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Texosome-based drug delivery system for cancer therapy: from past to present

Cancer Biology & Medicine 2015年第3期12卷 150-162页

作者： Hamideh Mahmoodzadeh Hosseini Raheleh Halabian Mohsen Amin abbas ali imani fooladi Applied Microbiology Research Center Baqiyatallah University of Medical Sciences Department of Drug and Food Control Faculty of Pharmacy Tehran University of Medical Sciences

Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor microenvironment, causes tumor growth and enhances tumor progression. Thus, cancer immunotherapy can be an appropriate approach to provoke the systemic immune system to combat tumor expansion. Texosomesj which are endogenous nanovesicles released by all tumor cells, contribute to cell-cell communication and modify the phenotypic features of recipient cells due to the texosomes＇ ability to transport biological components. For this reason, texosome-based delivery system can be a valuable strategy for therapeutic purposes. To improve the pharmaceutical behavior of this system and to facilitate its use in medical applications, biotechnology approaches and mimetic techniques have been utilized. In this review, we present the development history oftexosome-based delivery systems and discuss the advantages and disadvantages of each system.

关键词： Cancer therapy texosome mimetic tumor microenvironment immunotherapy

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Design of a multiplex PCR method for detection of toxigenicpathogenic in Vibrio cholerae

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Asian Pacific Journal of Tropical Medicine 2013年第2期6卷 115-118页

作者： abbas ali imani fooladi Iman Islamieh D Hosseini Doust R Karami A Marashi SM Applied Microbiology Research Center Baqiyatallah University of Medical SciencesTehranIran Department of Microbiology Faculty of Advance Sciences and TechnologyIslamic Azad University-Pharmaceutical Sciences BranchTehranIran Molecular Biology Research Center Baqiyatallah University of Medical SciencesTehranIran Department of Microbiology and Immunology Babol University of Medical SciencesBabolIran

Objective:To study virulence and regulatory genes(hlyA,ctxB,tcpI) in clinical strains of Vibrio ckolerae(***),***:Three important genes,tepI,hlyA and ctxB were used for detection of toxigenic and pathogenic *** by chain reaction assay method. Results:According to the results of the PCR,the incidence of hlyA,tcpI,and ctxB genes in clinical isolates was obtained as 94.7%(72 sample),90.8%(69 sample),and 92.1%(70 sample), *** strains possessed all genes except ctxB,six strains possessed all genes except tcpI,four strains possessed all genes except hlyA,one strain possessed only hlyA and 60 strains contained a combination of three *** hlyA,ctxB and tcpI,Conclusions:Result show that this method could be reliable to detect toxigenic-pathogenic strains of *** in Iran.

关键词： Vibrio cholerae Multiplex PCR Rapid detection

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Drug resistance pattern of Mycobacterium tuberculosis isolates from patients of five provinces of Iran

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Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 193-196页

作者： Mohammad Javad Nasiri Faranak Rezaei Samin Zamani Davod Darban-Sarokhalil abbas ali imani fooladi Hasan Shojaei Mohammad Mehdi Feizabadi Department of Microbiology School of Medicine.Tehran University of Medical Sciences Department of Microbiology School of Medicine.Alborz University of Medical Sciemces Applied Microbiology Research Centre Baqiyatallah University of Medical Sciences Department of Microbiology School of Medicine.Isfahan University of Medical Sciences

Objective:To determine the patterns of resistance to first line anti-tuberculosis(TB)drugs among a collection of Mycobacterium tuberculosis(MTB)isolates from 5 provinces of ***:A total of the 6 426 clinical specimens from patients suspected of active TB were collected from March 2010 to June *** specimens were subjected for microscopy and culture tests in the TB centers of studies *** susceptibility testing to the first line anti-TB drugs for culture positive MTB was performed on Lwenstein-Jensen(LJ)medium using proportion ***:Of 6 426 clinical specimens,261 were culture positive for mycobacteria,of which 252 were MTB and 9 were MOTT(mycobacteria other than tuberculosis).Of 252 MTB isolates.211(83.7%)were pan-susceptible and 41(16.3%)were resistant to at least one *** was most common to streptomycin.30 isolates(12.0%),followed by isoniuzid,20isolates(8.0%),rifampin,15 isolates(6.0%)and ethambutol,14 isolates(5.5%).Sixteen(6.3%)MTB isolates were MDR.A clear evidence of heterogeneity amongst the 5 provinces in the proportions with resistance to one or more drugs was observed[χ~2=12.209(4 degrees of freedom),P values=0.015 9].Conclusions:The prevalence of drug resistance in this study area underscoring the need for further enforcement of TB control strategies in the *** susceptibility testing for all TB cases to provide optimal treatment,establishing advanced diagnostic facilities for rapid detection of MDR-TB and continuous monitoring of drug resistance are recommended for prevention and control of drug-resistant TB.

关键词： Mycobacterium tuberculosis MDR tuberculosis Drug resistance Iran

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