the art Cowan model while the cold ionic contributions are adopted from the scaled binding energy *** Shock Hugoniot calculations are carried out for sodium and iron plasmas and our calculated results show excellent agreement with published results obtained by using either sophisticated self-consistent models or the first principle study.

关键词： self-consistent-field methods thermodynamics of plasmas average atom model shock Hugoniot calculation

Ion population fraction calculations using improved screened hydrogenic model with l-splitting

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Chinese Physics B 2018年第10期27卷 424-432页

作者： Amjad ali G Shabbir Naz Rukhsana Kouser Ghazala tasneem M Saleem Shahzad Aman-ur-Rehman M H Nasim Department of Physics and Applied Mathematics Pakistan Institute of Engineeringand Applied Sciences Department of Nuclear Engineering Pakistan Institute of Engineeringand Applied Sciences

Ion population fraction（IPF） calculations are very important to understand the radiative spectrum emitted from the hot dense matter. IPF calculations require detailed knowledge of all the ions and correlation interactions between the electrons of an ion which are present in a plasma environment. The average atom models, e.g., screened hydrogenic model with l-splitting（SHML）, now have the capabilities for such calculations and are becoming more popular for in line plasma calculations. In our previous work [ali A, Shabbir Naz G, Shahzad M S, Kouser R, Rehman A and Nasim M H 2018 High Energy Density Phys. 26 48], we have improved the continuum lowering model and included the exchange and correlation effects in SHML. This study presents the calculation of IPF using classical theory of fluctuation for our improved screened hydrogenic model with l-splitting（I-SHML） under local thermodynamic equilibrium conditions for iron and aluminum plasma over a wide range of densities and temperatures. We have compared our results with other models and have found a very good agreement among them.

关键词： self-consistent average atom model average ionization state ion population

Hollow fiber-based liquid phase microextraction followed by analytical instrumental techniques for quantitative analysis of heavy metal ions and pharmaceuticals

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Journal of Pharmaceutical Analysis 2020年第2期10卷 109-122页

作者： Wajid ali Khan Muhammad Balal Arain Yadollah Yamini Nasrullah Shah tasneem Gul Kazi Stig Pedersen-Bjergaard Mohammad Tajik Department of Chemistry Abdul Wali Khan University Mardan23200KPKPakistan Department of Chemistry University of Karachi75270KarachiPakistan Department of Chemistry Tarbiat Modares UniversityP.O.Box 14115-175TehranIran National Center of Excellence in Analytical Chemistry University of SindhJamshoro76080SindhPakistan School of Pharmacy University of OsloOsloNorway

Hollow-fiber liquid-phase microextraction(HF-LPME)and electromembrane extraction(EME)are miniaturized extraction techniques,and have been coupled with various analytical instruments for trace analysis of heavy metals,drugs and other organic compounds,in recent ***-LPME and EME provide high selectivity,efficient sample cleanup and enrichment,and reduce the consumption of organic sol-vents to a few micro-liters per ***-LPME and EME are compatible with different analytical in-struments for chromatography,electrophoresis,atomic spectroscopy,mass spectrometry,and electrochemical ***-LPME and EME have gained significant popularity during the recent *** review focuses on hollow fiber based techniques(especially HF-LPME and EME)of heavy metals and pharmaceuticals(published 2017 to May 2019),and their combinations with atomic spectroscopy,UV-VIS spectrophotometry,high performance liquid chromatography,gas chromatography,capillary elec-trophoresis,and voltammetry.

关键词： Hollow fiber liquid phase microextraction Electromembrane extraction Heavy metals Pharmaceuticals Instrumental techniques

Supporting tuberculosis program in active contact tracing:a case study from Pakistan

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Infectious Diseases of Poverty 2022年第2期11卷 72-76页

作者： Babar tasneem Shaikh Ahmed Khan Laghari Sulaiman Durrani alina Chaudhry Nabeela ali Integrated Health System Strengthening and Service Delivery(IHSS-SD)Activity JSI Research&Training Institute Inc.Mezzanine FloorThe Grand Hotel Street 1Sector E-11/1Islamabad 44000Pakistan

Tuberculosis(TB)is on the rise in Pakistan and there could be multiple reasons including poverty,difficulty in access to TB treatment services,non-compliance with treatment,social stigma *** to the TB program managers,limited treatment and testing sites for tuberculosis and lack of trained human resources play a major role in compromising TB management.A major lacuna in the TB control program is the absence of active contact tracing *** is essential for a disease where positive cases are known to be able to infect a further 10-15 individuals in a *** tuberculosis in Pakistan has been beleaguered by funding challenges and other systems’bottlenecks such as lack of skilled human resources and insufficient supply of medicines,despite the fact that disease burden is one of the highest in the *** it is a notifiable disease,active case finding,contact tracing and reporting is notoriously low throughout the *** to diagnostics and treatment facilities has been limited and stigma attached to the disease remains deeply entrenched among the *** have shown that enhanced and active approaches to contact investigation effectively identifies additional patients with TB among household contacts at a relatively modest ***’s Integrated Health Systems Strengthening and Service Delivery Activity extended support to the Health Departments of Sindh and Khyber Pakhtunkhwa *** collaboration with the two provincial TB programs,community based active contact tracing was conducted on 17,696 individuals,based on the index *** the contacts traced,243 cases were diagnosed as drug sensitive or drug resistant *** sessions were conducted to sensitize people on the various aspects of disease and importance of getting *** project also supported establishing three satellite Programmatic Management of Drug Resistant Tuberculosis(PMDT)sites for drug resistant TB treatment,enhancing the programs

关键词： Active contact tracing Community awareness Tuberculosis Pakistan

Effect of Growth Stage-Based Irrigation Schedules on Biomass Accumulation and Resource Use Efficiency of Wheat Cultivars

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American Journal of Plant Sciences 2013年第7期4卷 1435-1442页

作者： Muhammad Mubeen Ashfaq Ahmad tasneem Khaliq Syeda Refat Sultana Shahid Hussain Amjed ali Hakoomat ali Wajid Nasim Agro-Climatology Laboratory Department of Agronomy University of Agriculture Faisalabad Pakistan Agro-Climatology Laboratory Department of Agronomy University of Agriculture Faisalabad Pakistan Department of Agronomy Faculty of Agricultural Sciences and Technology Bahauddin Zakariya University Multan Pakistan Department of Environmental Sciences COMSATS Institute of Information Technology Vehari Pakistan. University College of Agriculture University of Sargodha Sargodha Pakistan

Climate and weather conditions greatly affect the performance of new wheat cultivars for yield and resource use efficiency. In order to know the effect of irrigation schedules based on growth stage (the most vital criterion in the region) on growth, yield and radiation use efficiency of wheat cultivars in Faisalabad conditions, a study was planned at Agronomic Research Area, University of Agriculture, Faisalabad during 2009-2010. Split plot design with irrigation levels in main plots and cultivars in sub-plots was implied. Irrigation levels were: IT = irrigation at tillering stage, ITS = irrigation at tillering and stem elongation stage, ISB = irrigation at stem elongation and booting stage and ITSBG = irrigation at tillering, stem elongation, booting and grain filling stage. Cultivars selected were: Faisalabad-2008, Lasani-2008, Miraj-2008, Shafaq-2006 and Chakwal-97. Irrigation treatment ITSBG gave higher grain yield (4.23 t·ha-1) followed by ISB (3.60 t·ha-1), however ITSBG was statistically similar to ISB in radiation use efficiency (RUE) for grain yield (RUEGY). Similarly the two treatments were statistically at par in maximum leaf area index, total dry matter (TDM) accumulation, cumulative photosynthetically active radiation (PAR), and RUETDM. Hence where less numbers of irrigations are available, irrigation at stem elongation and booting stage is suitable for achieving economic yield. Lasani-2008 produced maximum grain yield (4.37 t·ha-1) compared to other cultivars but it was statistically at par with Shafaq-2006 in plant height, TDM production and RUETDM. Depending on the availability, the two cultivars may be chosen under irrigated conditions of Faisalabad.

关键词： Triticum aestivum L. Irrigation Photosynthetically Active Radiation (PAR) Radiation Use Efficiency (RUE) Total Dry Matter (TDM)

A Survey on Fault Diagnosis and Fault Tolerant Methodologies for Permanent Magnet Synchronous Machines

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International Journal of Automation and computing 2020年第6期17卷 763-787页

作者： Erphan A.Bhuiyan Md.Maeenul Azad Akhand Sajal K.Das Md.F.ali Z.tasneem Md.R.Islam D.K.Saha Faisal R.Badal Md.H.Ahamed S.I.Moyeen Department of Mechatronics Engineering Rajshahi University of Engineering and TechnologyRajshahi 6204Bangladesh

This paper presents a comprehensive survey of fault diagnosis and fault tolerant approaches for permanent magnet synchronous machines(PMSM).PMSMs are prominent in the pervading usage of electric motors,for their high efficiency,great robustness,reliability and low torque *** spite of their extensive appliance,they can be quite non-resilient and inadequate in operation when faults appear in motor drive apparatus such as inverters,stator windings,sensors,*** may lead to insulation failure,torque fluctuations,overcurrent or even system *** that account,fault diagnosis and fault tolerant methods are equipped to enhance the stability and robustness in *** methodologies of PMSM fault diagnosis and tolerance are classified,discussed,reviewed and compared in this paper,beginning with mat hematical modeling of PMSM and then scrutinizing various fault conditions in ***,the scope of research on the topic is *** contribution of this review is to emphasize optimistic schemes and to assist researchers with the latest trends in this field for future directions.

关键词： Permanent magnet synchronous machine(PMSM) fault diagnosis fault tolerant control system(FTCS) fault detection stability.